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Protocol for evaluating the effects of the intelligent multimodal symptom assessment and response system in patients with pemphigus vulgaris: a randomised controlled trial
INTRODUCTION: Pemphigus vulgaris is a rare autoimmune blistering disease characterised by recurrent mucocutaneous erosions, high symptom burden and unpredictable relapse. Current management relies mainly on pharmacological therapy and hospital-based follow-up, with limited real-time monitoring and individualised support in home-based disease management. To address these challenges, this trial aims to evaluate the effectiveness of an Intelligent… →
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What AI Still Can’t Do for Leaders
As leaders weave generative AI tools like ChatGPT and Claude into their daily workflows, where does the output fall short? Moreover, where are leaders falling short for their organizations by giving away too much agency to artificial intelligence? MIT Sloan School of Management professors Deborah Ancona and Katherine W. Isaacs have thought deeply about the… →
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Can We Take the Doom Out of Scrolling?
You don’t have to be a doomscroller to know that social media is flooded with high emotions and hostility. Whether the topic is politics, sports, movies, or music, it often feels like the loudest and angriest voices dominate the conversation, creating a virtual shouting match that drowns out more-thoughtful opinions. Scientists have speculated that these… →
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VC: The $575B AI Bet (Biggest Since the World Wars) and the New Two-Buyer Reality in Software | Tomasz Tunguz, Theory Ventures
Listen on YouTube Listen on Apple Listen on Spotify If you spend time on X, you can also watch/listen to the entire episode on X. Brought to you by: AngelList Our LP base spans from individual operators to institutional allocators, and AngelList has been instrumental in supporting all of them. They handle everything from investor… →
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Pentoxifylline in children with acute encephalitis syndrome: a randomized control trial
Because of the excessive endogenous inflammatory mediators, acute encephalitis syndrome (AES) results in death, or sequelae in survivors. Pentoxifylline, a modulator of inflammation, can have beneficial role in AES. The primary objective was to assess the efficacy of pentoxifylline in terms of time taken for improvement in Glasgow coma scale (GCS) from baseline, in children… →
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Quantifying the Phoenix Sign: A Double-Blind Pilot Study on Lidocaine and Papaverine-Induced Vascular and Motor Changes After Common Peroneal Nerve Block in Diabetic Neuropathy
CONCLUSIONS: Peripheral nerve blocks with lidocaine or papaverine improved motor strength and macrovascular function in patients with diabetic peripheral neuropathy, though microvascular changes were not detected. These preliminary findings are consistent with the Phoenix Sign phenomenon and support further study as a potential clinical indicator. While these preliminary findings indicate support as a diagnostic tool,… →
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The Effect of Griffonia simplicifolia on Pain Intensity, Central and Peripheral Sensitization, and Pain Modulation in Healthy Volunteers-A Randomized, Double-Blinded, Placebo-Controlled Crossover Trial
Background: The plant Griffonia simplicifolia is marketed as a dietary supplement; it is said to have antidepressant and sleep-promoting properties. Its main ingredient, 5-hydroxytryptophan (5-HTP), is the immediate precursor of serotonin and crosses the blood-brain barrier, thereby enhancing central serotonergic neurotransmission. Reduced serotonergic activity has been associated with affective disorders, sleep disturbances, and impaired central… →
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Prayer for Pain and Anxiety in a Primary Care Setting: A Randomized Controlled Trial
CONCLUSION: Proximal intercessory prayer was safe, effective, and well-received as complementary treatment for pain and anxiety. Further studies are warranted. Proximal intercessory prayer may be a low-cost, non-pharmacologic, effective adjunct to standard care with particular relevance for underserved populations. →
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Equity Evaluation of an Intervention to Increase Colorectal Cancer Screening at Federally Qualified Health Centers
Racially and ethnically minoritized patients are underscreened for colorectal cancer (CRC), resulting in racial/ethnic disparities. This secondary analysis of a pragmatic patient-randomized clinical trial compared effects of a CRC intervention across race/ethnicity. The multicomponent intervention included a mailed fecal immunochemical test (FIT) for patients in Federally Qualified Health Centers due for screening, plus patient navigation… →
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Effectiveness of an anti-inflammatory diet intervention and cognitive behavioural therapy in endometriosis: protocol for a randomised controlled clinical trial
INTRODUCTION: Treatment for women with endometriosis is only partially or temporarily effective. Moreover, medical hormonal treatment is associated with debilitating side effects and interferes with fertility, while surgery has a relatively high risk of complications. Meanwhile, women with endometriosis show increasing interest in implementing lifestyle interventions to alleviate symptoms and improve health-related quality of life… →
