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Efficacy and Safety of Vibegron Add-On Therapy for Persistent Overactive Bladder Symptoms in Benign Prostatic Hyperplasia Patients With α1-Blocker Treatment: A Multi-Center Prospective Randomized Controlled Study (VATON Study)
CONCLUSIONS: Vibegron add-on therapy to an α(1)-blocker may be effective and safe for treating BPH with persistent OAB symptoms. →
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Effect of Prebiotic Supplementation With and Without Physiotherapy on Pain and Pain Sensitivity in People with Knee Osteoarthritis
Background: Emerging evidence links the gut microbiome to chronic pain processing. Inulin, a prebiotic fibre, modulates the gut microbiome, while physiotherapy-supported exercise (PSE) improves pain and function. We evaluated the effects of inulin supplementation with and without PSE on knee osteoarthritis (OA) pain. Methods: In a 2 × 2 factorial RCT, 117 community-dwelling adults with… →
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Effect of a digital training package on clinical outcomes in Malawi’s index case testing programme: a cluster randomised controlled trial
CONCLUSIONS: Enhanced digital training positively impacted meaningful clinical outcomes and could be replicated for expansion to other evidence-based interventions. →
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Effects of Exercise on Cognitive Impairment in Patients Receiving Chemotherapy: A Multicenter Phase III Randomized Controlled Trial
CONCLUSIONS: EXCAP may reduce CRCI and mental fatigue, particularly in patients receiving 2-week cycles of chemotherapy. A healthy inflammatory response, characterized by increases in both proinflammatory and anti-inflammatory cytokines, is associated with less cognitive impairment during chemotherapy. →
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The Growth OS Map: Winning in the Age of Channel Collapse
This edition felt like a particularly important one, given the speed at which channels are evolving. TL;DR The problem: CAC payback has hit 57 months. Traditional channels (SEO, Outbound, Ads) are collapsing under AI noise. The shift: You can no longer rent attention. You must build an Operating System of defensible “Growth Loops” that compound… →
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Can Nocebo Effects Be Reduced via Open- and Closed-Label Counterconditioning?
CONCLUSIONS: These results show that particularly open-label counterconditioning is an effective method to modulate nocebo effects on pressure pain. This provides promise in designing non-deceptive learning-based treatments to reduce nocebo effects in diverse patient groups, including chronic pain disorders. →
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Guided Tissue Regeneration and Subepithelial Connective Tissue Graft in the Treatment of Gingival Recession: A Randomized Clinical Trial
CONCLUSIONS: The findings of this study indicate that both surgical procedures may effectively treat Miller’s class I and II GRs, resulting in satisfactory root coverage. →
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Comparative efficacy of low-concentration trisodium citrate and low-concentration heparin for locking central venous hemodialysis catheters: a randomized controlled study
Central venous catheters (CVCs) are used in hemodialysis patients when arteriovenous fistulas (AVFs) or grafts (AVGs) are not feasible. Catheter-locking anticoagulants (CLAs), such as low-concentration trisodium citrate (TSC) and unfractionated heparin (UFH), are used to prevent catheter dysfunction (CD), but comparative data on their safety and efficacy — especially at low concentration remain limited. This… →
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Leaders at All Levels: Kraft Heinz’s 5X Speed Secret
Is 36 months too long for a new-product cycle? It was for Kraft Heinz. So, starting with a pilot project, it was able to cut time to market to just six months by redesigning how people worked. Today, units throughout the company are applying that model’s step-by-step approach to change and are seeing measurable improvements… →
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Using a Wearable-Based Animated Patient Avatar to Improve Patients’ Perception of Vital Signs: Multicenter Computer-Based Study
CONCLUSIONS: This computer-based study suggests that Visual Patient Wearable visualizations enhance patients’ ability to detect and recall simulated vital sign deviations. Participants found the system intuitive, easy to learn, and reassuring. The Visual Patient Wearable system provides an at-a-glance interface that may support patients’ understanding of their vital signs and could facilitate communication of relevant… →
