Clinical Trials
Category Added in a WPeMatico Campaign
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3D-Printed anterior repositioning splint versus stabilization splint for patients with anterior disc displacement with reduction: A randomized cross-over clinical trial
CONCLUSION: Within the limitations of this study, both splints are considered reliable treatment options for patients with anterior disc displacement. The ARS initially demonstrated a greater improvement in pain compared to the SS. However, after the 3-month follow-up period, no significant difference was observed between the two splints.
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The efficacy of methylprednisolone acetate nanogel in treating patients with sudden sensorineural hearing loss
Intratympanic injection of methylprednisolone acetate is considered to be one of the effective drugs in the treatment of sudden sensorineural hearing loss. In this study, the efficacy of intratympanic injection of methylprednisolone acetate nanogel in patients with sudden sensorineural hearing loss was investigated. It is a double-blind randomized clinical trial in one of Iran’s hospitals.…
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Immediate effect of ice and dry massage during rest breaks on recovery in MMA fighters : a randomized crossover clinical trial study
The MMA fight consists of 5 rounds of 5 min with minimal breaks between the rounds. The exertion load is excessive for the fighters, and the 1-minute breaks give little time for any intervention. This study aimed to examine the acute effects of two methods of regenerative strategies, ice massage and dry massage, and analyze…
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Selective removal of dental caries in permanent teeth: an 18-month clinical trial
CONCLUSION: SRCT was clinically effective in both mid-depth (D2) and deep (D3) lesions, addressing pulp sensitivity and restoration quality. In D3 lesions, it minimized the risk of pulp exposure while preserving dentin integrity, while in D2 lesions, it preserved tooth structure without compromising restoration performance.
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Mitomycin C augmented canalicular silicone intubation versus external dacryocystorhinostomy in primary acquired nasolacrimal duct obstruction: a retrospective study
CONCLUSION: Silicon intubation with MMC is comparable to external DCR in terms of safety and efficacy, with the advantage of being a less invasive procedure, more accessible with a shorter learning curve, and shorter operative time in primary acquired NLDO.
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Tooth sensitivity and whitening effect of an in-office bleaching gel containing 2% sodium fluoride: a randomized triple-blind clinical trial
CONCLUSIONS: The incorporation of 2% NaF into the bleaching gel significantly reduced cold sensitivity after 90d, with no detrimental effects on whitening effectiveness. (IRCT20200906048639N1) CLINICAL RELEVANCE: The in-office bleaching gel containing 2% NaF did not demonstrate a beneficial impact on BS. Nonetheless, it did not negatively affect the results of tooth whitening.
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Randomized controlled trial on the efficacy and safety of the combination therapy of topical 0.1% finasteride — 5% Minoxidil in male androgenetic alopecia
Current FDA-approved treatments for androgenetic alopecia (AGA) are oral finasteride and topical minoxidil. Topical finasteride offers a potential alternative with similar efficacy and fewer systemic side effects. This study evaluated the effectiveness and safety of combining topical finasteride and minoxidil for male AGA. This 12-week randomized controlled trial divided subjects into two groups which are…
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Therapeutic benefits of acupoint massage at Yuji (LU10) and Zhaohai (KI6) for postoperative hoarseness in thyroid surgery patients
CONCLUSION: Early postoperative acupoint massage stimulation of thenar and Zhaohai points is conducive to the recovery of patients with hoarseness after thyroid surgery, improve the quality of patients’ voice, and effectively promote the rehabilitation of voice.
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Risk expression using likelihood ratios and natural frequencies in Bayesian inference tasks-a preregistered randomized-controlled crossover trial
CONCLUSION: Teaching Odds/LR next to natural frequencies potentially improves medical students’ understanding of PPV and may enhance their ability to make future diagnostic decisions.
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The efficacy of an online exercise intervention for improving depressive symptoms among patients with subthreshold depression in primary care: protocol for a randomized controlled trial
BACKGROUND: Subthreshold depression is common in primary care and is associated with significant healthcare burden. There is emerging evidence for the benefits of Exercise can reduce depressive symptoms among people with diagnosed depression, but there is limited evidence for subthreshold depression in primary care setting. This study aims to examine the efficacy of a 12-week…