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Clinical Interchangeability of PD-L1 Immunohistochemistry Assays in First-Line Non-Small Cell Lung Cancer Management With Cemiplimab
CONCLUSION: Similar efficacy (OS and PFS) was observed with the 22C3+ and SP263+ populations, demonstrating the interchangeability of these PD-L1 IHC assays for selecting patients with PD-L1 ≥50% for first-line cemiplimab monotherapy for advanced NSCLC. →
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Vision-RAG vs Text-RAG: A Technical Comparison for Enterprise Search
«`html Vision-RAG vs Text-RAG: A Technical Comparison for Enterprise Search Understanding the Target Audience The target audience for this comparison includes enterprise decision-makers, data scientists, and AI practitioners focused on enhancing document retrieval systems. Their pain points often revolve around inefficiencies in current retrieval methods, particularly in handling visually rich documents. They seek solutions that… →
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A randomised controlled trial to assess the feasibility and acceptability of remote psychosocial and exercise interventions for people with lupus: The ADAPT feasibility trial
Limited psychosocial support is available for people with lupus despite the highly reduced quality of life. This study assessed the acceptability, feasibility, and effectiveness estimations, of three (two psychosocial, one exercise) interventions. Lupus patients (N = 124) were randomised to a control arm or one of three interventions delivered remotely over 8-12 weeks: (1) listening… →
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Multimodal prognostic modeling of individual cognitive trajectories to enhance trial efficiency in preclinical Alzheimer’s disease
INTRODUCTION: Cognitive decline in asymptomatic preclinical Alzheimer’s disease (AD) is slow and variable, limiting detection of treatment effects. This study developed models to forecast trajectories and improve trial efficiency. →
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Eribulin plus Pyrotinib in Trastuzumab-Resistant, HER2-Positive Advanced Breast Cancer: A Single-Arm, Multicenter Phase II Trial (EPIC Trial)
CONCLUSION: The combination of Eribulin and Pyrotinib emerges as a viable treatment option for HER2-positive advanced breast cancer patients who have exhibited resistance to trastuzumab. Despite advancements in anti-HER2 therapies, further research is required to address remaining challenges in this specific clinical scenario. →
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Alibaba’s Qwen3-Max: Production-Ready Thinking Mode, 1T+ Parameters, and Day-One Coding/Agentic Bench Signals
«`html Understanding Alibaba’s Qwen3-Max: Key Features and Market Implications Alibaba has launched Qwen3-Max, a trillion-parameter Mixture-of-Experts (MoE) model, marking its most advanced foundation model to date. This model is readily accessible through Qwen Chat and Alibaba Cloud’s Model Studio API. The introduction of Qwen3-Max signifies a shift from preview to production, with two distinct variants:… →
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Test3R: Learning to Reconstruct 3D at Test Time
Test3R is a novel and simple test-time learning technique that significantly improves 3D reconstruction quality. Unlike traditional pairwise methods such as DUSt3R, which often suffer from geometric inconsistencies and poor generalization, Test3R leverages image triplets and self-supervised optimization at inference to enforce cross-pair consistency. This makes it both robust and cost-efficient, requiring minimal overhead while delivering… →
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Culturally adapted hypocaloric diet improves hepatic steatosis, inflammatory and oxidative biomarkers in Egyptian MASLD patients: a single-arm interventional study
CONCLUSION: A culturally tailored hypocaloric diet effectively improved hepatic steatosis, inflammatory status, and antioxidant capacity in Egyptian MASLD patients. These improvements were partially weight-independent and partially mediated by anti-inflammatory responses. These findings support hypocaloric dietary strategies as a potentially scalable therapeutic option for MASLD management in resource-limited settings, though the absence of a control group… →
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CloudFlare AI Team Just Open-Sourced ‘VibeSDK’ that Lets Anyone Build and Deploy a Full AI Vibe Coding Platform with a Single Click
«`html CloudFlare AI Team Just Open-Sourced ‘VibeSDK’ The CloudFlare AI team has open-sourced VibeSDK, a full-stack “vibe coding” platform that can be deployed end-to-end with a single click on Cloudflare’s network or via a GitHub Repo Fork. This platform packages code generation, safe execution, live preview, and multi-tenant deployment, allowing teams to run their own… →
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Google AI Research Introduce a Novel Machine Learning Approach that Transforms TimesFM into a Few-Shot Learner
Google AI Research Introduces a Novel Machine Learning Approach that Transforms TimesFM into a Few-Shot Learner Target Audience Analysis The target audience for this research includes data scientists, machine learning engineers, and business managers involved in predictive analytics and time-series forecasting. Their pain points revolve around the complexity and resource intensity of traditional forecasting methods,… →