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Clinical study of silicone hydrogel multifocal soft contact lenses for correction of presbyopia
Objective: To evaluate the efficacy and safety of a novel silicone hydrogel multifocal soft contact lens for presbyopia correction, and to verify its non-inferiority compared with a conventional hydrogel multifocal contact lens. Methods: This was a prospective, randomized, open-label, parallel-group, multicenter non-inferiority clinical trial. From October 2024 to July 2025, 195 presbyopic subjects aged ≥40… →
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Patient Monitor Position and Operator Ability to Visualize a Desaturation Event During Intubation
CONCLUSION: Positioning of the patient monitor at the head of the bed results in delayed visualization of desaturation events during simulated direct and video-assisted laryngoscopy across different levels of experience. Ideally, the patient monitor should be positioned on the side of the bed and within the operator’s direct line of sight. Further research is warranted… →
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The Elusiveness of Merit-Based Hiring
Patrick George/Ikon Images Since early 2025, organizations seeking to curry favor with the current U.S. administration have disavowed earlier commitments to workforce diversity, equity, and inclusion (DEI) and proclaimed that their hiring practices are therefore meritocratic. But framing DEI and merit as antithetical dichotomies, as various executive orders have done, does not mean that abandoning… →
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The Efficacy and Safety of Pregabalin Combined with Venlafaxine in Fibromyalgia Patients: Protocol for a Prospective, Randomized, Open-Label, Blinded-Endpoint Trial
CONCLUSION: If the combination of pregabalin and venlafaxine proves to be more effective and better tolerated than pregabalin monotherapy, the combination therapy could establish a new standard of care for FM patients who struggle to achieve sufficient pain relief through nonpharmacological therapies. →
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OCT-Defined Plaque Morphology and Clinical Outcomes After Percutaneous Coronary Intervention: An ILUMIEN IV Substudy
CONCLUSIONS: Based on preprocedural OCT, PCI of calcific and fibrotic plaques was associated with the highest and lowest 2-year rates of TVF and ID-TVR, respectively, with lipidic plaques being of intermediate risk. This is the first report from a large-scale clinical trial that demonstrates the prognostic utility of baseline OCT plaque morphology on post-PCI outcomes.… →
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The Marketing Capability Paradox: Seven Forces Eroding Your Marketing Team’s Effectiveness
Alice Mollon/Ikon Images Marketing capabilities — the complex bundles of skills, processes, and organizational know-how that enable companies to implement customer-related activities and adapt to marketplace changes — are rated by marketing professionals as important to business success. At the same time, artificial intelligence is rewriting the rules of content creation, customer targeting, and performance… →
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How Today’s CEOs Can Prepare for Tomorrow’s Crises
Being the CEO or board member of a large company has never been easy. These leaders are responsible for making critical decisions that impact the health and long-term viability of an organization as well as its employees and their families. Today, these jobs are harder than ever. The same risks—and potential rewards—hold true, but there… →
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What Impact Investors Want from Companies with a Cause
When a company with a cause pitches itself to investors, which part of its identity should its leaders stress: its positive impact on society or its positive bottom line? The answer is both, according to William Towns, an adjunct professor in the Social Impact and Sustainability program at the Kellogg School. But the order matters.… →
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Antithrombotic strategy according to age in patients with atrial fibrillation and drug-eluting stents: a post hoc analysis of the ADAPT AF-DES randomised trial
CONCLUSIONS: In this post hoc analysis, NOAC monotherapy was associated with a lower risk of net adverse clinical events, specifically within the older age subgroup. Tailored approach regarding age and individual ischaemic risk may be needed. →
