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Five-year outcomes of the STOP-AD randomised controlled trial: Long-term effects of early emollient therapy in high-risk infants
CONCLUSIONS: Early, short-term emollient use initiated in the neonatal period was associated with lower AD prevalence and severity at 5 years in high-risk children. Although the effect estimate remained similar following multiple imputation, uncertainty due to attrition remained. These findings suggest that brief early-life barrier support may influence longer-term AD outcomes and support further investigation… →
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Reminder recall is associated with higher mammogram uptake among overdue repeat screeners: an exploratory telephone survey within a randomized trial
CONCLUSIONS: MR recall was associated with higher mammogram uptake among overdue repeat screeners. Timely reminders, simplified scheduling, and close follow-up remain key to overcoming behavioural barriers to screening in high-access health systems. →
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Patients’ perceptions on HIV testing and starting antiretroviral therapy during implementation of universal test and treat
CONCLUSIONS: The implementation of UTT in South Africa has provided a supportive framework for people to understand their diagnosis, accept it and adhere to ART in a caring space. →
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Effect of coffee bean chlorogenic acid on peripheral skin temperature and skin blood flow in healthy Japanese women with cold sensitivity: a placebo-controlled, randomized, double-blind, study
CONCLUSION: These results suggest that the ingestion of coffee bean CGA can suppress the decrease in SkT and SkBF in a cold environment. →
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Effectiveness of virtual reality exposure therapy in improving body dissatisfaction and shape-related concerns in adolescent girls with anorexia nervosa: a controlled, randomized, superiority trial
BACKGROUND: Anorexia nervosa (AN) involves qualitative and quantitative dietary restrictions, leading to significant weight loss and changes in body shape. Patients with AN are often more concerned about their body image than the general population is. Body dissatisfaction and shape-related concerns (BD-SRC), which are risk factors for relapse, are some of the most difficult AN… →
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The AI Governance Paradox
Getty Images Operations that run under extreme risk — such as nuclear power plants, aircraft carriers, and air traffic control centers — have long understood that safety depends not just on good technology but on how people exercise judgment under uncertainty. The scholarly field of high-reliability organizing (HRO) has identified a clear normative framework to… →
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Cost-Effectiveness of Remote Symptom Monitoring During Adjuvant Endocrine Therapy in Breast Cancer
CONCLUSIONS AND RELEVANCE: In this economic evaluation of RPM for women receiving AET, app-only RPM showed lower costs with similar QALY compared with EUC. Its simpler design may also be more readily scalable than the app plus feedback intervention, supporting its potential as a pragmatic, value-based supportive care strategy in oncology. →
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Role of magnesium as a protective agent in cisplatin-induced nephrotoxicity in head and neck cancer
CONCLUSIONS: Mg can serve as a protective agent against CIN, as it reduces renal injury biomarkers, including urinary KIM-1, urinary NGAL, serum sFasL, and serum MDA when incorporated into treatment regimens at different doses, compared to cisplatin alone. Moreover, Mg had a promising role in the improvement of quality of life in cases with HNC… →
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Spatial Acid-Associated Niches Inform Irinotecan-Based DEB-TACE in Colorectal Liver Metastases: A Multicentre Randomized Trial
CONCLUSIONS: Acid-associated spatial organization and drug-response predictions provide a rationale for local irinotecan delivery in CRLM. These findings support further evaluation of UniPearls-based DEB-TACE and prospective biomarker-stratified studies linking niche biology to clinical benefit. →
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Teacher-student-machine interaction autonomous learning: a structured LLM-integrated framework for developing independent clinical reasoning in residency training
CONCLUSIONS: The TSM-AL framework significantly enhanced clinical reasoning competencies that transferred to independent performance, demonstrating that structured LLM integration develops autonomous reasoning rather than fostering technological dependency. →