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Comparison of Hand-Held Doppler, Infra-Red Thermography and Indocyanine Green Angiography for Identification of Perforator in Antero-Lateral Thigh Flap: A Randomized Controlled Trial
CONCLUSION: The accuracy of ICG was better than IR Thermography and HHD in detecting perforators pre-operatively in patients undergoing ALT flap surgery. →
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Talking to migrant children and adolescents with cancer: development of a multimodal skills training in migrant-sensitive communication for paediatric oncologists
CONCLUSION: Even experienced paediatric oncologists identified a need to establish ongoing training in communication in an intercultural, family-centered setting and benefited from the multimodal training. →
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LED Photobiomodulation for Pain Reduction in Temporomandibular Disorder: A Randomized, Controlled, and Blinded Clinical Trial
This clinical, randomized, controlled, and blinded trial evaluated photobiomodulation (PBM) using 850 nm (infrared) and 660 nm (red) LED clusters on cervical and mandibular mobility and masticatory muscles in temporomandibular disorder (TMD) patients. PBM was applied to the temporomandibular joint (TMJ) region, masseter, temporal, scalene, and trapezius muscles over six non-consecutive sessions over 2 weeks.… →
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Effect of Mesenchymal Stem Cell Infusion in Stage II-IV Diabetic Nephropathy
CONCLUSION: MSC improved GFR and HbA1c at 6 months in patients with DKD (Stages II-IV). →
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Patient-reported outcomes in newly diagnosed patients with FLT3-internal-tandem-duplication-positive acute myeloid leukaemia receiving standard chemotherapy plus quizartinib or placebo (QuANTUM-First): a global, randomised, placebo-controlled, phase 3 trial
BACKGROUND: QuANTUM-First is a randomised phase 3 trial in individuals with newly diagnosed acute myeloid leukaemia (AML) that is FLT3 internal tandem duplication (ITD) positive, showing a survival advantage for quizartinib versus placebo plus standard induction and consolidation chemotherapy with or without transplantation, followed by single-agent maintenance therapy. We evaluated the impact of quizartinib on… →
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Genetic Testing for APOL1 in Adults With Hypertension: The GUARDD-US Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: Provision of APOL1 genotype high-risk results to participants and clinicians was not associated with SBP reduction overall. Among the subset of patients with uncontrolled BP, the intervention group had a significant SBP reduction. APOL1 disclosure also increased the rate of CKD screening and diagnosis. Effects of reporting APOL1 genotype merit further investigation… →
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The feasibility of an early-years motor skill school-based intervention research project in a low-resource area of South Africa
CONCLUSION: The study highlights the feasibility of conducting intervention research in low-resource settings. It notes the challenges of using the MABC-2 due to its cost and time requirements and reports on the initial effect of the program on the motor skills of the participants. Statistical significance of positive results was affected by the small sample… →
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How to Quash Your Fear of Messing Up
If you’ve ever felt anxiety that something exciting might be happening without you, you’re familiar with fear of missing out (FOMO). But what happens when you feel an underlying worry about making a mistake? Fear of messing up (FOMU) can have the opposite effect from FOMO. Instead of spurring you to action, FOMU can lead… →
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The “SAASpocalypse”
This is an important edition addressing sentiments around a looming “SAASpocalypse.” It was first published yesterday on X and is an article written by GTMfund’s General Partner, Max Altschuler. If you’re wondering about AI’s impact on software as a whole, this is a deep dive written in Max’s first person perspective below. Let’s get into… →
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A Phase I Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Fenebrutinib and Effect on the QT/QTc Interval in Healthy Participants
Fenebrutinib is a Bruton’s tyrosine kinase inhibitor under investigation for the treatment of multiple sclerosis. The goal of this study was to investigate the effect of fenebrutinib on cardiac repolarization (QT interval) as well as its safety, tolerability, and pharmacokinetics in healthy participants. Part A was a randomized, double-blind, placebo-controlled, single-ascending dose study of therapeutic… →
