The effects of exercise intensity on airway epithelial integrity markers and inflammatory responses remain unknown. Therefore, we investigated the effects of high- and moderate-intensity exercise on airway epithelial integrity markers (club cell protein 16 [CC16], surfactant protein D [SP-D], and the CC16/SP-D ratio), along with systemic inflammation assessed via high-sensitivity C-reactive protein [hs-CRP] in healthy… →

This study examined the efficacy of experiential play therapy in reducing behavioral problems among children with Conduct Disorder (CD). Between December 2022 and May 2024, a prospective clinical trial was conducted with 20 children aged 7-12 years (10 females, 10 males) diagnosed with CD according to DSM-5 criteria. The intervention involved eight weekly, 45-minute experiential… →

CONCLUSIONS: In this exploratory randomized controlled trial, the intervention did not show significant superiority over the control condition; findings should be interpreted cautiously given limited statistical power. Future psychotherapeutic group interventions for patients with PCS have to consider outcome measures beyond severity of persistent physical symptoms rather than evaluating global symptom scores. Group-based psychotherapeutic approaches… →

CONCLUSION: taVNS effectively alleviates depressive symptoms in MDD patients via dual complementary pathways: directly modulating neural activity in the right SFG to regulate depression-related brain function, and indirectly maintaining gut microbiota homeostasis by enriching beneficial taxa such as Faecalibacterium prausnitzii. These findings provide novel mechanistic insights into the brain-gut interaction underlying the antidepressant effects of… →

Early detection of cognitive impairment is essential for dementia prevention and timely care. However, implementation in primary care and community settings remains limited. Building dementia-prepared health systems requires scalable and adaptive pathways that integrate subjective, digital and biological indicators, while accounting for heterogeneity in risk, education and age. CogScreen I was a cluster-randomized trial conducted… →

CONCLUSION: This is the first pediatric clinical study to demonstrate the efficacy, safety, and pharmacokinetics of rifaximin in pediatric patients with HE. The efficacy signals were driven primarily by clinical and neurocognitive measures rather than biochemical (ammonia) changes. The safety and pharmacokinetics of rifaximin were similar to those for adult patients. →

CONCLUSION: These findings suggest that hypnosis significantly enhances patient comfort and key procedural parameters during BMB, warranting its consideration as addition to local anesthesia. Its integration into clinical practice may reduce the need for supplementary pharmacological interventions, including EMONO. →

CONCLUSIONS: Findings from this large study reporting FAF characteristics of iRORA highlight the heterogeneity of these lesions and the association of the multimodal phenotype on progression over time. →

CONCLUSION: Self-collected human papillomavirus sampling yields results diagnostically comparable to clinician-collected specimens. Self collected human papillomavirus sampling demonstrated similar human papillomavirus detection rates compared with clinician-collected specimens. Given its feasibility and high acceptability, self-collection may serve as an effective complementary approach in cervical cancer screening programs, particularly for reaching women who have not previously participated… →