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Risk factors and leprosy incidence among contacts in Bangladesh: A multilevel analysis
CONCLUSIONS AND RECOMMENDATIONS: BCG vaccination of contacts is effective in preventing leprosy, overall there is no clear benefit of adding SDR after BCG to reduce the number of excess leprosy cases after vaccination. SDR after BCG, however, appears effective to prevent leprosy in contacts of MB patients, smear positive index patients, and second degree blood-related… →
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Google AI Introduces Personal Health Agent (PHA): A Multi-Agent Framework that Enables Personalized Interactions to Address Individual Health Needs
Google AI Introduces Personal Health Agent (PHA): A Multi-Agent Framework that Enables Personalized Interactions to Address Individual Health Needs Table of contents What is a Personal Health Agent? How does the PHA framework operate? How was the PHA evaluated? Evaluation of the Data Science Agent Evaluation of the Domain Expert Agent Evaluation of the Health… →
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Clinical research of Zhuangdan Yanshi Decoction combined with dapoxetine hydrochloride in the treatment of premature ejaculation with cholestasis and phlegm disturbance syndrome
CONCLUSION: The combination therapy with Zhuangdan Yanshi Decoction and dapoxetine hydrochloride for premature ejaculation associated with cholestasis and phlegm disturbance syndrome is definite, and it can reduce the side effects of drugs, which is better than oral dapoxetine hydrochloride alone. →
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Effects of Focused Solution Model Nursing on quality of life and negative emotions of prostate cancer patients
CONCLUSION: Focused Solution Model Nursing intervention can effectively improve the quality of life and negative emotions of the prostate cancer patients in the clinical treatment. →
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Insights Into How Digital Health Interventions Shape Outcomes for Emerging Adults Living With Type 1 Diabetes: Qualitative Realist Process Evaluation
CONCLUSIONS: A multicomponent, text message-based digital intervention could support emerging adults living with T1D during their transition to adult care by enhancing their knowledge and motivation for self-management. Participant subgroups responded differently to various intervention components, which highlights that one-size-fits-all approaches are likely inadequate. Digital interventions should be developed and studied in a variety of… →
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Rapid Brain Adaptation to Hearing Amplification: A Randomized Crossover Trial of Personal Sound Amplification Products
Understanding speech in noise is a common challenge for older adults, often requiring increased listening effort that can deplete cognitive resources and impair higher-order functions. Hearing aids are the gold standard intervention for hearing loss, but cost and accessibility barriers have driven interest in alternatives such as Personal Sound Amplification Products (PSAPs). While PSAPs are… →
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How to Build a Complete End-to-End NLP Pipeline with Gensim: Topic Modeling, Word Embeddings, Semantic Search, and Advanced Text Analysis
«`html How to Build a Complete End-to-End NLP Pipeline with Gensim: Topic Modeling, Word Embeddings, Semantic Search, and Advanced Text Analysis In this tutorial, we present a complete end-to-end Natural Language Processing (NLP) pipeline built with Gensim and supporting libraries, designed to run seamlessly in Google Colab. It integrates multiple core techniques in modern NLP,… →
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The psychological impact of the disclosure of the diagnosis of Alzheimer’s disease on informal caregivers
INTRODUCTION: Receiving an Alzheimer’s disease (AD) diagnosis can be a distressing experience, for both the individual with the condition and the family. This cross-sectional study explored whether the disclosure of AD diagnosis generated post-traumatic stress symptoms (PTSSs) in caregivers and how this affected their psychological well-being. →
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An Open-Label, Single-Arm, Phase II Trial of Sintilimab Plus Anlotinib for Metastatic Non-Small Cell Lung Cancer After First-Line PD-(L)1 Inhibitor
CONCLUSION: Sintilimab combined with anlotinib exhibited favorable antitumor activity and tolerable toxicity in post-anti-PD-(L)1 therapy of metastatic NSCLC patients, supporting further randomized controlled trials. →
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De-escalated adjuvant radiotherapy versus standard adjuvant treatment for human papillomavirus-associated oropharyngeal squamous cell carcinoma (MC1675): a phase 3, open-label, randomised controlled trial
BACKGROUND: Standard adjuvant chemoradiotherapy (60-66 Gy) following surgery for HPV-associated oropharyngeal squamous cell carcinoma has excellent oncological control but high treatment morbidity. We aimed to compare toxicity of a 30-36 Gy regimen of de-escalated adjuvant radiotherapy and standard of care treatment. →
