Clinical Trials
Category Added in a WPeMatico Campaign
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Effectiveness of Self-etching Adhesive Only Versus in Combination with Gluma Desensitizer for Preventing Post-composite Sensitivity — A Prospective Study
CONCLUSION: Subjects belonging to the Gluma desensitizer group reported a statistically significant reduction in postoperative sensitivity to air blast stimuli, following composite restoration, at both 1 week and 1 month follow-up.
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Short-Term Effects of Kinesio Taping on Pain and Functionality in Patients With Cervical Spine Surgery
CONCLUSION: Integrating KT into a CR programme during the early postoperative phase of cervical spine surgery may improve clinical outcomes, specifically in pain intensity, PPT, disability levels and emotional components. However, the addition of KT to the CR programme does not appear to provide any meaningful benefits in terms of functionality compared to the CR…
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Interventional arterial chemotherapy versus sorafenib for advanced hepatocellular carcinoma in China: a health economic evaluation of open-label, randomised, phase 3 study
CONCLUSIONS: HAIC-FO is a more cost-effective treatment for advanced HCC than sorafenib from the Chinese payer’s perspective, particularly in patients with Vp4 PVTT and/or high tumour burden. Further research is needed to explore long-term economic implications and real-world effectiveness data.
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Twenty-year outcomes after repeat doses of antenatal corticosteroids prior to 32 weeks’ gestation: Follow-up of a randomised clinical trial
CONCLUSIONS: In this follow-up of a randomised clinical trial, our data suggest neither major harm nor benefit for the offspring in early adulthood following exposure to repeat dose(s) of antenatal corticosteroids compared with a single course prior to 32 weeks’ gestation. Smaller effects cannot be excluded and follow-up of adult offspring from other trials of…
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Impact of maintenance treatment on male gonadal function in patients treated for localized rhabdomyosarcoma in RMS2005 trial in France
CONCLUSIONS: Oral-CPM induces additional gonadal damage to the ifosfamide-based induction regimen. Fertility preservation could be considered in patients exposed to maintenance, especially those >5 years old and exposed to ≥12 months of oral-CPM.
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Investigation of the Effectiveness of Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) and Vestibular Rehabilitation in Patients with Unilateral Vestibular Hypofunction
Background: Vagus nerve stimulation (VNS) is a frequently used neuromodulation method in recent years. While the mechanism of improvement in diseases such as epilepsy, dementia, and depression is being studied, its potential effect on vestibular dysfunction is also being investigated. The aim of our study was to investigate the effect of transcutaneous auricular VNS (taVNS)…
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Core Exercise as Non-Pharmacological Strategy for Improving Metabolic Health in Prediabetic Women
Background and Objectives: Prediabetes (PD) is characterized by impaired glucose metabolism and is associated with an elevated risk of type 2 diabetes and cardiovascular diseases. This study aimed to investigate the effects of an 8-week core exercise intervention on glycemic control, lipid profiles, insulin sensitivity, body composition, and physical performance in prediabetic women. Materials and…
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Effect of Inspiratory Plus Expiratory Neuromuscular Electrical Stimulation on Diastasis Recti Abdominis in Postpartum
CONCLUSION: The addition of inspiratory plus expiratory neuromuscular electrical stimulation to conventional postpartum rehabilitation significantly improves outcomes in patients with postpartum DRA. Overall, these findings provide evidence for a novel therapeutic approach that targets both abdominal muscle function and respiratory mechanics, offering a promising direction for the management of DRA in postpartum women.
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Effectiveness of a Health Education Program to Reduce Recurrence of Stroke by Controlling Modifiable Risk Factors in a Specialized Hospital in Bangladesh: Randomized Controlled Trial
CONCLUSIONS: This study failed to demonstrate the effectiveness of health education in reducing recurrence, death, and stroke-related adverse events. However, health education enhanced medication adherence. Some causes of death could not be diagnosed due to inadequate health care systems. Further research with diagnostic facilities and a long observation period is necessary to explore the underlying…
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Treatment of Intractable Cancer Pain with Resiniferatoxin — An Interim Study
CONCLUSIONS: Intrathecal RTX is a single-administration, opioid-sparing analgesic in patients with intractable cancer pain. There were expected and unexpected AEs of various grades with an encouraging initial impact on pain. (Funded by the Intramural Research Program of the National Institutes of Health Clinical Center and others; ClinicalTrials.gov number, NCT00804154).