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Teacher-student-machine interaction autonomous learning: a structured LLM-integrated framework for developing independent clinical reasoning in residency training
CONCLUSIONS: The TSM-AL framework significantly enhanced clinical reasoning competencies that transferred to independent performance, demonstrating that structured LLM integration develops autonomous reasoning rather than fostering technological dependency. →
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A multi-center, single-arm, phase 2 trial of dasatinib in T follicular helper cell lymphomas
T follicular helper cell lymphomas (TFHL) harbor activating T cell receptor (TCR) signaling mutations and epigenetic alterations, such as TET2 mutations. Here, we conduct a multi-center, single-arm, phase 2 trial of the tyrosine kinase inhibitor dasatinib in patients with relapsed/refractory TFHLs (jRCT2031190079). The primary outcome is the overall response rate (ORR) according to CT-based Lugano… →
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Why Women Professors Are More Likely to Leave Their Jobs
Women professors are more likely than men to leave their jobs. And when they do, people often assume it’s because of difficulties juggling their professional and personal lives. “Much of the past literature on women academics—tenure-line professors in particular—talks about how one of the major barriers to success that may push them out of the… →
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For Loans, It Pays to Compare
Time and again, people settle for mediocre loans. It’s a baffling outcome, given that, with just a bit more searching, they could secure better rates and potentially save themselves thousands or tens of thousands of dollars. In the economist’s eye, the simple explanation for this behavior is that many people aren’t willing to put in… →
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When Bundling Hurts the Bottom Line
Lebron James versus Stephen Curry. Victor Wembanyama versus Luka Doncic. When the biggest names in the National Basketball Association get together to compete in the league’s annual All-Star game, fans from all around the world flock to the chosen city. The popularity of the event opens a brief but tremendous window of opportunity, not just… →
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Tiger Team, Assemble!
When an organization seeks transformational change—whether that’s a new approach to sales, a better product, or a cultural reset—it’s often left to the C-suite to generate new ideas. “The top decides a strategy, and they expect people to go out and execute on it,” says Sanjay Khosla, a senior fellow and adjunct professor of marketing… →
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Effects of Dual-Task Training With and Without Backward Walking on Balance, Functional Mobility, and Participation in Ambulatory Children With Spastic Diplegic Cerebral Palsy: A Randomized Controlled Trial
CONCLUSIONS: In ambulatory children with spastic diplegic CP (GMFCS Levels I-II), adding BW to DTT was associated with a small additional improvement in functional mobility over 4 weeks (approximately 1 s on the TUG) of uncertain clinical importance, whereas superiority for balance or participation was not demonstrated; the trial was not powered for these secondary… →
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Effect of Preoperative Intranasal Dexmedetomidine on Postoperative Myocardial Injury in Patients Undergoing Coronary Artery Bypass Grafting
CONCLUSION: In this single-center trial, two-dose preoperative intranasal dexmedetomidine was associated with lower postoperative hs-cTnT and CK-MB concentrations, better subjective preoperative sleep quality, and a lower observed incidence of postoperative delirium. These findings are preliminary and require confirmation in larger, adequately powered multicenter randomized trials to determine whether the biomarker reductions translate into clinically meaningful… →
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Microbiome-derived TOPOSCORE is associated with response to immune checkpoint inhibitor re-induction after chemotherapy in primary resistant metastatic melanoma
CONCLUSIONS: Baseline TOPOSCORE classification was insufficient to predict treatment outcome in this cohort. Longitudinal TOPOSCORE patterns were heterogeneous, and the small number of complete longitudinal profiles precludes conclusions that chemotherapy induced a favorable microbiome transition. These exploratory findings support further evaluation of microbiome ecosystem dynamics in larger prospective cohorts. →
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Effect of discharge planning rooted in the integrated Care for Older People Concept on the maintenance of intrinsic capacity in older adults
CONCLUSION: The ICOPE-based DP approach slows IC decline and enhances multiple functional domains, offering a valuable reference for transitional care for older adults. →
