CONCLUSIONS: The PREVSAM model and treatment as usual led to similar health outcomes and to similar total societal costs. Neither strategy was shown to be preferable on economic grounds at conventional cost-effectiveness thresholds. High individual variation implies that the screening process needs to be further refined to better identify those patients truly in need of… →

KM-819, a first-in-class inhibitor of Fas-associated factor 1 (FAF1), was investigated in a Phase 2 clinical trial in Korean patients with multiple system atrophy (MSA). Among 34 KM-819-treated patients, 11 met the case definition for suspected DILI, and 9 of these (26%) were adjudicated by an independent hepatic adjudication committee (HAC) as KM-819-related DILI; no… →

CONCLUSIONS: Clinical indication, LMCA bifurcation, and SB disease severity predicted 2-stent PCI. MACE did not differ according to planned strategy, whereas actual 2-stent PCI had higher MACE rates, likely reflecting a higher burden of complexity. The lowest event rates were observed with OCT-guided 1-stent PCI. →

INTRODUCTION: Blood cultures are essential for diagnosing bloodstream infections and guiding antimicrobial therapy, but sample contamination can influence test sensitivity and treatment decision-making. The ‘PIVO Pro’ is a needle-free device which allows blood collection from a peripheral intravenous catheter (PIVC), with its use potentially avoiding sample contamination and decreasing the amount of venepuncture instances. However,… →

CONCLUSION: These findings support the potential role of nurse-led prenatal genetic counseling in reducing anxiety and improving attitudes toward prenatal testing. Larger multicenter studies with longer follow-up are required before educational or policy recommendations can be made. →

CONCLUSIONS: This study may contribute valuable knowledge regarding participant engagement and the potential impact of a multicomponent mobile cognitive behavioral intervention package on fatigue in patients with IBD. The findings will support future refinement of the intervention and inform large-scale evaluations and implementation efforts. →

CONCLUSIONS: In this open-label, proof-of-concept study, empagliflozin was associated with improved short-term natriuretic indices over 10 days in diabetic patients with decompensated cirrhosis and refractory ascites, without serious adverse events. Larger, blinded, longer-term trials are warranted to confirm these preliminary findings. →

CONCLUSIONS: In this randomized, double-arm, prospective, pilot study, the use of moisturizer 30 days before polidocanol 0.5% sclerotherapy did not reduce PSH. →