BACKGROUND Monitoring nociception is extraordinarily challenging during general anesthesia. This study aimed to observe pupillary dilation reflex by ultrasound and determine whether ultrasonic pupillary parameters are correlated with sufentanil dose during the induction period of general anesthesia. MATERIAL AND METHODS We enrolled 93 patients undergoing general anesthesia. They were randomly divided into 3 groups -… →

CONCLUSION: A combined therapeutic diet and physical activity program effectively improved body composition and biochemical parameters in recreational athletes with T2DM. This combined approach could be recommended as an integral strategy for diabetes management in physically active individuals. →

CONCLUSIONS: The incorporation of acyclovir into compounded mouthwash significantly reduced the incidence, severity, and duration of oral mucositis in patients undergoing chemotherapy, indicating its potential for expanded clinical application. Further large-scale studies are warranted to validate these findings and to standardize mouthwash formulations for institutional utilization. →

CONCLUSION: G-CBT significantly reduced depressive symptoms in newly diagnosed breast cancer patients and the effect of intervention sustains until third month follow-up. These findings emphasize the value of incorporating G-CBT into standard care practices to provide targeted psychological support and improve mental health outcomes in this vulnerable population. →

CONCLUSIONS: The addition of losartan to mFOLFIRINOX in the AFPAC study did not provide an early signal of efficacy in improving progression-free survival in advanced PDAC. The trial will not proceed to full accrual of phase 3 design. →

CONCLUSIONS: While the short, single-exposure SAS videos did not significantly enhance overall hope levels among Chinese adults, the effectiveness of humour in certain subgroups highlights the cultural adaptability of health communication strategies. Given its scalability and accessibility, this approach warrants further research to refine narrative techniques, optimise engagement across diverse populations, and explore its broader… →

INTRODUCTION: The cuff leak test (CLT) is hypothesised to help optimise extubation by assessing for laryngeal oedema which, if unrecognised and untreated, could lead to post-extubation stridor, post-extubation airway obstruction, and reintubation. However, the diagnostic accuracy of the CLT to detect post-extubation stridor (and hence potentially airway obstruction) remains uncertain. Given the equipoise that exists… →