Clinical Trials
Category Added in a WPeMatico Campaign
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Cuff leak test and airway obstruction in mechanically ventilated ICU patients (COSMIC): a pilot feasibility randomized controlled trial protocol
INTRODUCTION: The cuff leak test (CLT) is hypothesised to help optimise extubation by assessing for laryngeal oedema which, if unrecognised and untreated, could lead to post-extubation stridor, post-extubation airway obstruction, and reintubation. However, the diagnostic accuracy of the CLT to detect post-extubation stridor (and hence potentially airway obstruction) remains uncertain. Given the equipoise that exists…
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Cost-Effectiveness of an Interdisciplinary, Internet-Based Transgender Health Care Program in Germany: Economic Evaluation Alongside a Randomized Controlled Trial
CONCLUSIONS: From a societal perspective, i²TransHealth was unlikely to be cost-effective, even at high WTP per additional QALY. However, the comparison of i²TransHealth with a waiting list could have led to a distortion of the results with regard to health care service usage. When considering additional reliable improvement on the BSI-18 GSI as health effect…
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First-in-human phase 1 study of KHK2455 monotherapy and in combination with mogamulizumab in patients with advanced solid tumors
CONCLUSIONS: KHK2455 + mogamulizumab was safe and well tolerated with manageable toxicities, and resulted in dose-dependent suppression of IDO1 activity; signals of antitumor activity were observed.
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An examination of imaging findings in patients with clinically diagnosed gluteal tendinopathy: a secondary analysis of a randomised clinical trial
CONCLUSION: In a clinical trial of people with GT, a substantial number of participants had multiple tendons affected, as well as concomitant tendon tears and calcification. MRI detected changes were not associated with levels of pain, function or disability.
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A Resilience-Disclosure Intervention for Managing Stigmatised North Korean Refugee Identity: A Quasi-Randomised Controlled Trial
North Korean refugee (NKR) undergraduate students in South Korean universities often conceal their NKR identity to mitigate discrimination, a strategy that can impede social connection and access to vital resources for college adjustment. This study evaluates the effectiveness of a resilience-disclosure intervention designed to encourage strategic identity management over complete concealment. In a quasi-randomised controlled…
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Efficacy and safety of combined loratadine and mometasone furoate therapy in allergic rhinitis patients
CONCLUSION: The combination of loratadine and mometasone furoate effectively alleviates clinical symptoms in patients with allergic rhinitis while demonstrating a favorable safety profile, making it a promising option for clinical use.
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Long-term Progressive Improvement of Atopic Dermatitis by an Herbal Emollient Plus Combination in a 12-week Clinical Trial
Atopic dermatitis is a chronic inflammatory skin disease characterized by flare-ups of inflamed, dry, and itchy skin affecting over 200 million people worldwide. «Emollients plus» containing active cosmetic ingredients such as herbal extracts and phytochemicals have the potential to surpass the efficacy of conventional emollients, while avoiding side effects associated with pharmacological interventions. The reported…
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Impact of AI-Assisted Diagnosis on American Patients’ Trust in and Intention to Seek Help From Health Care Professionals: Randomized, Web-Based Survey Experiment
CONCLUSIONS: Despite AI’s growing role in medicine, patients still prefer human-only expertise, regardless of partisanship and demographics, underscoring the need for strategies to build trust in AI technologies in health care.
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Serious Illness Conversations in the Emergency Department for Older Adults With Advanced Illnesses: A Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this randomized clinical trial of seriously ill older adults in the ED, while a nurse-led SIC intervention did not significantly improve patient-reported engagement in ACP, it did increase clinician-documented SICs in the medical records. ED visits may serve as a critical access point to enhance SICs for seriously ill yet clinically…
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What is the impact on recruitment of a shortened compared with a standard-length participant information leaflet? PROMETHEUS in IBD-BOOST: study within a trial, a decentralised UK randomised controlled trial
CONCLUSION: We did not find evidence of a significant difference between RCT recruitment and retention rates in participants randomised to the standard-length PIL compared with the shortened. It may be that a shortened PIL has the same effect on recruitment and retention outcomes, providing that the trial does not require extensive information for other reasons…