Clinical Trials
Category Added in a WPeMatico Campaign
-
Fractional CO2 laser with topical insulin versus PRP for atrophic acne scars: a randomized split-face study
Atrophic acne scarring is a prevalent problem that has been treated with a variety of procedures, each with various degrees of success. For better results, combined regimens of treatment are recommended. Our aim was to compare the efficacy of topical insulin against topical platelet-rich plasma (PRP) as an adjunct treatment to fractional CO2 laser for…
-
The efficacy of topical cetirizine using microneedling in androgenetic alopecia male patients
CONCLUSION: The microneedling of 1% topical cetirizine proved efficient in promoting hair growth without problems in the treatment of male androgenetic alopecia.
-
Efficacy of intradermal tranexamic acid injection following IPL for the treatment of persistent post acne erythema: a split-face, controlled trial
Post-acne erythema (PAE) is a common consequence of acne vulgaris, often leading to significant psychological distress and social impairment. While Intense Pulsed Light (IPL) has been proven as a non-invasive option for reducing erythema, the addition of adjunctive therapies may enhance treatment outcomes. To evaluate the effects of intradermal tranexamic acid (TXA) injections on the…
-
A qualitative exploration of factors that influence engagement with a digital mental health intervention for women with metastatic breast cancer: Finding My Way-Advanced
CONCLUSIONS: This study confirms that while many DMHI facilitators and barriers are consistent with those identified in curatively treated settings, some factors become more salient in metastatic populations (e.g., time burden). This research also offers novel insights that deriving early personal benefit promotes engagement and provides targets for future program improvements to address navigation and…
-
Ticagrelor Compared to Clopidogrel in Acute Coronary Syndromes trial (TC4): a Bayesian pragmatic cluster randomized controlled trial
BACKGROUND: Dual antiplatelet therapy is the standard of care for acute coronary syndrome, but uncertainty exists regarding the optimal regimen for patients in North America. We sought to compare the effectiveness and safety of acetylsalicylic acid (ASA) and ticagrelor or clopidogrel in patients with acute coronary syndrome from a single tertiary academic centre in Montréal,…
-
Videoconference-Delivered Acceptance and Commitment Therapy for Family Caregivers of People With Dementia: Pilot Randomized Controlled Trial
CONCLUSIONS: The videoconference-delivered ACT program showed promise in improving mental health outcomes and ACT processes among family caregivers with depression who give care to individuals with dementia. Future studies should aim to replicate these findings with larger, more diverse caregiver populations and explore the long-term efficacy of videoconference-delivered ACT programs.
-
Effectiveness of Massage Gun Versus Myofascial Release Technique for Releasing Latent Trigger Points of the Calf Muscle: A Protocol for Randomized Clinical Trial
BACKGROUND AND PURPOSE: Trigger points can disrupt muscle activity patterns and cause cramping, fatigue, and weakening. Massage guns and myofascial release are widely employed for such circumstances, but their isolated outcomes are unknown. This study aimed to compare the effectiveness of a massage gun versus myofascial release technique on subjective pain, pain pressure threshold and…
-
Evaluating reliable and clinically significant changes in health outcomes of a mindfulness-based cognitive defusion training program among older adults with mild cognitive impairment: a randomized controlled trial
CONCLUSIONS: The M-bCCDT program positively impacted perceived stress and mindfulness awareness in older adults with MCI, facilitating the improvements in memory and psychomotor speed, with these benefits sustained for 20 weeks. It offers a systematic approach for community healthcare providers in MCI stress management.
-
A group psychological intervention for postnatal depression in British mothers of South Asian origin — the ROSHNI-2 RCT
CONCLUSIONS: The results of this study provide robust evidence that the culturally adapted psychological intervention for postnatal depression in South Asian women is effective at the primary end point and acceptable to women.
-
Group Interpersonal Psychotherapy for Adolescents With Non-suicidal Self-injury: A Randomized Controlled Study
Non-suicidal self-injury (NSSI) is a significant clinical concern in adolescents. The goal of this study was to evaluate the efficacy of group interpersonal psychotherapy (G-IPT) combined with treatment as usual (TAU) compared with TAU alone in treating adolescents with NSSI. A randomized controlled trial was conducted in a psychiatric outpatient clinic in Hubei Province, China,…