INTRODUCTION: Emerging evidence supports a role for interleukin 6 (IL-6), a pro-inflammatory cytokine, in the pathogenesis of treatment-resistant major depressive disorder (TRD). However, interventional studies targeting IL-6 in this population remain scarce. Tocilizumab is a humanised monoclonal antibody that inhibits IL-6 signalling and is approved for the treatment of autoimmune conditions such as rheumatoid arthritis.… →

CONCLUSION: Combined MEK and autophagy inhibition showed limited tolerability in human PDAC. Divergent efficacy between preclinical and clinical settings likely reflects differences in tumor cell state heterogeneity between models. Integration of diverse, representative preclinical models is critical to guide development of effective therapies in PDAC. →

This study investigates the impact of different types of personal protective equipment (PPE), specifically Powered Air-Purifying Respirators (PAPRs) and traditional N95 masks with face shields, on the physiological stress responses of healthcare workers (HWs) during the COVID-19 pandemic. Utilizing an interventional randomized crossover trial design, the research encompasses a simulation phase with ten participants followed… →

CONCLUSIONS: Compared with placebo, fermented noni polysaccharide supplementation showed numerically greater increases in NK cell activity at all three E:T ratios (50:1, 25:1, and 12.5:1) in the primary mITT/FAS analysis, although these between-group differences did not reach statistical significance. Prespecified per-protocol set (PPS) sensitivity analyses showed significant between-group differences at E:T ratios of 50:1 and… →

Post-9/11 U.S. combat veterans are clinically complex with multiple co-occurring mental and physical health conditions that often lead to difficulty reintegrating and functioning in civilian life after military service. Difficulty controlling anger is the most frequently reported reintegration problem and is often present across a wide range of both mental and physical conditions. This randomized… →

CONCLUSIONS: As a WeChat-delivered, behavior change wheel-informed intervention, WeMNT successfully reduced 2hPG, HbA1c, and GWG in GDM management. Its integrated self-management model yields robust evidence, validating this patient-centered tool as a viable option for clinical adoption. →

CONCLUSION: BV+AVD significantly improves PFS and reduces bleomycin-associated toxicity, supporting its adoption as a frontline regimen for advanced cHL. Extended follow-up is required to validate the observed survival benefits. →