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Capnography-detected respiratory depression during procedural sedation with remimazolam versus propofol: a randomised trial
Remimazolam, a novel ultra-short-acting benzodiazepine, has gained attention for its favourable safety profile, particularly its reduced risk of respiratory depression compared to propofol during procedural sedation. However, previous studies have primarily relied on visual assessment or pulse oximetry, which may underestimate the incidence of respiratory compromise. In this prospective randomized controlled trial, we compared the… →
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Nivolumab plus ipilimumab induce hyper-progression in renal medullary carcinoma: results of a phase II trial and preclinical evidence
Therapeutic options for patients with renal medullary carcinoma (RMC) are limited. Here we report the results of a phase II clinical trial (NCT03274258) of anti-PD1 nivolumab plus anti-CTLA4 ipilimumab in patients with RMC, with objective response rate as primary outcome. Enrollment was halted for futility at a prespecified interim analysis as all 10 treated patients… →
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Enhanced cognitive outcomes with triple-mode dialysis in kidney failure: role of protein-bound toxin clearance
This study aimed to investigate the effects of different dialysis modalities on cognitive function in patients with end stage renal disease and to explore their association with the clearance of protein bound uremic toxins. A total of 135 patients undergoing maintenance hemodialysis were enrolled and randomly assigned to one of three treatment groups hemodialysis HD… →
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Effect of Dual-Task Training on Cognitive Function in Community-Dwelling Older Adults With Mild Cognitive Impairment: Sequential Multiple Assignment Randomized Trial
CONCLUSIONS: This SMART trial established the first evidence-based adaptive intervention framework for community MCI prevention, demonstrating that virtual reality-enhanced Taichi combined with CT produced superior outcomes compared with traditional exercise and control conditions. Treatment intensification proved more effective than modality switching for nonresponders. Diabetes showed a better response enabling personalized intervention selection. These findings provide… →
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Inclusion in organisations: roots and routes
American organisations are rolling back initiatives on Equity, Diversity and Inclusion (EDI). But, is this relevant to firms operating in other countries? Charlie Lin writes that despite this American rollback showing visible effects on EU and UK companies, this fluctuating landscape could be an opportunity for organisations everywhere to reflect on their EDI practices. His… →
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Are You an Authentic Leader or an Authentic Jerk?
Neil Webb/Ikon Images Have you ever been told you have a “strong personality” or that you are very direct? Has anyone ever called you strong-willed or, worse, a moral crusader? If so, you might be walking a fine line between authenticity and abrasiveness. At a time when “bringing your whole self” to work is often… →
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Creating More, Not Less, With AI: GeekWire’s Todd Bishop
AI isn’t taking jobs — it’s changing what jobs are. On today’s episode of the Me, Myself, and AI podcast, GeekWire’s Todd Bishop joins host Sam Ransbotham to dive into how artificial intelligence is reshaping work, learning, and creativity — not by replacing humans but by amplifying what we can do. From classrooms where students… →
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Effect of the fluid management nursing intervention on improving biochemical test results and dialysis therapy in chronic kidney disease patients: a randomized controlled trial
CONCLUSION: The nursing intervention significantly improved laboratory test results and dialysis adequacy in patients with chronic renal failure and Excess Fluid Volume, highlighting its potential for enhancing patient management and nursing care. →
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The GTMnow Podcast Bonus: How to Identify Exceptional People Early | Cristina Cordova (Stripe, Notion, Linear)
The GTM Podcast is available on any major directory, including: Apple Podcasts Spotify YouTube This bonus episode dives into how Cristina Cordova (Stripe’s 20th hire, early leader at Notion, now COO at Linear) spots exceptional talent early, and how she pressure-tests whether a team and product are truly worth betting on. It’s a crisp, tactical… →
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Incidence of intraocular lens (IOL) tilt and decentration after secondary IOL sulcus implantation versus optic capture in pediatric aphakia
CONCLUSION: Secondary IOL implantation with the capture technique appears to provide a deeper AC and a wider angle than sulcus implantation but could result in greater IOL tilt. UBM discloses changes in IOL position that are not clinically detected during follow-up. →
