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A Controlled Trial on the Effect of Self-Compassion Group Psychotherapy on Adolescents With Major Depressive Disorder
Major depressive disorder (MDD) is a prevalent mental disorder among adolescents, yet its clinical management remains challenging. This controlled trial aimed to evaluate the effectiveness of self-compassion group psychotherapy as an adjunctive treatment for adolescents with MDD. Sixty adolescents with MDD were recruited from the First Affiliated Hospital of Chongqing Medical University between March and… →
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Phase II randomised, placebo-controlled study to evaluate the efficacy and safety of an MK2 inhibitor in ankylosing spondylitis
CONCLUSIONS: Inhibition of MK2 by CC-99677 was insufficient to lead to significant clinical benefits in AS. →
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Data Transformation Is the CEO’s Business
Aeriform/Ikon Image The Research The MIT Sloan Center for Information Systems Research conducted case study research at Caterpillar, a member of the MIT CISR research consortium since 2007. From July 2023 to December 2024, the authors conducted 56 interviews with 42 stakeholders. Interview participants also reviewed the case narrative as it was developed by the… →
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Effect of Integrated Internet-Based Acceptance and Commitment Therapy and Behavioral Activation Among Ethnic Minority Young Adults With Alcohol Use Disorder in Hong Kong: Pilot Randomized Controlled Trial
CONCLUSIONS: This study, unlike existing evidence, presents an innovative integration of ACT and BA delivered via an internet-based self-help format. The findings contribute to the field by providing preliminary evidence that this integrated intervention is feasible and promising for AUD. The main implication in the real world is to conduct a fully powered randomized controlled… →
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Factors associated with unplanned healthcare encounters in pediatric cancer patients
CONCLUSIONS: Unplanned healthcare utilization is common among newly diagnosed pediatric cancer patients. The association between unplanned healthcare utilization and standardized symptom screening and increasing physical full-time equivalents warrant further investigation. Key aspects to the implementation of routine symptom screening among pediatric patients with cancer will be resource allocation to prevent and manage common symptoms including… →
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Echocardiographic Parameters for Predicting Atrial Fibrillation Following Ischemic Stroke: The PER DIEM Echocardiography Substudy
CONCLUSIONS: In patients with ischemic stroke, LAVI and LV GLS were significantly associated with subsequent AF detection. These findings may help risk stratify AF monitoring strategies for postischemic stroke management. →
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Sustained on/off-treatment disease control with abrocitinib for moderate-to-severe atopic dermatitis
CONCLUSIONS: After 12 weeks of abrocitinib 200 mg, some patients achieved 40 weeks of sustained off-treatment disease control, with assessments demonstrating clear/mild AD, suggesting attainment of disease remission. →
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Absolute Eczema Area and Severity Index Responses with Lebrikizumab in Patients with Moderate-to-severe Atopic Dermatitis: A Secondary Analysis of Two Phase 3 Trials
The ADvocate trials (NCT04146363, NCT04178967) investigated adults/adolescents with moderate-to-severe atopic dermatitis (AD) receiving lebrikizumab (LEB) monotherapy, using percent improvement in the Eczema Area and Severity Index (EASI). In clinical trials, percent EASI improvement is used to compare study arms and measure treatment effect size/impact. In clinical practice, however, absolute EASI scores are used (especially in… →
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Why trust must (still) guide the UK’s approach to digital identity
In September 2025, Prime Minister Sir Keir Starmer announced that by the end of the current Parliament, the UK would have a new digital identity system. Professor Edgar Whitley argues that the government’s announcement, before conducting detailed policy development and consultation, undermined trust in the proposal from the start. Over 20 years ago, I was… →
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What It Takes to Scale Value-Based Industrial Solutions
Dante Terzigni/theispot.com B2B sales is fiercely competitive. Companies selling big-ticket products and services to other businesses must design solutions that meet their customers’ specific needs with a provable value proposition. Increasingly, that means engaging in value-based sales, where the benefits to the customer are defined, quantified, and managed by the vendor. That’s a challenging practice… →