CONCLUSION: Remimazolam with remifentanil provided better hemodynamic stability and respiratory safety than propofol in PRFA for liver cancer (Child-Pugh A/B, without severe comorbidities). The shorter recovery time, though partly confounded by flumazenil, supports remimazolam as a promising alternative. Further studies in higher-risk patients are needed. →

CONCLUSION: Both CAE and NiTi palatal expanders significantly improved airway dimensions and sleep parameters in UCLP patients. Anterior transverse widening (intercanine and intermolar width) correlated positively with airway volume gains, whereas basal skeletal widening (J-J’ width, basal bone width) and molar inclination did not, suggesting that the overall expansion effect rather than its mechanistic subtype… →

Green tea kombucha is an antioxidant-rich beverage with promising health benefits. However, evidence regarding its effects in physically active individuals remains limited. This study investigated the acute and chronic effects of green tea kombucha, with or without grape skin extract, on immune and oxidative stress markers in beginner runners. This 12-week randomized clinical trial included… →

CONCLUSION: A medical consortium-based chain management protocol effectively optimizes health service organization, strengthens interdisciplinary and inter-institutional collaboration, and improves the continuity, standardization, and efficiency of chronic wound care. This model shortens healing time, enhances patient satisfaction, and provides an implementable and scalable strategy for chronic wound management in the health service system. It offers important… →

Background: Polycystic ovary syndrome (PCOS) is frequently associated with insulin resistance and dyslipidemia. Evidence regarding the metabolic effects of probiotics in PCOS remains inconsistent. This secondary analysis evaluated whether multispecies probiotic supplementation influenced glucose homeostasis, insulin resistance, and the lipid profile in women with PCOS. Methods: Data were derived from a 12-week randomized, double-blind, placebo-controlled… →

CONCLUSIONS: The DECIDE-Children intervention improved body composition by reducing adiposity and increasing fat-free and muscle mass percentage, effects primarily mediated by dietary behaviour. These findings highlight dietary behaviour as a key component in paediatric obesity intervention. →

CONCLUSIONS: Omega-3 PUFA supplementation significantly altered lipid biomarker profiles in youth with migraine over 12 weeks, supporting a measurable whole-blood EPA + DHA response in this proof-of-concept trial. Future larger-scale trials with longer duration are needed to evaluate clinical effects. →

Background and Objectives: Myocardial protection during on-pump coronary artery bypass grafting (CABG) limits ischaemic injury, particularly in patients with left main coronary artery disease (LMCAD), in whom severe proximal stenosis may compromise antegrade cardioplegia delivery. We investigated whether combined antegrade-retrograde blood cardioplegia reduces postoperative high-sensitivity cardiac troponin I (hs-cTnI) concentrations, a marker of perioperative myocardial… →

Background and Objectives: This trial examined whether two task-complexity gait training protocols differentially affect EEG spectral activity, cognitive-motor interference, and gait performance in chronic stroke. Materials and Methods: Forty-four participants were randomly allocated to Progressive Task-Complexity Gait Training (PTCGT; n = 22) or Constant Task-Complexity Gait Training (CTCGT; n = 22). Both groups trained for… →

The ITALUNG trial (Italian Lung Cancer Screening Trial) is a randomised controlled trial that evaluated the efficacy of Low-Dose Computed Tomography (LDCT) for lung cancer screening of over 3100 high-risk individuals, smokers and ex-smokers, aged 55-69. ITALUNG was coordinated by the Institute for Cancer Prevention Research in Florence and carried out across Tuscany in three… →