-
Chatbot-Delivered Real-Time Support to Improve HIV Self-Testing Rates: A Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this randomized clinical trial, the HIVST-chatbot was noninferior to the HIVST-OIC in increasing HIVST uptake and counseling among HIVST users. These results suggest that the HIVST-chatbot might be an alternative to the evidence-based HIVST-OIC service for MSM. →
-
Effects of combined exercise training for adults with resistant major depression: a pilot study from the TRACE-RMD project
CONCLUSIONS: A supervised combined exercise program in people with RMD may induce positive and beneficial changes in functionality and clinical and QoL variables, and maintain body composition, CRF, and the biochemical profile. These preliminary results highlight the critical role of supervised exercise, regardless of intensity, in improving clinical symptoms in people with RMD. This study… →
-
A case-control study investigating the impact of gradient pressure therapy on chemotherapy-induced peripheral neuropathy symptoms and daily activities in paclitaxel-treated patients
CONCLUSION: Gradient pressure therapy effectively reduces symptoms of paclitaxel-induced peripheral neuropathy, improving patients’ daily activities. This intervention is recommended for clinical promotion and application. →
-
Parent-child agreement in reporting somatic distress, gastrointestinal symptoms, mental health, and general health in girls with functional abdominal pain
CONCLUSION: Findings indicated good parent- and child agreement for gastrointestinal and general somatic symptoms, but lower agreement for mental health and general health. →
-
The GTM Moat Series: Distribution is the Final Moat
Hello and welcome to The GTMnow Newsletter – the media brand of VC firm, GTMfund. Build, scale and invest with the best minds in tech. This is Part II of a series on how to build your GTM moat. You can find Part I on brand here. In AI, your product won’t be your moat… →
-
Adapted Safety Plans to Address Self-Harm and Suicide Behaviours in Autistic Adults: single arm feasibility trial and external pilot RCT
CONCLUSION: Autism Adapted Safety Plans are a potentially valuable intervention for autistic adults, provided that the process of creating it is flexible and sensitive to individual needs. The parameters of a future definitive trial of the clinical and cost-effectiveness of Autism Adapted Safety Plans are achievable, with minor recommended adaptations. Further testing of the Autism… →
-
Effect of tricalcium silicate-based intracanal dressing on antibacterial-antifungal activity and postoperative pain intensity after non-surgical endodontic retreatment: randomized controlled clinical trial
CONCLUSIONS: Both materials were effective in reducing microbial load; however, calcium hydroxide demonstrated superior antibacterial efficacy. Antifungal activity and postoperative pain outcomes were comparable between the groups. →
-
Vonoprazan attenuates proteinuria in diabetic kidney disease through potential direct renal mechanism
Our study investigates the effect of vonoprazan on albuminuria in diabetic kidney disease (DKD) patients compared to lansoprazole through a randomized controlled trial. Participants were randomized to receive either lansoprazole 30 mg or vonoprazan 20 mg. Specifically, 100 patients were included for H. pylori eradication, and 40 patients for other indications. The albumin/creatinine ratio (ACR)… →
-
Randomized crossover trial of hand and hydrostatic casting for custom lower limb prosthetic sockets: Assessing socket comfort and fabrication time
The aim of this study was to compare diagnostic sockets made by hand casting and standing hydrostatic pressure casting in persons with lower limb amputation. This multi-site, single-masked, randomized crossover trial (ClinicalTrials.gov NCT04141748) involved a prosthetist at each site taking one cast by hand (H) and another using hydrostatic casting (S). The process of casting,… →
-
Automated Oxygen Delivery in Home Setting for Patients with COPD on Long-Term Oxygen Therapy — A Randomized Crossover Feasibility Trial
CONCLUSION: Automated oxygen titration is feasible in the home setting, achieving more time with normoxia, but it required a wide flow range and continuous SpO2 monitoring. The patients reported a clinically relevant reductions in COPD symptoms measured with CCQ. The clinical importance of controlling SpO(2) needs to be examined in a larger study. →
