Immune checkpoint inhibitors (ICIs) show minimal efficacy in recurrent high-grade astrocytoma (rHGA). Laser interstitial thermal therapy (LITT), a minimally invasive cytoreductive approach, may prime rHGA for ICI response. A phase 1/randomized phase 2b trial (ClinicalTrials.gov: NCT02311582 ) was designed to test pembrolizumab in combination with LITT in patients with rHGA. Nine patients were enrolled in… →

CONCLUSIONS: The training did not increase total sleep time, likely due to insomnia’s multifactorial origin. However, training yielded beneficial effects on objective sleep quality and exercise-induced adaptation. Future research is needed to investigate the various etiologies of insomnia to develop tailored and personalized management approaches. →

The GTM Podcast is available on any major directory, including: Apple Podcasts Spotify YouTube Sheila Vashee(CMO of @Figma) joins GTMnow to share how she thinks about brand building across every stage. From selling brownies at age eight, to second marketing hire at Dropbox scaling to $1B+ in annualized revenue, to now leading marketing at one… →
The Eight Core Principles of Strategic Innovation Gina O’Connor and Christopher R. Meyer Key Insight: Mature companies that build a strategic innovation capability can systematically renew their product portfolios to sustain long-term growth. Top Takeaways: Many companies start off with a bang: the launch of an exciting breakthrough product or service. But as time passes,… →
We are firmly in the digital age, awash in data generated on every surface and in every layer of every business. Yet, despite decades of investment in technology, time, and effort, many organizations are still not seeing meaningful returns. A global survey of over 4,200 business and technology leaders conducted by research firm Gartner in… →
Matt Chinworth/theispot.com The Research The research behind this article was conducted in partnership with the Innovation Research Interchange, a professional association of R&D leaders in large industrial companies. More than 640 interviews were conducted over the three phases of the research program. In Phase 1, 12 project teams from 10 companies were followed for five… →
Matt Chinworth Venture studios are emerging as a compelling — if resource-intensive — way for organizations to maximize value creation through innovation. Pioneered by organizations such as Google, the studio model offers a structured and systematic approach to venture creation inside an organization. But before adopting it, leaders must ask: Is a studio the right… →
Matt Chinworth For most leaders, the ideal high-functioning team operates with smooth collaboration guided by a clear goal that was agreed upon at the outset. Researchers studying the innovation process have also found this model to be particularly important for helping teams communicate better, coordinate tasks, and resolve conflicts as they explore diverse ideas and… →
In the United States, milk is back on the menu. The Whole Milk for Healthy Kids Act, signed into law in January, restored whole milk’s eligibility for the National School Lunch Program that feeds tens of millions of American kids. New dietary guidelines released by the U.S. Department of Agriculture and the U.S. Department of… →
The GTM Podcast is available on any major directory, including: Apple Podcasts Spotify YouTube Bill Binch (Operating Partner at Battery Ventures) joins GTMnow to share the operational frameworks he’s built across 116 quarters on quota, and what actually changes when you move from driving revenue to advising an entire portfolio. Before Battery, Bill was employee… →