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Participant Experiences of Therapeutic Touch in Psilocybin-Assisted Therapy
CONCLUSIONS: Therapeutic touch may support emotional safety and affect regulation during acute psychedelic states. Findings highlight the importance of explicit preparation, consent, and attunement when incorporating touch into psychedelic therapy. Further research should inform therapist training, individualized consent frameworks, and safety protocols to guide ethical and effective use in clinical practice. →
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Improvements in quality-of-life dimensions through medium-chain triglyceride (MCT) supplementation in rheumatoid arthritis: updated findings from a randomised clinical trial
CONCLUSIONS: Patients with RA supplemented with MCTs obtained significant improvements in several health-related QOL components compared to control, and fibre inclusion did not interfere with MCT efficacy. These results underscore the importance of targeted non-pharmacological approaches integrated to drug therapy in managing patients with RA. →
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The BIOPREVENT machine-learning algorithm predicts chronic graft-versus-host disease and mortality risk using posttransplant biomarkers
BACKGROUNDChronic graft-versus-host disease (cGVHD) is a major contributor to nonrelapse mortality (NRM) following hematopoietic cell transplantation (HCT). Whether machine-learning (ML) models with biomarkers improve the accuracy for predicting future cGVHD/NRM is not established.METHODSWe developed BIOPREVENT (BIOmarkers PREVENTion), a ML algorithm using data from 1,310 HCT recipients, incorporating 7 plasma proteins measured at Day 90/100 post-HCT… →
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The Case for Making Bold Bets in Uncertain Times
Carolyn Geason-Beissel/MIT SMR | Getty Images In the investment world, taking risks during volatile periods can result in a windfall. During his 60 years at the helm of Berkshire Hathaway, Warren Buffett delivered compounded annual returns of nearly 20% — double what the S&P 500 achieved — guided by the rule “Be fearful when others… →
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Low-dose cyclophosphamide combined with standard immunosuppressive therapy improves early response rates in severe aplastic anemia
CONCLUSIONS: Low-dose CTX combined with standard IST appears to improve the early response rate in SAA/VSAA patients with manageable toxicity. →
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Probiotic Supplementation as an Adjuvant Therapy in Pediatric Drug-Resistant Epilepsy: A Double-Blind Placebo-Controlled Trial
CONCLUSION: Lactobacillus acidophilus supplementation appears to enhance the effectiveness of conventional antiepileptic drugs, reduce systemic inflammation, improve quality of life, and reduce seizure frequency in children with DRE. However, further validation is necessary. →
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Inpatient Schema Therapy: Results of a Multiple Baseline Case Series Study
This study tested a 10-week multidisciplinary schema therapy inpatient treatment protocol for patients with personality disorders, including two individual and two group sessions per week, supportive sessions with nurse cotherapists, as well as art, music, sports group and individual body therapy. Twenty patients with specific or mixed PD participated. A concurrent multiple baseline design was… →
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The Effects of Lidocaine Patches on Post-Radiofrequency Ablation Pain in Patients With Hepatocellular Carcinoma
CONCLUSIONS: VAS pain scores, the primary endpoint, were not significantly different between the two groups. However, the objective equivalent cumulative dose of residual morphine was significantly reduced, implying that the lidocaine patch lowered residual systemic opioid exposure. We conclude that the lidocaine patch may be useful to reduce opioid use post-RFA. →
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Comparison of Isolated Balance Exercise Regimen and Conventional Physiotherapy on Lumbar Flexion-Rotation Movement Impairment in Male Patients With Mechanical Low Back Pain
CONCLUSION: Isolated balance training is an effective and viable standalone intervention for managing MLBP due to Lumbopelvic flexion-rotation movement impairment syndrome. →
