Clinical Trials
Category Added in a WPeMatico Campaign
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Privacy Fact Sheets for Mitigating Disease-Related Privacy Concerns and Facilitating Equal Access to the Electronic Health Record: Randomized Controlled Trial
CONCLUSIONS: Our results demonstrate that PFSs may help to increase EHR uploads in people interacting with a realistic EHR click dummy, by mitigating privacy concerns in scenarios involving stigmatized diseases. Results further indicate that a PFS is mainly relevant and effective for people with increased privacy risk perceptions, whereas they neither benefit nor hurt others.…
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Effects of Electronic Sports on Community-Dwelling Older Adults With Mild Cognitive Impairment: A Randomized Controlled Study
CONCLUSIONS: The effects of eSports on cognitive function and psychiatric symptoms in older adults with MCI could not be confirmed in the present study. The potential of eSports to enhance cognition and alleviate psychiatric symptoms in older adults warrants further investigation through larger, rigorously designed studies to establish its efficacy.
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Exploring Adherence and Acceptability of an Intermittent Carbohydrate Restriction Regime (ICARB) in Free-Living Adults: A Feasibility Study
CONCLUSION: The ICARB protocol was feasible and acceptable over 4 weeks under free-living conditions. These findings support its short-term practicality and adherence potential, warranting longer-term and controlled studies to assess metabolic and behavioural outcomes.
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Trunk Impairment Scale and Stroke Impact Scale for Clinical Assessment of Patients in the Subacute Stage After Stroke Following Sensory Intervention
Stroke survivors frequently present with impaired trunk control, which is a key determinant of mobility, balance, and independence in activities of daily living (ADL). Reliable clinical tools are therefore needed to evaluate postural stability, particularly in patients unable to stand. This randomized controlled study assessed the applicability of the Trunk Impairment Scale (TIS) and Stroke…
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Effect of a digital sexual violence prevention education program on digital sexual violence prevention knowledge, self-protection behavior, and digital citizenship among fifth-grade children: a quasi-experimental study
CONCLUSION: The four-session digital sexual violence prevention education program effectively enhanced digital sexual violence prevention knowledge and bystander self-efficacy related to digital citizenship among fifth-grade students. Further research using a randomized controlled design with a larger sample size is recommended to confirm and extend these findings.
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Glecaprevir/Pibrentasvir for Post Traumatic Stress Disorder
CONCLUSIONS: GLE/PIB may be an effective treatment for PTSD. Furthermore, treatment may modulate inflammatory responses in PTSD. Future studies are required to confirm these findings regarding GLE/PIB, PTSD, and inflammation.
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Evaluation of the Efficacy and Safety of a 3D Navigation-Guided Transcatheter Aortic Valve Implantation Technique in Patients With Severe Aortic Stenosis and a High Risk of Atrioventricular Conduction Disorders: Results of a Pilot Randomized Study
Aim To evaluate the efficacy and safety of a new 3D navigation-guided technique for transcatheter aortic valve implantation (TAVI) in patients with severe aortic stenosis (AS) and a high risk of atrioventricular (AV) conduction disorder.Material and methods The study presents the results of a single-center prospective randomized pilot study. Sixty patients meeting inclusion and exclusion…
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The Effects of a Health Literacy Promotion Program on Health Behaviors and Blood Pressure Levels Among Uncontrolled Hypertensive Patients: A Quasi-Experimental Study
CONCLUSIONS: The health literacy promotion program significantly improved health behaviors and reduced systolic blood pressure, suggesting its feasibility for implementation in primary care settings. Future research should employ larger sample sizes and extended follow-up periods to thoroughly examine the program’s long-term effectiveness across diverse populations.
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Behavioral and electrophysiological evidence of reward processing deficits in repetitive negative thinking: Implications for depression
CONCLUSIONS: RNT may transiently disrupt behavioral and neural indicators of reward functioning. These findings suggest that cognitive states such as RNT can exacerbate or reveal the latent reward-processing deficits typically observed in individuals with anhedonia. This state-dependent sensitivity highlights the potential utility of targeting RNT to restore reward processing in depression.
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White light imaging versus artificial intelligence-assisted white light imaging for colorectal neoplasia detection: a randomised trial
CONCLUSIONS: AI-assisted colonoscopy demonstrated high ADR and NDR. While without statistical relevance overall, marginal significance was observed for screening patients.