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Irinotecan with trifluridine/tipiracil and bevacizumab for second-line metastatic colorectal cancer: a phase II multicenter study
Patients diagnosed with metastatic colorectal cancer (mCRC) face a constrained therapeutic landscape following the failure of initial treatment. This multicenter, single-arm, phase II trial (NCT06202001) aimed to assess the efficacy and safety of a novel second-line regimen comprising trifluridine/tipiracil (TAS-102), irinotecan, and bevacizumab. Patients with mCRC resistant to prior fluoropyrimidine and oxaliplatin-based chemotherapy were enrolled.… →
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Sex differences in risk factor control and medication adherence post-ACS: insights from the TEXTMEDS randomised clinical trial
CONCLUSION: This study reveals that female patients are less likely to achieve LDL-C targets and engage in physical activity but more likely to maintain a healthy BMI. Although females showed lower medication adherence, this association weakened after adjusting for socio-economic factors. These findings highlight the importance of sex-sensitive strategies focusing on risk factor control and… →
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Rethink Responsibility in the Age of AI
Mark Airs/Ikon Images Early one morning in 2018, a self-driving Uber vehicle fatally struck a pedestrian in Tempe, Arizona. The world had questions: Who was responsible? Was it the safety driver behind the wheel? The engineers who designed the algorithms? Uber’s leadership? Or the regulators who had allowed autonomous-vehicle testing? The inability to name a… →
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Comparison of VCV and PCV-VG modes on diaphragmatic function in diabetic patients undergoing laparoscopic colorectal surgery: a prospective randomized controlled study
CONCLUSION: PCV-VG mode can reduce intraoperative mechanical power, better preserve postoperative diaphragmatic function. However, these improvements did not translate into clinical benefits, as evidenced by the lack of reduction in the incidence of PPCs. →
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A trifold prehabilitation model prior to induction chemotherapy in patients with leukemia: a randomized controlled trial
CONCLUSIONS: This study demonstrates that prehabilitation is safe, feasible, and potentially beneficial for physical, nutritional, and psychological outcomes in leukemia patients. →
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Prevalence and Incidence of Chlamydia trachomatis and Neisseria gonorrhoeae Among Women Who Initiated HIV PrEP During Pregnancy in Kenya
CONCLUSIONS: CT/NG incidence was high among women who initiated preexposure prophylaxis in pregnancy, indicating that CT/NG testing would be high yield in this population. →
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Gain Consumer Insight With Generative AI
Stuart Kinlough/Ikon Images Marketing leaders often face a dilemma: Deriving the insights they need in order to make confident decisions can cost tens of thousands of dollars and involve several months of data gathering and analysis, by which time market conditions may have shifted. Can generative AI fundamentally reshape this calculus? Drawing on recent research,… →
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Impact of hypnosis during coronarography
CONCLUSION: Our results demonstrated a significant reduction of perceived pain, anxiety, and use of analgesic drugs in hypnosis responder patients. Hypnosis could be an alternative or complementary method to improve patient comfort significantly, during coronarography. →
