CONCLUSIONS: OC using ice-cold saline effectively reduces the day 14 incidence and severity of HD-MTX-induced OM and improves mucositis-free survival in pediatric ALL. These findings were supported by the reference-based imputation analysis. This intervention appears to be safe and feasible; however, confirmation through ITT analyses and multicenter trials using age-stratified randomization is required before its… →

CONCLUSION: This study first identified distinct uACR trajectory patterns in HFpEF patients. The fluctuating high trajectory was associated with increased cardiovascular risk and heart failure hospitalization, while the association between the decreasing trajectory and myocardial infarction was exploratory and requires validation. →

CONCLUSIONS: The DIMS spectacle lens was noninferior to OKL for slowing axial elongation after 18 months of therapy in myopic children. The DIMS spectacle lens was not superior to OKL. There was no statistically significant difference in overall eye length growth between the DIMS spectacle lens and OKL after 18 months of therapy in myopic… →

CONCLUSIONS: In this study, it was observed that the implementation of a nursing checklist was associated with significant improvements in the quality of airway care and patient outcomes during mechanical ventilation in patients with severe pneumonia, leading to a significant reduction in the duration of mechanical ventilation and improved oxygenation status and prognosis of patients. →

CONCLUSIONS: Early vitamin D deficiency before 20 weeks of gestation was associated with altered metabolic trajectories during pregnancy, including greater increases in LDL cholesterol and ketone body concentrations in women with overweight or obesity, as well as higher cord blood ketone levels in their offspring. These findings suggest that early maternal vitamin D status may… →

Acute elevation in circulating lipids induces reversible insulin resistance and alters triglyceride-rich lipoprotein flux. Whether insulin-regulated remodelling of high-density lipoprotein (HDL)-associated apolipoproteins is altered during defined lipid stress in women with polyendocrine metabolic ovarian syndrome (PMOS) remains unclear. In this exploratory, randomized, cross-over study, 10 healthy women and 12 women with PMOS underwent 5-h saline… →