-
The effect of mindfulness-based cognitive therapy on non-suicidal self-injury in hospitalized adolescents with depressive disorders: a randomized controlled trial
CONCLUSIONS: MBCT-A is effective in reducing NSSI behavior and improving mindfulness, emotion regulation, and depressive symptoms among adolescents with depressive disorder and NSSI. These findings support the clinical application of MBCT-A for this high-risk population. →
-
Comparative efficacy of an 8-week core stability program versus foot-ankle strengthening on pain, function, and distal structural parameters in individuals with knee osteoarthritis: a randomized controlled trial
Knee osteoarthritis (OA) is a common musculoskeletal condition linked to aberrant joint loading, pain, and reduced function. While effective rehabilitation should target both local knee problems and the entire kinetic chain, direct comparisons between proximal (core stability) and distal (foot-ankle) interventions are limited. This randomized controlled trial evaluated the efficacy of an 8-week core stability… →
-
Total body photography for standardised documentation of mpox skin lesions in remote study sites in the Democratic Republic of the Congo
We designed and successfully implemented photography protocols for the PALM007 (Pamoja Tulinde Maisha — Together Save Lives in Swahili) randomised clinical trial evaluating tecovirimat for the treatment of mpox in the Democratic Republic of the Congo (DRC). We addressed the unique challenges and limitations of conducting standardised photography procedures on patients with mpox in high-risk… →
-
How a Healthy Work Culture Helps Trauma Survivors
Donna Grethen/Ikon Images Over the past few decades, there has been burgeoning interest in how leaders and organizations can support employees in the aftermath of traumatic events.1 But there is another pervasive and often hidden source of trauma that originates well before individuals enter the workforce. Childhood adversity, referred to as adverse childhood experiences (ACEs),… →
-
Sex-specific predictors of self-stigma reduction in psychosis resulting from metacognitive interventions: Results from a randomized clinical trial
CONCLUSION: Distinct pathways of self-stigma recovery emerged for women and men, underscoring the need for gender-sensitive interventions. These findings underscore the need for tailored stigma-reduction interventions that consider gender-specific factors influencing mental health outcomes. Longitudinal research should assess durability and further clarify gender-related mechanisms. →
-
Reducing Screen Time in Children With Borderline IQ: A Randomized Controlled Trial of a Parent-Mediated Screen Time Usage Module
Objective: The rapid expansion of mobile technology has significantly altered children’s screen time behaviors, contributing to concerns about excessive usage. These changes are particularly relevant for children with borderline intellectual functioning, in whom unmanaged screen time may exacerbate developmental challenges. This study aimed to evaluate the effectiveness of a parent-mediated screen time usage module (PM-STUM)… →
-
Ultrasound-Guided Stellate Ganglion Block in Fibromyalgia: A Randomized, Single-Center, Single-Blind, Sham-Controlled Trial
CONCLUSION: In treatment-resistant fibromyalgia patients receiving stable duloxetine, ultrasound-guided SGB produced clinically meaningful short-term improvements in fibromyalgia impact and pain with an acceptable safety profile. However, the large effect sizes should be interpreted cautiously given potential unblinding and placebo effects. Larger, multicenter trials with longer follow-up, objective outcome measures, and formal blinding assessment are warranted. →
-
Safety, Tolerability, Pharmacokinetics, Food Effect of Ribitol, and Its Effect on QTcF in Healthy Adults: First-in-Human, Randomized, Double-Blind (Sponsor Unblinded), Placebo-Controlled Studies
Limb-girdle muscle dystrophy Type R9 (LGMDR9), also known as LGMD Type 2I, is a rare genetic disease caused by partial loss of function of fukutin-related protein (FKRP) enzyme which glycosylates alpha-dystroglycan, thereby stabilizing myocytes during contraction. Hypoglycosylation leads to progressive muscle injury and impaired function including loss of ambulation. Ribitol is an endogenous pentose alcohol… →
-
SSGJ-613 Alleviates Pain and Reduces the Risk of Acute Flares in Patients With Gout: A Randomized, Double-Blind, Phase II Study
CONCLUSION: A single injection of SSGJ-613 demonstrated rapid pain relief comparable to corticosteroid therapy at 72 h and provided superior protection against gout flare recurrence over 12 weeks in Chinese patients, supporting its potential as an effective treatment option for acute gouty arthritis with prolonged therapeutic benefits. →
-
Antithrombotic treatment for migraine in patients with patent foramen ovale: multicentre, randomised, active controlled, open label trial
CONCLUSIONS: The antithrombotic agents evaluated in this trial (aspirin, clopidogrel, and rivaroxaban) were all non-inferior to metoprolol for responder rate in participants with PFO and migraine. Rivaroxaban also showed superior responder rates over metoprolol without an increase in major bleeding events. →
