Clinical Trials
Category Added in a WPeMatico Campaign
-
Akita Japan population-based colonoscopy screening trial: report of initial colonoscopy
CONCLUSIONS: Adequate performance in compliance, ADR, and safety was confirmed in the intervention arm of the RCT evaluating the efficacy of screening colonoscopy. The high quality of screening colonoscopy observed in the trial suggests its feasibility as a population-based screening approach.
-
Effect of drama-education for alcohol/substance user on attitudes toward violence against women: randomized controlled design
CONCLUSION: The findings suggest that creative drama education may have a beneficial effect on improving attitudes toward VAW among men with alcohol and substance use disorders. Further studies with larger and more diverse samples are recommended to confirm the generalizability and long-term impact of this approach.
-
Effects of an interprofessional care concept in nursing homes evaluated in the SaarPHIR project: A cluster-randomized controlled trial
CONCLUSION: All-cause hospitalization was not significantly affected in the relatively short duration of the intervention. Nevertheless, secondary outcomes suggest some positive effects for the intervention group. However, participation in the intervention group was lower than expected at both the nursing home and resident levels, limiting the validity of the results.
-
Anaerobutyricum soehngenii improves glycemic control and other markers of cardio-metabolic health in adults at risk of type 2 diabetes
Anaerobutyricum soehngenii (previously Eubacterium hallii) is a butyrate-producing next-generation beneficial microbe generally recognized as safe. Several short-term intervention trials by A. soehngenii L2-7 have shown improvement of insulin sensitivity in prediabetic subjects and type 2 diabetes patients. To determine the long-term cardiometabolic benefits and safety, we performed a 3-month double-blind, randomized placebo-controlled intervention in 98…
-
Comparison of two maneuvers to identify Carnett’s sign in patients with chronic abdominal pain. Randomized controlled clinical trial
CONCLUSION: The two ways of exploring the Carnett sign have similar efficacy. Infiltration with 2% lidocaine produced rapid and significant improvement of pain with minimal side effects. Not knowing the Carnett sign increases health costs.
-
Non-Inferiority of Subcutaneous Efepoetin Alfa Compared to Methoxy Polyethylene Glycol-Epoetin Beta in Stage 3 or 4 CKD Patients: Insights From a Phase 3 Trial
CONCLUSION: Efepoetin alfa demonstrated non-inferiority to methoxy polyethylene glycol-epoetin beta in correcting anaemia and maintaining haemoglobin (Hb) levels among stage 3 and 4 CKD patients. Moreover, the safety profile of efepoetin alfa was comparable to methoxy polyethylene glycol-epoetin beta.
-
Molecular characterization and predictors of relapse in patients with Ph + ALL after frontline ponatinib and blinatumomab
CONCLUSIONS: WBC ≥ 70 × 10⁹/L is a high-risk feature in patients with Ph + ALL receiving frontline blinatumomab and ponatinib and may supersede the prognostic importance of baseline molecular features. Alternative frontline treatment strategies may be needed for these patients to reduce the risk of relapse and improve long-term outcomes.
-
Synergistic Enhancement of Compromised Skin Radiance: A Clinical Investigation of Prinsepia utilis Royle Polysaccharides and Nonapeptide Co-Application
CONCLUSION: PCA analysis revealed PUR9-2 uniquely modulated gene expression compared to PURP and EQ9. Functional enrichment analysis based on Gene Ontology (GO) demonstrated PUR9-2 restored UVA-suppressed TNFAIP3 and CRNN gene. The results of RT-PCR also indicated that PUR9-2 enhanced skin barrier integrity in 3D models via upregulated expression of FLG, LOR, and DSG1. The Chou-Talalay…
-
Transdiagnostic Cognitive Remediation Therapy for Patients with Eating Disorders: A Randomized Controlled Trial
Background/Objectives: Eating disorders (EDs) are associated with cognitive inefficiencies related to cognitive flexibility, central coherence, and inhibition. Transdiagnostic cognitive remediation therapy (TCRT) is a new adaption of cognitive remediation therapy aimed at addressing these difficulties across ED diagnoses. This study investigates the effects of TCRT as an adjunctive treatment for patients with EDs on cognitive…
-
Comparison of extrafine and non-extrafine inhaled corticosteroids/long-acting beta2-agonists as maintenance and reliever therapy in asthma: a randomized open-label crossover trial
CONCLUSION: Our study demonstrated that extrafine ICS treatment provided no significant advantage over non-extrafine ICS in improving small airway obstruction or overall asthma control in moderate asthma. This suggests that factors other than particle size may contribute to treatment outcomes.