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Short-Course Radiotherapy-Based Total Neoadjuvant Therapy plus Tislelizumab for Locally Advanced Rectal Cancer (Neo-STAR): Early Outcomes of a Randomized Phase II Trial
Background: Short-course radiotherapy (SCRT)-based total neoadjuvant therapy (TNT) is used for locally advanced rectal cancer (LARC). However, the pathological complete response (pCR) rate still hovers around 30%. Radiotherapy and immune checkpoint inhibitors have been shown to exert synergistic anticancer effects. This phase II randomized clinical trial aimed to evaluate the efficacy and safety of SCRT… →
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Effects of total-etch and self-etch bonding systems on pulp sensitivity and the incidence of long-term complications following resin filling of posterior teeth
CONCLUSIONS: Self-etching and bonding 3M-Z350 nano-composite resin to fill teeth can effectively improve the therapeutic effect, reduce postoperative pulp sensitivity, enhance chewing function and have good interface sealing performance. The incidence of complications such as post-operation fillings and pulpitis pain is relatively low. →
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Effectiveness of peer-delivered Problem Management Plus for Immigrants (PMP-I) in reducing stress, anxiety, and depressive symptoms among Bhutanese adults resettled in Massachusetts, United States: a pilot randomized controlled trial
CONCLUSIONS: The PMP-I improved the mental, social and emotional well-being of Bhutanese adults (PHQ-9 score ≤ 14) resettled in Massachusetts. Peer-delivered, family-centred PMP-I offers a significant public health benefit; however, a large-scale, RCT involving diverse refugee groups is necessary to replicate its success nationwide and beyond. →
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Effect of photobiomodulation on fatigue-related errors in ankle joint position reproduction: the moderating role of perceived ankle instability in a randomized, placebo-controlled trial
To investigate whether pre-exercise photobiomodulation (PBM) attenuates fatigue-induced decline in ankle joint position reproduction (JPR) and determine whether perceived ankle instability modifies this response. In this randomized, placebo-controlled trial with participant blinding and blinded outcome assessment, 30 healthy young adults (age: 24.3 ± 3.7 years; 15 male, 15 female) received either PBM or placebo treatment… →
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Feasibility and clinical value of a prostate cancer screening model based on biparametric magnetic resonance imaging combined with prostate-specific antigen in a Chinese population
CONCLUSION: The prostate cancer screening model based on serum tPSA combined with bpMRI demonstrates good feasibility, reduces unnecessary biopsies, optimizes the allocation of screening resources, and provides a basis for precision screening strategies. →
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Effect of pictorial-based information about atherosclerosis on adherence to lifestyle recommendations: results from the VIPVIZA randomised controlled trial
CONCLUSION: Our findings provide some evidence for the contributory role of pictorial-based information about subclinical atherosclerosis in promoting sustained healthy lifestyle habits. →
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Digital Mahjong-Based Cognitive Engagement Intervention for Older Adults: Randomized Controlled Trial
CONCLUSIONS: This 6-month home-based digital mahjong intervention improved delayed recall and increased right insular ReHo. Integrating culturally familiar cognitive challenges with lifestyle engagement may be a feasible strategy associated with salience network-related functional changes and memory performance. Future large-scale trials should use active control conditions and factorial designs to rigorously isolate component-specific mechanisms. →
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How America out-deindustrialised Europe
Despite the prevailing narrative of Western deindustrialisation as one of a rigid Europe and a dynamic America, Richard Baldwin, Saul Estrin, and Bob Hancké argue that the comparison of the EU with the US turns this narrative on its head. While both have experienced deindustrialisation, it has been for different reasons and with the US’s running deeper. The familiar story of deindustrialisation says Europe is over-regulated, over-taxed and burdened by ageing factories, while the United States is… →
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Robots Are Coming — but Not Everywhere
Getty Images “The ChatGPT moment for robotics is coming,” declared Nvidia CEO Jensen Huang at the Consumer Electronics Show in January 2025. It’s a widespread expectation: that humanoid robots will follow the same explosive adoption curve as generative AI. Our research suggests the opposite. Humanoid robotics will be adopted unevenly, across diverging use cases and… →