-
Effectiveness and acceptability of biometrics to evaluate intervention coverage and contamination in a cluster randomised trial of community-based sexual and reproductive health services for youth in Zimbabwe
CONCLUSION: Biometric identification is useful for assessment of CRT coverage and contamination. →
-
What CEOs Need to Know About Sovereign AI
Carolyn Geason-Beissel/MIT SMR | Getty Images As multinational companies implement artificial intelligence workflows and look to adopt AI across their global operations, they are increasingly running up against country-specific regulations and policies that aim to govern AI and align its use with national priorities and local cultural norms. These regulations and policies — which fall… →
-
Effects and User-Reported Experiences of a Self-Management Mobile Health App for Grieving Adolescents: Randomized Controlled Trial
CONCLUSIONS: Overall, the findings indicate that Alba may be beneficial in reducing mental health symptoms among bereaved adolescents and highlight its potential as a safe, acceptable, and scalable mHealth intervention. →
-
Intranasal Oxytocin for Alcohol Use Disorder: A Randomized, Double-Blind, Placebo-Controlled Multisite Trial Assessing Efficacy and Safety
CONCLUSION: Intranasal oxytocin was well tolerated but did not significantly reduce drinking or AUD-related outcomes. Higher doses, longer treatment duration, or larger trials may be required to identify responsive subgroups and determine oxytocin’s efficacy in AUD. →
-
Individually designed fall prevention strategies compared to generic strategies for mastering complex fall risk situations in people with multiple sclerosis: study protocol of a randomised controlled trial
INTRODUCTION: Of individuals with mild-to-moderate multiple sclerosis (MS), 56% report falling at least once during a 3-month period. Several fall risk factors have been identified, but the issue is complex, with interactions between triggering factors and preceding activities and events. There is a lack of studies explicitly evaluating fall prevention strategies given as counselling over… →
-
Expectant management versus acetaminophen for early treatment of hemodynamically significant patent ductus arteriosus in very preterm infants: a randomized controlled trial
CONCLUSIONS: Early oral acetaminophen treatment in very preterm infants with hsPDA aged 4-7 days reduces the rate of persistent hsPDA at 14-17 days and demonstrates a favorable safety profile compared with expectant management, but does not affect hsPDA persistence at discharge or 36 weeks of corrected gestational age or the rate of moderate to severe… →
-
Continuous or Fixed-Duration Maintenance Therapy in Multiple Myeloma
CONCLUSIONS: In this phase 3 trial involving patients with standard-risk newly diagnosed multiple myeloma who were not undergoing up-front autologous stem-cell transplantation, indefinite-duration maintenance therapy after induction therapy did not result in significantly longer overall survival than fixed-duration maintenance therapy. (Funded by the National Cancer Institute of the National Institutes of Health and Amgen; ENDURANCE… →
-
Comparative effectiveness of extracorporeal shock wave therapy and high-intensity laser therapy in trigger finger: a randomized controlled trial
Trigger finger (TF) is stenosing tenosynovitis causing pain and impaired hand function. To compare extracorporeal shock wave therapy (ESWT) and high-intensity laser therapy (HILT) as adjuncts to home exercise in TF. In this three-arm randomized controlled trial, patients were allocated to ESWT, HILT, or home exercise alone. Active modalities were applied for 3 weeks (nine… →
-
Medication adherence in breast cancer: a comparative analysis of self-report tools and prescription refill data
CONCLUSION: Methodological variability significantly impacts reported adherence rates. While no single «gold standard» exists, integrating brief self-reported scales with objective metrics is feasible and provides a more comprehensive and clinically informative assessment of medication use. This multi-method approach is essential for identifying at-risk patients and tailoring adherence-support interventions in oncology. →
-
Non-Inferiority of a Ready-to-Drink Enteral Formula on Nutritional Status in Patients with Head and Neck Cancer: A Randomized Controlled Trial
Background/Objectives: Malnutrition affects 20-71% of patients with head and neck cancer (HNC), owing to tumor location, treatment-induced toxicities, and systemic inflammation. Enteral nutrition is preferred when oral intake is inadequate, yet standard powdered formulas require labor-intensive reconstitution and carry a contamination risk. PSU Blen, a ready-to-drink chicken-protein-based polymeric formula, was developed to address these limitations.… →
