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Therapeutic Impact of Systemic Probiotics Combined with Mechanical Debridement in Peri-Implant Disease: A Clinical and Microbiological Evaluation
CONCLUSION: Systemic probiotics, when used as an adjunct to mechanical debridement, significantly improve clinical and microbiological outcomes in peri-implantitis management. This combination may offer a synergistic approach for enhanced therapeutic efficacy. →
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Incidence, Risk Factors, and Outcomes in Stressor-Associated Atrial Fibrillation: Insights From the VITAL-AF Trial
CONCLUSIONS: Among >30 000 primary care patients with adjudicated AF events, nearly one-third of incident AF cases were stressor associated. Despite similar risk factor profiles and comparably high rates of adverse outcomes, oral anticoagulant initiation is lower when AF is stressor associated. Future work is needed to define optimal approaches to prevention, surveillance, and management… →
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What the UN Treaty on Cybercrime May Mean for You
Carolyn Geason-Beissel/MIT SMR | Getty Images In crimes such as robberies or kidnappings, both the criminals and victims must directly interact in person, so it is obvious that they must both be in the same country for the crime to be committed. Local and/or federal authorities address such crimes. But cybercrimes involving data theft and… →
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Podcast: How Do Those Valentine’s Day Roses End Up in Your Bouquet? It’s Complicated.
Valentine’s Day is a day of love. But for those who sell roses, it’s probably a day full of something else. “Probably a lot of stress, right? This is the chance to make money for everybody that’s concerned, right? This is the opportunity where you can clean up for the year,” says Martin Lariviere, a… →
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Cognitive Resilience Training to Prevent PTSD and Major Depressive Disorder in Paramedic Recruits: A Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this randomized clinical trial, participants receiving iCT-R were approximately 5 times less likely to develop PTSD or MDD at 1-year follow-up compared with psychoeducation and 4 times less likely when compared with standard practice. These findings suggest that iCT-R appears to decrease the likelihood of developing PTSD and MDD in early… →
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Sex differences in neurocognitive response to metacognitive training in first-episode psychosis: Implications for personalized interventions
CONCLUSIONS: MCT enhances specific neurocognitive functions in FEP and shows promising effects for women in verbal memory processes. These findings underscore the importance of incorporating sex and diagnostic factors when tailoring early interventions for psychosis and highlight the potential of MCT as a personalized cognitive strategy. →
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Improving Delirium Screening and Detection in the Emergency Department (ED): The Implementation and Evaluation of the ED Delirium Detection Program
CONCLUSIONS: Although a comprehensive ED delirium training program successfully increased delirium screening, detection remained low. These findings suggest that sustainable delirium detection in the ED requires not only robust training but also deeply embedded workflow solutions and clear post-detection action pathways. →
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Efficacy and Safety of Letrozole, Misoprostol and Their Combination in First Trimester Missed Miscarriage: A randomised clinical trial
CONCLUSION: Combining letrozole with misoprostol significantly improves complete miscarriage rates with tolerable safety. Letrozole alone is safer but less effective. Thus, combination therapy may offer an optimal non-surgical strategy for individualised management. →
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Effect of Ultrasound Combined with Microbubbles on Blood Perfusion in Invasive Breast Cancer-A Prospective Clinical Trial
IntroductionBlood perfusion insufficiency and hypoxia are the main causes of drug resistance to chemotherapy in breast cancer. Increasing blood perfusion can improve drug delivery. This study aimed to investigate the effects of ultrasound-stimulated microbubbles (USMBs) on hemoperfusion in invasive breast cancer (IBC).MethodsIn this prospective clinical trial, 36 patients diagnosed with IBC were enrolled sequentially. The… →
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Safety and Feasibility of Long-Term High-Intensity Interval Training With and Without Peer Support in Cancer Survivors
Despite the benefits of physical activity and exercise, including high-intensity interval training (HIIT), few cancer survivors meet the exercise oncology guidelines. Emerging evidence suggests peer support (i.e., assistance from individuals with lived experiences trained in behavior change techniques) may improve exercise adherence, yet its long-term safety and feasibility remain unclear. This study evaluates the safety… →
