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Efficacy of Microneedle Fractional Radiofrequency Combined With Platelet-Rich Plasma for the Treatment of Melasma: A Split-Face, Randomized Trial
CONCLUSIONS: MFR is an effective and safe option for melasma in patients with Fitzpatrick skin types III-IV. Adjunctive PRP did not further improve global clinical pigment scores or ultrasound-detected structural changes, but may offer added benefit for erythematous and pigmentary features detected by VISIA. →
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Financing STI testing among men in China: A mixed-methods study of pay-it-forward monetary donations
CONCLUSION: Our findings highlight key factors driving donations in a pay-it-forward program. Transparent fund allocation and real-time donor feedback can enhance trust and participation. →
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Investors are sitting in on live prospect calls
If you’re a founder or operator supporting a fundraising process, be ready for more than references in an investors diligence process. Be ready to be on a live prospect pitch with them. Often, what happens behind the scenes while investors are conducting diligence is they will talk to experts in this space, other investors, and… →
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A randomized controlled single-blinded study comparing a 30-gauge needle to a 34-gauge needle for intravitreal injections
CONCLUSION: The use of a 34-gauge needle was found to be less painful when used by a senior vitreoretinal surgeon and with similar safety profile as the 30 gauge needle. This may further improve patient satisfaction and increase treatment adherence. →
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Early pregnancy meal tolerance test responses and their association with later insulin sensitivity in overweight and obese women: an exploratory analysis
INTRODUCTION: Insulin resistance increases the risk for gestational diabetes mellitus (GDM) and hyperglycemia-associated pregnancy complications. GDM is generally diagnosed at 24-28 weeks of gestation, leaving limited time to address adverse consequences. To explore metabolic markers that predict changes in insulin sensitivity and glycemic responses earlier in pregnancy, we performed a meal tolerance test (MTT) during… →
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Vitamin D in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome After COVID-19 or Vaccination: A Randomized Controlled Trial
Background: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) can develop as post-vaccination syndrome (PVS) or Post-Acute Sequelae of SARS-CoV-2 infection (PASC). In our prior retrospective study, most patients with PVS who developed ME/CFS had vitamin D insufficiency or deficiency. We evaluated the efficacy of vitamin D replacement therapy guidance for ME/CFS symptom improvement in patients with vitamin… →
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Adipo-Myokine Modulation in Obesity: Integrative Effects of Spinach Thylakoids and Functional Training in Men with Obesity: A Randomized Controlled Clinical Trial
Objective: This study evaluated the effects of a 12-week High-Intensity Functional Training (HIFT) program combined with thylakoid supplementation on plasma adipo-myokine levels (Decorin, Myostatin, Follistatin, Activin A, and TGF-β1) in men with obesity. Secondary outcomes included anthropometric indices, lipid profiles, and insulin resistance markers. Methods: Sixty men with obesity (age: 27.6 ± 8.4 years; BMI:… →
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A Pilot Validation Study of Plant-Based and Allergy-Friendly Alternative for Testing Gastric Emptying: A Randomized Trial in Healthy Participants
CONCLUSIONS AND INFERENCES: The vegan meal demonstrated in vitro stability, in vivo performance comparable to the egg meal, and a COV(intra) of 18.8%, which was lower than the 23.8% reported in repeat egg meal GE studies. →
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Hypophosphatemia as a biomarker of metabolic intolerance to enhanced nutrition in the PICU: a secondary analysis of the PEPaNIC RCT
CONCLUSIONS: Development of hypophosphatemia may identify critically ill children who are particularly harmed by early-PN. This opens perspectives for its use as a biomarker of metabolic intolerance to enhanced nutrition, which requires further investigation. →
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Timing-dependent anti-inflammatory effects of empagliflozin in monocyte-derived macrophages from post-myocardial infarct patients with type 2 diabetes
CONCLUSION: Early empagliflozin administration in T2DM-AMI patients was associated with modulation of NLRP3-related inflammatory and senescence pathways in patient-derived macrophages, benefits observed when cells were stimulated ex-vivo with an inflammatory stimulus. These findings provide mechanistic insight into the timing-dependent anti-inflammatory effects of EMPA and underscore its potential for immediate post-AMI use to reduce inflammation and… →
