Category Added in a WPeMatico Campaign
CONCLUSION: A 10-min isometric core stabilisation exercise results in local lumbar EIH, while no systemic effects are observed. A higher degree of catastrophizing is associated with lower hypoalgesic responses.
BACKGROUND: Children in out-of-home care constitute a vulnerable population often experiencing mental health challenges related to early adversity and placement disruptions. The Circle of Security Parenting program^(®) (COS-P) is an attachment-based intervention designed to enhance carer sensitivity and reflective competence, ultimately improving the quality of carer-child relationships.
This trial aimed to identify the effects of providing pharmacogenomic (PGx) results and recommendations for patients with chronic pain treated in primary care practices compared to standard care. An open-label, prospective, largely virtual, type-2 hybrid effectiveness trial randomized participants to PGx or standard care arms. Adults with pain ≥ 3 months who were treated with…
In myelodysplastic syndromes (MDS), cytogenetic characteristics of the malignant bone marrow cells influence the clinical course. The aim of this study was to evaluate whether cytogenetics is useful to predict outcome and response in patients with del(5q) under azacitidine (AZA) ± lenalidomide (LEN) therapy. We therefore performed comprehensive cytogenetic analyses in MDS patients with del(5q)…
This study examined whether an emotion socialisation parenting program, Tuning in to Toddlers (TOTS), contributed to observed improvements in mother-toddler emotional availability. Parents of toddlers aged 18-36 months were recruited through childcare centres and maternal child health centres in Melbourne, Australia and were allocated to either an intervention or a waitlist control condition in a…
CONCLUSION: Reduced glutathione combined with entecavir significantly improves liver function, reduces liver fibrosis, and enhances HBV-DNA clearance in chronic hepatitis B patients without increasing adverse reactions.
CONCLUSION: Cicaglocal can enhance wound healing and lead to improved clinical outcomes following Mohs micrographic surgery.
CONCLUSION: This study presents a novel surgical endoscopy technique for closing direct medial inguinal hernia defects and provides anatomical feasibility. The advantages of the technique include preventing seromas and severe postoperative pain. Further randomized studies are warranted to assess long-term results of this technique and establish clinical indications for its use in surgical practice.
CONCLUSIONS: Olaparib does not have sufficient single-agent activity to warrant further development in IDH-mutant CCA. However, a subgroup of patients demonstrated CB, and exploratory analysis revealed this subgroup to be enriched for lower baseline 2-HG levels. Future clinical trials leveraging the HRD properties of IDH mutations are warranted with enhanced patient selection and novel combination…
CONCLUSION: Alemtuzumab was feasible to administer in adults with ALL receiving intensive chemotherapy, but was without evidence of benefit.