Clinical Trials
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Efficacy of photobiomodulation for the prevention and treatment of chemotherapy-induced oral mucositis in pediatric patients with hematologic cancers: a randomized clinical trial
CONCLUSION: PBM appears to be a safe and effective approach for the prevention of MTX-induced OM in pediatric patients with hematologic cancers. Additionally, PDT using ICG and a low-level laser demonstrates promising results in treating OM lesions. Therefore, these findings highlight the efficacy of PBM for managing MTX-induced OM in this patient group.
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Prognostic value of plasma biomarkers for informing clinical trial design in mild-to-moderate Alzheimer’s disease
CONCLUSIONS: Elevated baseline plasma NfL predicted more rapid clinical decline and MRI volume loss. Furthermore, increasing plasma NfL concentration over time was associated with worsening on the CDR-SB. Plasma NfL is an easily accessible biomarker that may enhance the design of clinical trials in mild-to-moderate AD.
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The effect of collagen sponge placed in the socket after surgical extraction of mandibular third molars on the incidence of alveolar osteitis: a split mouth randomized controlled trial
CONCLUSION: Intra-alveolar application of collagen sponge following surgical extraction of IL3rdM significantly reduced post-operative pain on days 3 and 7. Moreover, it can minimally decrease the incidence of AO.
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Efficacy of Adjunctive Cariprazine on Anxiety Symptoms in Patients With Major Depressive Disorder: Post Hoc Analysis of a Randomized Placebo-Controlled Trial
Objective: To evaluate the effects of adjunctive cariprazine on anxiety symptoms in adults with a DSM-5 diagnosis of major depressive disorder (MDD) and inadequate response to antidepressant therapy (ADT).
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Modified Borg Scale (mBorg), the Numerical Rating Scale (NRS), and the Dyspnea- 12 Scale (D- 12): cross-scale comparison assessing the development of dyspnea in early-stage lung cancer patients
CONCLUSION: This study highlights interscale concordance and key contributors to breathlessness in operable early-stage lung cancer patients. All three scales validly measure dyspnea, with the D-12 and NRS offering a holistic assessment by including affective-dyspnea scores.
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Trial and Participant Characteristics of a Home-Visiting Diabetes Intervention: The Together Overcoming Diabetes Study
Background: American Indians (AIs) endure the most severe health inequities in the nation, including disproportionately high rates of Type 2 diabetes (T2D). We describe baseline characteristics for AI participants enrolled in a culturally grounded, intergenerational, home-based T2D preventive intervention called Together Overcoming Diabetes (TOD). Methods: This community-based participatory research collaboration between five tribal nations and…
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Weight loss in MASLD restores the balance of liver fatty acid sources
BACKGROUNDLipogenesis contributes substantially to the pathological accumulation of intrahepatic triacylglycerol (IHTG) in metabolic dysfunction-associated steatotic liver disease (MASLD). Since hepatic lipogenesis is highly sensitive to energy intake, we hypothesized that mechanisms of MASLD regression induced by weight loss would be driven by a marked reduction in the lipogenic pathway.METHODSOverweight adults with high liver fat (HighLF;…
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Evaluation of scoring systems and hematological parameters in the severity stratification of early-phase acute pancreatitis
CONCLUSION: Independent risk factors for developing SAP include CRP(48), Ca^(2+), and PNI(48). CTSI, BISAP, and the combination of PNI(48) and the Ranson score can act as reliable predictors of SAP.
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Efficacy of acupuncture at pain-sensitive acupoints for diarrhoea-predominant irritable bowel syndrome (IBS-D): protocol of a multicentre, randomised, sham-controlled trial
INTRODUCTION: While recent research suggests that acupuncture may offer benefits to individuals with diarrhoea-predominant irritable bowel syndrome (IBS-D), high-quality studies are scarce in this area. We intend to investigate the efficacy and safety of individualised sensitised acupuncture in IBS-D.
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A prospective study comparing sleep quality using Pittsburgh Sleep Quality Index at 8 weeks after robotic-assisted versus conventional total knee arthroplasty: a single-center study
Total knee arthroplasty (TKA) is crucial for alleviating pain and improving the quality of life in patients with end-stage knee arthritis. Postoperative sleep disturbances are common and can persist for months following the surgery, potentially hindering the overall rehabilitation process and the quality of life. Robotic-assisted TKA (RATKA) offers greater precision and less invasiveness than…