CONCLUSION: Eight weeks of intervention did not affect objective sleep measures but improved subjective sleep quality, particularly in the FRT group. →

CONCLUSIONS: The DT developed on the MOTOmed cycling device is a safe intervention for people diagnosed with PD (stage 2-3) with or without mild or moderate cognitive impairment. This intervention, associated with a cognitive intervention, seems to show improvements in the speed of information processing. →

CONCLUSION: The findings of this study underscore the importance of addressing the impaired coactivation of the transverse abdominal and multifidus muscles in men suffering from chronic non-specific low back pain. By implementing water kinetic chain exercises, we can effectively enhance muscle coactivation, which may lead to significant reductions in pain and improvements in overall quality… →

CONCLUSION: While higher intra-abdominal pressure may be associated with mild hepatic stress, it does not appear to cause significant oxidative imbalance in geriatric patients. Both low and high-pressure pneumoperitoneum levels can be used safely during laparoscopic cholecystectomy in elderly individuals, provided that appropriate perioperative management is ensured. →

CONCLUSION: The results of this post-hoc analysis provide further evidence that a composite endpoint comprised of physiological, radiological and patient-reported outcomes is a promising endpoint for SSc-ILD trials. Future validation studies are needed. →

CONCLUSIONS: We developed a novel syringe handle for one-handed AC paracentesis, which improved the safety and precision of the procedure while reducing procedural time. Its low-cost, reusable design and compatibility with standard syringes make it a practical tool for the procedure. Further clinical studies are warranted to explore broader applications. →

CONCLUSIONS: Earmuffs combined with sleep eye masks as an adjunct to metoclopramide significantly enhance early headache relief in the emergency department and represent a safe, low-cost complementary therapy. Participants were not blinded to the intervention due to practical constraints, and for the same reason, placebo control was not used. →

Melasma is a common hyperpigmentary skin disorder. Because of its high prevalence and serious complications, including negative psychiatric effects, early diagnosis and treatment would be essential. This randomized, double-blind, case-controlled clinical trial compared the efficacy of niosomal tranexamic acid (TXA) 2%/niacinamide (NCA) 2% cream and conventional TXA 5%/NCA 4% cream with topical hydroquinone (HQ) 4%… →

BACKGROUND: There is a high unmet need for effective HIV prevention options, including vaccines, for individuals at high risk of HIV acquisition who choose not to use pre-exposure prophylaxis or other prevention strategies. This study evaluated the efficacy and safety of an HIV-1 vaccine regimen consisting of tetravalent mosaic adenovirus serotype 26-based vaccine (Ad26.Mos4.HIV) and… →

CONCLUSIONS: Among elderly patients with AF, msMR is associated with an increased risk of the primary composite endpoint of death, disabling stroke, serious bleeding or cardiac arrest. →