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  • Refining Home-Based Squat Training: The Role of Hip Adduction in Improving Neuromuscular Control for Clinically Diagnosed Patellofemoral Pain Syndrome

    13 октября, 2026

    BACKGROUND Patellofemoral pain syndrome (PFPS) often stems from neuromuscular imbalances, particularly vastus medialis obliques (VMO) dysfunction impairing patellar tracking. Research is shifting toward integrated rehabilitation strategies, such as combining hip adduction with squats to enhance VMO recruitment. MATERIAL AND METHODS Thirty participants with PFPS were randomized to traditional squatting (SQU, n=15) or squatting with hip… →

    Clinical Trials
  • Improvement in peripheral airway function after a 12-week exercise intervention in COPD

    13 октября, 2026

    CONCLUSIONS: IOS measures improved after the exercise intervention, suggesting physiological adaptations beyond skeletal muscle conditioning that resulted in improved airway mechanics and ventilation distribution in the peripheral lung, while other lung function measures remained largely unchanged. →

    Clinical Trials
  • Effect of pre-visit computer-assisted history-taking with a structured copy-ready summary on documentation completeness in screening for inflammatory rheumatic diseases: a randomized pilot study

    13 октября, 2026

    CONCLUSIONS: Pre-visit CAHT combined with a structured, copy-ready summary substantially increased the completeness with which predefined screening-relevant information was transferred into clinical documentation while also suggesting high acceptance among both patients and physicians. These findings support further evaluation in a larger trial assessing workflow impact and clinical impact. →

    Clinical Trials
  • Oral eplerenone in first-episode acute central serous chorioretinopathy: results of a double-masked randomized trial

    13 октября, 2026

    CONCLUSION: Eplerenone accelerates SRF resolution and enhances choriocapillaris perfusion in acute CSCR, although visual outcomes remain comparable to placebo. Early MR antagonism may offer anatomical and microvascular benefits in CSCR management. →

    Clinical Trials
  • Impact of Extent of Coronary Artery Disease in Transcatheter Aortic Valve Replacement: A PRO-TAVI Substudy

    13 октября, 2026

    CONCLUSIONS: In patients with concomitant coronary artery disease undergoing TAVR, deferral of PCI reduced bleeding risk and appeared safe across all SS categories. Deferral of PCI in patients with more complex coronary artery disease (SS >17) was associated with higher risk for the ischemic composite outcome. These post hoc findings require confirmation in randomized trials.… →

    Clinical Trials
  • Occlusion-Focused Triage vs Very-High-Risk NSTEMI Criteria: A DIFOCCULT-3 Substudy

    13 октября, 2026

    CONCLUSIONS: An occlusion-focused diagnostic approach was associated with substantially higher rates of immediate invasive management and earlier identification of patients with adjudicated ACO. →

    Clinical Trials
  • Combined Effect of Hypnotic-Cognitive Therapy With Therapeutic Exercise on Quality of Life in Individuals With Fibromyalgia: A Randomized Controlled Trial Protocol

    13 октября, 2026

    BACKGROUND: A multidisciplinary approach is viewed as the primary treatment strategy for fibromyalgia (FM). Therapeutic exercise is an important component of this approach. Hypnotic cognitive therapy (HYP-CT), a relatively new intervention strategy, has not traditionally been incorporated in FM treatment, although it has shown beneficial effects in other chronic pain conditions. This study aims to… →

    Clinical Trials
  • Effectiveness of a self-management intervention on clinical outcomes among patients with type 2 diabetes at high risk for Diabetic Kidney Disease: A Randomised Controlled Trial

    12 октября, 2026

    CONCLUSIONS: The self-management intervention effectively improved HbA1c, eGFR, SBP and LDL-C among T2DM patients at high risk of DKD. These findings suggest that integrating structured self-management into routine diabetes care may help improve modifiable risk factors and support early DKD prevention. →

    Clinical Trials
  • Long-Term Neurodevelopmental Outcome Following Three Randomized Controlled Trials of Choline in Fetal Alcohol Spectrum Disorder (FASD)

    12 октября, 2026

    CONCLUSIONS: Very few RCTs have been conducted in FASD, and interventions targeting cognitive functioning are needed. The data reported here suggest that choline supplementation has long-lasting neurodevelopmental benefits, especially in non-verbal IQ and working memory for individuals with FASD. →

    Clinical Trials
  • Effect of injectable platelet rich fibrin augmented with vitamin c compared to injectable platelet rich fibrin alone on healing of necrotic mature single rooted teeth with chronic periapical periodontitis following regenerative endodontic therapy (a randomized controlled trial)

    12 октября, 2026

    CONCLUSIONS: Both i-PRF combined with vitamin C and i-PRF alone appear to be effective regenerative scaffolds, demonstrating comparable clinical and radiographic outcomes in regenerative endodontic procedures. →

    Clinical Trials
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