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Absolute Eczema Area and Severity Index Responses with Lebrikizumab in Patients with Moderate-to-severe Atopic Dermatitis: A Secondary Analysis of Two Phase 3 Trials
The ADvocate trials (NCT04146363, NCT04178967) investigated adults/adolescents with moderate-to-severe atopic dermatitis (AD) receiving lebrikizumab (LEB) monotherapy, using percent improvement in the Eczema Area and Severity Index (EASI). In clinical trials, percent EASI improvement is used to compare study arms and measure treatment effect size/impact. In clinical practice, however, absolute EASI scores are used (especially in… →
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Why trust must (still) guide the UK’s approach to digital identity
In September 2025, Prime Minister Sir Keir Starmer announced that by the end of the current Parliament, the UK would have a new digital identity system. Professor Edgar Whitley argues that the government’s announcement, before conducting detailed policy development and consultation, undermined trust in the proposal from the start. Over 20 years ago, I was… →
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What It Takes to Scale Value-Based Industrial Solutions
Dante Terzigni/theispot.com B2B sales is fiercely competitive. Companies selling big-ticket products and services to other businesses must design solutions that meet their customers’ specific needs with a provable value proposition. Increasingly, that means engaging in value-based sales, where the benefits to the customer are defined, quantified, and managed by the vendor. That’s a challenging practice… →
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Is AI Mastering the Art of Persuasion?
Imagine scrolling through a social-media landscape curated just for you—subtly and perfectly shaped to your tastes, speech patterns, and core values. That kind of hyper-personalized future is not here yet, says Jake Teeny, an associate professor of marketing at Kellogg. But as generative AI supercharges companies’ ability to use their customers’ personal information to craft… →
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In a Race to Blow the Whistle, Compliance Culture Matters
Business leaders who don’t pay close attention to antitrust compliance may have recently received a wake-up call. In January 2026, the U.S. Department of Justice’s antitrust division announced its first-ever whistleblower award. A bid-rigging scheme involving the online used vehicle auction platform EBlock led to a $3.3 million fine for the company. And under a… →
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The effect of 5-hydroxytryptophan, a serotonin precursor, on adults with high levels of Attention Deficit Hyperactivity Disorder traits: A randomised, controlled trial
BACKGROUND: Although several effective therapies exist for Attention Deficit Hyperactivity Disorder (ADHD), current pharmaceutical treatment carries a high risk of misuse and high levels of discontinuation, evidencing a need for alternatives. One possible avenue is serotonergic intervention, particularly within the serotonin synthesis pathway, where there are several potential loci of dysfunction in ADHD. This study… →
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Amino Acid Profile and Composite Metabolic Markers in Postsurgical Oncology Patients Receiving Combined Nutritional Therapy
CONCLUSION: Cancer patients following abdominal surgery exhibit a pronounced amino acid imbalance that is partially correctable by combined nutritional support. The BCAA/AAA, UreaCycle, and arginine indices reflect the metabolic response and correlate with disease severity and nitrogen balance. The rate of correction of these disorders is comparable in both the group receiving Aminoven 10% and… →
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SEO Is Not Enough Anymore: Webflow’s CEO on the Rise of AEO | Linda Tong
The GTM Podcast is available on any major directory, including: Apple Podcasts Spotify YouTube The future of websites isn’t a builder problem anymore. It’s an agent problem. In this episode of GTMnow, Sophie Buonassisi sits down with Linda Tong, CEO of Webflow, to unpack how the entire web is being rewritten for a world where… →
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Effect of probiotics derivatives (postbiotics and metabiotics) on glycemic control in individuals with type 2 diabetes: a randomized clinical trial (DELI_Diab study)
CONCLUSIONS: Three-month supplementation with L. rhamnosus DV lysate significantly improves glycemic control (HbA1c) and reduces waist circumference compared to placebo in T2D patients. While positive trends in insulin sensitivity and anthropometrics were observed, further large-scale studies are required to confirm these metabolic benefits and assess long-term sustainability. →
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Clinical efficacy of Fufang Zaofan Pills and their immunomodulatory effects on peripheral blood dendritic cells in individuals with lower-risk myelodysplastic syndrome
The aim of this study is to evaluate the clinical efficacy of Fufang Zaofan Pills in individuals diagnosed with lower-risk myelodysplastic syndrome (MDS) and to assess associated changes in peripheral blood dendritic cell (DC) levels. A cohort of 60 individuals with newly diagnosed lower-risk MDS were enrolled at the Department of Hematology, Jiading Central Hospital,… →
