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  • MCPs: The GTM Unlock

    16 мая, 2026

    After seeing the GTM unlock that MCPs provide, we teamed up with Alex Shartsis to provide a comprehensive deep dive. Alex is the founder and CEO of Skyp, AI-native outbound for high-ACV sales and advisor to AI founders. He previously led acquisitions at Opendoor, GTM at Kleiner and Sequoia backed Drawbridge, and was a founder… →

    AI Sales
  • The effect of a targeted mobilization program applied after cesarean surgery on care outcomes: a randomized controlled study

    15 мая, 2026

    CONCLUSION: The targeted mobilization program applied after cesarean surgery enhanced overall postoperative recovery by accelerating bowel function, reducing abdominal distension and pain, and improving breastfeeding outcomes. These findings support the integration of structured mobilization strategies into routine post-cesarean care. →

    Clinical Trials
  • Short-Term and Late-Term Effects of Psilocybin on Symptoms in Major Depression: A Randomized Clinical Trial

    15 мая, 2026

    CONCLUSIONS AND RELEVANCE: In this randomized clinical trial of MDD, a single dose of psilocybin was associated with rapid antidepressant effects, observed by day 2 and persisting for more than 3 months on secondary outcomes; psilocybin was generally well tolerated, but some individuals required additional support after dosing due to anxiety. These results suggest that… →

    Clinical Trials
  • Effects of Experimental Intermittent Theta Burst Stimulation on Negative Symptoms of Schizophrenia: A Double-Blind Sham-Controlled Study

    15 мая, 2026

    Background: Negative symptoms remain among the most debilitating and treatment-resistant features of schizophrenia. Repetitive transcranial magnetic stimulation, particularly intermittent theta burst stimulation (iTBS), is emerging as a promising intervention targeting these domains. →

    Clinical Trials
  • Aripiprazole Once-Monthly for Patients Diagnosed With Schizophrenia: Number Needed to Treat, Number Needed to Harm, and Likelihood to be Helped or Harmed

    15 мая, 2026

    Objective: This post hoc analysis assessed the benefit-risk of aripiprazole once-monthly 400 mg (AOM 400) as acute and long-term maintenance treatment for patients diagnosed with schizophrenia, based on number needed to treat (NNT), number needed to harm (NNH), and likelihood to be helped or harmed (LHH). →

    Clinical Trials
  • Mobile Application-Based Self-Management and Chronic Disease Platform Program for Improved Transitional Care of Older Adults With Diabetes

    15 мая, 2026

    CONCLUSIONS: The program has the potential to improve transitional care in older adults with diabetes, warranting further promotion. →

    Clinical Trials
  • Metastatic tropism of molecularly defined clear-cell renal cell carcinoma clusters

    15 мая, 2026

    BACKGROUNDThe relationship between molecular subgroups in clear-cell renal cell carcinoma (ccRCC) and metastatic tropism is poorly understood.METHODSWe analyzed over 5,000 metastatic sites from 305 treatment-naive ccRCC patients in the IMmotion150 phase II clinical trial, where patients were randomized to atezolizumab, atezolizumab/bevacizumab, or sunitinib.RESULTSAngiogenic tumors (clusters 1 and 2) had a higher rate of pancreatic (21%… →

    Clinical Trials
  • Safety, tolerability, and concordance with interferon-gamma release assays of a recombinant ESAT6-MPT64 skin test: a phase 1 randomized clinical trial

    15 мая, 2026

    CONCLUSION: The recombinant EM skin test is safe, well-tolerated, and demonstrates preliminary diagnostic accuracy comparable to IGRAs. By successfully validating the translational utility of the MPT64 (RD2) antigen in a human cohort, this study provides a strong proof-of-concept for the EM skin test as a scalable, specific, and cost-effective immunodiagnostic tool. →

    Clinical Trials
  • Correction: Safety, tolerability, and concordance with interferon-gamma release assays of a recombinant ESAT6-MPT64 skin test: a phase 1 randomized clinical trial

    15 мая, 2026

    [This corrects the article DOI: 10.3389/fimmu.2026.1780294.]. →

    Clinical Trials
  • Morning versus afternoon administration of immune checkpoint inhibitors in metastatic non-small-cell lung cancer

    15 мая, 2026

    CONCLUSIONS: Morning ICI infusions confer a modest but clinically meaningful survival benefit that is absent in chemotherapy controls, supporting a causal chronotherapeutic effect. Scheduling ICIs before noon represents a low-cost, immediately actionable strategy warranting prospective confirmation. →

    Clinical Trials
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