Clinical Trials
Category Added in a WPeMatico Campaign
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Antithrombotic strategy according to age in patients with atrial fibrillation and drug-eluting stents: a post hoc analysis of the ADAPT AF-DES randomised trial
CONCLUSIONS: In this post hoc analysis, NOAC monotherapy was associated with a lower risk of net adverse clinical events, specifically within the older age subgroup. Tailored approach regarding age and individual ischaemic risk may be needed.
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The Effect of Transpulmonary Pressure-Guided Positive End-Expiratory Pressure Titration on Pulmonary Arterial Compliance in Acute Respiratory Distress Syndrome Patients: A Single-Center, Randomized Controlled Pilot Pathophysiological Study
CONCLUSIONS: Ptp-guided PEEP titration was superior to traditional lung-protective ventilation in maintaining a higher Cpa and preserving right ventricular function in patients with moderate-to-severe ARDS caused by pneumonia.
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Effects of vitamin D supplementation on insulin resistance and lipid metabolic profiles in women with gestational diabetes mellitus: A randomized controlled trial
Gestational diabetes mellitus (GDM) commonly presents as insulin resistance and altered lipid metabolism, with evidence linking vitamin D deficiency to its pathogenesis. In this randomized, double-blind, placebo-controlled trial, 120 pregnant women diagnosed with GDM were assigned to receive either vitamin D3 supplements (2000 IU/day) or a placebo for 3 months. Serum vitamin D status, glycemic…
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Evaluation of microscopically quantitative loads of bacilli as early predictors of TB treatment outcome
BACKGROUNDTwo-month smear conversion has been adopted instead of cultures to predict unfavourable bacteriological outcomes in TB treatment. However, this approach is limited by lower sensitivity and specificity.OBJECTIVEIn absence of early-stage biomarkers of treatment response, we investigated the association between bacteriological outcome and microscopy data with auramine and fluorescein diacetate stains at baseline and during the…
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Exploring patient and NHS staff acceptability of artificial intelligence-supported surgical wound monitoring within the WISDOM feasibility study: a multi-centre qualitative interview study
CONCLUSION: AI-supported digital surgical wound monitoring appeared acceptable to participants within this feasibility study. Further research is needed to evaluate implementation in broader settings.
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Safety and feasibility of tumor treating fields initiated before and during radiotherapy for newly diagnosed glioblastoma: results from the Arm A feasibility cohort of a phase I/II trial (PriCoTTF)
CONCLUSIONS: Initiation of TTFields before and during radiotherapy was feasible and was not associated with protocol-defined treatment-limiting toxicity in the Arm A cohort. Because the TLT definition was narrow and efficacy analyses were exploratory and exposure-conditioned, these findings should be interpreted as feasibility data rather than evidence of improved tumor control or survival. The results…
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Racial outcomes in patients with diabetic cardiomyopathy treated with an aldose reductase inhibitor: the ARISE-HF trial
CONCLUSION: Black and Hispanic participants with DbCM experienced faster disease progression, with black participants showing the most pronounced functional and quality of life declines. The effect of AT-001 on peak VO(2) changes was not statistically significant with similar effects between racial and ethnic groups (NCT04083339).
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Application of gastric tube removal strategy based on the combination of Gugging Swallowing Screen (GUSS) and National Institutes of Health Stroke Scale (NIHSS) scores in patients following acute stroke: A randomized controlled trial
CONCLUSION: An NIHSS score < 15 and a GUSS score ≥ 15 can be used to approve the removal of a gastric tube from acute stroke patients; this represents a reliable and safe strategy that reduces the risk of adverse events.
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Mechanical vs. sutureless aortic valve replacement: clinical outcomes and the contribution of preoperative multislice CT
CONCLUSION: Preoperative computed tomography is a reliable tool for planning AVR. Sutureless biological valves provide shorter cross-clamp and bypass times and favourable haemodynamic performance, whereas mechanical valves are more often associated with smaller valve sizes and longer procedures. Early postoperative outcomes were comparable between groups.
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The effect of mindfulness-based cognitive therapy on non-suicidal self-injury in hospitalized adolescents with depressive disorders: a randomized controlled trial
CONCLUSIONS: MBCT-A is effective in reducing NSSI behavior and improving mindfulness, emotion regulation, and depressive symptoms among adolescents with depressive disorder and NSSI. These findings support the clinical application of MBCT-A for this high-risk population.