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The Cost and Intermediate Cost-Effectiveness of a Randomized Control Trial Delivering U=U Messaging to Increase HIV Testing Among South African Men
CONCLUSION: Delivering tailored U=U messaging can increase HIV testing and ART uptake among men while saving costs over standard untargeted HIV testing messaging and other HIV self-test distribution models. →
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Impact for Treatment Decision-Making and Clinical Outcome of Angiography-Derived Fractional Flow Reserve
CONCLUSIONS: Angiography-derived FFR-guided revascularization was noninferior to pressure wire-based FFR-guided strategy for determining revascularization in patients with stable coronary artery disease. This finding suggests that angiography-derived FFR may serve as a practical, wire-free alternative for physiologic guidance of coronary revascularization, warranting confirmation in larger outcome-driven trials. (PROVISION; UMIN000049230). →
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Effectiveness of different educational interventions on knowledge, attitude and willingness to undergo cervical cancer screening in rural Indonesia: a quasi-experimental study
CONCLUSIONS: In conclusion, the video-based educational intervention demonstrated the greatest improvements in knowledge, attitude, and willngness to undergo CCS compared to other methods. →
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How to Avoid Innovation One-Hit Wonders
Andy Carter/Ikon Images Innovation leaders often know how to manage success well. A fairly good idea is recognized, a strong contributor is rewarded, and the lessons from the win are carried into the next team project. In many cases, that is exactly the right organizational response. But, sooner or later, most organizations have a… →
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Application of a Wearable Wrist Moxibustion Device for Radial Styloid Stenosing Tenosynovitis
This protocol describes the standardized procedure for using a wearable wrist moxibustion device in patients with radial styloid stenosing tenosynovitis. The study is designed as a small-sample, exploratory randomized controlled trial. Participants meeting the diagnostic criteria for radial styloid stenosing tenosynovitis are enrolled and randomly allocated in a 1:1 ratio to either the control group… →
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Facilitation of Health Plan-Clinic Partnerships to Improve Colorectal Cancer Screening for Rural Medicaid Enrollees: A Qualitative Study
CONCLUSIONS: Practice facilitation can successfully support partnered health plan-clinic implementation of mailed FIT and patient navigation in rural clinics. Our findings highlight the importance of assessing support needs across all partnering organizations when implementing multilevel preventive care interventions and underscore the importance of subject matter expertise in practice facilitation. →
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Airway microbial compartmentalization under mechanical ventilation: a randomized pilot study comparing an endotracheal tube with suction and continuous cuff pressure control (Venner PneuX®) to standard intubation
CONCLUSIONS: Standard intubation produced progressive microbial convergence between airway compartments, while the VT system did not. The findings provide biological plausibility for previously reported VAP reductions with the VT system and show that microbiota sampling can detect device-related differences in airway community structure, warranting further investigation as an endpoint for evaluating airway devices. →
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Comparison of Oliceridine and Hydromorphone for Postoperative Analgesia in Adults Undergoing Lower Limb Fracture Surgery: A Randomized Controlled Non-Inferiority Trial
CONCLUSION: For post-operative analgesia after lower limb fracture surgery, oliceridine provides analgesic efficacy comparable to hydromorphone. Observations suggest a potential for a lower incidence of PONV with oliceridine, which may offer a favorable opioid option within multimodal analgesic regimens for this population. →
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Quality of life and functional recovery after venous stent placement for postthrombotic syndrome: insights from the ARIVA multinational randomized trial
CONCLUSION: Over the 6 months after endovascular treatment accessory to standard care for PTS, both PTS severity measured by the Villalta score and QoL measured by CIVIQ-20 improved. However, greater PTS severity and female sex were independently associated with worse QoL outcomes. →
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Effects of Prehabilitation by Physical Activity on Fatigue After Surgery for Colorectal Cancer. Results From Secondary Analyses in the Randomized Controlled Trial PHYSSURG-C
CONCLUSION: This exploratory study found a suggestion of less postoperative fatigue in the intervention group. Further studies are needed to define the role of unsupervised moderate exercise, if any, before and after surgery in regard to postoperative fatigue in patients with colorectal cancer. →
