Clinical Trials
Category Added in a WPeMatico Campaign
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Visual Acuity Screening By by School Teachers in Far West Nepal: A randomized trial of alternate screening models
Background Studies have not examined alternate school visual acuity screening methods in Nepal in terms of accuracy and cost. Objective To validate recent evidence from India of the effectiveness and cost of alternate school visual acuity screening models involving all class teachers (ACTs) versus a few selected teachers (STs). Method This was a prospective cluster…
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Behaviorally Informed Text Messaging to Promote Colon Cancer Screening: A Quality Improvement Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this quality improvement randomized clinical trial, a behaviorally informed text messaging strategy was associated with significantly improved FIT completion compared with usual nurse-led telephone outreach. Automated messaging may offer a scalable, low-cost strategy to promote preventive care and reduce staff burden in underserved populations.
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The Impact of Endoscopic Ultrasound and Multidisciplinary Team Evaluation on the Management of Pancreatic Cystic Lesions
CONCLUSION: While susceptible to cognitive bias, EUS significantly improves MDT assessment of PCL. MDT establishes a high bar for iterative additions of biomarkers to PCL analysis.
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Effect of the online Rethink My Drink alcohol intervention on alcohol use and cognition in older adults in Australia: a randomised controlled trial
BACKGROUND: Alcohol use is increasing among older adults and is associated with cognitive impairment and dementia. The efficacy of scalable approaches to reduce alcohol use and related harms in older adults has not been tested. This study aimed to evaluate the efficacy of an online alcohol intervention in reducing alcohol use and cognitive decline in…
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Efficacy of a simplified photobiomodulation protocol in orthodontic patients: a randomized crossover clinical trial
CONCLUSION: The study shows that photobiomodulation can help control orthodontic pain, being well accepted by participants and not extending clinical time. However, the analgesic effects are still limited, indicating the need to refine the protocol to enhance its effectiveness.
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The impact of muscle energy technique and aromatherapy on pain, disability, and sleep quality in office workers with nonspecific neck pain: randomized controlled study
CONCLUSION: This study provides evidence that both aromatherapy and muscle energy technique are safe and practical treatments, which are efficacious in the reduction of pain, disability, and sleep quality in nonspecific neck pain.
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Topical ROCK inhibition accelerates recovery after Descemetorhexis Without Endothelial Keratoplasty (DWEK) in Fuchs endothelial corneal dystrophy: a prospective comparative clinical trial
CONCLUSIONS: Adjunctive topical ripasudil after DWEK accelerates endothelial recovery, corneal deturgescence, and visual rehabilitation compared with DWEK alone, without compromising safety.
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The journey to diagnosis and care of functional neurological disorder (FND)
CONCLUSION: The findings emphasize the need for personalised and compassionate care for individuals suffering from FND, underpinned by increased service provision within the healthcare system.
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Effects of VIVIFRAIL intervention on multidimensional frailty in older nursing home residents: a randomised-controlled feasibility study
CONCLUSIONS: The VIVIFRAIL exercise program was determined to be feasible for older adults residing in nursing homes and significantly improved frailty status, health indicators, ADLs and QOL. These findings support the incorporation of structured exercise interventions as an essential component of routine care provided by health-care professionals in nursing home settings.
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Clinical efficacy of abdominal moxibustion at the Zhongji (CV3) in combination with Yiqi Tonglin Yangyin decoction and antibiotics for treating elderly female patients with complicated urinary tract infection
CONCLUSION: Abdominal moxibustion at the Zhongji (CV3), combined with Yiqi Tonglin Yangyin decoction and antibiotics for treating complicated urinary tract infections in elderly women, can effectively improve the clinical symptoms, TCM syndromes, and immune function of patients. Additionally, it can reduce oxidative stress, promote patient recovery, and lower the recurrence rate with pronounced comprehensive efficacy.