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Comparison of [18F]flortaucipir and [18F]MK6240 for the detection of tau pathology in Alzheimer’s disease (HEAD): a multicentre, prospective, cross-sectional, within-participant study
BACKGROUND: Tau PET imaging has emerged as a critical biomarker for Alzheimer’s disease, informing diagnosis, staging, and therapeutic selection. We investigated whether PET tracer selection alters tau detection. →
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Intraoperative radiotherapy after resection of newly diagnosed brain metastases in adult patients — results of a prospective phase II trial (INTRAMET)
CONCLUSION: IORT to the resection cavity was associated with favorable local control and an acceptable safety profile. It may represent a feasible alternative to postoperative stereotactic radiosurgery in selected patients. →
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Intravitreal dexamethasone sodium phosphate challenge to predict implant response in refractory diabetic macular edema: a pilot study
CONCLUSION: A short-term dexamethasone sodium phosphate challenge is a safe, low-cost, and highly specific predictor of dexamethasone implant efficacy. This «test-and-treat» strategy may optimize resource allocation in resource-constrained settings by identifying responders before high-cost implantation. →
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When Employees Are Drowning in Change
Patrick George/Ikon Images In 2021-2022, CareRx was handling an ambitious expansion. In a span of 20 months, the Canadian pharmacy services company tripled its business through a series of acquisitions. Each acquired company brought its own processes, systems, and cultural norms. Employees barely had time to adjust before the next change arrived. “We were growing… →
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Protocol for evaluating the effects of the intelligent multimodal symptom assessment and response system in patients with pemphigus vulgaris: a randomised controlled trial
INTRODUCTION: Pemphigus vulgaris is a rare autoimmune blistering disease characterised by recurrent mucocutaneous erosions, high symptom burden and unpredictable relapse. Current management relies mainly on pharmacological therapy and hospital-based follow-up, with limited real-time monitoring and individualised support in home-based disease management. To address these challenges, this trial aims to evaluate the effectiveness of an Intelligent… →
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What AI Still Can’t Do for Leaders
As leaders weave generative AI tools like ChatGPT and Claude into their daily workflows, where does the output fall short? Moreover, where are leaders falling short for their organizations by giving away too much agency to artificial intelligence? MIT Sloan School of Management professors Deborah Ancona and Katherine W. Isaacs have thought deeply about the… →
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Can We Take the Doom Out of Scrolling?
You don’t have to be a doomscroller to know that social media is flooded with high emotions and hostility. Whether the topic is politics, sports, movies, or music, it often feels like the loudest and angriest voices dominate the conversation, creating a virtual shouting match that drowns out more-thoughtful opinions. Scientists have speculated that these… →
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VC: The $575B AI Bet (Biggest Since the World Wars) and the New Two-Buyer Reality in Software | Tomasz Tunguz, Theory Ventures
Listen on YouTube Listen on Apple Listen on Spotify If you spend time on X, you can also watch/listen to the entire episode on X. Brought to you by: AngelList Our LP base spans from individual operators to institutional allocators, and AngelList has been instrumental in supporting all of them. They handle everything from investor… →
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Pentoxifylline in children with acute encephalitis syndrome: a randomized control trial
Because of the excessive endogenous inflammatory mediators, acute encephalitis syndrome (AES) results in death, or sequelae in survivors. Pentoxifylline, a modulator of inflammation, can have beneficial role in AES. The primary objective was to assess the efficacy of pentoxifylline in terms of time taken for improvement in Glasgow coma scale (GCS) from baseline, in children… →
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Quantifying the Phoenix Sign: A Double-Blind Pilot Study on Lidocaine and Papaverine-Induced Vascular and Motor Changes After Common Peroneal Nerve Block in Diabetic Neuropathy
CONCLUSIONS: Peripheral nerve blocks with lidocaine or papaverine improved motor strength and macrovascular function in patients with diabetic peripheral neuropathy, though microvascular changes were not detected. These preliminary findings are consistent with the Phoenix Sign phenomenon and support further study as a potential clinical indicator. While these preliminary findings indicate support as a diagnostic tool,… →
