Clinical Trials
Category Added in a WPeMatico Campaign
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Implementation of Site-Specific Hepatitis C Virus Treatment Workflows for Vulnerable, High-Risk Populations: A Prospective Single-Arm Trial
CONCLUSIONS: We identified gaps along the HCV care cascade between: (1) enrolled to prescribed treatment and (2) completed treatment to assessed for cure. Site-specific HCV treatment workflows were insufficient to engage participants in care and avoid treatment delays. Novel approaches are needed and these may include patient outreach, patient navigation, test-and-treat protocols, and removing financial…
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Electrocardiometry for the Management of Pediatric Septic Shock: A Pilot Randomized Controlled Trial
CONCLUSIONS: Advanced hemodynamic monitoring with electrocardiometry along with clinical assessment led to a restrictive fluid strategy in addition to minimizing the risk of fluid overload.
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Randomized controlled trial evaluating the benefit of the app-based clinical decision support system for the management of venous thromboembolism
CONCLUSIONS: App-based CDSS (DECIDE-COAG^(®)) demonstrates a significant improvement in the accuracy of anticoagulant prescriptions and VTE management. Further studies that specifically investigate the clinical benefits of app-based CDSS in real-world clinical practice are warranted.
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The effect of music on patient anxiety undergoing bronchoscopy: a randomized controlled trial
CONCLUSION: The music improved comfort level of patients undergoing bronchoscopy.
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The effect of a social network-based intervention to promote HIV testing and linkage to HIV services among fishermen in Kenya: a cluster-randomised trial
BACKGROUND: In sub-Saharan Africa, highly mobile men such as fishermen have a low uptake of HIV testing, prevention, and treatment. This study aimed to examine whether a HIV status-neutral, social network-based intervention could improve testing and linkage to prevention and treatment among fishermen in Kenya.
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Comparison of Effectiveness Between Protein and BCAA in Late Evening Snack on Vietnamese Liver Cirrhotic Outpatients: a Randomized Clinical Trial
CONCLUSIONS: A protein snack is an effective dietary intervention in improving albumin, biochemical parameters, and nutritional status for compensated liver cirrhosis outpatients. Considering cost, availability, and taste, a BCAA snack might be unnecessary for liver cirrhosis outpatients.
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Impact of Various Doses of Dobutamine on Myocardial Viability and the Effects of β-Blockers in Patients With Ischemic Cardiomyopathy: An Assessment Using Stress Echocardiography
CONCLUSION: Moderate-dose DSE exhibited the optimal diagnostic performance in assessing myocardial viability in patients with ICM. Furthermore, the use of β-blockers effectively enhances the sensitivity and accuracy of the diagnosis, providing important practical guidance for the clinical evaluation of myocardial viability.
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Efficacy of Low-Dose Fluconazole for Primary Prophylaxis of Invasive Candida Infections in Patients With Acute Leukemia: A Double-Blind Randomized Clinical Trial
CONCLUSION: Low-dose fluconazole is an effective alternative to high-dose regimens for preventing Candida infections in acute leukemia patients, with similar efficacy and safety. The rising threat of aspergillosis highlights the need for targeted prophylaxis. Further research is needed to refine strategies for high-risk patients.
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Exploring trauma-informed prenatal care preferences through diverse pregnant voices
CONCLUSIONS: Patient preferences identified by this study underscore the need for prenatal care to address the psychological health needs of pregnant patients to deliver high quality, comprehensive prenatal care that is trauma-informed and culturally-responsive.
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Comparison of ezetimibe and atorvastatin versus atorvastatin alone on short-term major adverse cardiac events after percutaneous coronary intervention, a double-blind placebo-controlled randomized clinical trial
CONCLUSION: Although adding ezetimibe to atorvastatin can decrease LDL and hs-CRP levels in short-term follow-up; it is not effective in lowering short-term major cardiovascular events in patients after PCI. Studies with longer-term follow-up are recommended.