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  • Emotional support or problem-solving? A randomized controlled trial of function-specific AI Chatbots for digital stress in college students

    20 августа, 2026

    Digital stress has emerged as a salient risk factor for the mental health of emerging adults, yet targeted interventions remain limited. Generative AI chatbots offer a scalable approach to delivering context-sensitive supportive interactions that users may perceive as emotional or informational support. This randomized controlled trial tested two functionally specialized AI chatbots-emotional-support and problem-solving-in reducing… →

    Clinical Trials
  • Effect of Mendelsohn maneuver combined with heat-sensitive moxibustion at Lianquan (CV23) on swallowing function and complications in patients with post-stroke dysphagia

    20 августа, 2026

    CONCLUSIONS: The Mendelsohn maneuver combined with heat-sensitive moxibustion at CV23 can effectively activate the pharyngeal constrictor muscles, improve sEMG signals, promote the recovery of swallowing function in patients with post-stroke dysphagia, and exert positive effects in reducing related complications, improving nutritional status and quality of life. →

    Clinical Trials
  • Providing Feedback on Previous Pain Scores Did Not Affect Weekly Pain Variability: A Cohort-Nested Randomised Study

    20 августа, 2026

    CONCLUSIONS: Providing participants with feedback on their previous pain score did not meaningfully influence within-person pain variability or retention during 60 weeks of weekly monitoring. These findings aid the interpretation of repeated longitudinal pain assessments by showing that the observed variability was robust to this specific study design. →

    Clinical Trials
  • Improving emergency management of status epilepticus: a randomized high-fidelity simulator-based trial

    20 августа, 2026

    CONCLUSIONS: Condensed SE guidelines improved adherence to selected emergency interventions compared with both full NCS guidelines and no guideline support. Guideline usability may represent a modifiable target for improving time-critical neurological emergencies. →

    Clinical Trials
  • Therapist-guided and self-guided internet-based behavioural activation versus treatment as usual for adolescents with depression: randomised controlled trial with economic evaluation

    20 августа, 2026

    CONCLUSIONS: Therapist-guided I-BA reduced depressive symptoms at lower cost than TAU, but clinical importance and robustness are uncertain. Self-guided I-BA showed no clear superiority but was cost-efficient. →

    Clinical Trials
  • The Five Inclusive Behaviors Board Chairs Overlook

    20 августа, 2026

    Curt Merlo/theispot.com Many companies around the world have made significant progress in adding a higher proportion of board directors from traditionally underrepresented groups, such as women and people of color. But despite the increased diversity, many boards lag on inclusivity — that is, ensuring that diverse voices are actually heard and that all board members… →

    Management
  • A Women-Centered Internet-Based Cognitive Behavioral Therapy for Depressive Symptoms (the 3D Program): Protocol for a Randomized Controlled Trial

    19 августа, 2026

    CONCLUSIONS: This trial aims to address critical gaps in accessible, personalized, and gender-sensitive mental health care. If effective, the 3D Program may serve as a scalable, cost-efficient adjunct to routine care for women with depressive symptoms in public health systems, while biomarker findings may lay the groundwork for future trials examining predictors of response. →

    Clinical Trials
  • Comparative Evaluation of Virtual Reality versus Standard Nursing Care in Managing Pain and Fear during Lumbar Puncture Procedures: A Randomised Controlled Trial

    19 августа, 2026

    CONCLUSIONS: The research shows that the use of VR prior to LP significantly reduces level of pain and fear compared to standard care. These results support VR as a non-pharmacological intervention for fear and pain to improve patient experience during invasive procedures. In contrast, the control group experienced no improvement.Trial Registration: The IRCT code for… →

    Clinical Trials
  • Online psychoeducation and assessment for borderline personality disorder as a first step of care: A pilot study assessing safety, feasibility, and mechanisms of change

    19 августа, 2026

    CONCLUSION: Online psychoeducational videos and assessment were safe, feasible, and acceptable to participants with newly diagnosed BPD. Psychoeducation with personalized feedback appears to be more effective than either BPD or general psychoeducation alone in improving deficits in self-functioning, which may relate to an increased capacity to be alone with fewer symptoms. →

    Clinical Trials
  • Integrating NCCN and LATITUDE in metastatic castration-sensitive prostate cancer: a TITAN analysis

    19 августа, 2026

    To evaluate whether an integrated classification combining the CHAARTED and LATITUDE criteria improves prognostic stratification and to explore treatment effects across risk groups, including further stratification by metastasis timing, in metastatic castration-sensitive prostate cancer (mCSPC). This post hoc analysis included 1,052 patients from the TITAN trial (NCT02489318) randomized to receive apalutamide plus androgen deprivation therapy… →

    Clinical Trials
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