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Palliative Care Coaching for Family Caregivers of Patients With Advanced Cancer: A Randomized Clinical Trial
CONCLUSIONS: This randomized clinical trial of a telehealth intervention for African American and rural-dwelling caregivers of patients with advanced cancer found no differences in caregiver and patient outcomes at 24 weeks. However, an exploratory sensitivity analysis indicated potential improvements in caregiver anxiety and patient mental health QOL. →
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Adjunctive Psychosocial Interventions and Opioid Abstinence Among Patients Receiving Buprenorphine: A Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this randomized clinical trial, CBT and PRS had no effect on rates of opioid abstinence in the year following the initiation of MOUD. →
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A Randomized Trial of Interval Likelihood Ratios for Clinical Decision-Making
CONCLUSIONS: Presenting diagnostic test information using ILRs improved vignette-based clinical decisions. The magnitude of improvement appeared to vary by case vignette. →
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Efficacy of vunakizumab in patients with moderate-to-severe plaque psoriasis across diverse disease features: a post hoc analysis of a phase-III trial
CONCLUSION: Vunakizumab shows satisfactory efficacy in patients with moderate-to-severe plaque psoriasis, regardless of psoriasis duration and severity. →
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First-in-human (phase I) trial of SOL-116, a humanised IgG4 monoclonal antibody targeting bile salt-stimulated lipase, in healthy participants and rheumatoid arthritis patients
CONCLUSIONS: This study demonstrated that SOL-116 has a favourable safety and PK profile. Combined with effective reduction of free BSSL in the circulation, findings in this study support ongoing clinical development of SOL-116, with a focus on elucidating the efficacy and mechanism of action of BSSL in the treatment of chronic inflammation, primarily RA. →
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Impact of Financial Incentives on Electronic Health Record-Driven Recruitment of Underrepresented Communities in Research: Randomized Controlled Trial
CONCLUSIONS: Patients with cancer who identify as part of a historically underrepresented group were less likely to view and respond to recruitment messages for research studies through their EHR patient portal. Age was also found to significantly impact engagement, with older patients less likely to view and respond. Finally, a modest US $20 financial incentive… →
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Resolving Muddled Objectives in Corporate Venture Capital
Carolyn Geason-Beissel/MIT SMR | Getty Images The Research The authors compared the approaches of prominent corporate venture capital (CVC) units, including those owned by Intel, Cisco, General Electric, Siemens, NTT Docomo, Hitachi, Panasonic, and Sompo. They examined 59 of the most active CVCs tracked by research firm CB Insights from 2017 through 2024 and mapped… →
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Effect of Bone Cement Viscosity on Leakage and Outcomes in Vertebroplasty
Percutaneous vertebroplasty provides rapid pain relief in elderly patients with acute osteoporotic vertebral compression fractures; however, bone cement leakage remains a major safety concern, and the influence of cement viscosity on leakage and clinical outcomes is not fully established. This study evaluated whether high-viscosity cement reduces leakage without compromising efficacy or safety. In this single-center,… →
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A randomized crossover clinical trial of the Deseyne contact lens for presbyopia with extended depth of focus
CONCLUSIONS: The Deseyne contact lens for presbyopia with extended depth of focus extends the depth of focus of the eye and thus improves intermediate and near visual acuity. →
