Clinical Trials
Category Added in a WPeMatico Campaign
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Effectiveness of photobiomodulation therapy as an adjunct to surface spinal stimulation and activity-based therapy in compressive cervical myelopathy: a parallel group, non-blinded randomized controlled trial
To reverse the progression of compressive cervical myelopathy (CCM) by repairing injured nerve tissue, improving sensory integration, balance, disability, and quality of life (QoL) with Photobiomodulation Therapy (PBMT) as an adjunct to Surface Spinal Stimulation (SSS) and Activity-Based Therapy (ABT). Thirty-two individuals in the age group between, 20 and 65 years diagnosed with sub-acute CCM…
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Impact of an interdisciplinary digital consultation platform on general practitioner referrals for musculoskeletal symptoms: a stepped wedge cluster randomized trial
CONCLUSIONS: We observed a modest increase in appropriate referrals for orthopaedic review among GP practices randomized to the platform. On a larger scale, this could contribute to more sustainable access to specialist care.
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High-intensity exercise improves multidimensional fatigue and health-related quality of life in rheumatoid arthritis: a randomized controlled study
CONCLUSIONS: The high-intensity exercise intervention had a beneficial effect on multidimensional fatigue, and health-related quality of life in people with RA. The effect on fatigue and health-related quality of life persisted during the 12 months-follow up period indicating long-term effects.
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Effects of 2-year cocoa extract supplementation on inflammaging biomarkers in older US adults: findings from the COcoa Supplement and Multivitamin Outcomes Study randomised clinical trial
CONCLUSION: Cocoa extract supplementation significantly decreased hsCRP, supporting a role in modulating the chronic inflammaging process as a potential mechanism underlying its cardio-protective effects, including a 27% reduction in cardiovascular disease death in the COSMOS trial. The biological effect of increased IFN-γ by cocoa extract warrants further exploration.
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Synergistic effects of exercise, cognitive training and vitamin D on gait performance and falls in mild cognitive impairment-secondary outcomes from the SYNERGIC trial
CONCLUSION: Aerobic-resistance exercise combined with sequential computerised cognitive training improved gait performance at 6 months and decreased the risk of falls and injuries at 12 months in older adults with MCI. The addition of vitamin D did not produce benefits.
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Effectiveness of Smartwatch Device on Adherence to Home-Based Cardiac Rehabilitation in Patients With Coronary Heart Disease: Randomized Controlled Trial
CONCLUSIONS: This study demonstrates that a smartwatch-facilitated HBCR model is both feasible and effective in enhancing adherence and improving clinical outcomes among patients with CHD. These findings support the integration of wearable technology into routine HBCR and lay the groundwork for future large-scale, multicenter trials.
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Prospective associations between sleep quality and sexual satisfaction in distressed breast cancer survivors: Secondary analysis from the Apps Reaching Cancer Survivors randomized trial
CONCLUSIONS: Poor sleep and low sexual satisfaction commonly co-occur among distressed breast cancer survivors and are cross-sectionally related. However, changes in these domains occurred independently over time, highlighting the importance of evaluating both concerns and providing domain-specific survivorship care.
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Efficacy of β-Blockers in Older Adults With Hypertension Combined With Vascular Dementia
CONCLUSION: The β-blocker metoprolol effectively controlled blood pressure, significantly reduced levels of pro-inflammatory factors and specific vascular injury markers, and improved cognitive function and behavioral symptoms in older patients with hypertension combined with vascular dementia, suggesting its therapeutic efficacy for this condition. However, attention should be paid to its associated adverse reactions.
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Effect of Fospropofol Disodium on Perioperative Neurocognitive Function in Elderly Patients Undergoing Total Hip Arthroplasty
CONCLUSION: Fospropofol disodium may be a viable alternative in settings where injection pain and PONV are primary concerns, provided that hemodynamic stability is actively managed in elderly THA patients, with non-inferior efficacy in preventing PND compared to propofol and fewer adverse effects. Age and preoperative cognitive function are critical predictors of PND, warranting careful consideration…
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Clinical Efficacy of Acupuncture Combined With Acupoint Patching in Treating Chronic Pelvic Pain as a Sequela of Pelvic Inflammatory Disease
CONCLUSION: Acupuncture combined with acupoint patching demonstrates significant efficacy in treating SPID-CPP. This combined therapy effectively reduces pain in SPID-CPP patients, decreases serum levels of inflammatory factors, and significantly improves patients’ quality of life.