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Cost-utility and cost-effectiveness of SELFIE, a transdiagnostic ecological momentary intervention for improving self-esteem in youth aged 12-26 years exposed to childhood adversity: Findings from a multicenter randomized controlled trial
CONCLUSIONS: At the societal level, the SELFIE intervention exceeded the WTP threshold. Tests for robustness showed higher probabilities of cost-effectiveness from a healthcare perspective, likely reflecting the absence of educational productivity loss costs in the societal perspective, and in youth recruited from specialized mental health services. The innovative field of blended EMIs yields encouraging first… →
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Deutenzalutamide, a novel androgen receptor inhibitor, after progression on docetaxel and abiraterone in metastatic castration-resistant prostate cancer: results from the randomized phase III HC-1119-04 trial
Metastatic castration-resistant prostate cancer (mCRPC) after treatment with docetaxel and androgen receptor signaling inhibitors (ARSIs) has limited treatment options. Although enzalutamide has shown activity after abiraterone and docetaxel, robust evidence from randomized phase III trials is lacking. Deutenzalutamide, a novel derivative with slower metabolism and improved pharmacokinetics, may offer enhanced safety and efficacy. This phase… →
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Emotional Response to Pleasant Sounds Plays a Role in the Effectiveness of the Positive Focus Intervention
Individuals with hearing loss, even when using hearing aids, often perceive pleasant environmental sounds as less pleasant than do those with normal hearing. This bias in emotional response may negatively impact well-being, leading to decreased social participation and increased loneliness. The present study examined whether the Positive Focus intervention-encouraging hearing aid users to focus on… →
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The Trap That Skilled Negotiators Miss
Brian Stauffer/theispot.com Say you walk into a car dealership determined to stay within budget. The salesperson shows you a car you like and quotes a price of $41,435. You know there’s room to negotiate, but when it’s time to counter, that first number quietly takes over. Your counteroffer, the concessions, and the final deal all… →
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Consistent benefit of physiology-guided complete revascularization across the spectrum of frailty in older patients with myocardial infarction: a prespecified analysis of the FIRE trial
CONCLUSIONS: Frailty, as assessed by the CFS, was independently associated with adverse outcomes. Complete revascularization was effective regardless of frailty status and should be considered in all older MI patients with multivessel disease undergoing an invasive strategy. →
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AI Conference HumanX Takeaways and Frameworks
6,714 AI leaders from around the world just gathered for a massive AI conference in San Francisco. There were people from 79 countries and 500+ sessions. From over 35,000 minutes of content at the event, these are the 9 takeaways to know. There are also frameworks and mental models after the takeaways – one you… →
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Effectiveness of a Parent-Child Interaction Therapy-Based Trauma-Focused Interaction Module for Trauma-Exposed Children: A Pilot Randomized Controlled Trial
CONCLUSION: These findings provide preliminary evidence that TFI-PCIT may be a promising, developmentally sensitive intervention for young traumatized children and their caregivers. →
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Parasternal electromyography in participants with mild or moderate chronic obstructive pulmonary disease in primary care: cohort study to assess technical and clinical application
CONCLUSIONS: EMG(para) measurement is feasible in primary care. In this group of COPD patients, lung function was stable across the three time points and EMG(para) was associated with the degree of airflow obstruction. In the resting stable state in mild/moderate disease, there was no association between EMG(para) and participant-reported outcomes. Further work should investigate the… →
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Enhancing Clinical Reasoning for Speech Sound Disorders: A Randomized Trial of Online Learning Modules
CONCLUSIONS: Both instructional modules improved students’ clinical reasoning for SSD assessment. The demonstration-based module, which explicitly modelled expert decision-making, showed indications of additional benefits in supporting reflective clinical reasoning. Delivered through a cloud-based, self-directed format, this approach offers a scalable instructional framework applicable to broader areas of speech-language pathology education. →
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Irinotecan with trifluridine/tipiracil and bevacizumab for second-line metastatic colorectal cancer: a phase II multicenter study
Patients diagnosed with metastatic colorectal cancer (mCRC) face a constrained therapeutic landscape following the failure of initial treatment. This multicenter, single-arm, phase II trial (NCT06202001) aimed to assess the efficacy and safety of a novel second-line regimen comprising trifluridine/tipiracil (TAS-102), irinotecan, and bevacizumab. Patients with mCRC resistant to prior fluoropyrimidine and oxaliplatin-based chemotherapy were enrolled.… →
