CONCLUSIONS: Among those with evidence of cognitive impairment at randomisation, an invasive treatment strategy did not reduce the primary composite outcome of cardiovascular death or nonfatal MI, and there was no evidence of treatment effect heterogeneity based on cognition. The reduction in nonfatal MI events among those with cognitive impairment should be interpreted as an… →

CONCLUSION: The results of this study suggest, that in people with MCI, notable improvement in global cognition can be achieved in a six-months intervention period. When CCT is combined with digital nutritional counseling, the form of intervention — whether elaborate or basic — apparently did not modify the outcome; rather, this data set suggests that… →

CONCLUSION: A culturally adaptable lacto-vegetarian diet combined with a 14-hour time-restricted fasting regimen safely improves metabolic control and insulin sensitivity in women with Type 2 Diabetes, offering a practical, women-centric strategy that may be implementable within structured clinical nutrition services, although its staffing requirements, cost, and scalability require further evaluation. →

Irritable bowel syndrome (IBS) is diagnosed using symptom-based criteria because no established physiological test objectively supports the diagnosis. We developed and evaluated a computerized bowel sound analysis system incorporating a dichotic listening task as a psychological stress challenge in three phases. In Phase 1, a short-time energy (STE)-based bowel sound extraction algorithm showed high sensitivity… →

CONCLUSION: Acupuncture was feasible, safe, and well accepted in this postoperative setting. Pain levels and opioid requirements remained low throughout the postoperative period. Further controlled studies are warranted to assess efficacy and to refine patient selection and acupuncture techniques in this setting. →

CONCLUSIONS: The results provide evidence that the SCL-5 has adequate psychometric properties in a Norwegian sample of perpetrators and victims of IPV. →

CONCLUSION: Twelve weeks of standardized OMT had no significant effect on AHI, desaturation measures or ESS score in treatment-naive patients newly diagnosed with OSA. →

Psychedelic-assisted therapy, particularly with psilocybin, is increasingly proposed as a treatment for major depressive disorder, yet the neural and psychological mechanisms underlying its effects remain under investigation. In a randomized, double-blind, placebo-controlled clinical trial, individuals diagnosed with major depressive disorder received a single, moderate dose of psilocybin (0.215 mg kg-1) or placebo, with the same… →

CONCLUSIONS AND RELEVANCE: In this trial of adults with SCD and ECW, extended courses of inhaled mometasone were associated with worsened markers of disease severity. Inhaled mometasone should not be used long-term in patients with SCD and ECW without a definitive diagnosis of asthma. →