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Occlusion-Focused Triage vs Very-High-Risk NSTEMI Criteria: A DIFOCCULT-3 Substudy
CONCLUSIONS: An occlusion-focused diagnostic approach was associated with substantially higher rates of immediate invasive management and earlier identification of patients with adjudicated ACO. →
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Combined Effect of Hypnotic-Cognitive Therapy With Therapeutic Exercise on Quality of Life in Individuals With Fibromyalgia: A Randomized Controlled Trial Protocol
BACKGROUND: A multidisciplinary approach is viewed as the primary treatment strategy for fibromyalgia (FM). Therapeutic exercise is an important component of this approach. Hypnotic cognitive therapy (HYP-CT), a relatively new intervention strategy, has not traditionally been incorporated in FM treatment, although it has shown beneficial effects in other chronic pain conditions. This study aims to… →
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Effectiveness of a self-management intervention on clinical outcomes among patients with type 2 diabetes at high risk for Diabetic Kidney Disease: A Randomised Controlled Trial
CONCLUSIONS: The self-management intervention effectively improved HbA1c, eGFR, SBP and LDL-C among T2DM patients at high risk of DKD. These findings suggest that integrating structured self-management into routine diabetes care may help improve modifiable risk factors and support early DKD prevention. →
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Long-Term Neurodevelopmental Outcome Following Three Randomized Controlled Trials of Choline in Fetal Alcohol Spectrum Disorder (FASD)
CONCLUSIONS: Very few RCTs have been conducted in FASD, and interventions targeting cognitive functioning are needed. The data reported here suggest that choline supplementation has long-lasting neurodevelopmental benefits, especially in non-verbal IQ and working memory for individuals with FASD. →
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Effect of injectable platelet rich fibrin augmented with vitamin c compared to injectable platelet rich fibrin alone on healing of necrotic mature single rooted teeth with chronic periapical periodontitis following regenerative endodontic therapy (a randomized controlled trial)
CONCLUSIONS: Both i-PRF combined with vitamin C and i-PRF alone appear to be effective regenerative scaffolds, demonstrating comparable clinical and radiographic outcomes in regenerative endodontic procedures. →
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Remimazolam ED95 for Preoperative Sedation in Children with Obstructive Sleep Apnea, with Obesity or a Reference-Range BMI: A Biased-Coin Dose-Finding Study
CONCLUSION: The protocol-specific ED95 values of a 1-min remimazolam bolus for RSS ≥4 at 3 min were 0.38 mg/kg in children with obesity and 0.44 mg/kg in children with a reference-range BMI. →
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Enhancing computational thinking in early childhood: A cluster-randomized controlled trial of interactive STEM app intervention and the role of engagement
This cluster-randomized controlled trial investigated whether a 12-week interactive STEM app intervention enhances computational thinking skills among young children aged 4-6 years and whether app usage engagement predicts learning outcomes. Ten classrooms from five kindergartens in Northern China were randomly assigned within each kindergarten to an intervention condition (5 classrooms, 125 children) that received structured… →
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Building Engagement Using Financial Incentives for Colorectal Cancer Screening (BENEFIT-C) in a Rural Louisiana Federally Qualified Health Center
CONCLUSION: Financial incentives significantly increased completion of CRC screening. Future research should confirm findings in larger samples and evaluate cost-effectiveness to inform health system policies. →
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Lung ultrasound-guided protocolized fluid management versus conventional central venous pressure-based management in monitoring extravascular lung water during the perioperative period of percutaneous nephrolithotomy: a randomized controlled trial
CONCLUSIONS: An LUS-guided fluid management protocol integrating real-time EVLW assessment with predefined intervention thresholds outperformed conventional CVP-based management during the perioperative period of PCNL. The superior sensitivity of LUS for detecting early EVLW elevation, combined with protocolized early intervention, reduced postoperative hypoxemia incidence, shortened extubation time and PACU stay duration, and improved short-term perioperative recovery. →
