CONCLUSIONS AND RELEVANCE: In this randomized clinical trial, relative to message invitations, invitations with guaranteed, small financial incentives but not lottery incentives increased enrollment of economically but not necessarily racially or ethnically diverse participants to a study that aimed to increase enrollment in clinical studies. →

CONCLUSIONS: This pilot study demonstrated the feasibility of family-administered delirium care in ICU settings. However, the likely impact of the COVID-19 pandemic cannot be overlooked. The study faced recruitment challenges and demonstrated the difficulties of family involvement in delirium care, particularly during restricted family presence. A full evaluation of effectiveness requires a hypothesis-testing trial with… →

CONCLUSION: The study confirmed the feasibility of using home-based self-swabs for remote disease diagnosis and digital PRO tracking for symptoms during ILI events in a large-scale, pragmatic randomized trial. While the approach proved viable, the findings also highlighted areas for improvement in participant engagement and data collection efficiency. →

BACKGROUND AND OBJECTIVES: Accurate interpretation of electrodiagnostic (EDX) studies is essential for the diagnosis and management of neuromuscular disorders. Artificial intelligence (AI) based tools may improve consistency and quality of EDX reporting and reduce workload. The aim of this study is to evaluate the performance of an AI-assisted, multi-agent framework (INSPIRE) in comparison with standard… →

CONCLUSIONS: Ultra-early and short-term administration of TXA to patients with SAH is not cost-effective. Therefore, we recommend against using TXA for this patient group. →

CONCLUSION: Hydromorphone combined with dexmedetomidine PCIA is effective in relieving HZ-related pain, and reducing the occurrence of postherpetic neuralgia (PHN). It shows a good therapeutic effect, a high safety profile, and an easy clinical application. →

We tested the efficacy of docosahexaenoic acid (DHA) supplementation on aggressive behavior among people with dementia. We used secondary data from a randomized, double-blind, placebo-controlled trial. Analyses included 402 individuals with dementia. We compared group differences in mean aggressive behavior change at baseline vs six (primary), 12, and 18 months (secondary outcome). We used independent… →

CONCLUSION: Telerehabilitation was found to be clinically non-inferior to face-to-face physical therapy for improving knee function, pain, and quality of life in patients with degenerative meniscal tears. It offered significant cost savings, making it a cost-effective alternative to traditional in-person rehabilitation. →

Repetitive transcranial magnetic stimulation (rTMS) holds promise as a noninvasive pain treatment. Given the link between individual peak alpha frequency (PAF) of resting-state electroencephalographic recordings and pain sensitivity, and the potential for rTMS to modulate PAF, we investigated these relationships through a secondary analysis of established rTMS-induced analgesia in an experimental model of sustained muscle… →