Clinical Trials
Category Added in a WPeMatico Campaign
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Short-term structured dietary and exercise interventions delay diabetes onset in prediabetic patients: a prospective quasi-experimental study
CONCLUSIONS: Short-term intervention with SAIDEs exhibited significant anti-inflammatory activity and reduced the prevalence of abnormal blood glucose markers. These benefits persisted even after 6 months of follow-up. However, over the 8-year follow-up period, intensive SAIDEs did not reduce diabetes incidence among prediabetic patients but did delay its onset.
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Ecological Momentary Assessment versus Weekly Questionnaire Assessment of Change in Depression
CONCLUSIONS: Although clinical interviews, questionnaires, and EMA outcomes are related, they assess changes in depression differently. EMA may be more sensitive to intervention effects, but all three methods harbor potential bias, raising validity and reliability questions. Therefore, to enhance the validity and reliability of clinical trial assessments, we emphasize the importance of EMA approaches that…
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Factorial design study of self-management using Dnurse App in T2DM patients
CONCLUSIONS: The diabetes APP has a tendency to improve the HbA(1c) compliance rate of T2DM patients. The APP can help reduce patients’ BP, and patients have a high satisfaction evaluation of the APP. Therefore, the study supports the use of the APP for self-management in people with type 2 diabetes.
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Point of care v/s central lab automated blood culture system in decreasing antibiotic usage in NICU: A randomized controlled trial
BackgroundAntibiotic usage is rampant in NICUs. The time of stoppage of antibiotics depends predominantly on clinical condition of the neonate and final blood culture report. Delay in availability of report due to lab logistics might delay the stoppage of antibiotic. Hence, we hypothesized that having a point of care BACTEC system in NICU premises might…
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Evaluation of a novel elbow joint torque measurement device in healthy subjects and stroke patients: a randomized trial
Current clinical practice lacks quantitative assessment methods for elbow joint movements. In response to existing research limitations, this study introduces the innovative elbow joint torque measurement device (EJTMD), which concurrently measures muscle strength and active range of motion (AROM) using a five-bar linkage system governed by a sliding mode control algorithm. Healthy subjects (n =…
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Comparing Effects of Caffeine and Total Motion Release Technique on Cognitive, Neuromuscular, and Anaerobic Function in Semi-Professional Male Sprinters: A Randomized Controlled Trial
BACKGROUND AND PURPOSE: As sprinting gains popularity, enhancing anaerobic capacity, neuromuscular function, and cognitive performance is crucial. This study evaluated the effects of Total Motion Release (TMR) and caffeine on these functions in male sprinters to optimize performance strategies.
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Indirect calorimetry and nitrogen balance guided nutrition therapy in ICU patients with acute kidney injury
Data on the benefits of early integration of indirect calorimetry (IC) for caloric guidance and maintaining a positive nitrogen balance in critically ill patients with acute kidney injury (AKI) are scarce. This study aimed to evaluate the impact of the nutritional therapeutic approach on mortality and renal outcomes in these patients. We conducted an open-label…
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Symptom Attribution, Help Seeking and Willingness to Undergo Diagnostic Investigations for Bowel Cancer Symptoms in People With Anxiety and/or Depression-A Vignette Study
CONCLUSIONS: People with A/D should be encouraged to take bodily changes typical of cancer seriously and be proactive in help seeking and taking tests. Clinicians need to be aware that people with A/D may misattribute bodily changes associated with cancer and support them to seek help and undergo testing.
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Measuring cognitive change in secondary progressive MS: an analysis of the ASCEND cognition substudy
CONCLUSIONS: Improvements in SDMT and PASAT performance were observed regardless of treatment arm. These findings are consistent with prior studies in MS. As it is unlikely that cognition improves over time in people with a chronic neurologic disease, these results support the need for cognitive outcomes that overcome practice and learning effects to accurately quantify…
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Effects of Pomegranate Extract on Inflammatory Markers and Cardiometabolic Risk Factors in Adults Aged 55-70 Years: A Randomised Controlled Parallel Trial
Background: Chronic inflammation increases morbidity in older adults and significantly impacts healthy ageing. Pomegranate extract (PE), rich in polyphenols, has been suggested to reduce inflammation and could prevent cardiovascular disease. However, there is limited research examining the potential of PE in disease prevention in ageing. Methods: A two-arm double-blind parallel trial was conducted, in which…