Clinical Trials
Category Added in a WPeMatico Campaign
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Predicting Cognitive Decline Using Baseline Data in Cognitively Unimpaired Older Adults: Results from the A4 Trial (P2-3.018)
CONCLUSIONS: These findings underscore the importance of baseline neuropsychological scores and plasma P-tau217 in predicting cognitive decline. Predictive models using these practical measures can improve clinical trial design and optimize participant selection, enhancing the effectiveness of interventions. Disclaimer: Abstracts were not reviewed by Neurology® and do not reflect the views of Neurology® editors or staff.…
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The Impact of Ampreloxetine on Supine Hypertension: An Ambulatory Blood Pressure Monitoring Study. (S9.002)
CONCLUSIONS: We saw no signal for worsening of supine hypertension on ampreloxetine in patients with alpha-synucleinopathies and nOH. This suggests that, if the ongoing phase 3 study confirms safety and efficacy, ampreloxetine may be the first drug to treat nOH without exacerbating supine hypertension, which should not worsen intravascular volume loss overnight or add to…
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Distal access and procedural anticoagulation to prevent radial artery occlusion after coronary angiography — the randomised RAPID trial
CONCLUSIONS: While distal TRA did not reduce the risk of RAO, procedural AC proved effective in all patients undergoing transradial CAG including those on pre-existing oral AC. (Strategies to Maintain Radial Artery Patency Following Diagnostic Coronary Angiography [RAPID] trial; ClinicalTrials.gov: NCT04301921 [RAPID-1] and NCT04362020 [RAPID-2]).
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The effect of radio-frequency ablation in treating pulmonary ground glass nodule patients and its influence on pulmonary function
CONCLUSION: RFA for the therapy of pulmonary GGN is safe and effective, without surgical scar, and is less traumatic to the body, which has a good application prospect.
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Comparison of Liposomal Bupivacaine versus Bupivacaine in Superficial Parasternal Intercostal Plane Block for Cardiac Surgery with Median Sternotomy
CONCLUSIONS: Lip-BPVC initially increased inflammatory markers postoperatively, but levels were comparable to BPVC by 72 hours. It provided superior pain control and reduced opioid use compared to standard BPVC in CABG patients, with similar safety and recovery outcomes.
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Investigating the effectiveness and mechanism of Xinbao pill in micro vascular angina treatment
Coronary micro vascular dysfunction is attracting increasing attention, yet effective treatments remain inadequate. This study analysed the clinical efficacy and potential mechanisms of Xinbao pill in patients with microvascular angina (MVA). 200 MVA patients admitted from January 2020 to June 2021 were randomly divided into the control group (n = 100) and an observation group…
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The impact of refined nursing management on the diagnosis of early gastric cancer under ME-NBI
CONCLUSION: The application of refined nursing management combined with ME-NBI technology for the diagnosis of early gastric cancer can significantly improve patient compliance, gastric mucosal visibility, and gastric cancer detection rate, which is worthy of clinical promotion and application.
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Cryo-Induced Hypoalgesia: The Effects of an Acute Cryochamber Exposure on Pain Perception-A Randomised Controlled Cross-Over Trial
CONCLUSIONS: This study demonstrates that a three-minute cryochamber exposure induces robust hypoalgesia in healthy participants, as indicated by increased PPT, lasting up to 30 min but gradually declining over time.
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Efficacy of topical tacrolimus 0.03% ointment in combination with microneedling versus topical phenytoin 2% cream in combination with microneedling for the treatment of non-segmental facial vitiligo
CONCLUSION: Our results provide additional evidence for the potential positive role of phenytoin as a therapeutic option in patients with non segmental vitiligo. However, tacrolimus 0.03% ointment combined with microneedling was associated with a better response than phenytoin 2% cream combined with microneedling.
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Internet-based digital intervention to support the self-management of hypertension compared to usual care: results of the HALCYON randomized controlled trial
CONCLUSIONS: The present study shows first promising results of liebria’s effects on systolic blood pressure and social and work-related functioning. Future studies should aim to replicate effects in a larger sample to increase statistical power.