-
Prehospital Use of Non-Invasive Ventilation for Acute Respiratory Failure due to Acute Exacerbation of Chronic Obstructive Pulmonary Disease. A Randomised Trial
CONCLUSION: The clinical effect of prehospital non-invasive ventilation could not be determined due to early termination. This trial highlights important challenges relevant to future clinical trials in the prehospital setting, including patient selection, diagnostic requirements and implementation of complex interventions. →
-
12-weeks fisetin supplementation and interval resistance with aerobic training: changes in Maresin-1 and inflammatory markers in men with obesity: a randomized controlled trial
CONCLUSION: Twelve weeks of concurrent interval resistance-aerobic training, especially when combined with fisetin, improved inflammatory resolution (↑Maresin‑1, ↓IL‑6, and ↓TNF‑α) and metabolic control (↓FBS, ↓insulin, and ↓HOMA‑IR) in obese men. The synergy between exercise‑induced adaptations and fisetin’s anti‑inflammatory properties offers a promising non‑pharmacological strategy for mitigating obesity‑related metabolic risk. →
-
The Distribution Era
This article is a really important one to us at GTMfund. It’s the result of weeks of writing and years of compounding market perspective. It’s the belief that we founded GTMfund on, and it feels more important today than ever. Hope you enjoy reading it as much as we enjoyed writing it. The full thing… →
-
A Personalised and Gamified Digital Decision Aid for Colorectal Cancer Screening: A Randomised Controlled Pilot Study
CONCLUSIONS: Preliminary findings suggest that a digital DA with personalised and gamified content may enhance CRC screening uptake and partially support informed choice. Larger, multisite studies are warranted to evaluate scalability, inclusivity, and long-term effectiveness in population-based cancer prevention. →
-
Expressive writing intervention on optimism and coping modes of newly diagnosed people with human immunodeficiency virus: A randomized controlled trial
CONCLUSION: The expressive writing intervention would improve optimism and promote more positive coping modes for newly diagnosed people with HIV. →
-
Exploring transdiagnostic factors for mental health screening in primary care: a secondary analysis of a randomised controlled pilot study
OBJECTIVE: This secondary analysis of a randomised controlled pilot study (n = 87 patients) examined how transdiagnostic factors-including emotion regulation mechanisms (emotion beliefs, cognitive reappraisal, emotion suppression and experiential avoidance) and negative affectivity-relate to depressive, anxiety and somatic symptoms in the primary care setting, and whether emotion regulation mechanisms provide potential screening relevance beyond negative… →
-
Fit your own mask first: Leading under pressure
“Fit your own oxygen mask first” is a universally accepted safety instruction, but can the same logic be applied to leadership? Marita, Ming, Saher, Adam, Egan, and Dongsoo, argue that in high pressure environments, the ability for managers to self-regulate their own stress is a prerequisite for effective decision-making, emotional presence, and team performance. When… →
-
Lorazepam Versus Diazepam in Alcohol Dependence Syndrome: Which Is Better?
Objective: To compare the efficacy of lorazepam and diazepam in managing alcohol withdrawal and associated anxiety and depressive symptoms in alcohol dependence syndrome. →
-
VC: Tomasz Tunguz on AI’s $575B Bet, the 5th-Largest Infrastructure Project Ever
Listen on YouTube Listen on Apple Listen on Spotify You can also watch/listen to the entire episode on X. Bigger Than Apollo, Bigger Than the Highway System: Inside the $575B AI Infrastructure Bet Hyperscalers are spending every dollar of free cash flow they generate. Then they’re borrowing more. Meta, Google, and Oracle are now levered roughly… →
-
A Staff-Directed Electronic Medical Record Alert to Increase Chlamydia Screening: A Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this randomized clinical trial of chlamydia screening, an alert directed to medical assistants was associated with increased odds of a test ordered in primary care practices. This study’s results suggest that an alert could increase the proportion of women screened for chlamydia and reduce the reproductive sequelae of this common STD. →
