CONCLUSIONS: We dismantled a complex digital multiple behavior intervention and examined it using a factorial design to provide novel insights into the effectiveness of the intervention’s different components. Both marginal and synergistic effects were observed across multiple behaviors, providing evidence regarding which components are most promising in complex interventions. These findings should be considered in… →

Mycoplasma pneumoniae is a common cause of pneumonia in children, and the emergence of macrolide-resistant strains underscores the need to explore effective adjunctive therapies. This article introduces a randomized controlled trial protocol to evaluate the clinical and immunological effects of acupuncture as an adjunctive therapy. The study includes children diagnosed with Mycoplasma pneumoniae pneumonia who… →

CONCLUSIONS AND RELEVANCE: This randomized clinical trial found that elective HFOV reduced the incidence of BPD in preterm infants born at 34 weeks’ gestation or earlier with NARDS compared with CMV. The results of this study suggest that elective HFOV is a promising strategy for preventing BPD in this high-risk population, especially the more severe… →

To investigate bimekizumab efficacy in scalp, nail and palmoplantar psoriasis. →

CONCLUSION: Conbercept combined with DEX is an efficient and safe treatment for ME by providing accelerated visual and anatomical improvements in short term and maintaining similar long-term efficacy with fewer injections compared to conbercept monotherapy. OCT biomarkers display prognostic value. HE is associated with poor visual prognosis. →

CONCLUSIONS: Given the trial was underpowered, there was no evidence of a difference in the 12-month seizure risk between the randomised groups and limited evidence regarding potential cost-effectiveness. The role of prophylactic antiseizure medication in glioma surgery remains undefined. →

BACKGROUND: Anticoagulants, classified as high-risk medications, are commonly used and are associated with significant potential harm in postoperative patients. Patients with colorectal cancer (CRC) are among the most susceptible populations. Single-component pharmacist intervention has demonstrated conflicting efficacy in improving anticoagulant safety. Meanwhile, it remains unclear whether comprehensive medication therapy management (MTM), which integrates medication review,… →

CONCLUSIONS: The findings indicate that when CBT is delivered comprehensively in a multicomponent format targeting maladaptive cognitions, emotion dysregulation and self-control deficits, it can serve as an effective intervention for adolescents with IED. →

CONCLUSION: The accuracy of ICG was better than IR Thermography and HHD in detecting perforators pre-operatively in patients undergoing ALT flap surgery. →