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OCT-Defined Plaque Morphology and Clinical Outcomes After Percutaneous Coronary Intervention: An ILUMIEN IV Substudy
CONCLUSIONS: Based on preprocedural OCT, PCI of calcific and fibrotic plaques was associated with the highest and lowest 2-year rates of TVF and ID-TVR, respectively, with lipidic plaques being of intermediate risk. This is the first report from a large-scale clinical trial that demonstrates the prognostic utility of baseline OCT plaque morphology on post-PCI outcomes.… →
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The Marketing Capability Paradox: Seven Forces Eroding Your Marketing Team’s Effectiveness
Alice Mollon/Ikon Images Marketing capabilities — the complex bundles of skills, processes, and organizational know-how that enable companies to implement customer-related activities and adapt to marketplace changes — are rated by marketing professionals as important to business success. At the same time, artificial intelligence is rewriting the rules of content creation, customer targeting, and performance… →
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How Today’s CEOs Can Prepare for Tomorrow’s Crises
Being the CEO or board member of a large company has never been easy. These leaders are responsible for making critical decisions that impact the health and long-term viability of an organization as well as its employees and their families. Today, these jobs are harder than ever. The same risks—and potential rewards—hold true, but there… →
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What Impact Investors Want from Companies with a Cause
When a company with a cause pitches itself to investors, which part of its identity should its leaders stress: its positive impact on society or its positive bottom line? The answer is both, according to William Towns, an adjunct professor in the Social Impact and Sustainability program at the Kellogg School. But the order matters.… →
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Antithrombotic strategy according to age in patients with atrial fibrillation and drug-eluting stents: a post hoc analysis of the ADAPT AF-DES randomised trial
CONCLUSIONS: In this post hoc analysis, NOAC monotherapy was associated with a lower risk of net adverse clinical events, specifically within the older age subgroup. Tailored approach regarding age and individual ischaemic risk may be needed. →
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The Effect of Transpulmonary Pressure-Guided Positive End-Expiratory Pressure Titration on Pulmonary Arterial Compliance in Acute Respiratory Distress Syndrome Patients: A Single-Center, Randomized Controlled Pilot Pathophysiological Study
CONCLUSIONS: Ptp-guided PEEP titration was superior to traditional lung-protective ventilation in maintaining a higher Cpa and preserving right ventricular function in patients with moderate-to-severe ARDS caused by pneumonia. →
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Effects of vitamin D supplementation on insulin resistance and lipid metabolic profiles in women with gestational diabetes mellitus: A randomized controlled trial
Gestational diabetes mellitus (GDM) commonly presents as insulin resistance and altered lipid metabolism, with evidence linking vitamin D deficiency to its pathogenesis. In this randomized, double-blind, placebo-controlled trial, 120 pregnant women diagnosed with GDM were assigned to receive either vitamin D3 supplements (2000 IU/day) or a placebo for 3 months. Serum vitamin D status, glycemic… →
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To Spot AI Fakes, a Little Training Goes a Long Way
Earlier this year, Matthew Groh instructed ChatGPT to create images of a man playing guitar with Bruce Springsteen and tennis with Rafael Nadal and Roger Federer. At first glance, the two pictures looked pretty convincing. But Groh, an assistant professor of management and organizations at Kellogg, spotted a couple of tell-tale signs that they were… →
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How a Different AI Approach Can Cut the Queue
When a person arrives at the emergency room complaining of shortness of breath, they’ll likely be sent for a chest X-ray. Then they’ll probably need to sit and wait to be seen by a doctor—sometimes for a while. Instead of treating patients on a first-come, first-served basis, the U.S. healthcare system typically relies on a… →
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How Big Companies Use Patents to Play Defense
In popular perception, a patent represents innovation—the legal landmark between an inventor’s idea and the next must-have gizmo. With big companies churning out more and more patents, you might think that bodes well for innovation. After all, each of those bright new ideas could eventually show up as new products or features on store shelves,… →