CONCLUSION: Tissue-free detection of ctDNA 2 years after adjuvant chemotherapy was highly prognostic in an early-stage breast cancer cohort, and can be used to stratify patients with early-stage breast cancer at high risk for recurrence during follow-up who may benefit from early interventions. →

CONCLUSIONS AND RELEVANCE: In this randomized clinical trial of 1793 adolescents, the CBT-based intervention reduced gaming disorder symptoms and unspecified internet use disorder symptoms more effectively than the media literacy-based intervention among adolescents at high risk. These findings support the use of CBT-based approaches primarily within indicated, rather than universal, prevention. →

Purpose To compare safety and feasibility between a novel CT-guided robotic system and the conventional freehand technique for puncture biopsy of thoracoabdominal lesions. Materials and Methods In this prospective multicenter randomized trial, individuals with suspected lesions were enrolled between July 2023 and April 2024 across three university teaching hospitals and randomized to the robot-assisted group… →

CONCLUSIONS: In this prespecified subgroup of pregnant women with ICD-10 affective or stress-related disorders, the eMBI was associated with clinically meaningful reductions in depressive symptoms from late pregnancy to 4-6 weeks post partum. Effects at 6 months post partum were attenuated and less stable across missing-data assumptions. These findings support eMBIs as a scalable, nonpharmacological… →

Introduction/ObjectivesThis study examined factors affecting implementation of a primary care team expansion designed to improve timely diagnosis of causes of new anemia. This intervention introduced nurse navigators, who enrolled eligible patients and coordinated follow-up testing, and a clinical pathologist, who provided diagnostic interpretations to primary care providers.MethodsPatients were enrolled between December 2023 and December 2025… →

CONCLUSION: Compared with propofol-based deep sedation, the oxycodone-based conscious analgesia strategy was associated with a lower incidence of hypoxemia, fewer airway interventions, less hypotension, lower propofol exposure, and faster recovery. These findings reflect a comparison of two sedation strategies and do not establish improved respiratory function. →

CONCLUSIONS: In this prematurely terminated trial, ECCO₂R-facilitated early extubation using a device with a capacity to eliminate more than 50% of the average CO(2) production, was associated with a shorter duration of invasive mechanical ventilation. Numerical trends favored ECCO(2)R across several secondary outcomes, although interpretation is limited by premature termination and the very small sample… →

CONCLUSIONS: These findings show that both interventions are effective in enhancing caregivers’ SWB, with CSFP providing longer-lasting effects. Future studies should further examine the effectiveness of these interventions and explore how they can be adapted to different groups. Additionally, integrating CSFP into psychosocial and rehabilitation programs could be beneficial in reducing caregiver burden and improving… →

Immersive virtual reality (VR) may provide reproducible environments for training time-critical emergency workflows, but evidence in paramedic education remains limited. In this single-center randomized controlled trial, 125 German paramedic trainees participated in dyadic simulations after allocation to either one standardized multi-user VR anaphylaxis scenario (VR-C, n = 61) or repeated exposure to the identical scenario… →