CONCLUSION: Both appliances were associated with reductions in AHI. The non-prespecified between-appliance comparison detected no statistically significant difference and does not establish equivalence. Complete confounding between period and measurement methodology, together with insufficient adherence, titration and adverse-event data, limits conclusions about the overall comparative merits of the appliances. →

Placement of rigid oral retractors during transoral robotic surgery (TORS) elicits a sympathetic hemodynamic response that may be harmful in high-risk patients. The glossopharyngeal nerve provides sensory innervation to the oropharyngeal structures stimulated during retractor placement, yet no previous trial has evaluated glossopharyngeal nerve block (GPN block) for attenuating this response. In this prospective, single-center,… →

The worldwide prevalence of vulvar intraepithelial neoplasia is increasing and is characterized by the high risk of recurrence and evolution towards vulvar cancer. Positive margins following surgical excision are the most important criteria of recurrence risk. We conducted a pilot clinical study to assess the fluorescence-based cartography of VIN lesions using methyl aminolevulinate (m-ALA), which… →

CONCLUSIONS AND RELEVANCE: In this randomized clinical trial of user interface designs, simple prompts encouraged responsible behavior online. Prompts on posts led to more intervening and less sharing of cancer misinformation. →

CONCLUSION: While obesity is associated with worse baseline status and outcomes, it was not shown to significantly alter the relative effectiveness of AF ablation compared to drug therapy. These findings support a multifaceted approach integrating rhythm control with upstream interventions targeting obesity-related atrial remodelling and comorbidity management. →

CONCLUSIONS: The digital twin-inspired patient-specific eye-lens simulation framework generated pediatric postcycloplegic prescription estimates that agreed more closely with subjective refraction than traditional autorefraction, particularly for SE. These findings support its feasibility as an upstream decision support component, although real-world spectacle wear feedback and longitudinal model updating require further study. →

CONCLUSION: Vunakizumab is not significantly associated with the occurrence of any AE or most selected AE categories in patients with moderate-to-severe plaque psoriasis, whereas vunakizumab is associated with a higher likelihood of injection site reaction and a lower likelihood of skin and subcutaneous tissue diseases. The observed lower incidence of skin and subcutaneous tissue diseases… →

CONCLUSIONS: These findings support the value of CR for people with schizophrenia, demonstrate that EAP deficits are malleable, and that cognitive and functional gains can occur for EAP impaired patients, regardless of whether EAP training is provided. →