Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance and impaired insulin secretion, and curcumin-a polyphenolic compound derived from Curcuma longa-has shown potential anti-inflammatory and antioxidant effects. This randomized, double-blind, placebo-controlled trial evaluated the effects of 1500 mg/day curcumin supplementation for 12 months in 114 adults with T2DM, with assessments… →

NG101 is a recombinant antibody that neutralizes the nerve growth inhibitor Nogo-A, promoting neural repair and improving upper extremity motor function in spinal cord injury (SCI). This study evaluated spinal cord MRI biomarkers to detect treatment-related structural changes and enhance patient stratification using data from 106 participants with acute cervical SCI in the phase 2b… →

CONCLUSION: Polypropylene and polyester meshes demonstrated comparable short-term pain, chronic pain, and recurrence outcomes following Lichtenstein inguinal hernia repair. Polyester mesh was associated with lower early postoperative inflammatory markers and reduced early swelling, although these differences did not translate into significant differences in 3-month pain outcomes. Larger multicentric studies with longer follow-up are required to… →

CONCLUSIONS: Patients generally perceived AI-HEALS as a useful source of ongoing education, behavioral prompting, and everyday support for diabetes self-management. The findings suggest that artificial intelligence-enabled education may work not only by increasing knowledge but also by reinforcing awareness, translating guidance into feasible daily action, and supporting psychological adaptation. At the same time, the intervention’s… →

Background: Post-traumatic stress disorder (PTSD) and substance use disorders frequently co-occur, with their comorbidity linked to poorer treatment outcomes. Beyond this epidemiological overlap, PTSD and, in particular, cocaine use disorder (CUD) have also been conceptually linked, as maladaptive memory processes are thought to play a central role in both of their etiopathogeneses. PTSD and CUD… →

CONCLUSION: Electroacupuncture at Yifeng (TE17) and Fengchi (GB20) can effectively promote the recovery of voluntary movement in the middle and lower facial muscles of patients with moderate-to-severe peripheral facial paralysis in the acute stage, and improve their physical and social functions, demonstrating a high clinical application value. →

CONCLUSION: For patients aged ≥ 50 years and 3 years post diagnosis, less-frequent mammograms were non-inferior and cost-effective compared with annual mammograms, with no detriment to patients’ quality of life. Mammo-50 provides evidence to inform guideline development. →

Early, intensive dietary intervention may open a therapeutic window for type 2 diabetes (T2D) remission. We conducted a randomized, 2:1 crossover trial in 34 newly diagnosed overweight or obese patients with T2D. Participants were assigned to receive either high-fiber nutritional therapy (HFNT)-a 7-day very-low-calorie, high-fiber diet followed by a 23-day standard diabetes diet-or conventional diabetes… →

CONCLUSION: In this phase II single-arm study, olaparib plus abiraterone and ADT showed preliminary activity and a manageable safety profile in patients with HRR-mutated mHSPC, but these findings need to be confirmed in larger phase III studies. →