CONCLUSIONS: Although characterized as immunosuppressive drugs, PIs improved RV delivery to MM cells but also enhanced anti-MM efficacy through immune-mediated killing of myeloma cells, independently of their PI sensitivity. These results highlight a more generalizable use of PIs as therapeutic companions to support oncolytic-based therapies in cancers. →
CONCLUSION: Comprehension of study information using an information video is non-inferior to a paper-based consent method. Using information videos for consent processes shows promise as a person-centred and context-sensitive approach to enhance the informed consent process and should be encouraged by ethics committees. →
BACKGROUND: Support for the treatment of uncomplicated appendicitis with non-operative management rather than surgery has been increasing in the literature. We aimed to investigate whether treatment of uncomplicated appendicitis with antibiotics in children is inferior to appendicectomy by comparing failure rates for the two treatments. →
Large Language Models (LLMs) have made significant progress in natural language processing, excelling in tasks like understanding, generation, and reasoning. However, challenges remain. Achieving robust reasoning often requires extensive supervised fine-tuning, which limits scalability and generalization. Furthermore, issues like poor readability and balancing computational efficiency with reasoning complexity persist, prompting researchers to explore new approaches.… →
AI and ML are expanding at a remarkable rate, which is marked by the evolution of numerous specialized subdomains. Recently, two core branches that have become central in academic research and industrial applications are Generative AI and Predictive AI. While they share foundational principles of machine learning, their objectives, methodologies, and outcomes differ significantly. This… →
Large language models rely heavily on open datasets to train, which poses significant legal, technical, and ethical challenges in managing such datasets. There are uncertainties around the legal implications of using data based on varying copyright laws and changing regulations regarding safe usage. The lack of global standards or centralized databases to validate and license… →
Traditional psychological counseling, often conducted in person, remains limited to individuals actively seeking help for psychological concerns. In contrast, online automated counseling presents a viable option for those hesitant to pursue therapy due to stigma or shame. Cognitive Behavioral Therapy (CBT), a widely practiced approach in psychological counseling, aims to help individuals identify and correct… →
The automation of radiology report generation has become one of the significant areas of focus in biomedical natural language processing. This is driven by the vast and exponentially growing medical imaging data and a dependency on highly accurate diagnostic interpretation in modern health care. Advancements in artificial intelligence make image analysis combined with natural language… →
One of the most frequently impacted locations by psoriasis is the scalp. It is seen in about 80% of psoriasis cases worldwide, and its treatment is challenging. To compare the efficacy and safety of excimer light versus topical methotrexate (MTX) 1% hydrogel in treatment of scalp psoriasis. This randomized prospective intra-patient comparative study was carried… →