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Mitigation of COVID-19 through onsite testing and education among formerly incarcerated individuals (the MOSAIC study): an open-label, single-centre, randomised controlled trial
BACKGROUND: Criminal legal system-involved individuals face barriers to care after release from carceral settings. Elevated SARS-CoV-2 risk while incarcerated, together with living in congregate settings post-incarceration, increase the risk of respiratory viral infection transmission. This study evaluated a community health worker-led point-of-care SARS-CoV-2 testing and education intervention in a re-entry-focused community-based organisation compared with standard… →
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Three Approaches to Measuring and Managing AI ROI
Matt Harrison Clough/Ikon Images After several years of AI experiments and pilot initiatives, a crucial question remains open for most companies: How much of a return — and what kinds of returns — are we getting from all of this AI investment? To many executives, AI ROI still often feels more like art than science:… →
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Improving the field accuracy of a malaria diagnostic algorithm combining sequential interpretation of rapid diagnostic test detecting PfHRP2 and pLDH in febrile children in a seasonal hyperendemic malaria transmission area in Burkina Faso
CONCLUSIONS: The sequential diagnostic approach improves the diagnosis of malaria in a real world setting, compared to the use of PfHRP2-(only) based RDT. However, relying only on history of antimalarial treatment in undetermined cases may decrease algorithm’s sensitivity, which could result in missing active or recurrent malaria infections. →
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Do probiotics modulate dietary intake? Pilot data from a randomized controlled sub-study of the ProBioHRV clinical trial in patients with depression and healthy controls
CONCLUSION: Probiotic supplementation did not produce consistent changes in nutrient intake but showed exploratory, time- and group-dependent patterns for selected measures, including vitamin D intake and dietary variety and diversity. Given the pilot nature of the study, these findings are descriptive and hypothesis- generating. Larger, well-powered studies with objective nutritional and microbiome measures are required. →
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Sleep deprivation increases levels of the synaptic density marker SV2A in the human brain
Sleep is essential for synaptic homeostasis, a proposed mechanism whereby wakefulness leads to synaptic potentiation and sleep facilitates synaptic down-selection. Synaptic vesicle glycoprotein 2A (SV2A), whose availability is quantifiable by [¹⁸F]SynVesT-1 positron emission tomography (PET), is commonly interpreted as a proxy for synaptic density. In this randomized study, we examined 40 healthy adults (mean age… →
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Live: Revolutionary Drone STEM Kit from DroneBlocks
DroneBlocks provides a complete educational platform for STEM educators, combining drones and robotics to bring cutting-edge technology into the classroom. See how you can elevate the learning experience for students or yourself on this episode of OpenCV Live. Join our Patreon for just $2/mo to watch ad-free live streams and get DRM-free downloads of every… →
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Palliative Care Coaching for Family Caregivers of Patients With Advanced Cancer: A Randomized Clinical Trial
CONCLUSIONS: This randomized clinical trial of a telehealth intervention for African American and rural-dwelling caregivers of patients with advanced cancer found no differences in caregiver and patient outcomes at 24 weeks. However, an exploratory sensitivity analysis indicated potential improvements in caregiver anxiety and patient mental health QOL. →
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Adjunctive Psychosocial Interventions and Opioid Abstinence Among Patients Receiving Buprenorphine: A Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this randomized clinical trial, CBT and PRS had no effect on rates of opioid abstinence in the year following the initiation of MOUD. →
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A Randomized Trial of Interval Likelihood Ratios for Clinical Decision-Making
CONCLUSIONS: Presenting diagnostic test information using ILRs improved vignette-based clinical decisions. The magnitude of improvement appeared to vary by case vignette. →
