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Resolve the Conflict Between Efficiency and Resilience
Ellice Weaver/Ikon Images Operational efficiency is critical for both financial success and customer satisfaction. Efficient systems, characterized by minimal buffers and idle time, tight schedules, and maximum asset utilization, allow organizations to do more with less, thereby boosting revenue and appealing to time-sensitive customers. However, such systems often lack resilience, increasing an organization’s vulnerability to… →
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Ensitrelvir for Covid-19 Postexposure Prophylaxis in Household Contacts
CONCLUSIONS: Ensitrelvir administered to household contacts of a patient with Covid-19 within 72 hours after symptom onset in the index patient was effective in preventing Covid-19 in the contacts. (Funded by Shionogi; SCORPIO-PEP Japan Registry for Clinical Trials number, jRCT2031230124; ClinicalTrials.gov number, NCT05897541.). →
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VC: “Software Is Basically Worth Zero Now” | Tyler Hogge, Ex-Pelion
The GTM Podcast is available on any major directory, including: Apple Podcasts Spotify YouTube Tyler Hogge helped take Divvy from zero to a $2.5B acquisition by Bill.com. Now, as General Partner at Pelion Ventures, he argues that charging for software is dead, per-seat pricing is collapsing, and the next decade of venture-scale companies will be built… →
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Curcumin Supplementation Reduces Inflammation, Neutrophil-to-Lymphocyte Ratio (NLR), and Antioxidant Status in Obese Patients with Type 2 Diabetes: A Randomized Controlled Trial
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance and impaired insulin secretion, and curcumin-a polyphenolic compound derived from Curcuma longa-has shown potential anti-inflammatory and antioxidant effects. This randomized, double-blind, placebo-controlled trial evaluated the effects of 1500 mg/day curcumin supplementation for 12 months in 114 adults with T2DM, with assessments… →
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Anti-Nogo-A NG101 treatment induces changes in spinal cord micro- and macrostructure following spinal cord injury
NG101 is a recombinant antibody that neutralizes the nerve growth inhibitor Nogo-A, promoting neural repair and improving upper extremity motor function in spinal cord injury (SCI). This study evaluated spinal cord MRI biomarkers to detect treatment-related structural changes and enhance patient stratification using data from 106 participants with acute cervical SCI in the phase 2b… →
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Beyond Verification — What Responsible AI Really Demands of Human Experts
For the fifth year in a row, MIT Sloan Management Review and Boston Consulting Group (BCG) have assembled an international panel of AI experts that includes academics and practitioners to help us understand how responsible artificial intelligence is being implemented across organizations worldwide. In our first post this year, we explored how organizations should think… →
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Comparison of polypropylene versus polyester mesh in lichtenstein inguinal hernia repair with respect to chronic pain and inflammatory changes
CONCLUSION: Polypropylene and polyester meshes demonstrated comparable short-term pain, chronic pain, and recurrence outcomes following Lichtenstein inguinal hernia repair. Polyester mesh was associated with lower early postoperative inflammatory markers and reduced early swelling, although these differences did not translate into significant differences in 3-month pain outcomes. Larger multicentric studies with longer follow-up are required to… →
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Experiences and Perceived Influence of the Artificial Intelligence-Based Health Education Accurately Linking System (AI-HEALS) on Health Behaviors Among Patients With Type 2 Diabetes: Qualitative Study
CONCLUSIONS: Patients generally perceived AI-HEALS as a useful source of ongoing education, behavioral prompting, and everyday support for diabetes self-management. The findings suggest that artificial intelligence-enabled education may work not only by increasing knowledge but also by reinforcing awareness, translating guidance into feasible daily action, and supporting psychological adaptation. At the same time, the intervention’s… →
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Attenuating trauma- and cocaine-related intrusions by blocking memory reconsolidation with minocycline: protocol for a transdiagnostic randomized controlled trial
Background: Post-traumatic stress disorder (PTSD) and substance use disorders frequently co-occur, with their comorbidity linked to poorer treatment outcomes. Beyond this epidemiological overlap, PTSD and, in particular, cocaine use disorder (CUD) have also been conceptually linked, as maladaptive memory processes are thought to play a central role in both of their etiopathogeneses. PTSD and CUD… →
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Effect of electroacupuncture at Yifeng (TE17) and Fengchi (GB20) on prognosis of moderate-to-severe peripheral facial paralysis in the acute stage: a randomized controlled trial
CONCLUSION: Electroacupuncture at Yifeng (TE17) and Fengchi (GB20) can effectively promote the recovery of voluntary movement in the middle and lower facial muscles of patients with moderate-to-severe peripheral facial paralysis in the acute stage, and improve their physical and social functions, demonstrating a high clinical application value. →
