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Early pregnancy meal tolerance test responses and their association with later insulin sensitivity in overweight and obese women: an exploratory analysis
INTRODUCTION: Insulin resistance increases the risk for gestational diabetes mellitus (GDM) and hyperglycemia-associated pregnancy complications. GDM is generally diagnosed at 24-28 weeks of gestation, leaving limited time to address adverse consequences. To explore metabolic markers that predict changes in insulin sensitivity and glycemic responses earlier in pregnancy, we performed a meal tolerance test (MTT) during… →
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Vitamin D in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome After COVID-19 or Vaccination: A Randomized Controlled Trial
Background: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) can develop as post-vaccination syndrome (PVS) or Post-Acute Sequelae of SARS-CoV-2 infection (PASC). In our prior retrospective study, most patients with PVS who developed ME/CFS had vitamin D insufficiency or deficiency. We evaluated the efficacy of vitamin D replacement therapy guidance for ME/CFS symptom improvement in patients with vitamin… →
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Adipo-Myokine Modulation in Obesity: Integrative Effects of Spinach Thylakoids and Functional Training in Men with Obesity: A Randomized Controlled Clinical Trial
Objective: This study evaluated the effects of a 12-week High-Intensity Functional Training (HIFT) program combined with thylakoid supplementation on plasma adipo-myokine levels (Decorin, Myostatin, Follistatin, Activin A, and TGF-β1) in men with obesity. Secondary outcomes included anthropometric indices, lipid profiles, and insulin resistance markers. Methods: Sixty men with obesity (age: 27.6 ± 8.4 years; BMI:… →
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A Pilot Validation Study of Plant-Based and Allergy-Friendly Alternative for Testing Gastric Emptying: A Randomized Trial in Healthy Participants
CONCLUSIONS AND INFERENCES: The vegan meal demonstrated in vitro stability, in vivo performance comparable to the egg meal, and a COV(intra) of 18.8%, which was lower than the 23.8% reported in repeat egg meal GE studies. →
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Hypophosphatemia as a biomarker of metabolic intolerance to enhanced nutrition in the PICU: a secondary analysis of the PEPaNIC RCT
CONCLUSIONS: Development of hypophosphatemia may identify critically ill children who are particularly harmed by early-PN. This opens perspectives for its use as a biomarker of metabolic intolerance to enhanced nutrition, which requires further investigation. →
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Timing-dependent anti-inflammatory effects of empagliflozin in monocyte-derived macrophages from post-myocardial infarct patients with type 2 diabetes
CONCLUSION: Early empagliflozin administration in T2DM-AMI patients was associated with modulation of NLRP3-related inflammatory and senescence pathways in patient-derived macrophages, benefits observed when cells were stimulated ex-vivo with an inflammatory stimulus. These findings provide mechanistic insight into the timing-dependent anti-inflammatory effects of EMPA and underscore its potential for immediate post-AMI use to reduce inflammation and… →
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AI Coding Tools for Knowledge Work: What Executives Need to Know
Patrick George/Ikon Images In conversations with executives, I’ve noticed a common pattern: Many are aware of agentic AI coding assistants like Claude Code but assume that these tools are relevant only to software developers. This assumption, while understandable, is rapidly being proved wrong. It turns out that the features that make AI coding tools useful… →
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Why Salespeople Fear Pitching Radical Innovation
Dean Rohrer/theispot.com Across industries, companies are investing heavily in radical innovations, such as new software layers for traditional hardware, AI-powered industrial tools, and smart services that promise to transform how customers create value. Yet, when these offerings reach the market, sales pipelines often stall. Salesforce, for example, struggled with the early commercialization of a radical… →
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Effect of self-viewing of sleep-apnoea videos on positive airway pressure adherence in moderate to severe obstructive sleep apnoea: a prospective, parallel-group, randomised controlled trial
CONCLUSIONS: This study supports the clinical utility of patient-specific visual feedback to improve PAP adherence. SVSV-a simple, low-cost, and scalable strategy-resulted in a higher proportion of patients achieving good adherence and greater usage. 1. Current Knowledge/Study Rationale: Adherence to positive airway pressure therapy in obstructive sleep apnoea is often inadequate, limiting its therapeutic benefit. Previous… →
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Recovery with vistula tart cherries following a marathon
CONCLUSIONS: The marathon caused changes in muscle damage and inflammation indices. Despite no functional or soreness differences, the TC group showed lower inflammation levels, offering insights into Vistula tart cherries for recovery. →
