Systemic antifungals such as terbinafine and itraconazole are often limited by drug interactions and side effects in the treatment of onychomycosis. We tested a new topical solution to address the clinical need for safer and more effective topical therapies. The solution (containing urea, lactic acid, ethoxydiglycol, decylene glycol, and polyquaternium-7) was applied twice daily for… →

Methylphenidate (MPH) is a psychostimulant widely used to enhance attention and executive functions through increased dopaminergic and noradrenergic transmission. Although its effects on cognitive performance are well documented, its acute influence on cortical oscillatory activity, particularly α power, during tasks requiring simultaneous motor and cognitive processing remains poorly understood in healthy adults.To investigate the acute… →

Obstructive sleep apnea (OSA) is associated with chronic obstructive pulmonary disease (COPD) and obesity, and all three are linked to reduced health-related quality of life (HRQoL). Coexistence of OSA and COPD increases morbidity and mortality compared to each condition alone. Liraglutide, a glucagon-like peptide 1 receptor agonist, may influence respiratory and HRQoL outcomes. In this… →

CONCLUSION: Perfluorohexyloctane was well tolerated and improved the signs and symptoms of DED associated with MGD in patients with different baseline disease severity compared to saline control. →

CONCLUSION: We concluded that motivational interviewing was effective in enhancing stress coping, improving functionality, and increasing quality of life in individuals with bipolar disorder. It is suggested that it is important for psychiatric nurses to be familiar with motivational interviewing techniques, and that this practice should be disseminated in psychiatric clinics. →

BACKGROUND: Direct transfer to angiography suite (DTAS) for patients with suspected stroke primarily admitted to an endovascular-capable centre could accelerate in-hospital workflow and improve outcome. We aimed to assess the safety and efficacy of DTAS for patients with acute severe neurological deficit highly suggestive of ischaemic stroke due to a large vessel occlusion (ASND-LVO). →

Introduction: Open gynecological surgery results in a large wound and severe postoperative pain, and adequate postoperative analgesia is necessary. Rectus sheath block (RSB) is used to block the sensory nerves of the anterior abdominal wall, thereby contributing to pain relief after lower abdominal surgeries. RSB provides effective perioperative analgesia and is related to lower perioperative… →

Introduction: Hysterectomies are one of the most common major open gynecologic surgeries. Open gynecological surgery results in a large wound and severe postoperative pain, and adequate postoperative analgesia is necessary. As part of multimodal analgesia strategies, regional anesthesia techniques are widely used in such surgeries to reduce opioid consumption and enhance analgesic efficacy. Spinal anesthesia,… →