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Angiography-Based Index of Microcirculatory Resistance in Assessing the MVO and Infarct Size in STEMI Patients
CONCLUSIONS: In STEMI patients, a single bolus of r-SAK before PCI was associated with numeric reductions in post-PCI angio-IMR, MVO, MVO extent and IS. Additionally, angio-IMR exhibited a significantly positive correlation with both MVO extent and IS, demonstrating the diagnostic value of this wire-free method for assessing microvascular injury. →
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Serplulimab combined with bevacizumab and chemotherapy as first-line treatment for recurrent or metastatic cervical cancer (ASTRUM-CC01): a phase II trial
CONCLUSION: First-line treatment with serplulimab in combination with bevacizumab and chemotherapy demonstrated promising antitumor activity and acceptable safety in R/M cervical cancer. These findings support further evaluation in phase III trials. →
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Combined hyperbaric oxygen and repetitive transcranial magnetic stimulation for vascular cognitive impairment: a randomized controlled trail
CONCLUSION: Combined HBOT and rTMS therapy demonstrates superior efficacy in improving cognitive function which may be mediated by the primary somatosensory cortex and primary motor cortex of the brain. However, the combined regimen did not yield greater improvement in daily function or mood. Combined HBOT + rTMS is a promising cognitive rehabilitation strategy in the… →
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Impact of leuprolide and goserelin on androgen suppression and adverse events in patients with prostate cancer
CONCLUSION: ADT effectively achieves hormonal suppression in prostate cancer; however, differences between LHRH agonists influence clinical and metabolic outcomes. Leuprolide 22.5 mg showed superior PSA reduction but higher rates of vasomotor symptoms and weight gain, while goserelin 10.8 mg was associated with hormonal instability and cardiovascular risk. Genetic findings suggest that BRCA2 variants may affect… →
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Over and Out
For this final issue of MIT Sloan Management Review, Benjamin Laker and Maria Papacosta offer advice on ending things well. In that spirit, we want to reflect on the impact our editorially independent publication has had in its 67 years. Over the past few months, we’ve been buoyed by many messages and online comments validating… →
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What Kind of Chief Purpose Officer Does Your Company Need?
Rob Dobi The Research The authors identified 56 individuals with purpose leadership roles who were representative of a variety of industries, company sizes, and regions. Of the CPOs interviewed, 60% identified as female and 40% as male. They conducted semi-structured interviews online from 2022 to 2025 to explore participants’ role experiences, strategic practices, and key… →
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Dethroning Loyalty
Rob Dobi What’s wrong with loyalty? Isn’t it a virtue to display steadfast allegiance to something or someone other than oneself? After all, loyalty has been celebrated as a virtue across many cultures for millennia. As economic headwinds and a tough job market appear to be empowering more authoritarian styles of leadership, it’s a good… →
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How Leadership Anxiety Derails Transformation
Rob Dobi The Research This article draws on a four-year ethnographic study of a professional services firm whose leaders initiated a major transformation to reverse declining performance. The research involved nearly 760 hours of observation across leadership and project team meetings, more than 300 interviews, and analyses of internal documents spanning the full life of… →
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Why Politicians Keep Campaigning on Culture
“It’s the economy, stupid.” For the past three decades, this phrase has been a reliable shorthand for describing what voters really care about. But these days, political rhetoric often centers on cultural flashpoints like religion or immigration instead of the economy. This tendency to highlight cultural issues over economic ones is surprising, as voters consistently… →