Clinical Trials
Category Added in a WPeMatico Campaign
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Effectiveness and cost-effectiveness of risk-based topical fluoride intervention on early childhood caries in Jiangnan District, Nanning City
CONCLUSIONS: The PSC-MCAT tool is effective and cost-effective for caries risk assessment and may serve as a practical framework for caries prevention.
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The time sensitivity of aspirational interventions: Evidence from a role-modeling RCT
This paper investigates the short-run effects of an aspiration-raising intervention delivered as part of a randomized controlled trial among postgraduate students at a UK university during the Covid-19 pandemic. We document suggestive evidence, that a video-based role-modeling intervention led to an immediate increase in aspirations and a delayed increase in self-reported effort. However, both effects…
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Community Optometrist-Led Monitoring of Quiescent Neovascular Age-Related Macular Degeneration: The FENETRE Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this randomized clinical trial, community optometrist-led monitoring of quiescent nAMD was noninferior to hospital monitoring for detecting disease activity requiring treatment. These results provide evidence for its use in integrated clinical care models.
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Tumor-derived cell-free DNA detected in cerebrospinal fluid enables minimally invasive profiling of pediatric brain tumors
BACKGROUNDLiquid biopsy has emerged as a minimally invasive method for tumor diagnosis, monitoring, and therapeutic guidance. For CNS tumors, cerebrospinal fluid (CSF) provides a reliable and accessible source of tumor-derived cell-free DNA (ctDNA).METHODSThis study evaluates the clinical utility of CSF liquid biopsy in a real-world prospective setting. A total of 148 CSF samples from 120…
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Effectiveness of an online vaccine misinformation game for Arabic-speaking Australians: a randomized controlled trial
BACKGROUND: Vaccine misinformation can undermine vaccine confidence, institutional trust, and uptake. Arabic speakers in Australia are disproportionately susceptible to vaccine misinformation and have experienced adverse health outcomes. This randomized controlled trial tested the effectiveness of Cranky Uncle — Vaccine (Arabic), a gamified psychological inoculation intervention, in improving vaccine attitudes, misinformation discernment, and institutional trust among…
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Comparison of the Effects of Incubator and Radiant Environments on Physiological Criteria and Pain-Stress Levels during Heel Lance in Neonates in the Neonatal Intensive Care Unit: A Randomized Controlled Trial
CONCLUSION: Although body temperature increased significantly in the radiant heater environment compared with the incubator environment, this difference did not appear to play a vital role in affecting the physiological parameters of the newborn.
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Effect of a prior hypercapnia experience on recognition of hypercapnia in divers: a randomised controlled study
CONCLUSIONS: Although no significant training benefit was shown, becoming familiar with the sensations associated with hypercapnia under appropriate supervision could be useful to rebreather divers both recreationally and within occupational settings.
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Disease outcomes with ublituximab in treatment-naïve participants: subpopulation analyses of the phase 3 ULTIMATE I and II studies in participants with relapsing multiple sclerosis
CONCLUSIONS: Ublituximab was associated with significant treatment benefits at Week 96 in treatment-naïve participants and those receiving treatment within three years of symptom onset.
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Impact of a multiplex respiratory PCR panel on antibiotic stewardship in hospitalized pediatric pneumonia: a randomized clinical trial
CONCLUSION: Integrating FILMARRAY® into pediatric pneumonia clinical management did not significantly boost initial overall antibiotic modification rates. However, exploratory analysis showed it improved targeted antimicrobial adjustments and facilitated antibiotic de-escalation, suggesting FILMARRAY® may add value to antibiotic stewardship. Subsequent trials could substantiate this theoretical proposition.
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DEEP SELF-REGULATION METHOD: A HYPNOTHERAPEUTICAL AND COACHING APPROACH TO STRESS AND BURNOUT
CONCLUSION: The integration of hypnosuggestive interventions and algorithmic coaching within the proposed method is an effective alternative to traditional approaches, ensuring resistance to professional destruction.