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Attachment Orientations and Treatment Outcomes in Psychotherapy: Does the Alliance Mediate the Association?
Previous research has demonstrated associations between patients’ attachment orientations and psychotherapy outcomes. Both theoretical and clinical literature suggest that the therapeutic alliance may serve as a mediator in this relationship. The present study investigated whether the therapeutic alliance mediates the connection between adult attachment and treatment outcomes in a clinical sample. One hundred eighteen patients… →
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The cost-effectiveness of the stopping elderly accidents, deaths and injuries options randomised quality improvement trial to prevent falls among older adults
CONCLUSION: Within the study cohort, the intervention was highly likely to be cost-effective. However, differences in medically treated falls and total healthcare costs were not statistically significant; therefore, we cannot rule out the possibility that the intervention had no impact. →
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Leaders at All Levels: How DBS Bank Makes Everyone an Innovator
DBS Bank believes that innovation is critical to its survival, and to reinforce that objective, it made innovation a KPI representing 20% of every team and individual’s performance review. In this episode of Leaders at All Levels, hosts Katherine W. Isaacs and Michele Zanini speak with Bidyut Dumra, group head of innovation and future of… →
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Ads in ChatGPT Are Coming. What B2B Marketers Should Do Right Now | Keith Delany, CEO Primer
Listen on YouTube // Apple // Spotify Who we sat down with LinkedIn CPMs just hit $800. AI is flooding every channel with content. Outbound is dying. So where should B2B marketers actually spend their ad budget right now? Keith Putnam-Delaney, co-founder & CEO of Primer, joins Sophie to break down the complete state of… →
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Group Therapy for Posttraumatic Stress Disorder Symptoms Among Veterans With Military Sexual Trauma: A Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: This randomized clinical trial showed that both treatments demonstrated efficacy in reducing PTSD symptoms, but the MST-focused treatment compared with the active control demonstrated greater improvements in posttraumatic cognitions. The results support the use of the MST-focused group treatment for PTSD symptoms associated with MST. →
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Baseline serum metabolites predict fractures in individuals who were Black and had type 2 diabetes
CONCLUSION: In summary, the metabolic differences identified here highlight the role of altered systemic metabolism and its relationship to fracture risk. Future investigations will determine if the identified metabolites serve as predictors of fracture in patients with T2D who are not Black. →
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Phase Ib, multicentre, open-label, dose-escalation study to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of subcutaneously administered mosunetuzumab in participants with systemic lupus erythematosus
CONCLUSIONS: Mosunetuzumab demonstrated dose-dependent peripheral B-cell depletion and a safety profile consistent with prior studies in follicular lymphoma. Based on these data, mosunetuzumab is currently being evaluated in a phase II study in severe SLE (NCT07598396). →
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Trauma-focused therapy integrated with cognitive behavioural therapy for psychosis for people with post-traumatic stress disorder and psychosis (the STAR trial): a multicentre, pragmatic, randomised trial in the UK
BACKGROUND: People with psychosis have high rates of post-traumatic stress disorder (PTSD), which is associated with a poor prognosis. We aimed to investigate the effectiveness of a trauma-focused therapy integrated with cognitive behavioural therapy for psychosis (CBTp) in people with psychosis. →
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Safety and efficacy of levacetylleucine in ataxia-telangiectasia: a phase 3, randomised, double-blind, placebo-controlled crossover trial
BACKGROUND: Ataxia-telangiectasia is a rare, autosomal recessive neurodegenerative disorder. Levacetylleucine (N-acetyl-L-leucine) has been shown to be efficacious for the treatment of neurological manifestations and to have a disease-modifying effect in lysosomal storage disorders such as Niemann-Pick disease type C. We aimed to assess the safety and efficacy of levacetylleucine for paediatric and adult patients with… →
