CONCLUSION: PRF enhances bone regeneration after apicoectomy, especially when combined with Bio-Oss, without increasing postoperative morbidity. CBCT volumetric assessment provides superior evaluation of regenerative outcomes. →

CONCLUSIONS: Standardized patient-based training was associated with improved clinical diagnostic performance, particularly among students with average or lower academic standing. These findings support the integration of standardized patients into hybrid clinical curricula to strengthen diagnostic competence and communication skills. →

CONCLUSION: This study provides a robust, prospective, informative dataset on bleeding rates in participants receiving factor replacement therapy over a mean follow-up of ∼1 year. Although FVIII/FIX prophylaxis was generally well tolerated, bleeding rate data illustrate the limitations of current standard-of-care factor prophylaxis. →

This study investigated the effects of ashwagandha root extract (ARE) supplementation on core attention-deficit/hyperactivity disorder (ADHD) symptoms, executive functioning, and patient-reported outcomes in children and adolescents with mild ADHD. Fifty-eight children and adolescents with clinically diagnosed mild ADHD were randomly assigned to either the ARE group (ARE; n = 29) or a placebo group (PLA;… →

CONCLUSIONS: OC using ice-cold saline effectively reduces the day 14 incidence and severity of HD-MTX-induced OM and improves mucositis-free survival in pediatric ALL. These findings were supported by the reference-based imputation analysis. This intervention appears to be safe and feasible; however, confirmation through ITT analyses and multicenter trials using age-stratified randomization is required before its… →

CONCLUSION: This study first identified distinct uACR trajectory patterns in HFpEF patients. The fluctuating high trajectory was associated with increased cardiovascular risk and heart failure hospitalization, while the association between the decreasing trajectory and myocardial infarction was exploratory and requires validation. →

CONCLUSIONS: The DIMS spectacle lens was noninferior to OKL for slowing axial elongation after 18 months of therapy in myopic children. The DIMS spectacle lens was not superior to OKL. There was no statistically significant difference in overall eye length growth between the DIMS spectacle lens and OKL after 18 months of therapy in myopic… →

CONCLUSIONS: In this study, it was observed that the implementation of a nursing checklist was associated with significant improvements in the quality of airway care and patient outcomes during mechanical ventilation in patients with severe pneumonia, leading to a significant reduction in the duration of mechanical ventilation and improved oxygenation status and prognosis of patients. →

CONCLUSIONS: Early vitamin D deficiency before 20 weeks of gestation was associated with altered metabolic trajectories during pregnancy, including greater increases in LDL cholesterol and ketone body concentrations in women with overweight or obesity, as well as higher cord blood ketone levels in their offspring. These findings suggest that early maternal vitamin D status may… →