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  • Care Navigation, Self-Measured Blood Pressure, and Health Coaching for Postpartum Care: A Randomized Clinical Trial

    7 августа, 2026

    CONCLUSIONS AND RELEVANCE: The health coaching intervention combined with self-measured BP monitoring significantly increased health care engagement and BP control by 12 months post partum. These findings support health coaching as an effective strategy for reducing long-term uncontrolled hypertension among patients with HDP. →

    Clinical Trials
  • Clinical comparison of CAD/CAM nanohybrid composite and hybrid ceramic overlays in children with molar-incisor hypomineralisation: a split-mouth prospective randomized clinical trial

    7 августа, 2026

    CONCLUSIONS: CAD/CAM-fabricated NCOs and HCOs showed favorable short-term clinical performance in selected MIH-affected FPMs up to the 12-month follow-up. Preliminary 18-month findings should be interpreted with caution, and longer-term follow-up of the complete cohort is required to determine comparative durability. →

    Clinical Trials
  • Comparative study of the efficacy and safety of Ranquilon and Afobazol in the treatment of patients with anxiety associated with neurasthenia and adjustment disorders. (Results of an open, randomized, multicenter, phase IV clinical study)

    7 августа, 2026

    CONCLUSION: Ranquilon 1 mg tablets at 6 mg/day demonstrate greater efficacy than Afobazol 10 mg tablets at 30 mg/day in alleviating anxiety associated with neurasthenia and adjustment disorders. The safety profile of Ranquilon is favorable and comparable to that of Afobazol. →

    Clinical Trials
  • Plasma P-tau217 for detecting amyloid clearance after donanemab in Alzheimer’s disease

    7 августа, 2026

    INTRODUCTION: This analysis of the phase 3 TRAILBLAZER-ALZ 2 trial examined whether plasma tau protein phosphorylated at threonine 217 (p-tau217) level can reliably monitor treatment-related amyloid clearance (TRAC) after donanemab treatment in early symptomatic Alzheimer’s disease (AD). →

    Clinical Trials
  • Effect of Sleep Report Feedback With Health Guidance Using a Sleep Monitoring Device for Improving Sleep in Community-Dwelling Older People: A Three-Arm Randomized Controlled Trial

    7 августа, 2026

    CONCLUSIONS: Combining sleep report feedback with telephone-based health guidance may support improvement in subjective sleep status among community-dwelling older adults. →

    Clinical Trials
  • DECIDER-2: Prospective randomized multicenter phase III trial of decitabine and venetoclax administered in combination with all-trans retinoic acid or placebo in patients with acute myeloid leukemia who are ineligible for induction chemotherapy

    7 августа, 2026

    BACKGROUND: Acute myeloid leukemia (AML) is predominantly a disease of older patients with a poor long-term survival. Approval of the combination of venetoclax (VEN) with azacitidine (AZA) or decitabine (DAC) in the European Union in 2021 for the treatment of patients with newly diagnosed AML who are ineligible for induction chemotherapy has become the treatment… →

    Clinical Trials
  • Delayed secondary repair of third- and fourth-degree obstetric anal sphincter injuries: a randomized controlled trial comparing overlapping versus end-to-end sphincter repair

    7 августа, 2026

    CONCLUSION: In delayed secondary OASI repair, overlapping sphincteroplasty provided superior continence outcomes and lower complication rates than end-to-end repair, when combined with meticulous muscle mobilization and a standardized postoperative regimen. These findings support overlapping repair as the preferred technique in this setting. →

    Clinical Trials
  • Evaluation of patient centred digital adherence technology for tuberculosis treatment outcomes: pragmatic randomised controlled trial

    7 августа, 2026

    CONCLUSIONS: A multifaceted, interactive digital adherence tool improved tuberculosis treatment outcomes, particularly among younger participants and women, showing feasibility and effectiveness in supporting adherence to tuberculosis treatment in low resource settings. Future research should evaluate the impact of app engagement, context factors such as the covid-19 pandemic, cost effectiveness, and use of the tool beyond… →

    Clinical Trials
  • Accuracy of tympanometry cutoff points in children from Central-Western Brazil

    7 августа, 2026

    CONCLUSION: The cutoff point of -180 daPa combined with static compliance <0.2 mL improved screening accuracy and reduced unnecessary referrals. It provided the best balance between specificity, sensitivity, and accuracy, aligning more closely with TEOAEs results and supporting updating this tympanometric criterion in infant hearing screening. →

    Clinical Trials
  • Accuracy of operative time prediction in endometriosis surgery: results of a prospective randomized multicenter pilot study

    6 августа, 2026

    CONCLUSIONS: The results demonstrate that neither diagnostic strategy provided a measurable advantage in predicting operative time or improvement of surgical outcome parameters. →

    Clinical Trials
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