Metastatic clear cell renal cell carcinoma (ccRCC) remains largely incurable, and the efficacy of pembrolizumab plus axitinib may be limited by hypoxia-associated signaling, immunosuppressive cytokines, and metabolic reprogramming involving the TGF-β1/HIF axis. Seleno-L-methionine (SLM) is a pharmacologic inhibitor of this axis and its downstream effectors, including PD-L1 and VEGF. In a phase I/II pilot study… →

Rehabilitation is a key component of Parkinson’s disease (PD) management, although individual responses differ substantially. Genetic factors involved in neuroplasticity and inflammation may contribute to this variability. We investigated whether selected polymorphisms in inflammation- and neuroplasticity-related genes influence motor outcomes following intensive multidisciplinary rehabilitation in patients with PD. Sixty-six patients with a diagnosis of idiopathic… →

BACKGROUND: This study is a randomized controlled trial evaluating a telehealth version of the Brief Alcohol Screening and Intervention for College Students (BASICS) program as an equally efficacious alternative to the traditional in-person implementation. →

CONCLUSIONS: The literature supports the benefit of CTAR in improving swallowing in community-dwelling older adults. Our study has demonstrated that older, frail adults are able to perform CTAR and could use the ExerPhager. A future study should investigate the benefits of CTAR-SwiFt in community-dwelling older, frail adults after pneumonia. →

CONCLUSION: This prospective randomized study demonstrates that LEOVIT PHARMA enteral nutrition product for patients with type 2 diabetes mellitus undergoing amputation is a highly effective and safe therapeutic component. →

Background: Insomnia disorder affects 10%-35% of the general population and is maintained by pathological cortical hyperarousal amenable to inhibitory neuromodulation. Continuous theta burst stimulation (cTBS) produces rapid inhibitory effects on cortical excitability, but its efficacy in insomnia disorder has not been evaluated in adequately powered randomized sham-controlled trials. →

CONCLUSIONS: Two weeks of moving cupping reduced multifidus stiffness more than sham cupping, and the difference persisted 1 week after treatment. Pain decreased more with moving cupping, although the between-group difference was small, and there were no significant effects on disability or quality of life. Moving cupping may reduce paraspinal muscle stiffness but is not… →

CONCLUSION: In this pilot trial of patients with subacute stroke undergoing inpatient rehabilitation, SBT was feasible and well tolerated but did not demonstrate superiority over tied-belt training for balance, walking speed, or activities of daily living. An exploratory signal in seated reach warrants confirmation in adequately powered trials. →

CONCLUSION: Guideline implementation efforts in RACFs may benefit from a multifaceted implementation approach involving early engagement with aged care leadership and contextualised delivery of implementation strategies according to staff preferences and needs. →

CONCLUSIONS: Cadonilimab plus lenvatinib and TACE showed encouraging antitumor activity in patients with non-metastatic unresectable HCC. The safety profile was tolerable and manageable. The encouraging results observed warrant further study in larger clinical trials for this treatment combination. →