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A phase 2, randomized, multicenter, double-blind, placebo-controlled trial of S-adenosyl methionine in participants with mild cognitive impairment or dementia due to Alzheimer’s disease
INTRODUCTION: S-adenosyl methionine (SAMe) is a pivotal metabolite in multiple neuronal pathways, including tau dephosphorylation. Reduced SAMe availability has been reported in the Alzheimer’s disease (AD) brain, prompting interest in supplementation as a potential therapeutic strategy. →
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The Human Side of AI Adoption: Lessons From the Field
Carolyn Geason-Beissel/MIT SMR Not a day goes by without another article being published about how AI could disrupt yet another aspect of our business or personal lives. In recent years, AI adoption has indeed taken off. However, if you pay close attention, you’ll notice a dichotomy. Many examples of successful early adoption of artificial intelligence… →
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The Association of Preoperative Cognitive Dysfunction to Common Intraoperative Electroencephalographic Parameters and Cerebral Hypoxia During Cardiac Surgery
CONCLUSIONS: Preoperative cognitive dysfunction was associated with significantly lower SEFs, indicating increased isoflurane sensitivity without affecting BS or correlating with CO. SEF shows potential as a marker for cognitive vulnerabilities, but further studies are needed to validate its clinical utility and establish thresholds to optimize perioperative care. →
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How P&G Uses AI to Understand Human Behavior
Computer vision isn’t just for self-driving cars and robots. At Procter & Gamble, it’s helping researchers understand human behavior, generate synthetic data, and build 3D models of people, at a scale most labs can only dream of. We’re excited to announce that Oya Aran, Director of R&D Data Science and AI at P&G, will be… →
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Lattice-tip vs. standard irrigated focal-tip catheter for radiofrequency ablation of the cavotricuspid isthmus — the LINEAR randomized trial
CONCLUSION: The lattice tip catheter resulted in higher acute procedural success for radiofrequency CTI ablation compared to the standard irrigated focal-tip catheter. Future studies are needed to assess long-term efficacy and clinical outcomes. →
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Efficacy and Safety of Pre-Endoscopy Regimens for Mucosal Visualization During Sedated Esophagogastro-duodenoscopy: A Randomized Controlled Trial
CONCLUSIONS: Simethicone and N-acetylcysteine given two hours before endoscopy effectively enhanced mucosal visibility and procedural efficiency without compromising safety, offering a practical alternative to more complex regimens. →
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Effects of a Mediterranean Diet-Based Program on Cognitive Decline: Non-Blinded Non-Randomized Controlled Trial of the CESPORT Program
Background: Age-related cognitive deccline is a significant health issue in Spain, especially among adults over 60 years of age. Addressing this involves establishing intervention guidelines and identifying early diagnostic biomarkers. Objective: To evaluate changes in urine of Brain-Derived Neurotrophic Factor, concentration and cognitive performance after the implementation of the multicomponent CESPORT program (incorporating a Mediterranean… →
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Rationale, Design, and Participant Baseline Characteristics of a Parallel Randomized Trial of the Effect of Replacing SSBs with Cow’s Milk Versus Soymilk on Intrahepatocellular Lipid and Other Cardiometabolic Risk Factors in Adults with Obesity Who Consume Sugar-Sweetened Beverages: The Soy Treatment Evaluation for Metabolic health (STEM) Trial
Background/Objectives: Liver fat represents an early metabolic lesion in the development of diabetes and its cardiometabolic complications. Diets high in free sugars, particularly from sugar-sweetened beverages (SSBs), are associated with abdominal obesity and increased cardiometabolic risk, prompting global guidelines to limit SSBs as a major public health strategy. Low-fat cow’s milk is promoted as the… →
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Modulation of Glucose Homeostasis, Metabolic Endotoxemia and Circulating Short-Chain Fatty Acids Following Multi-Species Probiotic Supplementation: Findings from a 12-Week Randomised Placebo-Controlled Trial
Background: Altered gut microbiota and gut-derived inflammation impair glucose regulation and promote metabolic endotoxemia, yet evidence on probiotic effects across combined glycaemic, inflammatory and short-chain fatty acid (SCFA) outcomes remains limited. This study investigated the effects of a 12-week multi-species probiotic on glucose homeostasis, incretin hormones, inflammatory biomarkers and circulating SCFAs in adults with subthreshold… →
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Managing Up: A Skill Set That Matters Now
Carolyn Geason-Beissel/MIT SMR | Getty Images Are you skilled at managing up? If your talents are lacking when it comes to managing and dealing with the people above you in the organizational hierarchy, you can find yourself mired in some unpleasant and career-harming situations. Maybe you’re frustrated by a micromanaging supervisor or feeling marginalized by… →