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Comparative analysis of neutralization assays performed using live SARS-CoV-2 virus and pseudovirus to assess immunogenicity of a bivalent SARS-CoV-2 protein vaccine in humans
CONCLUSIONS: Our findings demonstrate a strong correlation between PVNA and LVNA results, supporting PVNA as a safe, scalable, and reliable surrogate for LVNA in evaluating vaccine immunogenicity. →
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The effectiveness of radial extracorporeal shock wave therapy (rESWT) in plantar fasciitis: a 12 months randomised controlled trial in a Tunisian rehabilitation department
CONCLUSION: Both protocols (rESWT and physiotherapy combined to ultrasound) were effective for improving morning pain at short term and midterm follow-up periods. Foot disorders should be initially evaluated and considered while treating. →
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Enhanced external counter pulsation as a novel therapy to maintain cardiac output during hemodialysis: a preliminary randomized controlled study
Intradialytic cardiac output (CO) decline normally occurs during hemodialysis (HD) and results in short-term intradialytic hypotension to longer-term increased cardiovascular morbidity and mortality in chronic HD patients. Enhanced external counter pulsation (EECP) is a novel non-invasive device that has been demonstrated to improve coronary blood flow and maintain systemic hemodynamics in patients without kidney dysfunction.… →
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Cost analysis of integrating depression treatment into chronic care in Malawi: evidence from a cluster randomised controlled trial
CONCLUSIONS: These findings indicate that integrating depression care services into the Malawian health system is financially feasible and successfully reached many individuals with major depressive disorder. →
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Effect of prophylactic fibrinogen concentrate in scoliosis surgery (EFISS): a randomised pilot trial
CONCLUSIONS: This study demonstrates that the prophylactic administration of fibrinogen during scoliosis surgery in children is feasible and appears to be safe. Due to the limited sample size, no conclusions can be drawn regarding the efficacy of pre-emptive fibrinogen administration on clinical outcomes. However, the results provide valuable data to inform sample size calculation for… →
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RA3: Mid-Training with Temporal Action Abstractions for Faster Reinforcement Learning (RL) Post-Training in Code LLMs
RA3: Mid-Training with Temporal Action Abstractions for Faster Reinforcement Learning (RL) Post-Training in Code LLMs The recent research from Apple formalizes the concept of “mid-training” and its impact on reinforcement learning (RL) post-training. This study introduces RA3 (Reasoning as Action Abstractions), an iterative procedure that enhances model training through the following strategies: 1. Pruning to… →
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Why Agency Helps Employees Cope With Change
Marie Montocchio/Ikon Images Workplace developments like hybrid working and artificial intelligence have brought a cascade of sometimes destabilizing changes that many people have struggled to keep up with. Such changes can leave employees feeling as if the rug has been pulled out from under them. How can leaders stop change from undermining workers’ morale and… →
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Stanford Researchers Released AgentFlow: In-the-Flow Reinforcement Learning RL for Modular, Tool-Using AI Agents
«`html Stanford Researchers Released AgentFlow: In-the-Flow Reinforcement Learning for Modular, Tool-Using AI Agents Understanding the Target Audience The target audience for AgentFlow primarily includes AI researchers, business leaders in technology, and developers interested in advanced AI applications. These individuals are typically well-versed in machine learning concepts and seek innovative solutions to enhance AI capabilities in… →
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Dipsticks and point-of-care Microscopy in Urinary Tract Infections in primary care: Results of the MicUTI pilot cluster randomised controlled trial
CONCLUSION: The POCT-guided management approach for suspected uUTIs is feasible but presents implementation and methodological challenges. Recruitment varied across sites and was lower in the control group practices, highlighting the risk of differential recruitment. Retention was below the expected 80%, indicating the need for efficient follow-up strategies in future trials. Explorative analyses suggest that simply… →
