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Does Cognitive Bias Modification for Appraisals Change Symptom-Cognition Relations in PTSD? Preliminary Evidence from Network Analysis in a Randomized Controlled Trial
CONCLUSION: Given the small sample and moderate network stability, findings are preliminary but suggest that CBM-APP may influence the relational structure of PTSD symptoms and cognitions. →
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A phase III double-blind, placebo-controlled, randomized withdrawal trial of 5-aminolevulinic acid hydrochloride with sodium ferrous citrate for efficacy and safety in patients diagnosed as Leigh syndrome
CONCLUSION: These findings suggest that SPP-004 is safe and may provide therapeutic effect for LS patients who achieved an initial clinical response. →
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Accuracy and safety of C-TST for tuberculosis infection: A clinical trial in Brazil
CONCLUSION: In BCG‑vaccinated adults, C-TST showed a trade-off of higher specificity and lower sensitivity than PPD RT-23 at the 5-mm cut-off; and a favourable safety profile. Adding erythema to readings did not improve accuracy, suggesting that C-TST may be a useful alternative for programmatic TBI screening in high-burden settings. →
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Comparison of Early Bracing Versus Splinting for the Initial Treatment of Acute Humeral Shaft Fractures (The COBRAS Trial)
CONCLUSIONS: Immediate Sarmiento bracing was associated with increased patient-reported pain (roughly 1 point on the 0-10 numeric rating scale) and higher skin complication rates during the initial 10-day period after injury compared with initial coaptation splinting for acute humeral shaft fractures, without demonstrable benefits in function, analgesic requirements, or patient satisfaction. These findings support the… →
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Effectiveness and acceptability of biometrics to evaluate intervention coverage and contamination in a cluster randomised trial of community-based sexual and reproductive health services for youth in Zimbabwe
CONCLUSION: Biometric identification is useful for assessment of CRT coverage and contamination. →
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What CEOs Need to Know About Sovereign AI
Carolyn Geason-Beissel/MIT SMR | Getty Images As multinational companies implement artificial intelligence workflows and look to adopt AI across their global operations, they are increasingly running up against country-specific regulations and policies that aim to govern AI and align its use with national priorities and local cultural norms. These regulations and policies — which fall… →
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Effects and User-Reported Experiences of a Self-Management Mobile Health App for Grieving Adolescents: Randomized Controlled Trial
CONCLUSIONS: Overall, the findings indicate that Alba may be beneficial in reducing mental health symptoms among bereaved adolescents and highlight its potential as a safe, acceptable, and scalable mHealth intervention. →
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Intranasal Oxytocin for Alcohol Use Disorder: A Randomized, Double-Blind, Placebo-Controlled Multisite Trial Assessing Efficacy and Safety
CONCLUSION: Intranasal oxytocin was well tolerated but did not significantly reduce drinking or AUD-related outcomes. Higher doses, longer treatment duration, or larger trials may be required to identify responsive subgroups and determine oxytocin’s efficacy in AUD. →
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Individually designed fall prevention strategies compared to generic strategies for mastering complex fall risk situations in people with multiple sclerosis: study protocol of a randomised controlled trial
INTRODUCTION: Of individuals with mild-to-moderate multiple sclerosis (MS), 56% report falling at least once during a 3-month period. Several fall risk factors have been identified, but the issue is complex, with interactions between triggering factors and preceding activities and events. There is a lack of studies explicitly evaluating fall prevention strategies given as counselling over… →
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Expectant management versus acetaminophen for early treatment of hemodynamically significant patent ductus arteriosus in very preterm infants: a randomized controlled trial
CONCLUSIONS: Early oral acetaminophen treatment in very preterm infants with hsPDA aged 4-7 days reduces the rate of persistent hsPDA at 14-17 days and demonstrates a favorable safety profile compared with expectant management, but does not affect hsPDA persistence at discharge or 36 weeks of corrected gestational age or the rate of moderate to severe… →
