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Denecimig (Mim8) prophylaxis over 52 weeks in adolescents and adults with hemophilia A: FRONTIER2 extension study
CONCLUSIONS: Denecimig maintained low ABRs over 52 weeks, was well tolerated, and improved patient-reported outcomes in adolescents and adults with HA with or without inhibitors. →
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Wound dehiscence following biportal endoscopic versus microscopic spine surgery for single-level lumbar decompression: a post hoc analysis of two randomized controlled trials
CONCLUSIONS: BESS was associated with significantly lower wound dehiscence rates compared with MSS in patients undergoing single-level lumbar decompression or discectomy. Drainage volume ≥ 100 mL may serve as a clinical indicator for enhanced wound surveillance in MSS patients. These hypothesis-generating findings warrant validation in independent cohorts. →
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Does baseline physical function modify the response to a physical activity intervention in adults with arthritis? A secondary analysis of a randomized trial
Responses to physical activity interventions vary among adults with arthritis, and baseline functional limitations may affect increases in walking. To determine whether baseline physical function moderated changes in accelerometer-measured steps/day after a telephone-delivered Walk With Ease (WWE-T) intervention. This secondary analysis included 267 adults from a randomized trial of WWE-T versus wait-list control. Baseline function… →
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A secondary analysis of the SODa-BIC randomized clinical trial using multiple hierarchical composite outcomes
CONCLUSION: In this post-hoc analysis of the SODa-BIC trial, the use of hierarchical composite outcomes did not alter the neutral overall interpretation of the original trial. However, this analysis provides additional insight into the relative contribution of individual components of the primary outcome. →
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Clinical Characteristics and Factors Associated with One-Year Smoking Cessation Among Smokers with COPD: A Subgroup Analysis of a Multicentre Randomised Trial
CONCLUSION: Immediate referral to a cessation clinic was the factor most strongly associated with one-year abstinence, together with absence of comorbidity and, tentatively, repeated hospitalisation; greater disease severity was associated with quitting only in unadjusted comparisons. These exploratory findings support structured cessation pathways in routine COPD care. →
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Why Is the U.S. Stock Market Outpacing Europe’s?
Welcome to the United States of Europe. It’s a large, Western nation with a population similar to that of the United States of America. Its workforce is roughly comparable to America’s, too, as is the quality of its academic institutions and its overall economic development. Of course, the United States of Europe doesn’t really exist.… →
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What Hostage Diplomacy Can Teach Us About Everyday Negotiation
In February 2022, WNBA star Brittney Griner was arrested at a Moscow airport with cannabis oil in her luggage. She was charged, tried, convicted, and sentenced to nine years in a penal colony. The legal process, though ordinary on the surface, was political theater. Ten months later, Griner walked free, exchanged for notorious Russian arms… →
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There’s a Higher Bar for Working from Home
Most remote job listings look like any other—until you read the fine print. More skills are required. More experience is expected. That’s the pattern that Letian Zhang, an associate professor of management and organizations at Kellogg, began to notice while studying how technological changes reshape work and management. Zhang collaborated with Kellogg PhD candidate Shinan… →
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When the Leader Becomes the Brand
History is full of entrepreneurs and inventors who’ve shaped entire markets: Thomas Edison who turned electricity from a curiosity into a practical public utility, Marie Kondo who popularized joy in personal organization, Bill Gates who helped make personal computers a mass-market reality. But for every Edison, there have been countless others whose names didn’t become… →