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Integrated exposure-based therapy for co-occurring post-traumatic stress and substance use among young people: a randomized controlled trial
Background: Despite well-documented evidence demonstrating the efficacy and safety of integrated treatments for post-traumatic stress disorder (PTSD) and substance use disorder (SUD) in adults, few studies have been conducted among adolescents and young adults, developmental periods when these disorders typically have their onset.Objective: This randomized controlled trial compared the efficacy of an integrated exposure-based treatment… →
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Efficacy of Reticulocyte Haemoglobin Equivalent-Guided Versus Transferrin Saturation-Guided Iron Supplement Protocol in Haemodialysis Patients: A Multicenter Cluster Randomized Controlled Trial
CONCLUSION: RET-He-guided intravenous iron supplementation was non-inferior to TSAT-guided supplementation for reducing ERI over 6 months. Use of RET-He may offer a lower-cost and more accessible strategy for anaemia management in haemodialysis patients, particularly in resource-limited settings. →
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How Leaders Unlock Innovation on the Front Lines
PPaint/Ikon Images Balancing the daily grind of operations with the spark of innovation is one of the most persistent challenges managers face.1 Regulatory compliance, performance metrics, and the never-ending demands of customers can easily crowd out creative thinking. Work overload or mismanaged operations elevate employee stress, which directly constrains ideation capacity. This cognitive bottleneck triggers… →
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Digital Mental Health Treatment and Symptoms of Depression and Anxiety in Breast Cancer Survivors: A Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: This randomized trial found that BCS can benefit from a DMHT program, particularly for reducing anxiety. Coaching may promote consistent engagement with a DMHT for those with difficulty engaging initially. →
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Instructional Emphasis and PHQ-9 and GAD-7 Scores Among Participants With Anxiety or Depression: A Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this randomized clinical trial of instructional emphasis on PHQ-9 and GAD-7 scores among participants with anxiety or depression, findings suggest that variation in how questionnaire instructions are emphasized can influence PHQ-9 and GAD-7 scores, underscoring the need for standardized administration in clinical, research, and digital settings. →
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Paramedic analgesia comparing ketamine and morphine in trauma. A synopsis of the PACKMaN double-blind RCT
CONCLUSION: Ketamine does not provide superior analgesia than morphine when treating acute severe trauma pain. Ketamine is a suitable alternative that is safe for use by paramedics. →
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Early Detection and Temporal Progression of Hemidiaphragmatic Paralysis After Supraclavicular Brachial Plexus Block with 20 mL vs 30 mL Ropivacaine: A Randomized Controlled Trial
CONCLUSION: HDP can be detected as early as 5 minutes after SCBPB, with incidence plateauing by 20 minutes while CMAP amplitude continues declining. Higher volume (30 mL) nearly doubles HDP risk (RR=1.972). Respiratory monitoring should begin within 5 minutes of block placement. →
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Cardiac Rehabilitation for Cardiovascular Risk Modification in Patients With Rheumatoid Arthritis and Hypertension: A Randomized Controlled Trial
CONCLUSION: In selected patients with clinically stable rheumatoid arthritis and coexisting hypertension who were receiving stable pharmacologic therapy and were able to participate in supervised exercise, a structured cardiac rehabilitation program was associated with improvements in estimated cardiovascular risk profiles, ambulatory systolic blood pressure, and cardiorespiratory fitness without worsening disease activity. These findings support further… →
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Subgingival air polishing (glycine powder) versus minocycline hydrochloride: efficacy in residual periodontal pockets following endoscope-assisted scaling and root planing
CONCLUSIONS: Combining E-SRP with glycine air polishing or local minocycline improved periodontal conditions, suppressed early biofilm and inflammation, and promoted healing of deep residual pockets. Both treatments produced equivalent outcomes at all follow-up time points, with stage-specific therapeutic effects observed among patients at different periodontal stages. The 4-week early adjunct approach is practicable in clinical… →
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A clinical study on fall risk assessment and preventive nursing in older adults with non-Hodgkin’s lymphoma undergoing chemotherapy-a randomized controlled trial
CONCLUSION: A targeted, multifactorial nursing intervention substantially reduced falls and fall-related complications among older adults with NHL receiving chemotherapy. Integration of fall prevention measures into routine oncologic care is strongly recommended to safeguard treatment continuity and patient well-being. Further multicenter and long-term studies are warranted to validate these findings and refine comprehensive fall prevention strategies. →
