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Non-invasive endotyping improves treatment satisfaction and prescribing appropriateness in patients with angina and no obstructive coronary artery disease
CONCLUSIONS: In patients with ANOCA, non-invasive CMR-guided endotyping substantially improves treatment satisfaction and enables more appropriate, mechanism-targeted pharmacotherapy compared with angiography-guided care. →
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A Peer-Led, Nurse-Involved Blended Online and Offline Peer Support Program (PNO2PSP) for Psychosocial Adjustment in Young- to Middle-Aged Patients With Breast Cancer: Cluster Randomized Clinical Trial
CONCLUSIONS: The PNO2PSP effectively improved psychosocial adjustment, social support, and positive coping in young- to middle-aged patients with breast cancer. Its scientifically validated, feasible, and patient-centered design supports its recommendation for wider clinical implementation, with continued training for peer supporters and sustained delivery of peer support. →
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Long-Term Outcomes, Moderators, and Predictors in Online Mindfulness-Based Cognitive Therapy for People With Cancer: Secondary Analysis of a Randomized Controlled Trial
CONCLUSIONS: Group-blended and individual-unguided eMBCTs effectively reduced psychological distress and improved well-being among people with cancer and survivors, with greater benefits for those with fewer psychological resources. However, individuals experiencing higher levels of distress were more likely to discontinue group-blended eMBCT. These findings highlight the importance of considering individual preferences and pragmatic factors in treatment… →
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Podcast: When It Comes to Biases, AI’s Only Human
Just like the humans who train them, generative AI models can skew a certain way. As a leader, it’s important to understand how those biases can creep in. “If you care about innovation, if you care about being someone who can step outside the box and predict what is next in the industry, use AI… →
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Who Should Decide the Outcome for a Clinical Trial? Comparing the Views of Stakeholders on Intervention Benefit Using Multi-Criteria Decision Modelling of Cognitive Remediation
CONCLUSIONS: This study shows how stakeholder values can identify nuances in outcomes depending on the value placed on treatment benefits. Embedding this approach into trial design can strengthen the alignment of outcomes with patient and service priorities and help close the gap between randomized trials and service implementation. →
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Does Attention-Deficit/Hyperactivity Disorder Predominant Presentation Matter? Examining Functional and Symptom Changes After Cognitive Behavioural Therapy
CONCLUSIONS: CBT is highly effective and durable across ADHD presentations and formats. Although the combined presentation exhibited a more pronounced reduction in core symptoms, this differential trajectory represents a promising clinical trend requiring cautious interpretation. While brief formats efficiently address core symptoms, standard programs may better optimize long-term functional recovery. →
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Comparing the response of triple therapy and conventional treatment in male congenital hypogonadotropic hypogonadism: a randomized controlled trial
CONCLUSIONS: Triple therapy provided a better quality of life without compromising spermatogenesis. The AMH and Inh B provided an effective means of monitoring. →
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Lessons From Innovation Pioneer Florence Nightingale
Carolyn Geason-Beissel/MIT SMR | Wellcome Collection Florence Nightingale may be best remembered as the epitome of a kind, caring nurse, but she was also a force for disruptive innovation in health care. Three distinct elements of her work — communicating data compellingly, publicizing clear and simple instructions, and expanding professionalized training — carry timeless lessons… →
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How Buyers Now Decide Before Talking to Sales | Sam Senior, Founder & CEO of TestBox
The GTM Podcast is available on any major directory, including: Apple Podcasts Spotify YouTube AI isn’t just changing how we sell. It’s changing how buyers make decisions before they ever talk to you. Sam Senior, Founder and CEO of TestBox, joins Sophie Buonassisi on The GTMnow Podcast to break down exactly what’s happening to the… →
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Optimal Switching Antiplatelet Regimen in Patients with Ticagrelor to a Thienopyridine in Korean Patients (SWAPT-K Study)
BackgroundDual antiplatelet therapy (DAPT) with aspirin and potent P2Y(12) inhibitors such as ticagrelor effectively reduces ischemic events but increases bleeding risk. In patients requiring long-term DAPT, switching from ticagrelor to a thienopyridine is often considered to reduce bleeding risk or address other clinical concerns. However, such switching may cause a transient reduction in platelet inhibition,… →
