CONCLUSIONS: These data, together with those from other PI3K inhibitors, suggest that PI3Kδ is not a suitable pathway for the management of COPD, as the achieved target engagement did not translate into any pharmacodynamic anti-inflammatory effect. →
The effects of prolonged infrasound (IS) exposure on brain function and behavior are largely unknown, with only one prior study investigating functional connectivity (FC) changes. In a long-term randomized-controlled trial, 38 participants were exposed to inaudible airborne IS (6 Hz, 80-90 dB) or sham devices for four weeks (8 h/night). We assessed FC changes in… →
One of the most critical challenges of LLMs is how to align these models with human values and preferences, especially in generated texts. Most generated text outputs by models are inaccurate, biased, or potentially harmful—for example, hallucinations. This misalignment limits the potential usage of LLMs in real-world applications across domains such as education, health, and… →
Human beings possess innate extraordinary perceptual judgments, and when computer vision models are aligned with them, model’s performance can be improved manifold. Various attributes such as scene layout, subject location, camera pose, color, perspective, and semantics help us have a clear picture of the world and objects within. The alignment of vision models with visual… →
Visual and action data are interconnected in robotic tasks, forming a perception-action loop. Robots rely on control parameters for movement, while VFMs excel in processing visual data. However, a modality gap exists between visual and action data arising from the fundamental differences in their sensory modalities, abstraction levels, temporal dynamics, contextual dependence, and susceptibility to… →
Large language models (LLMs) like GPT-4, Gemini, and Llama 3 have revolutionized natural language processing through extensive pre-training and supervised fine-tuning (SFT). However, these models come with high computational costs for training and inference. Structured pruning has emerged as a promising method to improve LLM efficiency by selectively removing less critical components. Despite its potential,… →
The problem of over-optimization of likelihood in Direct Alignment Algorithms (DAAs), such as Direct Preference Optimisation (DPO) and Identity Preference Optimisation (IPO), arises when these methods fail to improve model performance despite increasing the likelihood of preferred outcomes. These algorithms, which are alternatives to Reinforcement Learning from Human Feedback (RLHF), aim to align language models… →
Large Language models (LLMs) have long been trained to process vast amounts of data to generate responses that align with patterns seen during training. However, researchers are exploring a more profound concept: introspection, the ability of LLMs to reflect on their behavior and gain knowledge that isn’t directly derived from their training data. This new… →
Point tracking is paramount in video; from 3d reconstruction to editing tasks, a precise approximation of points is necessary to achieve quality results. Over time, trackers have incorporated transformer and neural network-based designs to track individual and multiple points simultaneously. However, these neural networks could be fully exploited only with high-quality training data. Now, while… →
CONCLUSIONS: During the 12-month follow-up period, no TMP/SMX-sensitive OIs occurred in SLE patients receiving low-level immunosuppressive therapy, suggesting that primary prophylaxis with TMP/SMX may not significantly benefit this population. The high rate of ADRs observed underscores the need for clinicians to carefully consider the risks and benefits of TMP/SMX prophylaxis in these patients. →