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Erenumab for Chronic Cluster Headache: A Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this clinical trial of patients with CCH, blockade of the CGRP receptor with erenumab was not successful in the prophylaxis of attacks. Future studies should revisit the role of CGRP in CCH. →
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Multicenter clinical trial for the treatment of obstructive sleep apnea with a non-permanent orthodontic intraoral device in children
CONCLUSION: Participants showed objective and subjective OSA improvement, and all demonstrated maxillary expansion. Seventy-nine percent of participants showed AHI improvement, with 61.7% improving by 50% or more, and 17% resolved their OSA. Seventy-seven percent with moderate or severe OSA improved by 50%, while 93% with severe OSA achieved this milestone. This is the first study… →
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Lifestyle modification intervention among pregnant women with hypertension based on the self-determination theory using M-Health
CONCLUSION: The M-Health intervention led to improvements in lifestyle factors and self-determination constructs, with the exception of relatedness, which may be attributed to the limited features of the app. Although blood pressure did not change significantly, the reduction in systolic pressure could still be clinically meaningful. M-Health interventions grounded in self-determination theory show promise for… →
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Intranasal dexmedetomidine versus intranasal midazolam as a standard of care for pediatric patients undergoing transcatheter perimembranous ventricular septal defect (VSD) closure: a randomized controlled trial
CONCLUSIONS: Pediatric patients were successfully and effectively sedated with both intranasal dexmedetomidine and intranasal midazolam, with stable hemodynamics and oxygen saturation. →
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Clinical effect of Shugan Jieyu San for improving liver function and alleviating depression in patients with triple negative breast cancer
CONCLUSIONS: This TCM showed promising results in reducing depressive symptoms and improving daily abilities in patients with TNBC and comorbid depression, which was verified by the increase in serum levels of dopamine and serotonin, suggesting the potential involvement of these neurotransmitters in the therapeutic effects of this TCM. →
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Safety and efficacy of a novel intense pulsed light system in patients with meibomian gland dysfunction: a randomized, double-masked, intra-individual controlled study
CONCLUSION: To our knowledge this is the first prospective evaluation of a novel IPL device. There was a significant amelioration of subjective complaints and a tendency towards better expressibility in both study and control eyes. An intra-individual design might compound the individual analysis of either eyes in studies investigating IPL. →
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How to Use python-A2A to Create and Connect Financial Agents with Google’s Agent-to-Agent (A2A) Protocol
How to Use python-A2A to Create and Connect Financial Agents with Google’s Agent-to-Agent (A2A) Protocol Python A2A is an implementation of Google’s Agent-to-Agent (A2A) protocol, which enables AI agents to communicate with each other using a shared, standardized format—eliminating the need for custom integration between services. Target Audience Analysis The target audience for this tutorial… →
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EPFL Researchers Introduce MEMOIR: A Scalable Framework for Lifelong Model Editing in LLMs
EPFL Researchers Introduce MEMOIR: A Scalable Framework for Lifelong Model Editing in LLMs Understanding the Target Audience The target audience for the MEMOIR framework primarily includes AI researchers, data scientists, and business leaders interested in the practical applications of large language models (LLMs). These individuals are typically involved in the development and implementation of AI… →
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Preventing respiratory illness in cerebral palsy: Results of a pilot randomized controlled trial
CONCLUSIONS: RE-PACT is a feasible, acceptable intervention that can be delivered with high fidelity to diverse families caring for children with severe CP. These data inform the sample and design characteristics needed for efficacy testing of RE-PACT’s ability to prevent severe respiratory illness. →
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A Randomized Trial of Nutrition and Exercise Treatment in Patients With Pancreatic and Non-Small Cell Lung Cancer (NEXTAC-TWO)
CONCLUSIONS: The patients had good compliance with the 12-week NEXTAC program but failed to show significant improvements in disability-free survival as compared to observation alone. Further study on the progression of low muscle mass in the NEXTAC arm is needed. →
