CONCLUSIONS: Baseline TOPOSCORE classification was insufficient to predict treatment outcome in this cohort. Longitudinal TOPOSCORE patterns were heterogeneous, and the small number of complete longitudinal profiles precludes conclusions that chemotherapy induced a favorable microbiome transition. These exploratory findings support further evaluation of microbiome ecosystem dynamics in larger prospective cohorts. →

CONCLUSION: The ICOPE-based DP approach slows IC decline and enhances multiple functional domains, offering a valuable reference for transitional care for older adults. →

CONCLUSIONS: This study failed to demonstrate a survival advantage after eltrombopag addition, at variance with previous reports, but shows that initiating eltrombopag after chemotherapy washout is feasible and safe, and resulted in a decreased need for platelet transfusions. →

CONCLUSIONS: This study demonstrated a multilevel intervention (MAP) is feasible to deploy and acceptable. Importantly, MAP shows promise in building patient confidence about team-based active surveillance care delivery and increased primary care involvement through targeted education around the role or primary care. →

CONCLUSION: Early rehabilitation nursing for patients with AMI can effectively improve patients’ cardiac function indices and reduce the risk of MACE, thereby improving their quality of life. →

CONCLUSIONS: This study showed that a 12-week free sugar-restricted diet can lead to weight reduction and improvements in blood glucose and lipid profile parameters in women with PCOS. →

AIM: This study aims to determine the effect of applying Orem’s self-care model on balance and fatigue in patients with diabetic neuropathy. →

BACKGROUND: Obesity among college students may be accompanied by early metabolic and endothelial abnormalities before overt cardiometabolic disease develops. Freestyle swimming combines whole-body energy expenditure with low weight-bearing load. This randomized controlled trial will compare high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) freestyle swimming and examine the relationships between changes in glycolipid markers… →

BACKGROUND: Insomnia and poor sleep are highly prevalent among university students and are linked to impaired mental and physical health, reduced cognitive functioning, and lower academic performance. Existing interventions for insomnia include cognitive behavioural therapy for insomnia (CBT-I), mindfulness, and sleep hygiene. CBT-I is widely recognised as effective but remains difficult to access for the… →

CONCLUSION: APA produced a short-lived advantage in CIPN severity and more consistent improvement in interference, specifically with in-person delivery. Findings are preliminary: no blinding or attention control, differential attrition (52% vAPA versus 96% usual care), and exploratory quality-of-life analyses. →