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Take 5: Time to Negotiate
“You do not get what you want. You get what you negotiate.” Though these words by American businessman Harvey Mackay are mostly meant to be provocative, they’re not too far off from capturing what it’s like to navigate the business world today. Whether it’s a higher salary, a better deal, or the right to give… →
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Cost-Effectiveness of Community-Based Rehabilitation for People With Schizophrenia: A Secondary Analysis of a Cluster Randomized Trial
CONCLUSIONS AND RELEVANCE: In this secondary analysis of a cluster randomized trial, group-based CBR for schizophrenia in China was associated with improved outcomes and a high probability of cost savings, supporting its scaled implementation in resource-constrained settings. →
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Subcutaneous MG1113 in severe hemophilia A and B: phase 1b study for safety, pharmacokinetics, and pharmacodynamics
CONCLUSION: MG1113, administered subcutaneously as a prophylaxis in patients with severe hemophilia A or B without inhibitors for 8 weeks, demonstrated an acceptable safety profile with a PK profile suitable for once-a-week dosing. The pharmacodynamics marker changes were consistent with TFPI inhibition, which was associated with reductions in bleeding events. →
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Superior-head automated external defibrillator placement during single-rescuer cardiopulmonary resuscitation: a randomized crossover simulation study and retrospective multicenter cohort
CONCLUSION: Superior-head AED placement improved the efficiency, compression continuity, and workload of simulated single-rescuer CPR. The retrospective clinical findings were directionally consistent but statistically inconclusive and should be regarded as hypothesis-generating rather than confirmatory. Prospective validation is required before clinical implementation. →
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OpenCV Enhances Native Computer Vision Development for Windows on Snapdragon®
Planned work will focus on native builds, sustainable build-and-test infrastructure, and performance optimization for the open-source developer community PALO ALTO, Calif., Sept. 14, 2026 — The Open Source Vision Foundation (OSVF), the nonprofit organization that operates OpenCV, today announced plans to enhance OpenCV support for Windows on Snapdragon®. As part of this effort, OSVF is… →
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Detection and treatment of peritoneal metastases in colon cancer: COLOPEC trial compared to routine practice
CONCLUSION: Despite increased detection and more frequent treatment of peritoneal metastases in the COLOPEC trial, 5-year overall and disease-free survival were comparable to routine practice. →
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18F-FDG PET/CT metabolic parameter to predict pathological complete response and survival after neoadjuvant immunotherapy plus chemoradiotherapy in resectable esophageal squamous cell carcinoma
CONCLUSIONS: None of the single metabolic parameters of the primary tumor were significant predictors of pCR-tu. LnSUVmax2 has diagnostic value for lymph nodes metastasis. The patients with SUVmax2 ≥ 12.4 and LnSUVmax2 ≥ 7.9 had poorer OS and DFS, but they are not independent prognostic factors, which needs to be confirmed by larger scale clinical… →
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Efficacy of A Virtual Agent-Based Digital Intervention (Echo App V2.0) for Patients With Alcohol Use Disorder: Randomized Controlled Trial
CONCLUSIONS: Echo App V2.0 attenuated postdischarge craving increases and may reduce short-term relapse among patients with AUD. However, the relapse finding was sensitive to missing-data assumptions and was not sustained at 3 months. Postdischarge continuation strategies may be needed to maintain benefits. →
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Associations Between Short-Term Changes in Disease Activity and Long-Term Clinical Outcomes in Activated Phosphoinositide 3-Kinase Delta Syndrome
CONCLUSIONS: In this clinical trial setting, short-term improvements in immunodeficiency and dysregulation following treatment with leniolisib were associated with longer-term improvements in clinical outcomes, including infection rates and quality of life, for patients with APDS. →
