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Safety, Pharmacokinetics, and Efficiency of JS005, a Novel Anti-interleukin-17A Monoclonal Antibody, in Healthy Chinese Adults and Patients with Moderate to Severe Psoriasis
JS005 is a novel anti-IL-17A monoclonal antibody. A Phase Ia study (Study 1) in healthy adults, followed by a Phase Ib/II study (Study 2) in patients with moderate to severe plaque psoriasis (PsO), were designed to evaluate the safety, efficacy, and pharmacokinetic characteristics of JS005. Study 1 was a double-blind, randomized, placebo-controlled, single dose-escalation (15,… →
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Sirolimus treatment for intractable vascular anomalies (SIVA): An open-label, single-arm, multicenter, prospective trial
CONCLUSIONS: Sirolimus may reduce VA tissue volume and potentially improve symptoms and activities of daily living in patients with VAs. →
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Effects of neonatal behavioral assessment scale on postnatal depressive symptoms in mothers of very low birth weight infants: a pilot randomized controlled trial
CONCLUSION: Early intervention using the NBAS with mothers present may yield no positive and negative effects on the mothers’ depressive symptoms. Due to the small sample size of this pilot study, the results should be interpreted with caution, and there remains a need for further research about the effectiveness of the NBAS as early intervention. →
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A prospective study of vaginal topical pretreatment of compound sea-buckthorn oil suppository in postmenopausal women prior to colposcopy
Postmenopausal women are faced with difficulties in colposcopy, such as easy bleeding from epithelial atrophy, and thinning, atypical colposcopy images, unsatisfactory exposure, and decreased sensitivity of colposcopy. We aimed to improve the sensitivity and satisfaction of colposcopy in postmenopausal women and to evaluate the clinical efficacy of compound sea-buckthorn oil suppository on topical vaginal pretreatment… →
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Randomised controlled trial evaluating the impact of different methods of HPV DNA testing for cervical cancer screening in Singapore’s primary care settings: a study protocol
INTRODUCTION: Cervical cancer remains a significant public health concern in Singapore, with current screening rates at 43%, well below the national target of 70%. In 2019, human papillomavirus (HPV) DNA testing was introduced into the national cervical cancer screening programme, but barriers to participation include embarrassment, privacy concerns and discomfort with clinician-sampled tests. Self-sampled HPV… →
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K-Factor – Коэффициент вирусности. Показатель того, насколько продукт или сервис растёт благодаря пользователям, которые привлек…
K-Factor – Коэффициент вирусности. Показатель того, насколько продукт или сервис растёт благодаря пользователям, которые привлекают новых. Когда коэффициент больше 1, продукт растёт органически, без необходимости в масштабной рекламе. #ИИМаркетинг #Продукт #ИИ #Маркетинг #Менеджмент →
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This AI Paper Introduces PLAN-AND-ACT: A Modular Framework for Long-Horizon Planning in Web-Based Language Agents…
This AI Paper Introduces PLAN-AND-ACT: A Modular Framework for Long-Horizon Planning in Web-Based Language Agents Large language models are powering a new wave of digital agents to handle sophisticated web-based tasks. These agents are expected to interpret user instructions, navigate interfaces, and execute complex commands in ever-changing environments. The difficulty lies not in understanding language… →
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Cropping an Image Using OpenCV
Image cropping is a fundamental operation in image processing that involves selecting a specific region of interest (ROI) from an image and discarding the rest. This technique is widely used in various applications, such as object detection, face recognition, and image enhancement. OpenCV, a powerful open-source computer vision library, provides efficient methods for cropping images… →