Digital stress has emerged as a salient risk factor for the mental health of emerging adults, yet targeted interventions remain limited. Generative AI chatbots offer a scalable approach to delivering context-sensitive supportive interactions that users may perceive as emotional or informational support. This randomized controlled trial tested two functionally specialized AI chatbots-emotional-support and problem-solving-in reducing… →

CONCLUSIONS: The Mendelsohn maneuver combined with heat-sensitive moxibustion at CV23 can effectively activate the pharyngeal constrictor muscles, improve sEMG signals, promote the recovery of swallowing function in patients with post-stroke dysphagia, and exert positive effects in reducing related complications, improving nutritional status and quality of life. →

CONCLUSIONS: Providing participants with feedback on their previous pain score did not meaningfully influence within-person pain variability or retention during 60 weeks of weekly monitoring. These findings aid the interpretation of repeated longitudinal pain assessments by showing that the observed variability was robust to this specific study design. →

CONCLUSIONS: Condensed SE guidelines improved adherence to selected emergency interventions compared with both full NCS guidelines and no guideline support. Guideline usability may represent a modifiable target for improving time-critical neurological emergencies. →

CONCLUSIONS: Therapist-guided I-BA reduced depressive symptoms at lower cost than TAU, but clinical importance and robustness are uncertain. Self-guided I-BA showed no clear superiority but was cost-efficient. →

CONCLUSIONS: This trial aims to address critical gaps in accessible, personalized, and gender-sensitive mental health care. If effective, the 3D Program may serve as a scalable, cost-efficient adjunct to routine care for women with depressive symptoms in public health systems, while biomarker findings may lay the groundwork for future trials examining predictors of response. →

CONCLUSIONS: The research shows that the use of VR prior to LP significantly reduces level of pain and fear compared to standard care. These results support VR as a non-pharmacological intervention for fear and pain to improve patient experience during invasive procedures. In contrast, the control group experienced no improvement.Trial Registration: The IRCT code for… →

CONCLUSION: Online psychoeducational videos and assessment were safe, feasible, and acceptable to participants with newly diagnosed BPD. Psychoeducation with personalized feedback appears to be more effective than either BPD or general psychoeducation alone in improving deficits in self-functioning, which may relate to an increased capacity to be alone with fewer symptoms. →

To evaluate whether an integrated classification combining the CHAARTED and LATITUDE criteria improves prognostic stratification and to explore treatment effects across risk groups, including further stratification by metastasis timing, in metastatic castration-sensitive prostate cancer (mCSPC). This post hoc analysis included 1,052 patients from the TITAN trial (NCT02489318) randomized to receive apalutamide plus androgen deprivation therapy… →