Clinical Trials
Category Added in a WPeMatico Campaign
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Clinical observation on the mydriatic effects of different doses of compound tropicamide eye drops during fundus examination of premature infants
Objective: To evaluate the efficacy and safety of low-dose compound tropicamide eye drops for pupillary dilation in premature infants undergoing the fundus examination. Methods: A non-inferiority, randomized, controlled, crossover trial was conducted. Preterm infants hospitalized in the Department of Neonatology, the First Affiliated Hospital of Zhengzhou University scheduled for retinopathy of prematurity screening between October…
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Multimodal personalised executive function intervention (E-Fit) for school-aged children with complex congenital heart disease in Switzerland: a randomised controlled feasibility study
CONCLUSIONS: E-Fit is a feasible intervention suggesting EF and social responsiveness improvements in children with cCHD. Motivational strategies to improve adherence to computerised training should be refined before a full-scale efficacy trial.
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Prevalence and types of anxiety disorders among patients with cardiac conditions and elevated HADS-A scores: findings from the initial screening phase of the Heart and Mind trial in Denmark
CONCLUSIONS: The majority of individuals identified by the instrument also met the diagnostic criteria for an anxiety disorder. Generalised anxiety disorder and panic disorder were the most prevalent subtypes. Anxiety was common across the cardiac population, underscoring the need for routine assessment and targeted intervention in clinical practice.
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Cost-Effectiveness of Individualized Occupational Therapy for Inpatients With Schizophrenia: Two-Year Follow-Up of a Multicenter Randomized Controlled Trial
CONCLUSIONS AND RELEVANCE: IOT+GOT was more cost-effective than GOT alone over 2 yr, supporting its wider adoption as an economically sound rehabilitation strategy for clients with schizophrenia. Given the extent of missing cost data, the results should be interpreted with appropriate caution. These findings offer long-term economic evidence to inform mental health policies and resource…
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Furosemide stress test predicts discontinuation of continuous renal replacement treatments in critically ill patients with acute kidney injury: a prospective multicenter trial
ChiCTR2400091040.
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Clinical Decision Support for Chronic Kidney Disease in Primary Care: A Cluster Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this cluster randomized trial of a CDSS for CKD in primary care, both the intervention and control groups demonstrated comparable improvements in 6-month outcomes, with no independent effect of the CDSS detected.
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TACE plus lenvatinib and envafolimab for conversion therapy in unresectable HCC: a prospective pilot study
CONCLUSION: In this small pilot study, TACE combined with lenvatinib and envafolimab was associated with encouraging antitumor activity and a relatively high conversion-to-resection rate, with an acceptable safety profile. However, the limited sample size and single-arm design preclude definitive causal conclusions, and gastrointestinal bleeding emerged as an important risk. These preliminary findings suggest the need…
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A Comparative Analysis of Parent-Reported Treatment Acceptability in Collaborative and Proactive Solutions and Parent Management Training for Oppositional Youth
Evaluating treatment acceptability is crucial, as higher acceptability is associated with better adherence and lower dropout rates, a particular concern in treating youth with disruptive behavior disorders. This study built upon previous randomized controlled trials that demonstrated the efficacy of treatment for youth with oppositional defiant disorder (ODD) by comparing the acceptability of Collaborative and…
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Written Exposure Therapy for Posttraumatic Stress Disorder and Integration of a Mindfulness-Based App in China: A Pilot Randomized Controlled Trial
Despite posttraumatic stress disorder’s (PTSD) significant burden in China, accessible and effective treatments remain limited. This pilot randomized controlled trial examined the feasibility, acceptability, and preliminary efficacy of Written Exposure Therapy (WET) for PTSD in China and explored whether adding a mindfulness-based app (MBA) improved insomnia outcomes. Forty-six adults meeting Diagnostic and Statistical Manual of…
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A Randomized Controlled Trial Comparing Transdiagnostic Behavior Therapy and Disorder-Specific Psychotherapies in Veterans With Emotional Disorders
Transdiagnostic psychotherapies have been gaining in popularity due in part to their hypothesized ability to address multiple emotional disorders via a single protocol. However, to date, most randomized clinical trials of these treatments have focused on patients with anxiety disorders, or in mixed samples, limiting their use in other diagnoses. The present study compared Transdiagnostic…