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Consistent benefit of physiology-guided complete revascularization across the spectrum of frailty in older patients with myocardial infarction: a prespecified analysis of the FIRE trial
CONCLUSIONS: Frailty, as assessed by the CFS, was independently associated with adverse outcomes. Complete revascularization was effective regardless of frailty status and should be considered in all older MI patients with multivessel disease undergoing an invasive strategy. →
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AI Conference HumanX Takeaways and Frameworks
6,714 AI leaders from around the world just gathered for a massive AI conference in San Francisco. There were people from 79 countries and 500+ sessions. From over 35,000 minutes of content at the event, these are the 9 takeaways to know. There are also frameworks and mental models after the takeaways – one you… →
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Effectiveness of a Parent-Child Interaction Therapy-Based Trauma-Focused Interaction Module for Trauma-Exposed Children: A Pilot Randomized Controlled Trial
CONCLUSION: These findings provide preliminary evidence that TFI-PCIT may be a promising, developmentally sensitive intervention for young traumatized children and their caregivers. →
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Parasternal electromyography in participants with mild or moderate chronic obstructive pulmonary disease in primary care: cohort study to assess technical and clinical application
CONCLUSIONS: EMG(para) measurement is feasible in primary care. In this group of COPD patients, lung function was stable across the three time points and EMG(para) was associated with the degree of airflow obstruction. In the resting stable state in mild/moderate disease, there was no association between EMG(para) and participant-reported outcomes. Further work should investigate the… →
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Enhancing Clinical Reasoning for Speech Sound Disorders: A Randomized Trial of Online Learning Modules
CONCLUSIONS: Both instructional modules improved students’ clinical reasoning for SSD assessment. The demonstration-based module, which explicitly modelled expert decision-making, showed indications of additional benefits in supporting reflective clinical reasoning. Delivered through a cloud-based, self-directed format, this approach offers a scalable instructional framework applicable to broader areas of speech-language pathology education. →
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Irinotecan with trifluridine/tipiracil and bevacizumab for second-line metastatic colorectal cancer: a phase II multicenter study
Patients diagnosed with metastatic colorectal cancer (mCRC) face a constrained therapeutic landscape following the failure of initial treatment. This multicenter, single-arm, phase II trial (NCT06202001) aimed to assess the efficacy and safety of a novel second-line regimen comprising trifluridine/tipiracil (TAS-102), irinotecan, and bevacizumab. Patients with mCRC resistant to prior fluoropyrimidine and oxaliplatin-based chemotherapy were enrolled.… →
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Sex differences in risk factor control and medication adherence post-ACS: insights from the TEXTMEDS randomised clinical trial
CONCLUSION: This study reveals that female patients are less likely to achieve LDL-C targets and engage in physical activity but more likely to maintain a healthy BMI. Although females showed lower medication adherence, this association weakened after adjusting for socio-economic factors. These findings highlight the importance of sex-sensitive strategies focusing on risk factor control and… →
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Rethink Responsibility in the Age of AI
Mark Airs/Ikon Images Early one morning in 2018, a self-driving Uber vehicle fatally struck a pedestrian in Tempe, Arizona. The world had questions: Who was responsible? Was it the safety driver behind the wheel? The engineers who designed the algorithms? Uber’s leadership? Or the regulators who had allowed autonomous-vehicle testing? The inability to name a… →
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Comparison of VCV and PCV-VG modes on diaphragmatic function in diabetic patients undergoing laparoscopic colorectal surgery: a prospective randomized controlled study
CONCLUSION: PCV-VG mode can reduce intraoperative mechanical power, better preserve postoperative diaphragmatic function. However, these improvements did not translate into clinical benefits, as evidenced by the lack of reduction in the incidence of PPCs. →
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A trifold prehabilitation model prior to induction chemotherapy in patients with leukemia: a randomized controlled trial
CONCLUSIONS: This study demonstrates that prehabilitation is safe, feasible, and potentially beneficial for physical, nutritional, and psychological outcomes in leukemia patients. →
