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Novel application for the JAK inhibitor baricitinib in the treatment of Vogt-Koyanagi-Harada disease: a prospective cohort study
CONCLUSION: This study demonstrates that baricitinib is a promising therapeutic option for both early- and late-stage VKH disease. It effectively controls choroidal inflammation, improves visual function, and allows for a substantial reduction in corticosteroid burden with a favorable safety profile. →
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Sex Differences in Statin Intolerance: Insights From the CLEAR Outcomes Trial
CONCLUSIONS: This is the only cardiovascular outcomes trial to date that exclusively enrolled patients with statin intolerance, and the largest contemporary study of lipid lowering therapy in females, a group historically underrepresented in clinical trials. Bempedoic acid was equally tolerated by both sexes and represents a viable alternative to statins to reduce cardiovascular risk. →
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Vonoprazan Versus Tegoprazan-Amoxicillin Dual Therapy for Treatment-Naïve Patients With Helicobacter pylori Infection: A Prospective, Multicenter, Open-Label, Randomized Controlled Study
CONCLUSION: Vonoprazan/amoxicillin dual therapy achieved satisfactory H. pylori eradication rates with a favorable safety profile in treatment-naïve patients. Tegoprazan/amoxicillin dual therapy was associated with fewer gastrointestinal adverse event incidences, while optimizing tegoprazan dosing frequency may be necessary to improve the eradication. →
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The effect of inhaled dry salt on pulmonary mucociliary clearance in obstructive lung disease: A randomised, placebo-controlled, crossover study
CONCLUSIONS: Inhalation of 40 mg dry NaCl was well tolerated without acute adverse effects in COPD patients. However, early termination left the study underpowered, increasing the risk of type II error. Non-significant findings should not be interpreted as evidence of no effect. Larger, adequately powered trials are needed to clarify the impact of dry NaCl… →
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Psychologically informed reminder messages for promoting BRCA1/2 carrier screening: evidence from a large-scale population-based study
Psychologically Informed Reminder Messages (PIRMs) may promote health-behavior change, but their impact on preventive genetic screening is unclear. Due to low adherence to a screening program, Clalit Health Services initiated an intervention to encourage BRCA1/2 carrier screening in July 2022. This observational study assesses the effectiveness of the intervention in encouraging screening and its spillover… →
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The Best Customers to Study When Scaling Into a New Market
Carolyn Geason-Beissel/MIT SMR | Getty Images For tech companies worldwide, expanding into a new market is both a rite of passage and a moment of truth. It represents the transition from early promise to meaningful scale — an opportunity to increase revenue, signal growth potential to investors, and unlock powerful sources of differentiation, such as… →
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Are Apprentices an Endangered Species?
Well before he was leading the Rebellion and clashing lightsabers with Darth Vader, Luke Skywalker was a mere apprentice, training in the swamps of Dagobah while carrying his master Yoda on his back. The experience of apprentices and trainees in the real world is not that different from Luke’s. Take, for example, the junior lawyer… →
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When You’re Stuck on “Help Wanted”
“Nobody wants to work anymore.” Or at least that’s what many employers have been claiming, especially those who have trouble hiring workers. The National Federation of Independent Business, for example, found in its January 2026 report that 88 percent of small businesses looking to hire workers reported there were few or no qualified applicants to… →
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When Disaster Almost Strikes, Who Takes the Heat?
Sometimes, a near miss can feel almost as bad as an actual disaster. A soccer team may give up a last-minute goal that gets overturned on review. The stock market could approach the point of crashing. Or tensions between two countries may reach the brink of violence, before being negotiated back at the eleventh hour. … →
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How Faith Shapes Our Inclination to Punish
There are times when we can be sticklers for punishment, demanding retribution for even the smallest mistake. But what drives us to behave this way? That’s the question that Kellogg’s Maryam Kouchaki, along with Rajen A. Anderson of the University of Leeds and Benjamin C. Ruisch of the University of Kent, sought to investigate. Because… →