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Efficacy of Saffron as an Adjunct to Methylphenidate in Treating ADHD in Children Aged 6-12: A Randomized Clinical Trial
CONCLUSION: The findings suggest that the combination of saffron with methylphenidate may enhance subjective reports of ADHD symptoms, particularly hyperactivity and impulsivity; however, objective cognitive measures showed limited changes. Given the favorable safety profile of saffron and study limitations, this supports its potential role as a complementary option, pending confirmation in placebo-controlled trials with larger… →
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Long-term efficacy of lebrikizumab in treating head, neck and face involvement in patients with moderate-to-severe atopic dermatitis
CONCLUSIONS: Lebrikizumab provided durable, stable long-term HNF efficacy across diverse populations, including systemic-naive patients and those with prior biologic exposure. →
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Effect of a Subanesthetic Dose of Esketamine on Postoperative Sleep Disturbance After Oocyte Retrieval Under Intravenous Anesthesia: A Randomized Controlled Trial
CONCLUSION: A single subanesthetic dose of esketamine was associated with a lower incidence of short-term PSD on POD 3 in women undergoing oocyte retrieval under intravenous anesthesia. Larger multicenter studies are warranted to confirm these findings. →
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Gut Regulated Associations of Neuronal Signalling in High Blood Pressure (GRAINS-BP): a double-blinded randomised crossover placebo-controlled trial
BACKGROUND: Hypertension affects 1 in 3 Australian adults and is a major contributor to stroke and myocardial infarction. Despite the availability of various medications, over 50% of patients struggle to control their blood pressure (BP) due to nonadherence, difficulty finding the right treatment, or avoidance of medication. Diet plays a key role in cardiovascular health,… →
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Full-spectrum LED screen-bar lighting as an adjunct to artificial tears in visual display terminal-related dry eye: a randomized study
CONCLUSIONS: Adding a full-spectrum lamp to artificial tears was associated with a greater short-term improvement in subjective dry eye symptoms in VDT-related dry eye, without corresponding between-group differences in objective ocular surface parameters. Further studies are required to confirm these findings. Trial registration number ChiCTR2400084309, 2024/05/14. →
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Clinical Decision Support for Fall Prevention in Primary Care: The eSTEPS Cluster Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this cluster randomized clinical trial of an electronic health record-integrated decision support, falls and fall-related injuries were modestly reduced in older adults in primary care. These results suggest support for scalable, workflow-integrated fall prevention. →
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Preference for Resistance Training Volume After Acute Exercise in Women With Fibromyalgia: A Randomized Crossover Clinical Trial
BACKGROUND AND PURPOSE: To evaluate participants’ preferences following acute exposure to three resistance training protocols differing solely in the number of sets performed. →
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Chemical and laser desensitization approaches for managing dentin hypersensitivity after non-surgical periodontal therapy: A randomized clinical trial
PURPOSE: This randomized clinical trial aimed to evaluate and compare the desensitizing efficacy of Gluma, Er,Cr:YSGG laser irradiation, and their combined application in Stage III/IV periodontitis patients presenting dentin hypersensitivity (DH) following non-surgical periodontal therapy (NSPT). →
