MicroRNAs (miRNAs) play key roles in human diseases, including cancer and infectious diseases, by regulating gene expression. Modulating miRNAs or their gene targets with small molecules present a potential therapeutic approach for correcting disease-related cellular dysfunctions. However, predicting effective small molecules for specific miRNAs is difficult due to limited data on miRNA-small molecule interactions. Although… →
In a data-driven world, privacy and security have become pressing concerns for individuals and organizations alike. With data breaches and information misuse becoming alarmingly frequent, safeguarding sensitive information is critical. Among the most challenging aspects of data protection is managing Personally Identifiable Information (PII), such as names, addresses, and social security numbers, which are highly… →
CONCLUSIONS: HIVST is an effective strategy for enhancing regular HIV testing behavior among transgender women in China. This strategy should be combined with measures to address the financial vulnerability of the transgender women community to reduce subsequent risk behaviors, including condomless sex. →
Retrieval-augmented generation (RAG) systems, a key area of research in artificial intelligence, aim to enhance large language models (LLMs) by incorporating external sources of information for generating responses. This approach is particularly valuable in fields requiring accurate, fact-based answers, such as question-answering or information retrieval tasks. Yet, these systems often encounter substantial challenges in filtering… →
CONCLUSIONS: The POW trial evaluates the effectiveness of an eHealth PA intervention for improving depressive symptoms and increasing PA among postpartum individuals at high PPD risk. Results have implications for the design and delivery of behavioral interventions among vulnerable patients. →
There is currently a lack of prospective studies comparing multiple treatment options for single-sided deafness (SSD) in terms of long-term sound localization outcomes. This randomized controlled trial (RCT) aims to compare the objective and subjective sound localization abilities of SSD patients treated with a cochlear implant (CI), a bone conduction device (BCD), a contralateral routing… →
The rise of AI-assisted coding has undoubtedly revolutionized software development, but not without its challenges. One of the main pain points for developers has been the lack of choice and flexibility in selecting AI models that best suit their unique needs. GitHub Copilot, which emerged as a groundbreaking tool for code generation and assistance, has… →
Multimodal large language models (MLLMs) rapidly evolve in artificial intelligence, integrating vision and language processing to enhance comprehension and interaction across diverse data types. These models excel in tasks like image recognition and natural language understanding by combining visual and textual data processing into one coherent framework. This integrated approach allows MLLMs to perform highly… →
CONCLUSIONS: Recruitment and retention rates suggest a trial of lTRE in adolescents with T2D was feasible. lTRE was seen as acceptable by participants and adherence was high. A revised intervention, building on the successful elements of this pilot alongside adapting implementations strategies to augment adherence and engagement, should therefore be considered. →
BACKGROUND: Tranexamic acid, given within 3 h of birth, reduces bleeding deaths in women with postpartum haemorrhage. We examined whether giving tranexamic acid shortly after birth can prevent postpartum haemorrhage in women with moderate or severe anaemia. →