CONCLUSION: OnabotA was a cost-effective preventive treatment of chronic migraine versus topiramate. Although OnabotA had higher drug acquisition costs, these were offset by reduced HCRU costs due to fewer migraines, resulting in a low incremental cost per headache-day avoided versus topiramate. →

CONCLUSIONS: Support for a healthy checkout policy was high, especially when framed around benefits to child health. Adults with certain socio-demographic and clinical characteristics may especially support healthy checkout policies. →

CONCLUSION: Collectively, the BT intervention elicited the numerically greater cardiovascular function benefits, independent of weight loss, potentially via reducing arterial stiffness, enhancing parasympathetic activity, and modulating key cardiovascular biomarkers. However, the majority of these favorable numerical changes did not reach statistical significance when compared with standalone brisk walking (BW) or table tennis (TT). Meanwhile, several… →

CONCLUSIONS: This trial will provide critical, mechanistic evidence on whether the targeted action of L. crispatus can work additively with metformin to heal the intestinal mucosal barrier, arrest systemic endotoxemia, and rescue disrupted gut-brain-endocrine signaling. By validating this novel metabolic-inflammatory regimen against localized (calprotectin) and systemic (AGH and HOMA-IR) end points, this study intends to… →

OBJECTIVES: This study examines effects over time of a telephone-delivered 5-session manualized parenting education program for child-rearing parents with advanced cancer. Primary outcomes were parents’ depressed mood and anxiety, parenting skills, parenting self-efficacy, and child behavioral-emotional adjustment. →

CONCLUSION: In this single-center trial, preoperative chlorhexidine vaginal cleansing produced lower rates of postcesarean endometritis and SSI and of related infectious morbidity. As a low-cost intervention that can be integrated into existing perioperative workflows, it is a promising strategy for reducing maternal infection; however, adverse events were not systematically solicited, and neonatal exposure was not… →

CONCLUSIONS: CA-AKI ascertainment after intra-arterial contrast exposure is strongly biomarker-dependent. Historical creatinine-based definitions may underestimate early functional renal impairment and influence interpretation of preventive strategies. These findings highlight the importance of endpoint selection in CA-AKI clinical trials and support further investigation of sensitive functional biomarkers in larger prospective studies. →

The two parallel antibody-mediated prevention (AMP) efficacy trials evaluated whether intravenous infusion of the anti-CD4 binding site broadly neutralizing antibody VRC01 prevents HIV-1 acquisition. Here, we analyzed HIV-1 acquisition in AMP through the week 104 final study visit. Against viruses considered highly sensitive to VRC01 [80% inhibitory concentration (IC(80)) < 1 microgram/milliliter], VRC01 prophylaxis maintained… →