Clinical Trials
Category Added in a WPeMatico Campaign
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Impact of point-of-care maternal viral load testing at delivery on vertical HIV transmission risk assessment and neonatal prophylaxis: a cluster randomized trial
CONCLUSIONS: PoC maternal VL testing at delivery significantly increased the proportion of infants identified to be at high risk. Infants at high risk whose mothers received PoC VL at delivery were more often initiated on ePNP. However, the linkage of infants at high risk to appropriate prophylaxis remains suboptimal, warranting consideration of universal ePNP.
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Impact of a Targeted 8-Week Exercise Program on Pain Measures and Isokinetic Muscle Strength in Females With Patellofemoral Pain Syndrome: A Randomized Controlled Trial
BACKGROUND AND PURPOSES: Patellofemoral pain syndrome (PFPS) is a prevalent condition among physically active females and is often associated with reduced hip and knee muscle strength, altered biomechanics, and pain-related disability. Weight-bearing exercise programs may enhance neuromuscular control and functional outcomes, but their effects on multiple objective and subjective measures have not been comprehensively studied…
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Unreactive EEG Background Is Associated With Unfavorable Outcome in Patients With Disorders of Consciousness of Various Etiologies: An Adult Cohort Study
CONCLUSION: In this etiologically mixed cohort of critically ill adults, unreactive EEG predicted unfavorable outcome at 6 months with high specificity. EEG reactivity may reduce prognostic uncertainty not only for patients with HIBI, but also for other types of acute brain injury, such as TBI and ICH.
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Tolerability and Efficacy of Duloxetine Compared to Amitriptyline in Women With Chronic Pelvic Pain Syndrome: Findings From a Clinical Trial
CONCLUSIONS: These findings suggest that duloxetine is as effective as amitriptyline for managing CPP syndrome in women, with the added advantage of a more favorable safety profile.
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Evaluatıng the Role of Overactıve Bladder Dıagnosıs ın Predıctıng the Rısk of Postspınal Hypotensıon Durıng Electıve Cesarean Sectıon Operatıons: Randomızed Trıple-Blınded Study
CONCLUSION: The risk of postspinal hypotension in parturients with overactive bladder is higher. Higher caution must be taken for hypotension after SA intervention in patients with over active bladder.
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MANAGEMENT OF HYPERSENSITIVITY IN MOLAR INCISOR HYPOMINERALISATION USING PHOTOBIOMODULATION AND SEALANTS IN CHILDREN: A RANDOMIZED CLINICAL TRIAL
CONCLUSION: Both glass ionomer and resin-based sealants and PBM are effective in reducing hypersensitivity associated with MIH.
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The Desensitizing Effect of Nanosilver Fluoride Compared to Photobiomodulation Therapy in Molar-Incisor Hypomineralization: A Randomized Clinical Trial
CONCLUSION: NSF and PBMT reduced sensitivity associated with MIH and provided immediate pain relief. However, NSF was superior due to its longer-lasting effects on sensitivity and additional benefit in plaque reduction.
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A randomized controlled trial comparing large-volume band ligator and cyanoacrylate injection in the endoscopic management of actively bleeding gastric varices
Managing actively bleeding gastric varices (GV) is clinically challenging. This study assessed the safety and efficacy of endoscopic band ligation (EBL) using large-volume ligators compared with endoscopic variceal obturation (EVO) in managing actively bleeding GV. Patients who were diagnosed with active GV bleeding via endoscopy and underwent EBL with large-volume band ligators or EVO were…
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Effects of combined metformin and semaglutide therapy on body weight, metabolic parameters, and reproductive outcomes in overweight/obese women with polycystic ovary syndrome: a prospective, randomized, controlled, open-label clinical trial
CONCLUSION: Compared to MET monotherapy, combination therapy with semaglutide and MET significantly reduced body weight, improved insulin resistance, decreased inflammatory markers, alleviated and menstrual irregularities and increased natural pregnancy rates in overweight/obese women with PCOS.
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Disease activity and treatment response in early rheumatoid arthritis: an exploratory metabolomic profiling in the NORD-STAR cohort
CONCLUSIONS: Our study has identified several baseline metabolites and metabolic pathways associated with disease activity and response to different treatments in early RA. By integrating metabolomics and clinical data, we developed predictive models for response to treatment in early RA, though their predictive performance remains limited.