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Biomarker screen-guided care for preterm birth risk in nulliparous pregnancies: a subgroup analysis of the PRIME randomized controlled trial
CONCLUSIONS: In nulliparous PRIME trial participants, IGFBP4/SHBG screen-guided care reduced composite neonatal morbidity and NICU admissions compared to routine care. These findings support the clinical utility of biomarker-guided preventive strategies in first-time pregnancies lacking prior obstetric history. →
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Primary Care Integrated Management of chronic obstructive pulmonary disease (PRIM-COPD): study protocol for a cluster-randomised controlled trial
INTRODUCTION: Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide, with China bearing a particularly high burden. Major gaps persist in early diagnosis, guideline-based treatment and long-term disease management, especially in primary care. This study aims to evaluate the efficacy and feasibility of the National Essential Public Health Services (NEPHS)… →
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GenAI Success Metrics: Look Beyond Reduced Workload
Matt Harrison Clough / Ikon Images The Research The authors performed a four-year, fixed-window observational analysis of administrative work inside a large U.S. public higher-education institution. Generative AI tools were introduced to executive leaders, operational leaders, and student-facing professionals throughout the organization in 2026. Staffing levels and work hours remained stable across the period studied.… →
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Development and Validation of a Computational Histology Artificial Intelligence-Powered Biomarker in Metastatic Hormone-Sensitive Prostate Cancer on Randomized Phase III Trials
CONCLUSION: We developed and validated an image-only AI-based biomarker associated with clinical outcomes and potential benefit from treatment escalation in mHSPC independent of conventional clinicopathologic risk factors. →
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Optimizing treatment for depressed parents of children with emotional and behavioral disorders: A multi-site feasibility trial
CONCLUSION: Given that a priori progression criteria were met and we found preliminary indication of efficacy, we conclude that an RCT of ADAPT to determine efficacy is warranted. →
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Efficacy and safety of reduced-dose daratumumab plus bortezomib and dexamethasone (DVd-lite) in newly diagnosed MGRS patients
CONCLUSIONS: These findings demonstrated that the DVd-lite regimen is an effective and well-tolerated first-line treatment option for newly diagnosed MGRS patients. →
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Subliminal Priming Effects on Motor and Cognitive Performance: Pilot Evidence With Implications for Neurorehabilitation
CONCLUSIONS: Subliminal priming produced modest gender-dependent effects on maximal walking speed and reaction time. These preliminary findings indicate selective sensitivity of high-demand motor tasks to subliminal cues, warranting further investigation using larger sample sizes and clinical populations. →
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Leadership’s Blind Spot in the Age of AI
Carolyn Geason-Beissel/MIT SMR | Getty Images In 1951, philosopher Martin Heidegger told a small audience, “The most thought-provoking thing in our thought-provoking time is that we are still not thinking.” Few understood him then. Seventy-five years later, the observation has become unavoidable because AI has forced every leader to confront a question about the nature… →
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Hospital-Based Psychosocial Case Management and Suicide Prevention in South Korea: A Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this RCT of outpatients with MDD and high suicide risk, ACM significantly reduced C-SSRS total scores and psychological distress compared with usual care. These findings provide a critical, high-level evidence base for the national implementation of standardized, hospital-centered psychosocial interventions as a scalable public health strategy for suicide prevention. →
