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Efficacy and safety of avacopan for treatment of patients with ANCA-associated vasculitis receiving cyclophosphamide
CONCLUSIONS: This subgroup analysis of patients who received CYC shows similar rates of remission in the avacopan and prednisone taper groups. Compared with the prednisone taper regimen, the avacopan regimen was associated with a numerically lower relapse rate, greater improvement in eGFR, faster reduction in UACR, lower glucocorticoid-related toxicity and similar overall safety. These results… →
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Metabolomic profiling of patients with lupus nephritis reveals unique metabolites that are modulated through type I interferon inhibition by anifrolumab treatment in a phase 2 trial
CONCLUSION: Our findings establish a connection between type I interferon signalling, pyrimidine metabolism and uremic toxins in patients with LN and support the evaluation of urine uracil as a potential biomarker of response to anifrolumab. →
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Google DeepMind Introduces CodeMender: A New AI Agent that Uses Gemini Deep Think to Automatically Patch Critical Software Vulnerabilities
«`html Google DeepMind Introduces CodeMender: An AI Agent for Automated Software Vulnerability Patching Understanding the Target Audience The target audience for CodeMender primarily includes software developers, security professionals, and IT managers. Their pain points involve the increasing complexity of codebases and the growing number of vulnerabilities that need to be patched quickly and efficiently. They… →
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Building a Human Handoff Interface for AI-Powered Insurance Agent Using Parlant and Streamlit
«`html Building a Human Handoff Interface for AI-Powered Insurance Agent Using Parlant and Streamlit Human handoff is a key component of customer service automation—it ensures that when AI reaches its limits, a skilled human can seamlessly take over. In this tutorial, we’ll implement a human handoff system for an AI-powered insurance agent using Parlant. You’ll… →
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Business Model Innovation: Seven Essentials
Matt Harrison Clough / Ikon Images In an age where innovation reigns supreme, it’s easy for leaders to believe that a novel business model equals a ticket to success. The logic is appealing: Be the first to offer something new, or something familiar in a new way, and the profits will follow. This idea becomes… →
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Free or Paid Subscription? For Online Platforms, It’s a Dance.
“If the product is free, you are the product.” This phrase gained popularity as a description of the trade-off at the heart of many modern platforms—you use their service without paying, and they profit by selling your data. But there are other business models available to social-media companies, streaming services, and apps. Some platforms have… →
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OpenAI Debuts Agent Builder and AgentKit: A Visual-First Stack for Building, Deploying, and Evaluating AI Agents
OpenAI Debuts Agent Builder and AgentKit: A Visual-First Stack for Building, Deploying, and Evaluating AI Agents Understanding the Target Audience The target audience for OpenAI’s AgentKit includes AI developers, product managers, business analysts, and decision-makers within organizations looking to integrate AI solutions into their operations. This audience typically faces several pain points, including: Difficulty in… →
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The impact of a multi-component hospital avoidance programme in residential aged care homes: a stepped-wedge cluster randomised trial
CONCLUSIONS: Whilst not statistically significant, findings indicate that the intervention was associated with fewer ED transfers, but increased hospital admissions and overall hospital bed days. Programme implementation was impacted by major contextual barriers, notably the COVID-19 pandemic, which contributed to pressures on staffing and workload. →
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Empowering outpatients with breast cancer: The impact of a Continuous Care Program on self-efficacy-a randomized clinical trial
CONCLUSION: The study found that the CCP is effective in enhancing the self-efficacy of women with breast cancer in Iran. This program can be a beneficial method for improving patients’ well-being and delivering appropriate care to this population. The program can be shared with nurses in oncology departments to help them tailor their care plans… →
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A New Agency-Focused Supervision Approach Scales Software AI Agents With Only 78 Examples
A New Agency-Focused Supervision Approach Scales Software AI Agents With Only 78 Examples Understanding the Target Audience The target audience for this content primarily includes AI researchers, data scientists, software engineers, and business managers interested in implementing AI solutions. Their pain points include: Difficulty in effectively training AI models with limited data. Challenges in achieving… →