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Effectiveness evaluation of heat-sensitive moxibustion self-management in community patients with essential hypertension: a randomized controlled trial
CONCLUSIONS: Heat-sensitive moxibustion self-management can reduce systolic blood pressure, improve antihypertensive effective rate, and alleviate hypertension-related symptoms and quality of life in community patients with essential hypertension, with favorable safety and compliance. These findings suggest that heat-sensitive moxibustion can be promoted as an adjunctive management strategy for essential hypertension in community settings. →
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TACE combined with apatinib versus TACE alone for unresectable hepatocellular carcinoma in China: a cost-effectiveness and budget impact analysis
CONCLUSIONS: The TACE-apatinib regimen provides clear clinical benefit for uHCC in China, but its cost-effectiveness and budget feasibility are contingent on drug price. Successful national centralised procurement is the key policy lever to enable value-based access, as demonstrated by this integrated evidence framework. →
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Why Design Thinking Needs a Responsibility Reboot
Marie Montocchio/Ikon Images For years, social media companies have come under fire for promoting divisive, false, and dangerous content in order to monetize user engagement. But in March, when a jury in Los Angeles Superior Court found Meta and Google liable for causing harm to users due to the addictive nature of their products, the… →
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The Insightful Leader Live: Designing Your Post-Corporate Life
Tom O’Toole is a Clinical Professor of Marketing at the Kellogg School of Management. Previously, he was Associate Dean of Executive Programs and Executive Director of the Executive Fellows Program at Kellogg. O’Toole is a Senior Advisor to McKinsey & Company. He serves on the board of Alliant Energy and has been a director of… →
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Prophylactic vs Therapeutic Anticoagulation in Hospitalized Patients With COVID-19: A Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In patients hospitalized with COVID-19, in-hospital therapeutic anticoagulation with LMWH followed by edoxaban to day 42 did not statistically significantly reduce death and/or thromboembolic events compared with prophylactic anticoagulation followed by placebo. →
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Low Prevalence of Exploratory Biochemical Patterns Compatible with Osteomalacia in a Large Cohort of Participants with Low Serum 25-Hydroxyvitamin D Levels
The threshold for vitamin D deficiency is mainly based on osteomalacia prevention. Osteomalacia is diagnosed by bone biopsy, but may potentially also be identified biochemically. Our objective was to examine the prevalence of exploratory biochemical patterns compatible with osteomalacia in a population with low vitamin D status, as well as the effect of vitamin D… →
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Short-Term Clinical Comparison of Scapular Stabilization With and Without Added Kinetic-Chain Exercises on Pain, Scapular Kinematics, and Upper-Extremity Function in Overhead Athletes With Subacromial Pain Syndrome: A Randomized Controlled Trial
CONCLUSION: Both rehabilitation programs were associated with short-term improvements in patient-reported outcomes. However, adding kinetic-chain exercises did not result in a clear additional short-term benefit compared with scapular stabilization alone. Because the kinetic-chain group also completed more exercises overall, the specific contribution of the kinetic-chain component cannot be determined. Given the small sample size and… →
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A workbook- and audio-administered, telephone-guided, low-intensity cognitive behavioural therapy intervention (EJDeR) for parents of persons treated for cancer during childhood: protocol for the CHANGE-pilot randomised controlled trial
INTRODUCTION: Childhood cancer and its treatment place substantial demands on parents, causing significant disruptions in multiple areas of life. Parents report psychological, psychosocial, and economic consequences related to their child’s illness. In Sweden, psychosocial support is available to parents via paediatric oncology care during cancer treatment; however, only a minority of parents have access to… →
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A randomised, participant- and assessor-blinded, sham-controlled trial investigating acupuncture for disorders of gut-brain interaction in children (P-GAP)
BACKGROUND: Disorders of gut-brain interaction (DGBIs) affect approximately 25% of children worldwide and account for a substantial proportion of paediatric gastroenterology consultations. These conditions are associated with significant morbidity, including chronic pain, school absenteeism, anxiety and reduced quality of life. Current treatment options offer limited efficacy, particularly in paediatric populations. Acupuncture, a widely used complementary… →
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Real-Time Artificial Intelligence Diagnostic Copilot in Simulated Primary Care Consultations: Randomized Simulation Study
CONCLUSIONS: In this randomized, high-difficulty simulation study, real-time, voice-based AI assistance was associated with higher physician Top-3 diagnostic accuracy than an unassisted, resource-restricted comparator. Some sensitivity analyses were supportive, while others were directionally favorable but inconclusive, and the safety analysis suggested possible overreliance without statistically conclusive difference between conditions. These findings support further refinement and… →
