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Antithrombotic treatment for migraine in patients with patent foramen ovale: multicentre, randomised, active controlled, open label trial
CONCLUSIONS: The antithrombotic agents evaluated in this trial (aspirin, clopidogrel, and rivaroxaban) were all non-inferior to metoprolol for responder rate in participants with PFO and migraine. Rivaroxaban also showed superior responder rates over metoprolol without an increase in major bleeding events. →
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Randomized Controlled Trial on the Effect of Yoga on Anxiety Severity, Quality of Life, and Biomarkers in Individuals with Anxiety Disorder
Anxiety disorders are highly prevalent mental health conditions characterized by physiological dysregulation that includes heightened stress responses, low-grade systemic inflammation, and metabolic imbalance, which together contribute to impaired quality of life. Although yoga-based interventions are increasingly used as complementary therapies, evidence isolating the effects of slow pranayama (yoga breathing) and savasana (corpse pose) on psychological… →
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Client and therapist experiences with the Processing of Positive Memories Technique (PPMT) in a randomized controlled trial: insights for protocol refinement
Background: The Processing of Positive Memories Technique (PPMT) is a brief, memory-based intervention designed to enhance access to detailed positive autobiographical memories (AMs) in individuals with posttraumatic stress disorder (PTSD). Although research suggests that PPMT is feasible and may reduce PTSD symptoms, little is known about client and therapist experiences with PPMT when delivered to… →
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A Phase 1 clinical trial to evaluate the safety and tolerability of CLZ-2002 for the treatment of patients with Charcot-Marie-Tooth disease type 1
CONCLUSIONS: A single intramuscular dose of CLZ-2002 of up to 24 million cells was safe and well-tolerated in CMT1 patients. Exploratory efficacy assessments suggested possible clinical benefit, warranting continued investigation of CLZ-2002 in larger, controlled study populations. →
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The Link Between Explicit AI-Generated Images and Offline Crime
Dung Hoang/theispot.com The online revolution enabled frictionless access to virtually every type of content — including adult content. Generative AI has added a whole new, and potentially more dangerous, dimension to the boom in explicit content. In the absence of strong safeguards, AI users can transition from consumers to creators of their own explicit media… →
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Impact of a Staged Enteral Nutrition Nursing Pathway Based on Dynamic Assessment of Tolerance and Aspiration Risk vs Usual Care on Feeding Intolerance in Older Adult Patients With Acute Ischemic Stroke and Dysphagia: A Single-Center Randomized Controlled Trial
BACKGROUND Older adult patients with acute ischemic stroke have dysphagia and require early post-pyloric enteral nutrition, yet feeding intolerance and unstable energy delivery remain common, and practical pathways that integrate tolerance and aspiration risk are lacking. This trial evaluated whether a dual-axis staged nursing pathway, compared with usual care, was associated with lower feeding intolerance… →
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Patient perceptions and preferences during a community-based telehealth care model for moderate-to-severe hypertension in rural communities in Kenya and Uganda
CONCLUSIONS: Participants and providers indicated overall positive attitudes and receptivity to CHW-facilitated telehealth for hypertension care. CHW-delivered telehealth for community-based hypertension care offers one way to improve hypertension treatment outcomes in a manner that prioritizes patient-centeredness and maintains care quality. →
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Longitudinal Dietary Intake of Young People With a First Episode of Psychosis From the Time of Presentation to Six Months Follow-Up
CONCLUSION: Participants consistently reported unhealthy diets that did not adhere to guidelines, with no significant change over 6 months. This study reinforces the inequity of dietary health in people with psychosis, particularly those with lower levels of education. Dietary advice and support represent interventions with high marginal gain in this cohort, and should be part… →
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A Topographical Analysis of Visual Field Improvement in a Phase 2 Randomized Trial of Nicotinamide and Pyruvate for Open-Angle Glaucoma
CONCLUSIONS: Topographical, slope-based endpoints reveal localized arcuate VF improvement with nicotinamide and pyruvate that is missed by global indices and not explained by cognitive change. Bayesian modeling suits small early-phase neuroprotection trials, although structural priors added little over this short follow-up. →
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Tracheobronchial invasion by nontuberculous mycobacteria: a rare but overlooked clinical manifestation-a multicenter retrospective analysis
CONCLUSIONS: Tracheobronchial NTM infection is rare but clinically significant, often occurring in the context of disseminated disease with pulmonary involvement. Immunocompromised hosts, particularly those with AIDS or anti-IFN-γ autoantibody syndrome, are highly susceptible. Bronchoscopy typically reveals mass lesions causing luminal stenosis or occlusion. In this cohort, M. colombiense was the most frequently isolated NTM species.… →
