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  • Effects of Prehabilitation by Physical Activity on Fatigue After Surgery for Colorectal Cancer. Results From Secondary Analyses in the Randomized Controlled Trial PHYSSURG-C

    8 августа, 2026

    CONCLUSION: This exploratory study found a suggestion of less postoperative fatigue in the intervention group. Further studies are needed to define the role of unsupervised moderate exercise, if any, before and after surgery in regard to postoperative fatigue in patients with colorectal cancer. →

    Clinical Trials
  • ‘Better Conversations with Primary Progressive Aphasia and other rare dementias (BCPPA plus)’ telehealth communication partner training programme: protocol for an NHS embedded randomised controlled feasibility and implementation study

    8 августа, 2026

    INTRODUCTION: Language and communication difficulties are common across a range of dementias including primary progressive aphasia (PPA). Better Conversations with PPA (BCPPA) is a co-designed communication partner training intervention that aims to improve the experience of conversations for a person with communication difficulties. An NHS-based pilot study of face-to-face BCPPA demonstrated positive outcomes but also… →

    Clinical Trials
  • Graded Exercise Therapy and Cognitive Behavioral Therapy for Fatigue in Patients With Breast Cancer: Protocol for a Randomized Controlled Pilot Study

    8 августа, 2026

    CONCLUSIONS: This study will provide evidence on whether a combination of GET and CBT is feasible and acceptable for the treatment of fatigue in patients with BC in Singapore. It supports the refinement of evidence-based fatigue management guidelines and improvements in BC survivorship care. →

    Clinical Trials
  • The effect of CBT-based journaling on emotional responses to clothing styles

    8 августа, 2026

    CONCLUSION: CBT-based journaling is an effective and scalable intervention for improving emotional responses and reducing irrational beliefs related to clothing styles. Its efficacy highlights the potential for broad application in mental health promotion, particularly in appearance-sensitive contexts among adolescents and young adults. →

    Clinical Trials
  • Care Navigation, Self-Measured Blood Pressure, and Health Coaching for Postpartum Care: A Randomized Clinical Trial

    7 августа, 2026

    CONCLUSIONS AND RELEVANCE: The health coaching intervention combined with self-measured BP monitoring significantly increased health care engagement and BP control by 12 months post partum. These findings support health coaching as an effective strategy for reducing long-term uncontrolled hypertension among patients with HDP. →

    Clinical Trials
  • Clinical comparison of CAD/CAM nanohybrid composite and hybrid ceramic overlays in children with molar-incisor hypomineralisation: a split-mouth prospective randomized clinical trial

    7 августа, 2026

    CONCLUSIONS: CAD/CAM-fabricated NCOs and HCOs showed favorable short-term clinical performance in selected MIH-affected FPMs up to the 12-month follow-up. Preliminary 18-month findings should be interpreted with caution, and longer-term follow-up of the complete cohort is required to determine comparative durability. →

    Clinical Trials
  • Comparative study of the efficacy and safety of Ranquilon and Afobazol in the treatment of patients with anxiety associated with neurasthenia and adjustment disorders. (Results of an open, randomized, multicenter, phase IV clinical study)

    7 августа, 2026

    CONCLUSION: Ranquilon 1 mg tablets at 6 mg/day demonstrate greater efficacy than Afobazol 10 mg tablets at 30 mg/day in alleviating anxiety associated with neurasthenia and adjustment disorders. The safety profile of Ranquilon is favorable and comparable to that of Afobazol. →

    Clinical Trials
  • Plasma P-tau217 for detecting amyloid clearance after donanemab in Alzheimer’s disease

    7 августа, 2026

    INTRODUCTION: This analysis of the phase 3 TRAILBLAZER-ALZ 2 trial examined whether plasma tau protein phosphorylated at threonine 217 (p-tau217) level can reliably monitor treatment-related amyloid clearance (TRAC) after donanemab treatment in early symptomatic Alzheimer’s disease (AD). →

    Clinical Trials
  • Effect of Sleep Report Feedback With Health Guidance Using a Sleep Monitoring Device for Improving Sleep in Community-Dwelling Older People: A Three-Arm Randomized Controlled Trial

    7 августа, 2026

    CONCLUSIONS: Combining sleep report feedback with telephone-based health guidance may support improvement in subjective sleep status among community-dwelling older adults. →

    Clinical Trials
  • DECIDER-2: Prospective randomized multicenter phase III trial of decitabine and venetoclax administered in combination with all-trans retinoic acid or placebo in patients with acute myeloid leukemia who are ineligible for induction chemotherapy

    7 августа, 2026

    BACKGROUND: Acute myeloid leukemia (AML) is predominantly a disease of older patients with a poor long-term survival. Approval of the combination of venetoclax (VEN) with azacitidine (AZA) or decitabine (DAC) in the European Union in 2021 for the treatment of patients with newly diagnosed AML who are ineligible for induction chemotherapy has become the treatment… →

    Clinical Trials
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