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Clinical Validation of a Vaginal Cervical Cancer Screening Self-Collection Method for At-Home Use: A Nonrandomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this nonrandomized clinical trial, SC samples collected with the device showed equivalent clinical sensitivity and exceeded the PPA end point for cervical screening. This SC method was found to be easy to use and to be a preferred option with high clinical performance intended for use in an at-home setting. →
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Peri-Implant Diseases: Enhanced Antibacterial Photodynamic Therapy
CONCLUSIONS: Regularly applied dual-light aPDT reduces inflammation in the dental implant adjacent tissues. Dual-light aPDT approach holds promise as an effective home care tool for implant patients. →
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Brief intensive EMDR therapy for PTSD in adults with mild intellectual disability or borderline intellectual functioning and behavioural problems: a multiple baseline design study
Background: Individuals with mild intellectual disability (MID; IQ 50-70) or borderline intellectual functioning (BIF; IQ 70-85) are at an elevated risk of post-traumatic stress disorder (PTSD), with PTSD symptoms possibly associated with behavioural problems. It is important to test the effectiveness of trauma-focused treatments, such as eye movement desensitisation and reprocessing (EMDR) therapy, for adults… →
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Bisoprolol for patients with chronic obstructive pulmonary disease at high risk of exacerbation: the BICS RCT
CONCLUSIONS: In this underpowered study, the addition of bisoprolol to usual chronic obstructive pulmonary disease treatment did not reduce the likelihood of exacerbations, and bisoprolol cannot be recommended as a treatment for chronic obstructive pulmonary disease. →
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Albuterol Digihaler in COPD Disease Management: A Real-World Study to Assess Digihaler Inhalation Parameters, Thresholds and Their Use to Identify Deterioration in Clinical Practice
CONCLUSION: Our study suggests that alert thresholds based on Digihaler device-measured physiologic parameters may have value in a predictive model for clinical deterioration in COPD. →
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Effectiveness of biomarker-guided duration of antibiotic treatment in children hospitalised with confirmed or suspected bacterial infection: the BATCH RCT
CONCLUSIONS: In children hospitalised with confirmed or suspected bacterial infection, the addition of a procalcitonin-guided algorithm to usual care is non-inferior in terms of safety, but does not reduce duration of intravenous antibiotics, and is not cost-effective. In the presence of robust antimicrobial stewardship programmes to reduce antibiotic use, a procalcitonin-guided algorithm may offer little… →
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The Roller Coaster SLAM Dataset: High-Dynamic Visual-Inertial Benchmarks from Amusement Rides
This is the world’s first SLAM dataset recorded onboard real roller coasters, offering extreme motion dynamics, perceptual challenges, and unique conditions for benchmarking SLAM algorithms under aggressive real-world trajectories. Key Highlights: Unprecedented Motion Dynamics – Captures high-acceleration motion with rapid velocity changes, sharp turns, and steep vertical drops, providing a stress test for visual-inertial odometry and… →
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Bleaching efficacy and tooth sensitivity using violet LED — single-blind randomized controlled trial
This study aims to conduct a single-blind randomized controlled trial to evaluate the bleaching efficacy and tooth sensitivity (TS) following the use of violet LED associated or not with 35% hydrogen peroxide. Eighty-four participants were randomly allocated into three groups according to bleaching treatments (n = 28): 35% hydrogen peroxide (HP) only, Violet LED only… →
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Critical Security Vulnerabilities in the Model Context Protocol (MCP): How Malicious Tools and Deceptive Contexts Exploit AI Agents
Critical Security Vulnerabilities in the Model Context Protocol (MCP): How Malicious Tools and Deceptive Contexts Exploit AI Agents The Model Context Protocol (MCP) represents a significant shift in how large language models interact with tools, services, and external data sources. Designed to enable dynamic tool invocation, the MCP facilitates a standardized method for describing tool… →
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Reinforcement Learning Makes LLMs Search-Savvy: Ant Group Researchers Introduce SEM to Optimize Tool Usage and Reasoning Efficiency
Reinforcement Learning Makes LLMs Search-Savvy: Ant Group Researchers Introduce SEM to Optimize Tool Usage and Reasoning Efficiency Recent advancements in large language models (LLMs) demonstrate their capability to perform complex reasoning tasks and efficiently utilize external tools such as search engines. A significant challenge remains in teaching models when to rely on internal knowledge versus… →