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Long-term efficacy of lebrikizumab in treating head, neck and face involvement in patients with moderate-to-severe atopic dermatitis
CONCLUSIONS: Lebrikizumab provided durable, stable long-term HNF efficacy across diverse populations, including systemic-naive patients and those with prior biologic exposure. →
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Effect of a Subanesthetic Dose of Esketamine on Postoperative Sleep Disturbance After Oocyte Retrieval Under Intravenous Anesthesia: A Randomized Controlled Trial
CONCLUSION: A single subanesthetic dose of esketamine was associated with a lower incidence of short-term PSD on POD 3 in women undergoing oocyte retrieval under intravenous anesthesia. Larger multicenter studies are warranted to confirm these findings. →
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Gut Regulated Associations of Neuronal Signalling in High Blood Pressure (GRAINS-BP): a double-blinded randomised crossover placebo-controlled trial
BACKGROUND: Hypertension affects 1 in 3 Australian adults and is a major contributor to stroke and myocardial infarction. Despite the availability of various medications, over 50% of patients struggle to control their blood pressure (BP) due to nonadherence, difficulty finding the right treatment, or avoidance of medication. Diet plays a key role in cardiovascular health,… →
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Full-spectrum LED screen-bar lighting as an adjunct to artificial tears in visual display terminal-related dry eye: a randomized study
CONCLUSIONS: Adding a full-spectrum lamp to artificial tears was associated with a greater short-term improvement in subjective dry eye symptoms in VDT-related dry eye, without corresponding between-group differences in objective ocular surface parameters. Further studies are required to confirm these findings. Trial registration number ChiCTR2400084309, 2024/05/14. →
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Clinical Decision Support for Fall Prevention in Primary Care: The eSTEPS Cluster Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this cluster randomized clinical trial of an electronic health record-integrated decision support, falls and fall-related injuries were modestly reduced in older adults in primary care. These results suggest support for scalable, workflow-integrated fall prevention. →
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Preference for Resistance Training Volume After Acute Exercise in Women With Fibromyalgia: A Randomized Crossover Clinical Trial
BACKGROUND AND PURPOSE: To evaluate participants’ preferences following acute exposure to three resistance training protocols differing solely in the number of sets performed. →
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Chemical and laser desensitization approaches for managing dentin hypersensitivity after non-surgical periodontal therapy: A randomized clinical trial
PURPOSE: This randomized clinical trial aimed to evaluate and compare the desensitizing efficacy of Gluma, Er,Cr:YSGG laser irradiation, and their combined application in Stage III/IV periodontitis patients presenting dentin hypersensitivity (DH) following non-surgical periodontal therapy (NSPT). →
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Body weight following a multidomain lifestyle intervention in older adults at risk of dementia — A post-hoc analysis of the AgeWell.de-trial
CONCLUSIONS: In this post-hoc analysis, group allocation was not associated with lower body weight at follow-up. Despite high levels of motivation and confidence regarding weight loss and favorable changes in diet and physical activity in the intervention group, these changes did not translate into measurable weight loss. →
