CONCLUSIONS: The ingestion of high amounts of egg and peanut during pregnancy and lactation did not result in a significantly lower risk of the development of egg or peanut allergy in infants by 1 year of age than ingestion of low amounts of these foods. (Funded by the Australian National Health and Medical Research Council… →

CONCLUSIONS: In children with newly diagnosed high-risk B-cell ALL, replacement of two cycles of highly toxic conventional chemotherapy with blinatumomab resulted in a significantly greater percentage of patients with event-free survival at 4 years. (Funded by Deutsche Krebshilfe and others; AIEOP-BFM ALL 2017 EudraCT number, 2016-001935-12; EU Clinical Trials number, 2023-509856-32-00; and ClinicalTrials.gov number, NCT03643276.). →

CONCLUSIONS: In this interim analysis of a 10-year noninferiority trial, beginning surveillance colonoscopy at 5 years after polyp removal was noninferior to beginning at 3 years with respect to the cumulative incidence of colorectal cancer at 5 years among patients with high-risk adenomas. (Funded by the Research Council of Norway and others; EPoS II ClinicalTrials.gov… →

CONCLUSIONS: This study demonstrates that while users generally trust accurate AI-generated health information more than inaccurate information, higher self-reported learned dependency is associated with weaker trust calibration, predicting greater susceptibility to incorrect outputs. TVCs, such as text highlighting, are insufficient to mitigate this effect. These findings highlight the need for more effective design interventions to… →

Nonspecific low back pain (NLBP) is a prevalent condition associated with pain and functional limitation. This study evaluated the therapeutic efficacy and procedural feasibility of ultrasound-guided acupotomy combined with extracorporeal shock wave therapy (ESWT) compared with monotherapy approaches for NLBP. A total of 90 patients with NLBP were randomly allocated to three groups (n =… →

The dose-response profile of racemic ketamine in internalizing disorders is poorly characterized. This was a secondary analysis of outcome responses in patients with treatment-resistant depression, post-traumatic stress disorder, generalized and/or social anxiety, or obsessive-compulsive disorder. For each disorder, they received single intramuscular doses of racemic ketamine (0.5 and 1.0 mg/kg) and a psychoactive control, using… →

CONCLUSIONS: The toxicities were no more than expected with chemotherapy alone. Adding bortezomib to treatment of ATRT is feasible. →

CONCLUSIONS: Patients with CAD undergoing thoracic surgery had a higher risk of MINS and other ischaemic outcomes than non-CAD patients. There was no evidence that the effect of colchicine differed between patients with and without CAD; however, these analyses were limited by sample size and do not exclude modest differences between subgroups. →