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Efficacy and safety of immunosuppressive therapy versus cyclosporine combined with avatrombopag in older adults with severe aplastic anemia: a multicenter prospective study
This trial compared antithymocyte globulin (ATG) + cyclosporine A (CsA) + avatrombopag (AVA) and CsA + AVA in older adults with severe aplastic anemia (SAA). The patients were randomized to receive either ATG + CsA + AVA or CsA + AVA. Of 84 included patients, 42 were treated with ATG + CsA + AVA and… →
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What Is Context Engineering in AI? Techniques, Use Cases, and Why It Matters
«`html What Is Context Engineering in AI? Techniques, Use Cases, and Why It Matters Introduction: What is Context Engineering? Context engineering refers to the discipline of designing, organizing, and manipulating the context that is fed into large language models (LLMs) to optimize their performance. This practice focuses on the input—the prompts, system instructions, retrieved knowledge,… →
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A Coding Guide to Build Modular and Self-Correcting QA Systems with DSPy
A Coding Guide to Build Modular and Self-Correcting QA Systems with DSPy In this tutorial, we explore how to build an intelligent and self-correcting question-answering system using the DSPy framework, integrated with Google’s Gemini 1.5 Flash model. We begin by defining structured Signatures that clearly outline input-output behavior, which DSPy uses as its foundation for… →
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Chai Discovery Team Releases Chai-2: AI Model Achieves 16% Hit Rate in De Novo Antibody Design
«`html Chai Discovery Team Releases Chai-2: AI Model Achieves 16% Hit Rate in De Novo Antibody Design Chai Discovery Team introduces Chai-2, a multimodal AI model that enables zero-shot de novo antibody design. Achieving a 16% hit rate across 52 novel targets using ≤20 candidates per target, Chai-2 outperforms prior methods by over 100x and… →
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A randomized controlled trial comparing novel and traditional apical barrier techniques in endodontic procedures
CONCLUSIONS: N-ABT clinically improve clinical outcomes (> 20%) during the observation period, it also demonstrated enhanced filling quality and efficiency and reduced technical sensitivity. →
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A prospective comparative study of pre-op chemoradiotherapy followed by surgery versus upfront surgery followed by adjuvant chemoradiotherapy in locally advanced borderline resectable oral cavity cancer
CONCLUSION: The research findings indicate that the combination of NACRT and subsequent surgery is a viable option, resulting in favorable pathological complete responses. Given the significance of response to chemoradiotherapy as a prognostic indicator, these outcomes could potentially lead to improved disease-free survival rates in the future. →
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Effects of device-assisted practice of activities of daily living in a close-to-normal pattern on upper extremity motor recovery in individuals with moderate to severe stroke: study protocol of a randomized control trial
BACKGROUND: The majority of individuals with chronic stroke have residual upper extremity (UE) disability which they cite as their greatest barrier to recovery. Using orthoses, robotic devices, and functional electrical stimulation (FES) represent rehabilitation techniques that have demonstrated the ability to improve arm and hand function in the chronic stroke population, but individuals with more… →
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Efficacy of intramuscular glucocorticoid injection in patients with lumbar radicular pain: a randomized controlled trial
CONCLUSION: Intramuscular glucocorticoid administration provided improvements on pain, disability and quality of life of patients with LRP. Especially the effects on pain scores were superior to placebo. No superiority over placebo on ENMG findings has been demonstrated and further studies are needed in this regard. →
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AbstRaL: Teaching LLMs Abstract Reasoning via Reinforcement to Boost Robustness on GSM Benchmarks
«`html AbstRaL: Teaching LLMs Abstract Reasoning via Reinforcement to Boost Robustness on GSM Benchmarks Understanding the Target Audience The target audience for AbstRaL includes AI researchers, data scientists, and business leaders interested in enhancing the robustness of large language models (LLMs). Key pain points for this audience involve the limitations of existing LLMs in handling… →
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Impact of clinical pharmacy services on medication adherence and quality of life in pre-dialysis patients with CKDu: a randomized controlled trial from Sri Lanka
CONCLUSIONS: Intervention significantly enhanced medication adherence and QOL among pre-dialysis patients with CKDu, demonstrating the positive impact of added clinical pharmacy services to existing healthcare team in managing CKD patients. →
