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  • Leaders at All Levels: How Argenx Scaled to $4 Billion Without Bureaucracy

    30 апреля, 2026

    Biotech companies face the same dilemma as businesses in other industries: Innovation drops off dramatically with scale. European biotech Argenx has reached a market value of more than $40 billion, having so far escaped that innovation trap. How has it done this? The company shuns hierarchy and instead organizes into small teams, each dedicated to… →

    Management
  • Okta’s CRO: From $850M in Losses to $760M Profit (The AI Agent Bet) | Jon Addison

    30 апреля, 2026

    The GTM Podcast is available on any major directory, including: Apple Podcasts Spotify YouTube Okta’s CRO Jon Addison joins GTMnow host Sophie to break down the full story behind Okta’s remarkable revenue turnaround, the launch of Okta for AI Agents, and the go-to-market playbook that’s carrying them from $3B toward a $5B ARR target. From nearly $850M… →

    AI Sales
  • Streamlining Inherited Cancer Identification via an EMR-Integrated Risk Assessment Platform: A Nonrandomized Clinical Trial

    29 апреля, 2026

    CONCLUSIONS AND RELEVANCE: In this nonrandomized clinical trial, almost one-third of the population met national genetic counseling criteria for an inherited cancer syndrome, highlighting a substantial gap in usual care identification. Integrating patient-facing FHH collection and assessment tools for primary care patients improves inherited cancer risk identification and highlights opportunities to further enhance both risk… →

    Clinical Trials
  • Development of an intervention theory for a mobile mammography unit research project for breast cancer screening

    29 апреля, 2026

    SETTING: In France, participation rates in breast cancer screening have been decreasing, along with socio-territorial inequalities. To enhance women’s access to breast cancer screening, an interventional research project was implemented to assess the effectiveness, efficiency, and optimal modalities of a mobile mammography unit for women living remotely in Normandy. →

    Clinical Trials
  • In Vitro and Clinical Evaluation of Potential Interactions of Bemnifosbuvir with Drug-Metabolizing Enzymes

    29 апреля, 2026

    Bemnifosbuvir is a novel oral guanosine nucleotide prodrug with potent pan-genotypic inhibitory activity against hepatitis C virus. In vitro studies assessing the inhibition or induction potential of bemnifosbuvir on the CYP450 and UGT1A1 enzymes demonstrated that bemnifosbuvir is a weak inducer and a reversible and time-dependent inhibitor of CYP3A4. These results prompted further evaluation in… →

    Clinical Trials
  • A Phase 1, Open-Label, Single Ascending (Two Levels) Dose Study to Evaluate the Pharmacokinetics of Vorasidenib in Healthy Japanese and Non-Asian Participants

    29 апреля, 2026

    Vorasidenib was first approved in 2024 for the treatment of Grade 2 gliomas with isocitrate dehydrogenase 1 and 2 mutations and is now approved in over 40 countries, including Japan. During early development, vorasidenib pharmacokinetics (PK) was estimated in populations without Japanese participants. In 2019, this Phase 1 single ascending (two levels) dose study (NCT04145128)… →

    Clinical Trials
  • Dermatologic outcomes associated with glucagon-like peptide-1 receptor agonists in patients with type 2 diabetes: a large-scale target trial emulation

    29 апреля, 2026

    CONCLUSION: In a large, real-world study designed to emulate a clinical trial, GLP-1 RAs were linked to increased psoriasis and decreased autoimmune blistering diseases compared with DPP-4is over up to 4 years’ follow-up. These results provide a dermatologic safety context to guide incretin therapy selection and highlight the importance of ongoing skin monitoring. →

    Clinical Trials
  • Diagnostic Accuracy for Breathing Sounds in Using an AI-Assisted Stethoscope Versus a Conventional Stethoscope

    29 апреля, 2026

    Purpose: This study compares the accuracy of dental students in diagnosing different breathing sounds using traditional versus artificial intelligence-assisted precordial stethoscopes (AIPS). Methods: The study involved 45 3rd- and 4th-year dental students who completed a pre-test to assess their baseline knowledge of breathing sounds. After watching a learning video, participants were randomized into 3 groups:… →

    Clinical Trials
  • Safety and Efficacy of SOX Therapy After Preoperative Chemoradiotherapy for Advanced Lower Rectal Cancer: A Phase I Study

    29 апреля, 2026

    CONCLUSION: SOX therapy as consolidation chemotherapy after CRT was safe and well tolerated as part of the TNT for lower rectal cancer. To our knowledge, this is the first study to report the use of SOX in TNT. Further trials are warranted to evaluate the efficacy of SOX as consolidation therapy after CRT in larger… →

    Clinical Trials
  • The real risk of AI is not job loss — it is a failure of imagination

    29 апреля, 2026

    The most important economic question in the AI era is not how many jobs will be replaced. It is whether AI is expanding human capacity: what we can imagine, do, and want. Youngjin Yoo argues that the demand frontier of human capacity — the outer limit of what people want, attempt, and are willing to… →

    Management
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