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Evaluation of oncologic safety and clinical effectiveness of immediate autologous fat grafting in breast-conserving surgery: a multicenter, prospective, randomized controlled clinical trial for breast cancer
CONCLUSION: Our results provide clear evidence that IAFG is a safe and effective surgical technique that does not increase the risk of local or distant recurrence in breast cancer patients and yields higher satisfaction with postoperative breast appearance and psychosocial outcomes. →
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Impact of breathing frequency on respiratory oscillometry measurements: a randomised cross-over and observational study of asthma patients
CONCLUSION: Higher breathing frequencies significantly reduce total Rrs . When performing respiratory oscillometry, breathing frequency should be controlled at approximately 15 bpm to reduce risk of misclassification. →
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Cost-utility analysis of the Circle of Security-Parenting programme to reduce perinatal psychopathology in birthing parents in England
CONCLUSIONS: On average, COS-P was associated with higher costs and did not demonstrate improvements in health-related quality of life compared with TAU alone. Given the uncertainty surrounding the estimates, further research is warranted to explore potential longer term economic and clinical impacts of COS-P in perinatal mental health settings. →
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Three Myths Fueling Companies’ Icy Silence on Politics
Brian Stauffer/theispot.com In 1963, as the U.S. civil rights movement reached a new peak, most U.S. companies stayed quiet. That changed after events in Birmingham, Alabama. Images of peaceful demonstrators, including children, being attacked by police dogs and high-powered fire hoses shocked the country. Economic boycotts of segregated businesses in and near Birmingham followed. Under… →
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Podcast: The Global Trends Shaping the Way We Do Business
If your long-term business outlook doesn’t account for geopolitical trends, it might need amending. “We’ve been really lucky in being able to focus on building our businesses and designing our economic strategies mostly without thinking about geopolitics. That’s just not true anymore,” says Nancy Qian, a professor of managerial economics and decision sciences at Kellogg… →
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Evaluating context effects on PHQ-8 somatic item scores among people with a chronic medical condition: a scleroderma patient-centred intervention network randomised experiment
CONCLUSIONS: We did not find evidence that responses to PHQ-8 somatic items were influenced by whether participants were aware they were responding to items about depression. This finding supports the validity of self-reported questionnaires for depression symptom assessment in people with chronic medical conditions. →
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Earlier ICU Transfer after CONCERN Early Warning System Score Escalation Reduced Sepsis-related Mortality: Results from a Multi-site Pragmatic Cluster Randomized Controlled Trial
Early recognition and timely escalation of care are critical for improving sepsis outcomes. This post-hoc analysis of a multi-site clinical trial examined whether the timing of ICU transfer following CONCERN Early Warning System (EWS) score escalation was associated with in-hospital mortality among patients later diagnosed with sepsis. Among 54 patients with CONCERN score changes prior… →
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Safety and efficacy of fordadistrogene movaparvovec in ambulatory participants with Duchenne muscular dystrophy (CIFFREO): a phase 3, double-blind, randomised, placebo-controlled study
BACKGROUND: Gene transfer is a promising therapeutic approach for Duchenne muscular dystrophy as the disease results from mutations in a single gene. Fordadistrogene movaparvovec is an investigational recombinant adeno-associated virus 9 (rAAV9)-based vector encoding a mini-dystrophin transgene protein for Duchenne muscular dystrophy . We aimed to assess the safety and efficacy of fordadistrogene movaparvovec in… →
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Home-based extended rehabilitation for older people with frailty (HERO): a randomised controlled trial
CONCLUSIONS: We do not recommend routine commissioning of extended rehabilitation for older people with frailty after discharge home from hospital or intermediate care, following an acute admission with a medical illness or injury. →
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How to Price Your Product: A Pricing Model Decision Tree
Recently, we published an edition called How to Price Your AI Product, co-written with DealOps, that went through critical considerations for pricing. The demand that we got for more pricing information was overwhelmingly positive. We wrote this edition to answer that call and build out a true pricing model decision tree, along with a full… →