CONCLUSION: Exposure to hypoxia led to RVFWS impairment in more than one quarter of patients with COPD. Strain analysis is a promising, non-invasive method for evaluating RV dysfunction, even in subclinical cases and might be prognostically relevant in patients with lung diseases. →
BACKGROUND: Brain metastases are a common complication in patients with non-small-cell lung cancer (NSCLC) lacking actionable driver mutations, with limited treatment options and poor prognosis. We aimed to investigate the efficacy and safety of brain radiotherapy combined with camrelizumab and platinum-doublet chemotherapy in patients with newly diagnosed advanced NSCLC and brain metastases. →
The increasing prevalence of diabetes mellitus worldwide necessitates that medical undergraduates acquire a deep understanding of the disease to ensure accurate diagnosis and effective management. Traditional teaching methods, while foundational, often lack the interactive elements that enhance student engagement and knowledge retention. This study aimed to evaluate the effectiveness of a novel educational board game,… →
Early therapeutic intervention in high-risk smoldering multiple myeloma (HR-SMM) has shown benefits, however, no studies have assessed whether biochemical progression or response depth predicts long-term outcomes. The single-arm I-PRISM phase II trial (NCT02916771) evaluated ixazomib, lenalidomide, and dexamethasone in 55 patients with HR-SMM. The primary endpoint, median progression-free survival (PFS), was not reached (NR) (95%… →
In a time when global health faces persistent threats from emerging pandemics, the need for advanced biosurveillance and pathogen detection systems is increasingly evident. Traditional genomic analysis methods, while effective in isolated cases, often struggle to address the complexities of large-scale health monitoring. A significant challenge is identifying and understanding the genomic diversity in environments… →
Predicting transcriptomes directly from genome sequences is a significant challenge in microbial genomics, particularly for the numerous sequenced microbes that remain unculturable or require complex experimental protocols like RNA-seq. The gap between genomic information and functional understanding leaves us without knowledge of the microbial adaptive processes, survival mechanisms, and gene regulation functions. This must be… →
When it comes to AI tools, chatbots are often the first thing that comes to mind —conversation-based interfaces for users to write queries and receive responses. These dialogue interfaces are certainly useful, but they aren’t always the best fit for handling our everyday work. Often tacked on to the side of our workflows, chatbots supplement… →
Disaggregated systems are a new type of architecture designed to meet the high resource demands of modern applications like social networking, search, and in-memory databases. The systems intend to overcome the physical restrictions of the traditional servers by pooling and managing resources like memory and CPUs among multiple machines. Flexibility, better utilization of resources, and… →
Using LLMs in clinical diagnostics offers a promising way to improve doctor-patient interactions. Patient history-taking is central to medical diagnosis. However, factors such as increasing patient loads, limited access to care, brief consultations, and the rapid adoption of telemedicine—accelerated by the COVID-19 pandemic—have strained this traditional practice. These challenges threaten diagnostic accuracy, underscoring the need… →