CONCLUSIONS: Very few RCTs have been conducted in FASD, and interventions targeting cognitive functioning are needed. The data reported here suggest that choline supplementation has long-lasting neurodevelopmental benefits, especially in non-verbal IQ and working memory for individuals with FASD. →

CONCLUSIONS: Both i-PRF combined with vitamin C and i-PRF alone appear to be effective regenerative scaffolds, demonstrating comparable clinical and radiographic outcomes in regenerative endodontic procedures. →

CONCLUSION: The protocol-specific ED95 values of a 1-min remimazolam bolus for RSS ≥4 at 3 min were 0.38 mg/kg in children with obesity and 0.44 mg/kg in children with a reference-range BMI. →

This cluster-randomized controlled trial investigated whether a 12-week interactive STEM app intervention enhances computational thinking skills among young children aged 4-6 years and whether app usage engagement predicts learning outcomes. Ten classrooms from five kindergartens in Northern China were randomly assigned within each kindergarten to an intervention condition (5 classrooms, 125 children) that received structured… →

CONCLUSION: Financial incentives significantly increased completion of CRC screening. Future research should confirm findings in larger samples and evaluate cost-effectiveness to inform health system policies. →

CONCLUSIONS: An LUS-guided fluid management protocol integrating real-time EVLW assessment with predefined intervention thresholds outperformed conventional CVP-based management during the perioperative period of PCNL. The superior sensitivity of LUS for detecting early EVLW elevation, combined with protocolized early intervention, reduced postoperative hypoxemia incidence, shortened extubation time and PACU stay duration, and improved short-term perioperative recovery. →

CONCLUSIONS: The digital training substantially improved HCW fidelity to index and contact client protocols. A decentralized digital training can be used to improve HCW counselling behaviour. Future research should explore the methods of assessing fidelity in trials of complex digital training interventions in other settings. →

CONCLUSIONS: On an ad libitum low-fat plant-based (vegan) dietary intervention, the participants with type 2 diabetes experienced reductions in ectopic fat, particularly visceral and hepatocellular fat, improvements in insulin sensitivity, reductions in AGEs, and improvements in beta-cell function. →

CONCLUSIONS: A 12-week hybrid exercise program may improve the quality of daily-life walking, with the clearest effect observed on step length. Given the attenuation after multiplicity-aware interpretation and in sensitivity analyses, these findings should be interpreted as suggestive rather than definitive. →