Clinical Trials
Category Added in a WPeMatico Campaign
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Microbubble-enhanced transcranial focused ultrasound with temozolomide for patients with high-grade glioma (BT008NA): a multicentre, open-label, phase 1/2 trial
BACKGROUND: Brain-infiltrating tumour cells from high-grade glioma remain shielded from drug treatments by the blood-brain barrier, leading to inevitable recurrence. Microbubble-enhanced transcranial focused ultrasound (MB-FUS) enables controlled blood-brain barrier opening (BBBO), permitting localised drug delivery. We aimed to assess safety and feasibility of MB-FUS plus standard-of-care chemotherapy for individuals with high-grade glioma.
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Effects of Heavy-Load Strength Training During (Neo-)Adjuvant Chemotherapy on Cardiorespiratory Fitness, Aerobic Enzymes, Capillaries, Fatigue and Quality of Life in Women With Breast Cancer
To investigate the effects of heavy-load strength training during (neo-)adjuvant chemotherapy on cardiorespiratory fitness and muscle content of aerobic enzymes and capillaries, as well as to explore its effects on cancer-related fatigue and health-related quality of life (HR-QoL) in women with breast cancer. Women diagnosed with stage I-III breast cancer were randomized to a strength…
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A Randomized Clinical Trial Comparing Near-Infrared Imaging and Panoramic Radiography for Caries Detection
CONCLUSION: NIRI showed superior performance in early caries detection. Compared to panoramic radiography, NIRI is more sensitive and avoids ionizing radiation, making it safer and more comfortable. Its reliability and patient-friendly nature support its use as a promising tool in routine preventive dental care.
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Pharmacist-Led Hepatitis C Diagnosis and Rapid Management-In Community (PHARM-C): Results From a Phase IV Nonblinded Randomised Controlled Trial
This was a nonblinded randomised controlled trial comparing pharmacist-led hepatitis C virus (HCV) treatment in the community, to tertiary care hepatology. Of 34 antibody-positive individuals, 28 completed a rapid HCV RNA test in the pharmacy. The study was terminated after randomising 11 participants over 15 months (recruitment continued until ~27 months), as a result of…
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Pre-existing cardiovascular disease and hyperlipidemia and mortality in peritoneal dialysis patients
CONCLUSION: In patients undergoing CAPD, the coexistence of pre-existing cardiovascular disease and hyperlipidemia is associated with a significantly higher risk of all-cause mortality. This finding suggests that the comorbidity may contribute to worse long-term outcomes and highlights the importance of dyslipidemia management in clinical practice.
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Therapeutic efficacy of quetiapine combined with magnesium valproate in schizophrenia: Impact on serum BDNF and GFAP levels
This study evaluates the clinical efficacy and biomarker effects of quetiapine combined with magnesium valproate in patients with schizophrenia. A total of 156 patients diagnosed with schizophrenia were randomly assigned to 2 groups: 1 received magnesium valproate monotherapy (n = 78), and the other received combined therapy with quetiapine and magnesium valproate (n = 78).…
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A Pilot Randomized Controlled Trial of Extracorporeal Vaginal Peflex Weights for Enhancing Pelvic Floor Function and Relieving Stress Urinary Incontinence
CONCLUSIONS: Peflex weights effectively reduce SUI symptoms and improve muscle power and endurance, with high user satisfaction. However, there was no significant difference in the main outcome measure (ICIQ-UI-SF) between the Peflex and control groups. Further research is needed to identify which patients benefit most from this treatment.
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The Influence of Berberine on Vascular Function Parameters, Among Them VEGF, in Individuals with MAFLD: A Double-Blind, Randomized, Placebo-Controlled Trial
CONCLUSIONS: BBR appears to be a safe and promising adjunct in MAFLD therapy, potentially exerting reparative effects through VEGF modulation and vascular support. Further research is warranted to confirm its long-term impact and elucidate underlying protective mechanisms.
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Successful implementation of stroke risk screening for sickle cell anemia in the DISPLACE study: results of a cluster randomized trial
CONCLUSIONS: Our intervention approach in DISPLACE significantly improved stroke risk screening for children with SCA, with procedure-patient tracking emerging as an important component for improving care.
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Examining the effect of universal testing and treatment strategies for HIV prevention in Zambia and South Africa: generalizing the results of the HPTN 071 (PopART) trial
CONCLUSIONS: PopART interventions are estimated to be more protective in the population of interest than observed in the HPTN071 sample. These results partially explain the unexpected finding in arm A, providing further support for UTT strategies for HIV prevention. This analysis also highlights the importance of considering heterogeneous treatment effects among population subgroups when measuring…