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Mixed-method process evaluation of the Evidence-based Medication knowledge Brokers in Residential Aged CarE (EMBRACE) helix-counterbalanced randomised controlled trial
CONCLUSION: Guideline implementation efforts in RACFs may benefit from a multifaceted implementation approach involving early engagement with aged care leadership and contextualised delivery of implementation strategies according to staff preferences and needs. →
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Cadonilimab combined with lenvatinib and transarterial chemoembolization for non-metastatic unresectable hepatocellular carcinoma: a multicenter, open-label, phase 2 study
CONCLUSIONS: Cadonilimab plus lenvatinib and TACE showed encouraging antitumor activity in patients with non-metastatic unresectable HCC. The safety profile was tolerable and manageable. The encouraging results observed warrant further study in larger clinical trials for this treatment combination. →
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Effects of high-definition transcranial direct current stimulation on muscle strength, proprioception, cutaneous sensitivity and their relationship with balance in older adults with a history of falls
CONCLUSION: A 4-week HD-tDCS intervention significantly improves static and dynamic balance, hip strength, and ankle inversion proprioceptive in older adults with a history of falls. Improved static balance is positively correlated with increased hip abduction strength. →
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Empirical tuberculosis treatment in infants living with HIV hospitalised with severe pneumonia in Africa (EMPIRICAL): a multicentre, randomised, open-label, 2 2 factorial, controlled superiority trial
BACKGROUND: Mortality among infants with severe HIV-associated pneumonia remains high globally. The EMPIRICAL trial evaluated whether empirical tuberculosis treatment (eTB-T) improves survival compared with the currently recommended microbiologically and clinically guided strategy. →
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Lessons From Tech’s Diversity Disclosures
Aron Vellekoop León/Ikon Images Transparency can be a powerful lever, yet it is also combustible. When businesses raise visibility faster than they build the capacity to deliver on what they’ve disclosed, transparency produces resistance and often backlash from multiple directions, even from those who share the same social-progress goals. This dynamic is particularly explosive with… →
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Brief Report: Prognostic Value of Kaposi Sarcoma Herpes Virus-Associated Clinical Symptom Scores in HIV-Associated Kaposi Sarcoma
CONCLUSIONS: KSCS score symptoms are common, especially in advanced HIV-KS. KSCS score 3 is associated with higher risk of progressive KS disease or death, despite treatment with antiretrovirals and chemotherapy. This population may benefit from improved diagnostic and management options. →
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Conditioned pain modulation is associated with anesthesia efficacy in patients with temporomandibular disorder
Conditioned pain modulation (CPM) assesses descending pain inhibition in humans and has been shown to be clinically relevant. However, the possible contribution of the CPM response to the efficacy of local anesthetics remains poorly understood. This study aimed to evaluate the association between the CPM response and the efficacy of topical anesthesia applied to the… →
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Invasive versus conservative strategy for older patients with myocardial infarction based on cognitive function: the SENIOR-RITA cognition analysis
CONCLUSIONS: Among those with evidence of cognitive impairment at randomisation, an invasive treatment strategy did not reduce the primary composite outcome of cardiovascular death or nonfatal MI, and there was no evidence of treatment effect heterogeneity based on cognition. The reduction in nonfatal MI events among those with cognitive impairment should be interpreted as an… →
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Computerised cognitive training combined with nutritional counseling in mild cognitive impairment — results of a 2 2 factorial randomized controlled trial (BrainFit-nutrition study)
CONCLUSION: The results of this study suggest, that in people with MCI, notable improvement in global cognition can be achieved in a six-months intervention period. When CCT is combined with digital nutritional counseling, the form of intervention — whether elaborate or basic — apparently did not modify the outcome; rather, this data set suggests that… →
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Effect of a lacto-vegetarian diet combined with 14-hour time-restricted eating on metabolic outcomes in women with Type 2 diabetes: a 24-week randomized controlled trial
CONCLUSION: A culturally adaptable lacto-vegetarian diet combined with a 14-hour time-restricted fasting regimen safely improves metabolic control and insulin sensitivity in women with Type 2 Diabetes, offering a practical, women-centric strategy that may be implementable within structured clinical nutrition services, although its staffing requirements, cost, and scalability require further evaluation. →