Objective: To evaluate the efficacy and safety of a preservative-free tafluprost/timolol maleate fixed-dose combination compared with preservative-free tafluprost monotherapy in Chinese patients with open-angle glaucoma (OAG) or ocular hypertension (OHT). Methods: This was a multicenter, randomized, double-blind, parallel-controlled clinical trial conducted across 25 centers, including the Eye & ENT Hospital of Fudan University, from January… →

CONCLUSION: Findings provide translational evidence that alcohol is associated with multisystem biomarker changes relevant to chronic disease and that alcohol-related biomarker perturbations vary by dose and chronicity. →

CONCLUSION: Initiating febuxostat at a dose of 10 mg/day with gradual titration demonstrates a superior safety profile by effectively reducing early acute flares without compromising long-term urate control, which is particularly advantageous for high-risk cohorts, including obese patients. →

CONCLUSION: Paracetamol, ibuprofen, and dexketoprofen demonstrated similar efficacy in reducing pain and improving ankle joint ROM during the acute phase of ASs. These findings suggest that the early initiation of analgesic treatment in ASs contributes to clinical recovery. →

CONCLUSION: Technology-mediated community-based walking increased PA amount and intensity. These findings support further evaluation of this intervention as a potential option for ground-based walking training with objective measurement of exercise intensity. →

CONCLUSIONS: The user-centered mobile application was associated with improvements in overall and psychological quality of life among participants included in the 8-week analysis, while no significant intervention effects were observed for caregiver burden, neuropsychiatric symptoms, or caregiver distress. Larger studies with longer follow-up and more detailed assessment of application engagement are needed to evaluate the… →

The rapid development of artificial intelligence (AI) technology has brought new opportunities and challenges to the ever-evolving field of medical education. However, the specific impact of AI on the teaching of diagnostic assessments to medical students requires further investigation. The purpose of this study was to evaluate the effectiveness of ChatGPT-assisted teaching of diagnoses. Eighty… →

CONCLUSION: The 18-month clinical performance of restorations was found to be similar regardless of the universal adhesive application mode. Smoking status primarily influenced marginal discoloration and patient-reported postoperative hypersensitivity. →

CONCLUSION: Tissue-free detection of ctDNA 2 years after adjuvant chemotherapy was highly prognostic in an early-stage breast cancer cohort, and can be used to stratify patients with early-stage breast cancer at high risk for recurrence during follow-up who may benefit from early interventions. →

CONCLUSIONS AND RELEVANCE: In this randomized clinical trial of 1793 adolescents, the CBT-based intervention reduced gaming disorder symptoms and unspecified internet use disorder symptoms more effectively than the media literacy-based intervention among adolescents at high risk. These findings support the use of CBT-based approaches primarily within indicated, rather than universal, prevention. →