Clinical Trials
Category Added in a WPeMatico Campaign
-
Tai chi or cognitive behavioural therapy for treating insomnia in middle aged and older adults: randomised non-inferiority trial
CONCLUSION: Tai chi was inferior to CBT-I at month 3 but non-inferior at month 15. This finding supports the use of tai chi as an alternative approach for the long term management of chronic insomnia in middle aged and older adults.
-
De-Escalation Dual Antiplatelet Strategy in Stabilized Myocardial Infarction Patients With Diabetes Mellitus
CONCLUSIONS: In MI patients with DM, 1-month unguided de-escalation to clopidogrel after ticagrelor-based DAPT was associated with clinical benefit without increasing ischemic risk. These results warrant further prospective validation.
-
A rapid time-resolved host gene expression signature predicts responses to antibiotic treatment in neonatal bacterial sepsis
Sepsis is a leading cause of mortality and morbidity in neonates yet remains difficult to diagnose. This leads to widespread empiric antibiotic therapy, which can facilitate the development of antimicrobial resistance. How the dysregulated host response to infection and sepsis evolves after antibiotic treatment is poorly understood. Temporal gene expression in neonates with microbiologically confirmed…
-
A probiotic containing L. plantarum and P. acidilactici strains for treating upper respiratory infection in children aged 6 months to 5 years: a randomized, double-blind trial
CONCLUSION: Intervention with this probiotic formula was associated with a shorter duration of fever and pain/discomfort in pediatric URIs with pharyngitis.
-
Effect of ADOPT model-based nursing intervention on self-management ability in patients with middle and low rectal cancer after sphincter-preserving surgery
CONCLUSION: ADOPT model-based nursing intervention significantly improved self-management ability and quality of life while reducing postoperative complications in patients with middle and low rectal cancer after sphincter-preserving surgery. This structured approach provides evidence for incorporating ADOPT into clinical practice to optimize postoperative care.
-
Acupuncture Improves Functional Limitations for Cancer Patients with Chronic Pain: A Secondary Analysis of PEACE Randomized Clinical Trial
Chronic pain significantly impairs functional performance in patients with cancer. Although acupuncture is effective for cancer-related pain, its impact on pain-related functional interference remains unclear. This secondary analysis of the PEACE randomized clinical trial included patients with prior cancer diagnoses and musculoskeletal pain for ≥3 months. Participants were randomized to groups undergoing 10 weeks of…
-
Nixtamalization of Maize to Reduce Mycotoxin Exposure: A Human Biomonitoring Intervention Study in Soweto, South Africa
Mycotoxin contamination is a global threat to food safety and human health, especially in regions facing food insecurity, such as Sub-Saharan Africa. This intervention study evaluates the effectiveness of nixtamalization, a traditional alkaline cooking method, in reducing mycotoxin levels in maize and corresponding urinary biomarkers of exposure. Forty adult healthy volunteers from an informal settlement…
-
Stereotactic body radiation therapy combined with cadonilimab and lenvatinib in the treatment of hepatocellular carcinoma with Vp3 or Vp4 portal vein tumor thrombus: a prospective, multicenter, single-arm, phase II clinical trial
CONCLUSIONS: The combination of SBRT, cadonilimab, and lenvatinib showed promising efficacy and manageable toxicity in HCC patients with Vp3/4 PVTT. Early AFP or PIVKA-II response at 6 weeks may serve as a prognostic biomarker.
-
Effectiveness of digital co-creation platform in remote pulmonary rehabilitation for older adults with chronic obstructive pulmonary disease: a randomized controlled trial
CONCLUSION: These results indicate that digital co-creation enhances the active participation of older adults in Tele-PR and fosters the development of virtual communities along with the onset of altruistic behaviors in individuals. This approach encourages patients to apply their knowledge for self-management of health behaviors, which in turn, enhances their adherence to rehabilitation exercise and…
-
Effects of Metformin on children with Fragile X Syndrome: a randomized, double-blind, placebo-controlled trial
CONCLUSIONS: In this controlled trial, metformin did not significantly improve the primary outcome of ABC total score. However, significant improvements were observed in the hyperactivity subscale and key secondary outcomes, including sleep parameters, while maintaining a favorable safety profile. Although the primary endpoint was not met, these secondary findings support further investigation of metformin for…