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When Cultures Collide in Crisis
Sergio Ingravalle/Ikon Images High-stakes disruptions test businesses’ cultural agility as well as their operational resilience. As supply chains stretch across continents and leadership teams span time zones, cultural agility becomes a business essential. Many crises now unfold across cultures as much as they do across borders, but few executives are prepared for what happens when… →
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Extended in vivo activity of VRC01 HIV-1 prophylaxis entails initial protective efficacy and subsequent breakthrough infections
The two parallel antibody-mediated prevention (AMP) efficacy trials evaluated whether intravenous infusion of the anti-CD4 binding site broadly neutralizing antibody VRC01 prevents HIV-1 acquisition. Here, we analyzed HIV-1 acquisition in AMP through the week 104 final study visit. Against viruses considered highly sensitive to VRC01 [80% inhibitory concentration (IC(80)) < 1 microgram/milliliter], VRC01 prophylaxis maintained… →
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A randomized comparison of comprehensive weight loss intervention vs. usual care on recurrences of atrial fibrillation in obese patients after catheter ablation: HOBIT-AF trial
CONCLUSION: HOBIT-AF trial showed that despite the beneficial effect of body weight reduction on metabolic profile of obese patients with predominantly paroxysmal AF after CA, no reduction in AF/AT recurrence was observed in comparison with control patients. This may be likely due to low AF burden after previous CA, limiting further improvement. →
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Transbronchial Cryobiopsy for the Diagnosis of Peripheral Pulmonary Lesions: A Prospective Randomized Controlled Study
Peripheral pulmonary lesions (PPLs) are increasingly detected by chest computed tomography, yet bronchoscopic diagnosis remains challenging for small and distal lesions. This prospective, single-center, randomized controlled study evaluated radial endobronchial ultrasound combined with a guide sheath (R-EBUS-GS)-assisted transbronchial cryobiopsy using a 1.1-mm ultrathin cryoprobe. Fifty patients with PPLs were randomized after successful R-EBUS-GS localization to… →
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Longitudinal Remodeling and Network Architecture of the Proximal Aorta in Children and Adolescents With Marfan Syndrome
CONCLUSIONS: The proximal aorta shows a multisegment architecture in which organization across patients is stronger than within-patient coordination of change. Network findings complement, but do not replace, serial measurement of individual aortic levels, and their prognostic value requires independent validation. →
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Generative Artificial Intelligence Augmentation of a Clinical Trial of a Dermo-cosmetic Intervention for Acne Remission Maintenance
BACKGROUND: A practical application of artificial intelligence (AI) in healthcare is to generate artificial datasets that capture the characteristics of a real source dataset without exposing protected health information. This approach is particularly relevant to research settings where recruitment and long-term follow-up are barriers to generating robust clinical evidence. →
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Co-Designed Text Messaging Intervention for Parents of Children With Early Childhood Caries: Randomized Controlled Trial
CONCLUSIONS: These findings suggest that co-designed SMS text messaging-based programs show promise and may represent a feasible strategy for oral health behavior change. However, larger-scale and longer-term studies are needed to confirm sustained effectiveness using clinical outcomes. Future research should also explore ways mobile health can be scaled and cost-effectively embedded into comprehensive, interdisciplinary primary… →
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Contested coexistence: How global pressure reshaped labour rights in Lesotho
Lesotho’s garment-sector reforms emerged through a fragile interaction between international private regulation and public law. In this blog, Pauline Jerrentrup explains how foreign economic dependence enabled reform while also creating internal tensions over authority and ownership, and how Lesotho’s unique circumstances offer lessons for scholars and policymakers. In 2019, reports of widespread sexual harassment in… →