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An Open-Label, Dose-Escalation Trial of Psilocybin-Assisted Therapy for Bipolar II Depression
Objective: Individuals with bipolar II disorder (BD-II) and depression face limited treatment options and are often excluded from psilocybin therapy trials due to concerns about precipitating mania or psychosis. The objective of this study was to evaluate the safety, tolerability, and preliminary efficacy of psilocybin therapy in individuals with BD-II and depression. →
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Impact of Simulation-Based Training on Audiology Students’ Professional Competences: A Pilot Randomized Study
CONCLUSIONS: Simulation-based training was more effective than case-scenario observation, even when observation was paired with structured debriefing, highlighting the added value of hands-on, experiential participation. →
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Effects of exergame combined with elastic band resistance training on exercise self-efficacy and physical activity levels in older adults with cognitive frailty: A mixed-methods study
CONCLUSIONS: Exergame combined with elastic band resistance training effectively improves exercise self-efficacy and physical activity levels among community-dwelling older adults with cognitive frailty. The beneficial effects of this intervention may be attributed to its positive impacts on enhancing exercise enjoyment, promoting health perceptions, and improving social interaction. This program provides a practical exercise intervention model… →
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Enhancing Self-Awareness in Older Adults With Mild Cognitive Impairment: A Preliminary Randomized Controlled Trial of the Feuerstein Instrumental Enrichment Program
CONCLUSIONS: The FIE program produced significant and durable improvements in self-awareness of memory abilities in older adults with MCI. Findings support the clinical utility of mediated learning approaches for addressing metacognitive deficits in this at-risk population, with implications for rehabilitation engagement and dementia prevention efforts. →
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OpenCV DNN Module: Deep Learning Inference in OpenCV 5
OpenCV’s DNN module lets you run a trained neural network inside the same application that reads images, processes video, and draws results. You can export a model to ONNX, load it with OpenCV, and use its predictions without loading the training framework in your application. OpenCV 5 expands that workflow with a new inference engine… →
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High potency and water dispersible Boswellia extract reduces pain and inflammation in subjects with osteoarthritis of the knee: A randomized, double-blind, placebo-controlled trial
CONCLUSION: Based on the current study findings, it can be concluded that OLNP-27 is an effective and safe natural option for the management of symptoms associated with osteoarthritis of the knee. →
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Efficacy and Safety of Tofacitinib Versus Placebo in Patients With Early-Grade Knee Osteoarthritis: A Randomized, Double-Blind, Placebo-Controlled Trial
CONCLUSION: Tofacitinib was not superior to placebo in early-grade knee osteoarthritis, and the large within-group improvement rebounded toward baseline by 6 months, consistent with a predominantly non-specific (contextual) response. Because participants were selected radiographically without inflammatory phenotyping, these findings do not support tofacitinib in unselected early-grade disease but cannot exclude benefit in an inflammatory phenotype;… →
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Early-life serum protein profiles associated with bronchopulmonary dysplasia in extremely preterm infants
CONCLUSION: Differences in early serum protein trajectories are evident in infants who develop BPD. Our findings suggest associations consistent with proposed pathophysiological mechanisms. Clinical factors likely interact with immune-related proteins in the development of BPD. Mitigating inflammation by stabilising potential protective factors could be important for BPD prevention. →
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Bone lid technique versus standard curettage for maxillofacial cysts: a prospective 3D CBCT study of bone regeneration and tooth stability
CONCLUSION: The Bone Lid Technique was associated with more favorable early bone regeneration and enhanced tooth stability compared with standard curettage. However, the robustness of the surface-area finding should be interpreted cautiously because baseline lesion morphology differed between groups and the corresponding sensitivity estimate was less stable. It may be particularly beneficial for moderate-sized cystic… →
