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Bilateral posterior tibial nerve stimulation as a neuromodulation strategy for obstructed defecation: a randomized controlled trial
CONCLUSION: BT-PTNS is a safe and effective noninvasive treatment for ODS without anatomical abnormalities, significantly improving symptom severity and quality of life. Further multicentric trials are warranted to standardize treatment protocols and assess long-term outcomes. →
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Indocyanine green (ICG) fluorescence guided lymph node mapping for determination of resection margins in colon cancer — ISCAPE trial
CONCLUSIONS: In this trial, metastatic LNs were confined within ICG AFL in 95.6% of pN + cases. Although the predefined sensitivity threshold was not met, the result suggests potential for ICG mapping to guide resection margins in colon cancer surgery. →
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Qualifire AI Open-Sources Rogue: An End-to-End Agentic AI Testing Framework Designed to Evaluate the Performance, Compliance, and Reliability of AI Agents
Qualifire AI Open-Sources Rogue: An End-to-End Agentic AI Testing Framework Qualifire AI has introduced Rogue, a comprehensive framework designed to evaluate the performance, compliance, and reliability of AI agents. This open-source Python framework operates over the Agent-to-Agent (A2A) protocol, converting business policies into executable scenarios. It facilitates multi-turn interactions with target agents and generates deterministic… →
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Open-Label, Prospective Study of a Prebiotic Gel Cream on Its Efficacy of Mild to Moderate Acne Management and Effects on the Functional Skin Microbiome
CONCLUSIONS: This prebiotic-containing gel cream can be an effective form of management for acne vulgaris by creating beneficial shifts in the skin microbiome. →
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Effects of Aerobic-Resistance Training and Nutritional Intervention on Adiponectin, Interleukin-6, and hs-CRP Concentrations in Men with Abdominal Obesity-A Randomized Controlled Trial
The objective of this study was to assess the changes in adiponectin concentrations and inflammatory markers in men with abdominal obesity following physical exercise and exercise combined with dietary intervention. This study included 44 males with abdominal obesity (mean age 34.7 ± 5.5 years, waist circumference [WC] 110.3 ± 8.5, BMI 32.0 ± 3.9), who… →
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Evaluating the impact of easy-to-understand patient letters after discharge on patients’ health literacy: a randomized controlled study
CONCLUSIONS: Patient letters were associated with higher post-intervention health literacy in cardiologic patients and were well received. These results suggest that broad implementation of patient letters may benefit both patients and healthcare providers by enhancing patients’ understanding of medical information regarding diagnoses and treatment, potentially contributing to improved health-related outcomes. →
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Intravascular Imaging vs Angiography Guidance for PCI of Severely Calcified Lesions: The ECLIPSE Trial
CONCLUSIONS: IVI guidance during PCI of severely calcified lesions was associated with improved 1-year clinical outcomes compared with angiographic guidance alone, whether OA or BA was used for vessel preparation prior to drug-eluting stent placement. The adjusted difference in 1-year TVF rates were not significantly different with optical coherence tomographic guidance and IVUS guidance. →
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QeRL: NVFP4-Quantized Reinforcement Learning (RL) Brings 32B LLM Training to a Single H100—While Improving Exploration
QeRL: NVFP4-Quantized Reinforcement Learning (RL) Brings 32B LLM Training to a Single H100—While Improving Exploration Understanding the Target Audience The target audience for QeRL includes AI researchers, machine learning engineers, and business managers in tech companies focused on AI development. Their pain points often revolve around the high computational costs and time associated with training… →
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Integrate Sustainability and Innovation to Find New Opportunities
Patrick George/Ikon Image The Research The authors conducted in-depth case studies of five companies that are recognized as global innovation leaders actively pursuing ambitious sustainability objectives in a range of industries. As part of this work, coauthor Ernesto Ciorra shared his firsthand experiences as the former chief innovation and sustainability officer at Enel, one of… →
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For AI Productivity Gains, Let Team Leaders Write the Rules
Carolyn Geason-Beissel/MIT SMR | Getty Images Corporations are rushing to invest in artificial intelligence. But corporatewide AI policies alone can’t transform work, according to our recent research. For AI efforts to pay off, executives must set clear guardrails while enabling teams to write the rules that make tool adoption real. Only then will AI deliver… →