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Efficacy and safety of Ivarmacitinib in moderate-to-severe atopic dermatitis patients with or without previous systemic treatments: a post-hoc analysis of a phase III trial
CONCLUSION: Ivarmacitinib demonstrates good efficacy and a favorable safety profile in moderate-to-severe AD patients, irrespective of previous systemic treatments. →
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Fuzuloparib with or without apatinib as maintenance therapy in newly diagnosed, advanced ovarian cancer (FZOCUS-1): A multicenter, randomized, double-blind, placebo-controlled phase 3 trial
Although poly(adenosine diphosphate-ribose) polymerase inhibitors (PARPis) and bevacizumab were approved as first-line maintenance for advanced ovarian cancer (OC), evidence comparing this combination with PARPi monotherapy, especially in BRCA-mutated/homologous recombination-deficient (HRD) patients, is lacking. This study compared combined fuzuloparib (a PARPi) plus apatinib (a vascular endothelial growth factor receptor-2 inhibitor) with either fuzuloparib or placebo as… →
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Effectiveness and cost-effectiveness of risk-adapted colorectal cancer screening: a randomized controlled trial and modeling analysis
CONCLUSIONS: In this population-based CRC screening trial, risk-adapted screening, colonoscopy, and FIT demonstrated comparable effectiveness, but differed in participation rates, resource utilization, and cost-effectiveness. Risk-adapted screening could serve as a complementary approach to established strategies, particularly when health resources are limited. →
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Economic evaluation of a multi-component obesity prevention intervention in Chinese primary schools
CONCLUSIONS: The DECIDE-Children intervention is a cost-effective strategy for childhood obesity prevention, providing significant public health and economic benefits. Its integration of school, family, and digital components offers a scalable, sustainable model for addressing childhood obesity in China and other developing settings. →
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Effects of kefir on symptoms, sleep, and gut microbiota in children with ADHD: a randomised controlled trial
CONCLUSIONS: Kefir supplementation may support modest improvements in sleep quality, in children with ADHD. These findings contribute to our understanding of the potential role of nutrition in ADHD management and may inform clinical guidance for practitioners working with neurodivergent individuals. →
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Clinical efficacy of integrated 3D manual pelvic reduction, suspension training, and pelvic belt fixation for postpartum pubic symphysis diastasis
CONCLUSION: The combined protocol of 3D pelvic reduction, suspension training, and pelvic belt fixation effectively alleviates pain, restores pelvic alignment, enhances functional recovery, and improves QoL in postpartum PSD patients, representing a potentially promising therapeutic strategy for clinical adoption. →
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Esketamine prevents postoperative sleep disturbance in patients with preoperative sleep disorders: a role for oral microbiota
Patients with preexisting sleep disorders face a significantly increased risk of postoperative sleep disturbance (PSD) due to heightened sensitivity to surgical stress, anesthesia, and hospital-related environmental factors. There is a critical unmet need for effective prophylactic medications to prevent PSD, as current treatment options are limited and often inadequate. This study investigated the prophylactic effect… →
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Effect of azithromycin on post-discharge growth in Kenyan children
CONCLUSION: We did not observe statistically significant improvements in post-discharge growth among children receiving azithromycin at hospital discharge. →
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Negotiation Skills: How to Beat Anxiety and Boost Results
Neil Webb/Ikon Images Anxiety and low confidence are two of the most common feelings people experience during negotiations — just the thought of negotiating can send many people spinning. These reactions can cause people to preemptively throw in the towel and engage in behaviors that end up being self-sabotaging, including making lower first offers, responding… →
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Podcast: I Respectfully Disagree
Nothing sucks the air out of the room quite like learning the nice person you’ve been talking to completely disagrees with your worldview. Suddenly, your differences seem too stark to forge ahead with the conversation. Such encounters have seemingly become far too frequent, if you ask Steve Franconeri, a professor of management and organizations by… →