CONCLUSION: The combined application of PTS and blood lactate integrates physiological status and metabolic information, which can significantly improve the accuracy of early triage of pediatric compound injuries, guide the implementation of rescue measures, and effectively predict prognosis through dynamic monitoring, providing a reliable basis for precise personalized management. →

CONCLUSIONS: Selumetinib shows therapeutic potential against NF1-DN, although with a lower response than that observed against NF1-PN. The NF1-OPG findings herein for this drug were exploratory only because of the small number of cases, but they may provide an additional clinical context for evaluating the broader effects of selumetinib across NF1-associated lesions. →

CONCLUSIONS: Low testosterone at diagnosis does not appear to predict a reduced mortality risk when adding docetaxel to RT and ADT in otherwise healthy patients with nonmetastatic high-risk PC, whereas normal testosterone does, which provides evidence to support testosterone group as a predictive biomarker. →

CONCLUSION: In this study, no significant difference was observed in the short-term effects of LCE and LB combinations on plasma dopamine levels in patients with early-stage Parkinson’s disease with unilateral involvement. Further large-scale, multicenter studies with extended follow-up are required to assess long-term clinical outcomes, including motor response duration and adverse effects. →

Telemonitoring may improve glycemic control in type 2 diabetes. Usability plays a critical role in successful implementation of telemonitoring interventions. This study aimed to explore the usability of a telemonitoring system for people with insulin-treated type 2 diabetes. The analysis was based on data from a randomized controlled trial comparing telemonitoring to usual care. The… →

In fibromyalgia syndrome (FMS), current guidelines recommend combining pharmacological treatments such as duloxetine with exercise interventions. This randomized controlled trial aimed to evaluate the effectiveness of a home-based postural exercise program as an adjunct to pharmacological treatment in individuals with FMS. Fifty-one patients diagnosed with FMS according to the 2016 American College of Rheumatology criteria… →

The purpose of this randomized controlled clinical trial was to investigate the health effects of an education-based intervention performed at a nurse-led clinic, for patients who underwent endovascular treatment for abdominal aortic aneurysm. Fifty-four adult patients were randomized to the intervention group (n = 26) or the control group (n = 28). The control group… →

Cognitive Bias Modification — Interpretation (CBM-I) aims to alter maladaptive interpretations in social anxiety, yet effects are often small and outcome measures are diverse. Although CBM-I has shown promise, its underlying mechanisms remain unclear and integration with psychophysiological and neural measures has been limited. In this randomized controlled trial, eighty-eight participants with high levels of… →

CONCLUSIONS: Children aged 6-12 years were more likely to be testable. Regardless of age, half of all test-retest pairs were completed incorrectly, possibly due to examiner or participant-related factors. A greater than 4-line (0.20 logCS) change on the SpotChecks contrast sensitivity test is required to detect a change in contrast sensitivity function beyond measurement error… →

CONCLUSIONS: Blogshots can be an effective tool to disseminate child health information to parents. Due to the online dissemination, this approach could be scaled to a broader international level and applied to different health topics that are relevant across the world. →