Clinical Trials
Category Added in a WPeMatico Campaign
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Improving the field accuracy of a malaria diagnostic algorithm combining sequential interpretation of rapid diagnostic test detecting PfHRP2 and pLDH in febrile children in a seasonal hyperendemic malaria transmission area in Burkina Faso
CONCLUSIONS: The sequential diagnostic approach improves the diagnosis of malaria in a real world setting, compared to the use of PfHRP2-(only) based RDT. However, relying only on history of antimalarial treatment in undetermined cases may decrease algorithm’s sensitivity, which could result in missing active or recurrent malaria infections.
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Sleep deprivation increases levels of the synaptic density marker SV2A in the human brain
Sleep is essential for synaptic homeostasis, a proposed mechanism whereby wakefulness leads to synaptic potentiation and sleep facilitates synaptic down-selection. Synaptic vesicle glycoprotein 2A (SV2A), whose availability is quantifiable by [¹⁸F]SynVesT-1 positron emission tomography (PET), is commonly interpreted as a proxy for synaptic density. In this randomized study, we examined 40 healthy adults (mean age…
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Palliative Care Coaching for Family Caregivers of Patients With Advanced Cancer: A Randomized Clinical Trial
CONCLUSIONS: This randomized clinical trial of a telehealth intervention for African American and rural-dwelling caregivers of patients with advanced cancer found no differences in caregiver and patient outcomes at 24 weeks. However, an exploratory sensitivity analysis indicated potential improvements in caregiver anxiety and patient mental health QOL.
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Adjunctive Psychosocial Interventions and Opioid Abstinence Among Patients Receiving Buprenorphine: A Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this randomized clinical trial, CBT and PRS had no effect on rates of opioid abstinence in the year following the initiation of MOUD.
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Efficacy of vunakizumab in patients with moderate-to-severe plaque psoriasis across diverse disease features: a post hoc analysis of a phase-III trial
CONCLUSION: Vunakizumab shows satisfactory efficacy in patients with moderate-to-severe plaque psoriasis, regardless of psoriasis duration and severity.
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A Randomized Trial of Interval Likelihood Ratios for Clinical Decision-Making
CONCLUSIONS: Presenting diagnostic test information using ILRs improved vignette-based clinical decisions. The magnitude of improvement appeared to vary by case vignette.
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First-in-human (phase I) trial of SOL-116, a humanised IgG4 monoclonal antibody targeting bile salt-stimulated lipase, in healthy participants and rheumatoid arthritis patients
CONCLUSIONS: This study demonstrated that SOL-116 has a favourable safety and PK profile. Combined with effective reduction of free BSSL in the circulation, findings in this study support ongoing clinical development of SOL-116, with a focus on elucidating the efficacy and mechanism of action of BSSL in the treatment of chronic inflammation, primarily RA.
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Impact of Financial Incentives on Electronic Health Record-Driven Recruitment of Underrepresented Communities in Research: Randomized Controlled Trial
CONCLUSIONS: Patients with cancer who identify as part of a historically underrepresented group were less likely to view and respond to recruitment messages for research studies through their EHR patient portal. Age was also found to significantly impact engagement, with older patients less likely to view and respond. Finally, a modest US $20 financial incentive…
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Effect of Bone Cement Viscosity on Leakage and Outcomes in Vertebroplasty
Percutaneous vertebroplasty provides rapid pain relief in elderly patients with acute osteoporotic vertebral compression fractures; however, bone cement leakage remains a major safety concern, and the influence of cement viscosity on leakage and clinical outcomes is not fully established. This study evaluated whether high-viscosity cement reduces leakage without compromising efficacy or safety. In this single-center,…
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Efficacy of 8% arginine associated with low-level laser therapy in the treatment of dentin hypersensitivity: randomized double-blind clinical trial
CONCLUSIONS: All evaluated therapies were effective in reducing DH over the 8-week follow-up period, with a progressive reduction in symptoms over time. However, no statistically significant differences were observed between the interventions, and no additive effect was identified for the combined therapy.