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Effect of Chinese medicine compound on intestinal bifidobacteria recovery and CD4+ T-Cell activation in postoperative chemotherapy patients with breast cancer
CONCLUSION: The traditional Chinese medicine compound effectively maintained intestinal flora balance, promoted beneficial bacterial growth, reduced adverse reactions and offered better therapeutic prospects for breast cancer patients. →
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Improvements in Health-Related Quality of Life After Financial Navigation Among Cancer Survivors
CONCLUSIONS: Our findings demonstrate that receipt of FN decreased anxiety and depression and improved global mental health. Findings highlight the crucial role of FN in cancer care. →
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Dose-Response Relationship of Single Intravenous Remimazolam on Bispectral Index and Cardiorespiratory Effects
CONCLUSION: A dose-dependent relationship exists between single-dose remimazolam and BIS, with good respiratory and circulatory safety in the 0.2-0.6 mg/kg range and a plateau effect above 0.4 mg/kg. The extremely wide confidence interval for the ED(90) estimated using the BIS ≤ 60 threshold suggests that this endpoint may not be suitable for pharmacodynamic evaluation of… →
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Changes in perceived psychosocial working conditions after psychotherapeutic consultation at work — exploratory post-hoc analyses from a randomized controlled trial
CONCLUSIONS: Results may indicate that participation in PT-A is associated with long-term reductions in perceived emotional demands and dissolution, but not with improvement in perceived job resources. Confirmative research is needed given the exploratory study design and because findings did not remain statistically significant after adjustment for multiple testing. →
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Feasibility and acceptability of the Unified Protocol for anxiety and depression in Pakistan: a pilot randomized controlled trial
CONCLUSIONS: The UA-UP demonstrated high feasibility and acceptability as a culturally adapted transdiagnostic CBT intervention in Pakistan. These findings support the conduct of a fully powered randomized controlled trial to evaluate clinical effectiveness and inform scalable implementation in low-resource settings. →
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The effect of cycloplegia on corneal power and diameter measured by an auto-kerato-refractometer in presbyopic patients with type 2 diabetes mellitus: a post-hoc analysis of a randomized clinical trial
CONCLUSIONS: Post-cycloplegia keratometry and WTW measurements were comparable to pre-cycloplegia values in presbyopic patients with type 2 diabetes, suggesting that these measurements can be reliably obtained after cycloplegia. →
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Continuous Remote Patient Monitoring in Heart Failure Patients: The Heart Failure Cascade Study: Phase II and III Outcomes
ABSTRACT: OBJECTIVES: The objective of this study is to evaluate the effect of a continuous remote patient monitoring (CRPM) program on reducing 30-day readmissions in a case-versus-retrospective-propensity-matched-control study of heart failure (HF) patients. →
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How Sustainability Transformations Quietly Lose Their Edge
Gillian Blease/Ikon Images Corporate sustainability is facing headwinds. Net-zero pledges are being quietly walked back. Regulatory pressure is loosening in some parts of the world. Shareholders are demanding stronger business cases. Inside companies, sustainability leaders sometimes spend more time defending their function than expanding it. The familiar question “Where is the value?” has returned with… →
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Podcast: An Optimist’s Take on AI and the Future of Learning
The Insightful Leader brings you another episode of Life, Automated—a podcast from Kellogg’s Ryan Institute on Complexity. Kellogg Professor Sébastien Martin speaks with host Jess Love about AI’s pedagogical potential. In his own operations-management class, students trade PDFs for lifelike chatbots, log conversations with Socratic AI tutors, and use AI to explore the kinds of social… →
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Supporting the Primary Outcomes of the Mirai Trial for the Adjunctive Digital Therapeutic Rejoyn (CT-152) in the Treatment of Major Depressive Disorder: Meaningful Change Analysis in the Montgomery-Asberg Depression Rating Scale
CONCLUSIONS: Results are consistent with the primary findings of the Mirai trial, supporting the efficacy of Rejoyn as an adjunctive treatment to antidepressive medication monotherapy for adults with major depressive disorder. The MWPC analyses offered a measure of meaningful change on the MADRS, providing a framework of clinical meaningfulness for the Mirai trial findings. →
