Clinical Trials
Category Added in a WPeMatico Campaign
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Comparison of the Effects of Glycopyrrolate and Atropine on Postoperative Delirium in Older Adult Patients Undergoing Laparoscopic Colorectal Surgery: A Randomized Controlled Trial
CONCLUSION: The combination of glycopyrrolate and neostigmine was associated with a lower incidence of POD than atropine in older adults undergoing laparoscopic colorectal surgery.
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Synbiotic supplementation reduces intestinal permeability and inflammation in overweight or obese kidney transplant recipients: a randomized controlled trial
Increased intestinal permeability resulting from gut dysbiosis, cardiovascular disease (CVD), and graft failure is common among kidney transplant (KT) recipients. This study was designed to investigate the effects of synbiotics on intestinal permeability, systemic and vascular inflammation markers, oxidative stress, and fibrosis in KT recipients. In this randomized controlled trial, 46 KT recipients were randomly…
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Certolizumab pegol, abatacept, tocilizumab or active conventional therapy in early rheumatoid arthritis: 48-week patient-reported outcomes from the NORD-STAR trial
BACKGROUND: Pain, fatigue, and impaired health-related quality of life are common manifestations of rheumatoid arthritis. The aim of this study was to compare the effects of active conventional treatment with three different biological disease-modifying antirheumatic drugs (DMARDs) on patient-reported outcomes after 48 weeks, in patients with early rheumatoid arthritis using data from the NORD-STAR trial.
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Determinants of the Uptake and Frequency of Use of a Web Portal Digital Health Intervention in Patients With Type 2 Diabetes and/or Coronary Heart Disease: Secondary Analysis of a Randomized Controlled Trial
CONCLUSIONS: This study is innovative in jointly examining determinants of the uptake and frequency of use of the same DHI within a single context and sample. By demonstrating that factors driving uptake do not necessarily increase the frequency of use, it advances existing research. The study contributes to a more differentiated understanding of DHI use…
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Comparison of sesame oil wafers and lozenges as saliva substitutes for dry mouth in head and neck cancer patients: A crossover randomized control trial
CONCLUSION: To conclude, FD-SOESS significantly improved objective dry mouth and dysphagia but not subjective dry mouth. It received a relatively high level of satisfaction. Therefore, this newly developed product has the potential to be an alternative product for dry mouth patients.
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Effects of the mHealth Supportive Care Program for Family Caregivers of Individuals With Dementia and Diabetes: Pilot Randomized Controlled Trial
CONCLUSIONS: This theoretically grounded mHealth supportive care program effectively reduced burden and improved outcomes for FCGs managing dementia-diabetes comorbidity. The integrated online-offline delivery model shows particular promise for male, younger, manual labor, and lower-income caregivers, suggesting mHealth’s potential to address health equity. These findings provide a feasible model for scalable caregiver support in resource-limited primary…
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Improving cancer clinical trial enrollment and patient understanding using TrialTalk, a structured communication method: a pilot randomized controlled trial
CONCLUSION: Patients who met with TrialTalk-trained oncologists were more likely to sign consent to participate in a clinical trial. The decision-making conversation with the oncologist is a critical moment for patients considering clinical trial participation, and targeting these encounters has the potential to increase overall trial participation rates.
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Positional Release Technique Versus Muscle Energy Technique for Patients With Nonspecific Low Back Pain With Facet Joint Restriction: A Pilot Randomized Comparative Study
CONCLUSION: Based on this pilot RCT, the results indicate that the short-term outcomes of patients with NSLBP who also have facet joint restrictions were more significantly improved through the use of the MET technique in comparison with PRT. Further research is necessary to confirm the potential of the MET technique to reduce pain associated with…
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Six-month open-label clinical study of a novel topical solution for mild distal lateral subungual onychomycosis
Systemic antifungals such as terbinafine and itraconazole are often limited by drug interactions and side effects in the treatment of onychomycosis. We tested a new topical solution to address the clinical need for safer and more effective topical therapies. The solution (containing urea, lactic acid, ethoxydiglycol, decylene glycol, and polyquaternium-7) was applied twice daily for…
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Exploratory Analysis of Liraglutide Effects on Obstructive Sleep Apnea and Health-Related Quality of Life in Individuals With Obesity and COPD: A Secondary Analysis of a Randomised Controlled Trial
Obstructive sleep apnea (OSA) is associated with chronic obstructive pulmonary disease (COPD) and obesity, and all three are linked to reduced health-related quality of life (HRQoL). Coexistence of OSA and COPD increases morbidity and mortality compared to each condition alone. Liraglutide, a glucagon-like peptide 1 receptor agonist, may influence respiratory and HRQoL outcomes. In this…