Clinical Trials
Category Added in a WPeMatico Campaign
-
Sensitive Skin Improvement Through Bioinformatics-Identified Cosmetic Ingredients That Regulate Transcriptome-Derived Biomarkers
Sensitive skin is characterized by hypersensitivity to normal stimuli, and objective diagnostic tools and treatments are still limited. Currently, cosmetics for sensitive skin are developed through the exclusion of known irritants rather than investigation into the underlying mechanisms of sensitivity. In this study, we developed an integrated pipeline combining transcriptome analysis via microneedle-based skin sampling…
-
Evaluation of the Effect of Astragalus membranaceus Saponins Administration on Knee Function and Cartilage Biomarkers in Healthy Subjects with Knee Discomfort
CONCLUSIONS: 12 weeks of AMS supplementation was associated with improvements in selected functional, mobility, and outcomes in generally healthy adults with self-reported knee discomfort. AMS was also associated with changes in selected circulating biomarkers related to inflammation and cartilage metabolism. These findings should be interpreted as a preliminary, safe, complementary strategy to support joint health…
-
Effects of Modest Carbohydrate-Energy Supplementation on Resistance Training Adaptations in Trained Men: A Crossover Trial
Background/Objectives: Higher energy and carbohydrate intakes have been hypothesized to enhance resistance training adaptations, yet empirical evidence remains mixed. The purpose of this study was to investigate whether supplemental carbohydrate-energy intake improves muscle hypertrophy and strength. Methods: Twenty resistance-trained men (26.7 ± 4.9 years old, 9.7 ± 6.1 years training experience) completed a quasi-randomized, double-blinded,…
-
Geriatric team support in the emergency department-a randomised trial investigating the effects on hospital admission and community care in older adults (GerED-21)
CONCLUSIONS: By relieving pressure on inpatient services, the GT integration into ED workflows represents a scalable strategy for health systems facing demographic shifts and rising demand for age-sensitive care.
-
An Internet-Based Mindfulness- and Compassion-Based Intercare Program for Reducing Parental Burnout: Randomized Controlled Trial
CONCLUSIONS: The culturally adapted, internet-based IBAP-BP program was feasible, safe, and effective compared with the waitlist condition for reducing parental burnout in working mothers, with effects sustained over 9 months, although it did not demonstrate superiority over the active control at the primary end point. Internet-based mindfulness- and compassion-based interventions may offer scalable, equitable options…
-
Medical Record Abstraction for Quality Improvement in Sepsis Care Using Artificial Intelligence: A Cluster Randomized Trial
CONCLUSIONS AND RELEVANCE: In this cluster randomized trial of artificial intelligence (AI)-enabled medical record abstraction for sepsis care, rapid assessment of SEP-1 performance and targeted feedback improved overall compliance with the measure. AI-driven quality clinical integration may address limitations in existing hospital quality reporting and better support a learning health system.
-
Virtual Reality-Supported Speech Therapy in Children with Developmental Language Disorder: A Randomized Controlled Trial
CONCLUSIONS: VRRS-based activities integrated into conventional speech therapy appear feasible, safe, and well accepted in preschool children with DLD. Further controlled studies with larger samples are needed to confirm these findings.
-
Comparison of three different hpv self-sampling tools — a subanalysis of the prospective, randomized hannover self-collection study
CONCLUSION: HPV self-tests were highly accepted and effective for collecting sufficient DNA material. Direct provision of user-friendly self-tests may support screening participation, particularly among underscreened women. All three devices performed strongly and appear suitable for integration into cervical cancer screening programs.
-
A comparative analysis of the effects of moderate vs mild hypothermia on serum neuron-specific enolase, S100β, and near-infrared spectroscopy during cardiopulmonary bypass-assisted open-heart surgery: a single-centre study
CONCLUSION: Our findings suggest that moderate hypothermia may offer improved neuroprotection by attenuating S100β release without adversely affecting cerebral oxygenation or cognitive outcomes. Although these results are encouraging, further validation through larger, multicentre studies is warranted before definitive conclusions can be drawn.
-
SSGJ-608 in moderate-to-severe plaque psoriasis: a multicenter, randomized, open-label, phase 3 study
CONCLUSIONS: SSGJ-608 was highly effective for treating patients with moderate-to-severe plaque psoriasis at 80mg Q2W and 160mg Q4W in a larger population, especially in patients previously treated with anti-IL-17 therapy, and exhibited a favorable tolerability profile in Chinese patients with moderate-to-severe plaque psoriasis.