Clinical Trials
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Predictive Model of Acupuncture Adherence in Alzheimer Disease: Secondary Analysis of Randomized Controlled Trials
CONCLUSIONS: This study is the first to develop and validate a predictive model for acupuncture adherence in patients with AD. In clinical research, it can facilitate participant stratification and help identify individuals who may need additional adherence support, thereby reducing bias and enhancing trial quality. In clinical practice, the nomogram enables proactive adherence management by…
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Outcome of pars plana vitrectomy with and without internal limiting membrane peeling in proliferative diabetic retinopathy
CONCLUSION: ILM peeling during diabetic vitrectomy effectively minimizes the risk of postoperative ERM formation and reduces the need for further Anti-VEGF injections for DME. However, it does not confer a significant advantage in terms of visual acuity improvements.
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Impact of Artificial Intelligence for Detection of Precancerous Colonic Lesions in a Fecal Immunochemical Blood Test-Based Organized Screening Program in Italy: A Randomized Control Trial
CONCLUSIONS: In a FIT-based organized CRC screening setting, CADe did not enhance detection of AADR with a modest increase in withdrawal time. NCT04441580.
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Evaluation of Ahmed glaucoma valve versus Ex-PRESS shunt implantation with conbercept therapy in neovascular glaucoma
Neovascular glaucoma (NVG) is a vision-threatening condition commonly associated with uncontrolled intraocular pressure (IOP). Ahmed glaucoma valve (AGV) implantation and Ex-PRESS shunt insertion are 2 frequently applied surgical techniques. This study aimed to compare the short-term and 1-year outcomes of these procedures when combined with intravitreal conbercept therapy. Forty-four patients diagnosed with NVG were randomly…
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Reduction of adult employees’ anxiety disorder in the work environment: Implications for anthropological philosophers and a case of multivariate analysis
CONCLUSION: Based on the findings, we recommend that an intervention program be developed to identify and diagnose distorted or maladaptive financial attitudes and behavior in people suffering from various debt-related mental health disorders.
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Which arthralgia patients benefit most in reduction of subclinical joint inflammation by methotrexate treatment: results from the TREAT EARLIER trial
CONCLUSIONS: CSA patients with subclinical inflammation who responded best to methotrexate during the first year were identified by increased levels of subclinical inflammation at diagnosis, primarily due to multiple sites of tenosynovitis with/without osteitis. These data may contribute to personalised medicine for arthralgia at risk for RA.
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Effect of Lung Cancer Screening, Smoking Cessation, and Cessation Smartphone App to Health-Related Quality of Life Among Heavy Smokers: Randomized Controlled Trial
CONCLUSIONS: This is the first study to test a smoking cessation smartphone app in the context of lung cancer screening. The use of the developed app correlated with improved HRQoL, mainly by decreased pain and fatigue. To conclude, the studied app provides a feasible and effective cessation intervention that is readily implementable in population-based lung…
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Naldemedine for the Prevention of Recurrent Acute Pancreatitis: A Randomised, Double-Blind, Placebo-Controlled Trial
CONCLUSIONS: Treatment with naldemedine was safe and well-tolerated and may reduce the risk of recurrent acute pancreatitis. A larger confirmatory trial is needed to verify these findings.
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Digital Cognitive Behavioral Therapy for Chronic Insomnia in South Korea: Cost-Effectiveness Analysis Using Decision Tree and Markov Modeling Based on a Secondary Analysis of a Randomized Clinical Trial
CONCLUSIONS: Digital CBT for insomnia offers favorable clinical and economic value in South Korea. Using Korean clinical trial data and locally relevant societal cost inputs, this study provides policy-relevant evidence supporting early integration of digital CBT into routine insomnia care, employer health strategies, and national digital health policy.
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Surgical decision-making strategies in preterm neonates with necrotizing enterocolitis: A randomized controlled clinical trial
CONCLUSIONS: The strategy based on MD7 and paracentesis was superior to Bell’s criteria for guiding surgical decisions in preterm neonates with NEC, reducing mortality. The main limitation was a small number of non-therapeutic laparotomies, expected due to the greater sensitivity of the strategy.