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  • High-Frequency Oscillation vs Mechanical Ventilation for Neonatal Acute Respiratory Distress Syndrome: A Randomized Clinical Trial

    9 марта, 2026

    CONCLUSIONS AND RELEVANCE: This randomized clinical trial found that elective HFOV reduced the incidence of BPD in preterm infants born at 34 weeks’ gestation or earlier with NARDS compared with CMV. The results of this study suggest that elective HFOV is a promising strategy for preventing BPD in this high-risk population, especially the more severe… →

    Clinical Trials
  • Bimekizumab efficacy in scalp, nail and palmoplantar psoriasis versus comparators and over 4 years

    9 марта, 2026

    To investigate bimekizumab efficacy in scalp, nail and palmoplantar psoriasis. →

    Clinical Trials
  • Anti-Vascular Endothelial Growth Factor Combined with Dexamethasone Implant Therapy for Macular Edema: A Randomized Controlled Trial

    9 марта, 2026

    CONCLUSION: Conbercept combined with DEX is an efficient and safe treatment for ME by providing accelerated visual and anatomical improvements in short term and maintaining similar long-term efficacy with fewer injections compared to conbercept monotherapy. OCT biomarkers display prognostic value. HE is associated with poor visual prognosis. →

    Clinical Trials
  • Seizure prophylaxis in glioma surgery: a synopsis from the SPRING RCT

    9 марта, 2026

    CONCLUSIONS: Given the trial was underpowered, there was no evidence of a difference in the 12-month seizure risk between the randomised groups and limited evidence regarding potential cost-effectiveness. The role of prophylactic antiseizure medication in glioma surgery remains undefined. →

    Clinical Trials
  • Protocol for the impact of medication therapy management on efficacy and safety of postoperative anticoagulation therapy in patients with colorectal cancer: an open-label, prospective and randomized clinical trial

    9 марта, 2026

    BACKGROUND: Anticoagulants, classified as high-risk medications, are commonly used and are associated with significant potential harm in postoperative patients. Patients with colorectal cancer (CRC) are among the most susceptible populations. Single-component pharmacist intervention has demonstrated conflicting efficacy in improving anticoagulant safety. Meanwhile, it remains unclear whether comprehensive medication therapy management (MTM), which integrates medication review,… →

    Clinical Trials
  • Cognitive-Behavioural Therapy for Adolescents With Impulsive Aggressive Behaviour: A Randomised Controlled Trial

    9 марта, 2026

    CONCLUSIONS: The findings indicate that when CBT is delivered comprehensively in a multicomponent format targeting maladaptive cognitions, emotion dysregulation and self-control deficits, it can serve as an effective intervention for adolescents with IED. →

    Clinical Trials
  • Comparison of Hand-Held Doppler, Infra-Red Thermography and Indocyanine Green Angiography for Identification of Perforator in Antero-Lateral Thigh Flap: A Randomized Controlled Trial

    9 марта, 2026

    CONCLUSION: The accuracy of ICG was better than IR Thermography and HHD in detecting perforators pre-operatively in patients undergoing ALT flap surgery. →

    Clinical Trials
  • Talking to migrant children and adolescents with cancer: development of a multimodal skills training in migrant-sensitive communication for paediatric oncologists

    8 марта, 2026

    CONCLUSION: Even experienced paediatric oncologists identified a need to establish ongoing training in communication in an intercultural, family-centered setting and benefited from the multimodal training. →

    Clinical Trials
  • LED Photobiomodulation for Pain Reduction in Temporomandibular Disorder: A Randomized, Controlled, and Blinded Clinical Trial

    7 марта, 2026

    This clinical, randomized, controlled, and blinded trial evaluated photobiomodulation (PBM) using 850 nm (infrared) and 660 nm (red) LED clusters on cervical and mandibular mobility and masticatory muscles in temporomandibular disorder (TMD) patients. PBM was applied to the temporomandibular joint (TMJ) region, masseter, temporal, scalene, and trapezius muscles over six non-consecutive sessions over 2 weeks.… →

    Clinical Trials
  • Effect of Mesenchymal Stem Cell Infusion in Stage II-IV Diabetic Nephropathy

    7 марта, 2026

    CONCLUSION: MSC improved GFR and HbA1c at 6 months in patients with DKD (Stages II-IV). →

    Clinical Trials
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