CONCLUSIONS: This reconstructed-data post hoc analysis suggested exploratory time-dependent patterns in effect estimates without formal evidence of a time-varying treatment effect. Findings are descriptive, hypothesis-generating, and should not be extrapolated to molecularly confirmed HRR-proficient disease. →

CONCLUSION: Although adding toothbrushing to routine chlorhexidine oral care did not produce a statistically significant reduction in VAP incidence or mortality, a consistent trend toward clinical benefit was observed across multiple outcome measures, including lower rates of positive sputum cultures, reduced inotropic support requirements, and fewer new pulmonary infiltrates. These findings highlight the potential value… →

Local pain following orthodontic tooth movement negatively affects patients’ experience and compliance. Pulsed neodymium-doped yttrium-aluminum-garnet (Nd:YAG) laser, based on photobiomodulation therapy (PBMT), can effectively relieve this pain. This study applied pulsed Nd:YAG laser at different frequencies to orthodontic sites and used digital techniques to evaluate differences in pain relief after tooth movement, aiming to screen… →

CONCLUSIONS: In this cohort of hypertensive Black African adults, ECG criteria showed a moderate association with LVMI by echocardiography. Among established ECG criteria, Cornell voltage product-based measures demonstrated the most consistent diagnostic performance. Diagnostic characteristics were strongly influenced by cut-off selection and clinical context, underscoring the need for population-specific evaluation and external validation of ECG… →

This single-center, parallel-group randomized controlled educational intervention study evaluated the short-term outcomes of an integrated, multicomponent teaching package combining a Small Private Online Course (SPOC)-based blended teaching system with full-cycle training among medical imaging interns. Sixty eligible interns undertaking clinical placements in the Department of Interventional Radiology at Deyang People’s Hospital between May 2023 and… →

CONCLUSIONS: Treatment with dapagliflozin and empagliflozin reduced plasma concentrations of ac4C, which was correlated with parameters for vascular health. These exploratory findings may indicate inhibition of NAT10 activity as a potential contributor to the beneficial effects on cardiovascular and renal health by SGLT2 inhibitors. →

CONCLUSIONS: The Orthotrainer web application delivered diagnostic performance equivalent to that of conventional analogue training, proving particularly effective in radiographic analysis. Higher usability and user experience ratings support its integration into routine teaching. These findings suggest that structured digital tools can support the development of diagnostic reasoning and serve as a valuable addition to traditional… →

CONCLUSION: A single subcutaneous injection of Firsekibart is safe and well tolerated in the treatment of gout flares. It provides dose-dependent pain relief with favorable pharmacokinetic properties and potential for reducing the risk of gout flare recurrence. →

CONCLUSION: Low-dose aspirin had no effect on the rate of loss of healthspan among older community-dwelling adults. Future studies should explore lifestyle and behavioural interventions to extend healthspan. →

Rheumatoid arthritis (RA) is a chronic autoimmune disease associated with metabolic dysfunction-associated steatotic liver disease (MASLD), which may contribute to cardiovascular (CV) risk. This study aimed to examine the association between hepatic steatosis, measured by a non-invasive test, and CV risk markers in RA patients. This post-hoc analysis used cross-sectional and longitudinal data from the… →