BACKGROUND: Obesity among college students may be accompanied by early metabolic and endothelial abnormalities before overt cardiometabolic disease develops. Freestyle swimming combines whole-body energy expenditure with low weight-bearing load. This randomized controlled trial will compare high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) freestyle swimming and examine the relationships between changes in glycolipid markers… →

BACKGROUND: Insomnia and poor sleep are highly prevalent among university students and are linked to impaired mental and physical health, reduced cognitive functioning, and lower academic performance. Existing interventions for insomnia include cognitive behavioural therapy for insomnia (CBT-I), mindfulness, and sleep hygiene. CBT-I is widely recognised as effective but remains difficult to access for the… →

CONCLUSION: APA produced a short-lived advantage in CIPN severity and more consistent improvement in interference, specifically with in-person delivery. Findings are preliminary: no blinding or attention control, differential attrition (52% vAPA versus 96% usual care), and exploratory quality-of-life analyses. →

CONCLUSIONS: The FINI is a robust and valid measure assessing meaningful and important key functional impacts for people with narcolepsy. These findings support use of the instrument in clinical trials to evaluate treatment benefit in NT1. Given the FINI’s sensitivity to change, it can potentially facilitate treatment decisions and track longitudinal outcomes in clinical practice. →

CONCLUSIONS: This Phase I study showed that three repeated IT injections of UC-MSCs are safe and well-tolerated in children with ASD. Preliminary behavioral and biomarker improvements warrant further study in larger controlled trials. →

CONCLUSIONS: Combined regional anesthesia provided superior early analgesia and greater patient and surgeon satisfaction than general anesthesia. Exploratory post-hoc analyses suggested lower 24-hour cumulative pain burden, lower total perioperative cost and shorter operating room utilization. These economic and operational findings should be considered hypothesis-generating. →

CONCLUSION: VRG use during CTR was associated with lower pain immediately after the procedure and higher SpO₂ immediately after CTR. No significant effects were observed for SBP, DBP, HR, or RR. These findings suggest that VRG may be a useful non-pharmacological adjunct for short-term pain management during CTR following open-heart surgery. Further studies are needed… →

CONCLUSION: This external pilot showed no superiority of CO-OP plus creative dance over CO-OP alone for the prespecified primary outcome (executive function). Preliminary signals for global cognition and dual-task accuracy warrant confirmation in an adequately powered definitive trial with a prespecified, clinically meaningful primary endpoint. →

Anhedonia, which is characterized by a loss of pleasure and engagement in rewarding activities, is prevalent across diagnostic groups and is associated with worse clinical and treatment outcomes. Existing evidence-based treatments have only modest effects on improving anhedonia. Reward learning (RL) is an important driver of reward-responsive behavior, which could be leveraged to improve reward… →

CONCLUSION: Both appliances were associated with reductions in AHI. The non-prespecified between-appliance comparison detected no statistically significant difference and does not establish equivalence. Complete confounding between period and measurement methodology, together with insufficient adherence, titration and adverse-event data, limits conclusions about the overall comparative merits of the appliances. →