CONCLUSION: The combination of tamsulosin and tolterodine demonstrated superior efficacy in terms of stone expulsion rate and reduced expulsion time for distal ureteral stones compared to tamsulosin monotherapy. This combination therapy may offer a more effective medical expulsive therapy option for patients with distal ureteral calculi. →

CONCLUSIONS: Osteosarcopenia was associated with a multi-pathway serum metabolic signature that differed from osteoporosis alone, supporting the possibility that osteosarcopenia represents an integrated musculoskeletal phenotype rather than merely the additive coexistence of muscle and bone loss. The identified metabolites provide preliminary mechanistic insight and discovery-level biomarker candidates, but they require targeted quantitative validation and external… →

CONCLUSION: This is the first report to demonstrate that postoperative IL-18F levels are significantly associated with NRS pain scores and the number of analgesic doses in patients undergoing cholecystectomy. These findings suggest that IL-18F and IL-18BP may contribute to the acute-phase immune response to surgical trauma and its relationship with postoperative pain and analgesic requirements. →

CONCLUSIONS: Both groups demonstrated comparable clinical improvement; However, Patient-centred parameters were significantly better with the Microsurgical approach. Selection of the surgical approach should balance patient needs with practical considerations like cost, time, and clinician proficiency. →

CONCLUSIONS: Having a care process for weight management in primary care that includes guidance for billing can increase primary care practice revenue for weight-focused care. →

CONCLUSIONS: Among patients undergoing evacuation of acute subdural haematomas, the outcomes were similar in both groups. Additional surgery was required in a higher proportion of patients in the craniotomy group, but more wound complications occurred in the decompressive craniectomy group. →

CONCLUSION: E4/DRSP and DRSP-only had comparable effects on thrombin generation and TM-mediated anticoagulation in women with PCOS. E4/DRSP reduced hirsutism, supporting its consideration as a treatment option for PCOS. →

CONCLUSION: Benralizumab showed potential to rapidly reduce cough and/or dyspnea frequency, and to improve cough-specific HRQoL more quickly than placebo in patients with SEA, with sustained advantage in cough-related SGRQ items through Week 48. Improvements were pronounced in patients with higher baseline bEOS, potentially reflecting a higher disease burden. However, as this was an exploratory… →

CONCLUSIONS: S0777’s success underscores the importance of pre-specified interim monitoring plans and cautions against premature trial termination. →