Clinical Trials
Category Added in a WPeMatico Campaign
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Evaluation of Physical and Mental Workload and Transfusion Time in Trauma Resuscitation
CONCLUSIONS: These findings support the feasibility and justify a fully powered trial. WB may improve resuscitation efficiency and reduce cognitive burden, with potential implications for patient outcomes and nursing workflow.
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ENLIGHTENme: Translating the Benefits of Self-Administered Daytime Light Supplementation to Older Adults in the Real World
Controlled studies have demonstrated that light supplementation benefits circadian entrainment, sleep and mood. Translating these findings into effective, real-world usage of light supplementation is, however, challenging because naturalistic and supplemental light exposure are shaped by personal habits and environmental light conditions. Bridging this translation gap is especially critical for older adults, given the reduced ocular…
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Use of indocyanine green fluorescence versus patent blue V dye for sentinel lymph node biopsy in early breast cancer, a randomized controlled trial
CONCLUSION: ICG fluorescence achieved a higher SLN IR, shorter detection time, higher sensitivity, lower FNR, and fewer tracer-related adverse events than PBV as a single tracer for SLNB in patients with early-stage breast cancer. These findings suggest that ICG is a promising standalone tracer when radioisotope mapping is unavailable. Larger multicenter studies are required before…
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Does the use of benzodiazepine influence the effectiveness of lifestyle intervention? Secondary analysis from the Sarcopenia and Physical fRailty iN older people strategies (SPRINTT) trial
CONCLUSION: In frail older adults, benzodiazepine use significantly blunts the effectiveness of lifestyle interventions for preventing mobility disability. These findings support a prudent approach to benzodiazepine use in frail older patients.
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Self-Monitoring of Weight Loss Over Time: Secondary Data Analysis of a Randomized Controlled Trial
CONCLUSIONS: The study demonstrates that the effect of self-monitoring on weight loss is time-dependent. While a higher frequency of self-monitoring is associated with greater weight loss early in the intervention, its influence decreases as time progresses. These findings emphasize the importance of sustained engagement with self-monitoring rather than focusing solely on frequency, suggesting that interventions…
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Feasibility and Methodological Reflections From the Co-Creation of a Randomized Controlled Trial (The Kid’s Trial): Decentralized, Child-Led Citizen-Science Study
CONCLUSIONS: The Kid’s Trial demonstrates the feasibility of a decentralized, child-led RCT cocreated through participatory citizen-science methods. Children can meaningfully contribute to trial design and conduct, and experiential participation may support engagement with trial concepts. Future studies should enhance engagement through community partnerships, shorter intervals between steps, and embedded learning assessments to improve inclusivity and…
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Evaluation of a cornea-specialized large language model for diagnostic and management accuracy in complex corneal cases
CONCLUSIONS: A cornea-specialized LLM enhanced with RAG improved diagnostic accuracy in complex corneal cases, particularly among clinicians with lower baseline performance. Effects on management accuracy were inconsistent. Future studies should explore the use of open-ended management tasks and examine whether smaller, curated retrieval corpora yield better model performance.
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Angiography-Based Index of Microcirculatory Resistance in Assessing the MVO and Infarct Size in STEMI Patients
CONCLUSIONS: In STEMI patients, a single bolus of r-SAK before PCI was associated with numeric reductions in post-PCI angio-IMR, MVO, MVO extent and IS. Additionally, angio-IMR exhibited a significantly positive correlation with both MVO extent and IS, demonstrating the diagnostic value of this wire-free method for assessing microvascular injury.
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Combined hyperbaric oxygen and repetitive transcranial magnetic stimulation for vascular cognitive impairment: a randomized controlled trail
CONCLUSION: Combined HBOT and rTMS therapy demonstrates superior efficacy in improving cognitive function which may be mediated by the primary somatosensory cortex and primary motor cortex of the brain. However, the combined regimen did not yield greater improvement in daily function or mood. Combined HBOT + rTMS is a promising cognitive rehabilitation strategy in the…
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Serplulimab combined with bevacizumab and chemotherapy as first-line treatment for recurrent or metastatic cervical cancer (ASTRUM-CC01): a phase II trial
CONCLUSION: First-line treatment with serplulimab in combination with bevacizumab and chemotherapy demonstrated promising antitumor activity and acceptable safety in R/M cervical cancer. These findings support further evaluation in phase III trials.