Clinical Trials
Category Added in a WPeMatico Campaign
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Randomized Controlled Trial on the Effects of Metacognitive Training (MCT) in a Sample of Patients With Recent Onset Psychosis: Study of the Impact on the Severity and Dimensions of Delusions, Self-Esteem and Depression
CONCLUSIONS: In recent-onset psychosis patients, MCT demonstrated the expected benefits in conviction, as ‘sowing seeds of doubt’ is the core MCT mechanism of change. Despite functioning differently, both interventions improved patients’ self-esteem. No superiority of MCT was discovered in self-esteem or depression in the short-term follow-up studied.
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Probiotics for chronic constipation: A randomized, prospective, placebo-controlled study
CONCLUSION: GutBio Plus is a safe and effective treatment for chronic constipation, offering significant symptom relief and an improved quality of life. The sustained benefits highlight its potential as a reliable alternative to conventional laxatives.
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Feasibility, acceptability and efficacy of a nurse-led palliative care health coaching intervention (Educate, Nurture, Advise before Life Ends) for patients with heart failure and their caregivers in Singapore: a randomised wait-list controlled pilot study of health coaching in Asian heart failure
CONCLUSIONS: Proportion of participants who completed health coaching was high, though proportion of approached participants who consented was lower than expected. Our acceptability and efficacy targets were met. Further phase III testing is planned.
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Effects of music-based occupational therapy activities on attention executive functions in children with attention deficit and hyperactivity disorder
CONCLUSION: Overall, music-based occupational therapy activities demonstrated positive effects on attention levels, executive functions, and caregiver burden in children with ADHD. Future studies are encouraged to incorporate a broader range of musical instruments into occupational therapy intervention plans, aligned with specific therapeutic goals. It is considered important for therapists to develop strategies that tailor the…
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Effect of Subanesthetic Doses of Esketamine on Early Postoperative Pain Sensitivity in Patients Undergoing Salpingectomy: A Randomized Clinical Trial
CONCLUSION: Perioperative subanesthetic esketamine may provide modest improvement in early postoperative pain sensitivity, and may serve as a useful adjunct in multimodal postoperative analgesia for emergency laparoscopic salpingectomy.
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Effectiveness of intensive community care services for adolescents with acute psychiatric emergencies: findings from a feasibility multi-centre, parallel-group, single-blinded RCT
CONCLUSIONS: No definitive conclusions can be drawn from this study. Preliminary results suggest that Intensive Community Care Services may support a faster return to education, employment or training than treatment as usual. Intensive Community Care Services may be cost-effective compared to treatment as usual. Additional mental health professionals should be deployed to Intensive Community Care…
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Effect of Household Air Pollution on the Gut Microbiome and Virome of Adult Women Living in Uganda
BACKGROUND: Emerging observational studies suggest that air pollution can influence the gut microbiome. However, this association is often highly confounded by factors, such as diet and poverty. The gut virome may influence respiratory health independent of the gut microbiome. We recently demonstrated in a randomized waitlist-controlled trial (ClinicalTrials.gov NCT03351504) that a clean lighting intervention reduced…
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Effects of Tai Chi combined with dietary intervention on health-promoting lifestyle and metabolic and reproductive outcomes in female college students with polycystic ovary syndrome: a randomized controlled trial
INTRODUCTION: Polycystic ovary syndrome (PCOS) affects 5-20% of adolescent females worldwide, yet scalable non-pharmacological interventions remain scarce. Tai Chi, a traditional Chinese mind-body exercise, may address the complex metabolic, reproductive, and psychosocial dimensions of PCOS, but robust randomized controlled trial evidence is lacking.
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Influence of rhythmic music game intervention on executive function and sensorimotor ability of children with attention deficit hyperactivity disorder
CONCLUSION: Rhythmic music game intervention effectively enhances inhibitory control, cognitive flexibility, and sensorimotor coordination in children with ADHD. Given its engaging nature and accessibility, it holds promise as a valuable component within multidisciplinary intervention strategies, offering a practical approach to supporting the healthy development of children with ADHD.
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Susceptibility-Guided Versus Empirical Therapy for Helicobacter pylori Infection in a High Resistance Setting: A Randomised Controlled Trial
Clarithromycin resistance is a major determinant of treatment failure, and the benefits of susceptibility-guided therapy in high-resistance settings remains incompletely understood. To evaluate the clinical effectiveness of the susceptibility-guided compared with the empirical therapy in treatment-naïve H. pylori infection in a high resistance setting. In this single-centre, randomised, superiority trial, 500 treatment-naïve adults were allocated…