Clinical Trials
Category Added in a WPeMatico Campaign
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Effectiveness of peer-delivered Problem Management Plus for Immigrants (PMP-I) in reducing stress, anxiety, and depressive symptoms among Bhutanese adults resettled in Massachusetts, United States: a pilot randomized controlled trial
CONCLUSIONS: The PMP-I improved the mental, social and emotional well-being of Bhutanese adults (PHQ-9 score ≤ 14) resettled in Massachusetts. Peer-delivered, family-centred PMP-I offers a significant public health benefit; however, a large-scale, RCT involving diverse refugee groups is necessary to replicate its success nationwide and beyond.
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Effects of total-etch and self-etch bonding systems on pulp sensitivity and the incidence of long-term complications following resin filling of posterior teeth
CONCLUSIONS: Self-etching and bonding 3M-Z350 nano-composite resin to fill teeth can effectively improve the therapeutic effect, reduce postoperative pulp sensitivity, enhance chewing function and have good interface sealing performance. The incidence of complications such as post-operation fillings and pulpitis pain is relatively low.
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Effect of photobiomodulation on fatigue-related errors in ankle joint position reproduction: the moderating role of perceived ankle instability in a randomized, placebo-controlled trial
To investigate whether pre-exercise photobiomodulation (PBM) attenuates fatigue-induced decline in ankle joint position reproduction (JPR) and determine whether perceived ankle instability modifies this response. In this randomized, placebo-controlled trial with participant blinding and blinded outcome assessment, 30 healthy young adults (age: 24.3 ± 3.7 years; 15 male, 15 female) received either PBM or placebo treatment…
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Effect of pictorial-based information about atherosclerosis on adherence to lifestyle recommendations: results from the VIPVIZA randomised controlled trial
CONCLUSION: Our findings provide some evidence for the contributory role of pictorial-based information about subclinical atherosclerosis in promoting sustained healthy lifestyle habits.
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Feasibility and clinical value of a prostate cancer screening model based on biparametric magnetic resonance imaging combined with prostate-specific antigen in a Chinese population
CONCLUSION: The prostate cancer screening model based on serum tPSA combined with bpMRI demonstrates good feasibility, reduces unnecessary biopsies, optimizes the allocation of screening resources, and provides a basis for precision screening strategies.
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Digital Mahjong-Based Cognitive Engagement Intervention for Older Adults: Randomized Controlled Trial
CONCLUSIONS: This 6-month home-based digital mahjong intervention improved delayed recall and increased right insular ReHo. Integrating culturally familiar cognitive challenges with lifestyle engagement may be a feasible strategy associated with salience network-related functional changes and memory performance. Future large-scale trials should use active control conditions and factorial designs to rigorously isolate component-specific mechanisms.
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«My child before and now»: parental perceptions of changes in functioning following participation in the global integration method (Método de Integração Global) in children with autism spectrum disorder
CONCLUSION: Parents reported perceived changes in functioning following participation in MIG and described positive experiences related to the intervention process.
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Impact of Responsibility Allocation Structures on Diagnostic Quality in AI-Assisted Diagnosis: Randomized Controlled Experiment
CONCLUSIONS: The dynamic responsibility structure may enable health care organizations to use AI more fully and appropriately without compromising clinicians’ diagnostic performance, thereby improving the safety and quality of AI-assisted diagnosis.
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Digital Peer Support Intervention for Family Caregivers of Individuals With Neuromuscular Disease: Randomized Controlled Trial
CONCLUSIONS: Our 12-week digital peer support program had no effect on caregiver mastery or other caregiving or psychological outcomes among family caregivers of individuals with NMD. This might be partly due to moderate fidelity and variability in participant engagement. Unlike prior caregiver interventions that incorporated structured psychoeducation or self-management training, this intervention evaluated primarily peer…
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The Effects of High- and Moderate-Intensity Exercise on Epithelial Integrity Markers and Inflammatory Responses in Healthy Young Men
The effects of exercise intensity on airway epithelial integrity markers and inflammatory responses remain unknown. Therefore, we investigated the effects of high- and moderate-intensity exercise on airway epithelial integrity markers (club cell protein 16 [CC16], surfactant protein D [SP-D], and the CC16/SP-D ratio), along with systemic inflammation assessed via high-sensitivity C-reactive protein [hs-CRP] in healthy…