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Mediation Analysis of Urine Osmolality and Response to Tolvaptan in Autosomal Dominant Polycystic Kidney Disease: A Post Hoc Assessment
CONCLUSION: This study supported short-term change in Uosm as a predictive biomarker of longer-term kidney function in a non-Japanese cohort; the relationship was not significant in the smaller Japanese cohort. Tolvaptan exhibited a direct treatment effect on the growth of kidney volume in both cohorts of ADPKD patients. →
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Quantification of Immediate Surgical Stress After Major and Minor Thoracic Surgeries Through HRV: A Secondary Post Hoc Analysis of a Randomized Controlled Trial
CONCLUSION: HRV parameters reflected surgery-induced autonomic alterations, with more pronounced and persistent changes observed in patients undergoing PR compared with PM surgery. No clear recovery toward baseline was detected during the 2-day postoperative follow-up, suggesting prolonged autonomic disturbances after thoracic surgery. →
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Cost-effectiveness of a web-based peer-delivered physical activity program for breast cancer survivors
CONCLUSION: At a $150 000 per QALY threshold, webMFT appears cost-effective for improving QALYs among breast cancer survivors. Larger studies are needed to confirm these findings. →
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Wings of access: a cluster RCT on drone-based medical commodity delivery in remote Madagascar
CONCLUSION: In this cluster randomised trial, drone delivery did not measurably improve most stockout, service readiness, utilisation or client-reported quality outcomes. These findings suggest that drone delivery alone may be insufficient to improve commodity availability where upstream supply-chain constraints remain binding. Prior estimates of drone impact across a broad range of supplies may have been… →
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Exploring the relationship between HIV Testing frequency and sexual behavior, prevention prophylaxis use among MSM in Southern China
CONCLUSIONS: While frequent HIV testing demonstrates significant associations with increased sexual partner numbers, its role in facilitating consistent use of HIV exposure prevention prophylaxis remains clinically valuable. →
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How to Outcompete Your Client’s AI
Andy Carter/Ikon Images The in-house lawyers at real estate investment firm Alturas Capital Partners used to rely on outside counsel for much of its lease work. Thanks to generative AI, it can now do that work internally, saving the firm hundreds of thousands of dollars in spending and compressing lease work that once stalled for… →
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Prevention of sickness absence through early identification and rehabilitation of at-risk patients with musculoskeletal disorders (PREVSAM): a cost-effectiveness analysis comparing team-based rehabilitation in primary care vs treatment as usual
CONCLUSIONS: The PREVSAM model and treatment as usual led to similar health outcomes and to similar total societal costs. Neither strategy was shown to be preferable on economic grounds at conventional cost-effectiveness thresholds. High individual variation implies that the screening process needs to be further refined to better identify those patients truly in need of… →
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Risk of drug-induced liver injury in multiple system atrophy patients treated with KM-819 is potentially associated with the HLA-DPB1*05:01:01:01 allele
KM-819, a first-in-class inhibitor of Fas-associated factor 1 (FAF1), was investigated in a Phase 2 clinical trial in Korean patients with multiple system atrophy (MSA). Among 34 KM-819-treated patients, 11 met the case definition for suspected DILI, and 9 of these (26%) were adjudicated by an independent hepatic adjudication committee (HAC) as KM-819-related DILI; no… →
