Clinical Trials
Category Added in a WPeMatico Campaign
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Construction of a mobile health technology-based early identification model for postpartum depression and evaluation of its application effects in community postpartum visits
This study developed a mobile health-based early identification model for postpartum depression (PPD) and evaluated its effectiveness in community postpartum visits. A randomized controlled trial included 102 postpartum women (intervention: n=54; control: n=48). The intervention group used the «Maternal Love Guardian» app, integrating clinical risk factors and digital phenotyping (behavioral, emotional, cognitive, and voice data)…
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Blue LED photobiomodulation in the prevention of radiodermatitis in breast cancer survivors: a clinical trial
CONCLUSION: The findings suggest that blue LED may be a promising resource to improve the quality of life of patients undergoing RT.
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An Innovative Formula for Keratosis Pilaris Treatment-A Randomized Controlled Study Based on the «Exfoliation-Dissolution-Repair» Concept
CONCLUSION: The combined formula effectively reduced follicular papules, improved skin hydration, decreased TEWL, and alleviated depressive symptoms in KP patients.
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Effects of Dog-assisted Therapy in Anxiety Symptoms of Female Adolescents With Eating Disorders: A Controlled Trial
CONCLUSION: This study suggests that dog-assisted therapy may be an effective complementary intervention for reducing state anxiety in adolescents with eating disorders. Given the role of anxiety in the maintenance of anorexia nervosa, targeting this symptom could have therapeutic benefits. Additionally, improvements in interpersonal distrust and maturity fears were observed, highlighting the potential impact of…
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Automated Feedback After Internet-Based Depression Screening: Cost-Effectiveness Analysis of a Randomized Controlled Trial
CONCLUSIONS: Six months postintervention, feedback interventions had no statistically significant effect on costs from a societal perspective or on QALYs. Tailored feedback was associated with moderate cost-effectiveness probabilities compared to no feedback. Explorative subgroup analyses revealed subpopulations for which the interventions might be cost-effective.
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Impact of integrated nursing care on rehabilitation process of inpatients with multiple myeloma in an academic hematology department
Multiple myeloma (MM) is a complex hematologic malignancy often associated with complications and challenges in recovery. The research on the specific effects and influencing factors associated with the application of comprehensive nursing mode in hospitalized patients with multiple myeloma in hematology department is still limited. To explore the positive for potential benefits of a comprehensive…
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Comparison of 3 different flow rates of high-flow nasal cannula (1 L/kg/min versus 2 L/kg/min versus 3 L/kg/min) in management of children admitted with bronchiolitis: a randomized controlled trial
CONCLUSION: HHFNC at 1 L/kg/min showed good clinical with fewer improvement adverse events, while 2 L/kg/min had the lowest PICU admissions and ventilation needs. In contrast, 3 L/kg/min was linked to higher complications and longer hospital stay.
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Optimizing lenalidomide therapy in renal impairment: analysis of renal response in the prospective REMNANT study in transplant-eligible newly diagnosed multiple myeloma
Renal impairment (RI) is a serious complication in multiple myeloma (MM), linked to poor survival and early mortality. Rapid renal recovery improves outcomes, yet patients with RI have been excluded from most key trials in transplant-eligible newly diagnosed (TE-ND) MM. REMNANT is an ongoing, academic, multicenter phase 2/3 study in TE-NDMM patients aged 18-75, regardless…
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Concentrated ERP for Patients With Difficult-to-Treat OCD: Insight as a Predictor of Acute and Long-Term Outcomes
CONCLUSIONS: Baseline insight was not a strong predictor of short-term treatment outcomes following cET but was related to long-term OCD severity. Improvements in insight during cET were associated with achieving and maintaining reduced symptoms over time. These results suggest that improvements in OCD and enhanced insight are associated. Trial Registration: ClinicalTrials.gov identifier: NCT02656342.
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Multiparameter MRI assessment of metformin and exercise effects on skeletal muscle in prediabetes: a randomized controlled trial
CONCLUSION: Aerobic exercise favorably altered skeletal muscle tissue characteristics and metabolic markers in prediabetes. Metformin did not attenuate these effects and may enhance IMAT reduction in subjects with high baseline IMAT.