CONCLUSIONS AND RELEVANCE: In this randomized clinical trial, the web-based JEVaDA was not associated with a further reduction in decisional conflict compared with an active comparator but was associated with higher vaccine uptake. These findings suggest that decision aids can support informed, values-congruent choices in complex, preference-sensitive health decisions such as travel vaccination and beyond. →

CONCLUSIONS: This benefit-risk assessment using 24-week Heads Up trial data considered all key benefits and risks and demonstrated a higher benefit-risk score for dupilumab than upadacitinib. →

CONCLUSIONS: Peripheral defocus spectacles significantly controlled axial elongation and reduced myopia incidence in premyopic children with insufficient hyperopic reserve. Three-month choroidal thickness changes represent a valid early predictive biomarker for treatment response, enabling personalized intervention by 3 months rather than waiting 12 months for conventional outcomes. Early choroidal thickening identifies optimal responders, supporting choroidal perfusion… →

CONCLUSIONS: We developed and internally validated a prediction model incorporating fungal co-infection, admission glucose, antithrombin III, and interleukin-6 for early identification of septic shock risk in pediatric RSV bronchiolitis patients. The model demonstrated good discrimination (AUC 0.892) in this single-center cohort. However, given the modest sample size, external validation in larger, multicenter populations is essential… →

CONCLUSION: The clinical effect of prehospital non-invasive ventilation could not be determined due to early termination. This trial highlights important challenges relevant to future clinical trials in the prehospital setting, including patient selection, diagnostic requirements and implementation of complex interventions. →

CONCLUSION: Twelve weeks of concurrent interval resistance-aerobic training, especially when combined with fisetin, improved inflammatory resolution (↑Maresin‑1, ↓IL‑6, and ↓TNF‑α) and metabolic control (↓FBS, ↓insulin, and ↓HOMA‑IR) in obese men. The synergy between exercise‑induced adaptations and fisetin’s anti‑inflammatory properties offers a promising non‑pharmacological strategy for mitigating obesity‑related metabolic risk. →

CONCLUSIONS: Preliminary findings suggest that a digital DA with personalised and gamified content may enhance CRC screening uptake and partially support informed choice. Larger, multisite studies are warranted to evaluate scalability, inclusivity, and long-term effectiveness in population-based cancer prevention. →

CONCLUSION: The expressive writing intervention would improve optimism and promote more positive coping modes for newly diagnosed people with HIV. →

OBJECTIVE: This secondary analysis of a randomised controlled pilot study (n = 87 patients) examined how transdiagnostic factors-including emotion regulation mechanisms (emotion beliefs, cognitive reappraisal, emotion suppression and experiential avoidance) and negative affectivity-relate to depressive, anxiety and somatic symptoms in the primary care setting, and whether emotion regulation mechanisms provide potential screening relevance beyond negative… →