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Incidence, risk factors, and cardiovascular impact of hypertension in people with HIV: a secondary analysis of the REPRIEVE trial
BACKGROUND: People living with HIV have an increased risk of cardiovascular disease, but data on the development and consequences of hypertension remain limited. Using data from REPRIEVE, a global randomised trial of pitavastatin for primary cardiovascular prevention among people with HIV, we evaluated whether pitavastatin reduces the incidence of hypertension among participants without hypertension at… →
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What Happens When AI Transforms a Specialized Field Overnight?
Before AI came for your job, it came for the biologists’. In 2020, Google DeepMind researchers unveiled AlphaFold2, an AI model that tackled a major scientific challenge: Is it possible to determine a protein’s structure from its ingredients alone? The ability to do so without slow and expensive lab experiments carried the potential to revolutionize… →
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With Status Symbols, Let Someone Else Do the Bragging
Over a century ago, the economist Thorstein Veblen popularized the age-old idea that by purchasing luxury goods, and displaying them, people can communicate their elevated reputation—such as their wealth, success, or competence. This practice, which he referred to as “conspicuous consumption,” has been going on for millennia. Studies of Neolithic societies, for example, show evidence… →
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Swipe or Tap? How Age Shapes the Adoption of New Technologies
In Europe, over a fifth of the population is at least 65 years old. In Japan, the figure is nearly 30 percent. And the World Health Organization projects the percentage of people across the globe who are over 60 years old will reach 22 percent by 2050, just about double what it was in 2015. … →
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Deconstructing Cursor’s Growth Playbook: $4M to $2B ARR in 18 Months
This is Part IV of the Deconstructing GTM series. If you missed the previous editions, you can catch up on them here: Read Part I (ClickUp), Part II (Vanta at $100M), and Part III (Gamma at $100M). Slack took two and a half years to reach $100M ARR. Dropbox took four years. Cursor took twelve… →
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Durability of efficacy, safety, and quality of life 5 years after valoctocogene roxaparvovec gene transfer for severe hemophilia A: final phase 3 GENEr8-1 trial results
CONCLUSION: Valoctocogene roxaparvovec provides durable hemostatic efficacy, FVIII activity, and improved health-related quality of life for ≥5 years, with no new safety signals. →
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Deep Learning-Based Augmented Contrast-Enhancement and Denoising for Reduced-Iodine and Low-Radiation 70-kVp Cerebral CT Angiography: A Prospective Study
CONCLUSION: Cerebral CTA at 70-kVp using ultralow iodine enhanced arterial attenuation but increased image noise compared with the 100-kVp CTA protocol. DL-ACE and DL-DN significantly increased arterial attenuation and reduced image noise, resulting in higher CNR and better subjective image quality. →
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Factors Affecting Technology Acceptance and Usability of a Personalized Online Nutrition and Exercise Web-Based App (Heal-Me): A Multimethods Study
CONCLUSION: Performance expectancy emerged as the most influential factor predicting participants’ intention to use the Heal-Me web-based app, with findings clearly indicating a high level of acceptance of the first version of this technology. →
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Audit Yourself to Get More From GenAI
Carolyn Geason-Beissel/MIT SMR | Getty Images More than a year into using generative AI daily, I wondered whether I was getting the most out of my AI use. There was no benchmark or feedback loop, and no one was grading my sessions with ChatGPT and Claude — until I created a self-audit. I did what… →
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Effect of multicomponent exercise intervention on multidimensional frailty in older adults with mild cognitive impairment: a secondary analysis of the MIND-STEP randomised clinical trial
BACKGROUND: Frailty is common among older adults with mild cognitive impairment (MCI) and encompasses physical, cognitive, psychological and social domains, yet randomised evidence on theory-informed multicomponent exercise interventions targeting multidimensional frailty remains limited. This secondary analysis of the MIND-STEP RCT evaluated intervention effects across frailty domains. →
