The feasibility of conducting a fully remote, interventional, phase II decentralized clinical trial (DCT) was investigated in major depressive disorder (MDD). Key learnings were collated to improve future DCTs. A double-blind, placebo-controlled, parallel-group, DCT enrolled adult MDD patients with inadequate response to first-line antidepressant monotherapy (ongoing ≥8 weeks) and a Montgomery-Åsberg Depression Rating Scale total… →
Large Language Models (LLMs) have demonstrated impressive proficiency in numerous tasks, but their ability to perform multi-step reasoning remains a significant challenge. This limitation becomes particularly evident in complex scenarios such as mathematical problem-solving, embodied agent control, and web navigation. Traditional Reinforcement Learning (RL) methods, like Proximal Policy Optimization (PPO), have been applied to address… →
Large Language Models (LLMs) have demonstrated remarkable similarities to human cognitive processes’ ability to form abstractions and adapt to new situations. Just as humans have historically made sense of complex experiences through fundamental concepts like physics and mathematics, autoregressive transformers now show comparable capabilities through in-context learning (ICL). Recent research has highlighted how these models… →
The transformation of unstructured news texts into structured event data represents a critical challenge in social sciences, particularly in international relations and conflict studies. The process involves converting large text corpora into “who-did-what-to-whom” event data, which requires extensive domain expertise and computational knowledge. While domain experts possess the knowledge to interpret these texts accurately, the… →
CONCLUSION: Incorporating real-time ultrasound data post-PRB significantly enhances the predictive accuracy and risk reclassification capability of bleeding risk models. These findings provide critical insights for guiding clinical management decisions in patients undergoing renal biopsy. →
CONCLUSION: Incorporating additional visual tasks into physical exercise effectively enhances KVA, UDVA, and accommodative sensitivity in children. There is a significant positive correlation between KVA and UDVA as well as between KVA and accommodative sensitivity. These visual tasks directly impact UDVA and accommodative sensitivity and indirectly influence them through the mediating effect of KVA. →
The widespread use of large-scale language models (LLMs) in safety-critical areas has brought forward a crucial challenge: how to ensure their adherence to clear ethical and safety guidelines. Existing alignment techniques, such as supervised fine-tuning (SFT) and reinforcement learning from human feedback (RLHF), have limitations. Models can still produce harmful content when manipulated, refuse legitimate… →
The evolution of speech and language technology has led to improvements in areas like voice assistants, transcription, and sentiment analysis. However, many models struggle to capture the nuances of human emotion and intent. These systems often focus on accuracy in tasks like transcription or translation, neglecting the emotional context that underpins effective communication. This gap… →
Visual generative models have advanced significantly in terms of the ability to create high-quality images and videos. These developments, powered by AI, enable applications ranging from content creation to design. However, the capability of these models depends on the evaluation frameworks used to measure their performance, making efficient and accurate assessments a crucial area of… →
The analgesic efficacy and safety of liposomal bupivacaine (LB) in third molar extraction was evaluated in this phase 3, double-blind, placebo-controlled study of subjects undergoing bilateral third molar extraction. Subjects were randomized 2: 1 to infiltration with LB (133 mg/10 mL) or placebo, and received opioid rescue medication as needed. Primary efficacy measure was cumulative… →