Clinical Trials
Category Added in a WPeMatico Campaign
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Agreement between intraocular pressure measurement using Goldmann applanation tonometry with and without fluorescein in consecutive Ghanaian patients
CONCLUSION: Unadjusted IOP measurement without fluorescein was approximately 3 mmHg significantly lower than with fluorescein. We recommend practitioners maintain the gold standard GAT with fluorescein to guide accurate glaucoma diagnosis and management decision-making.
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Efficacy of semilunar ganglion radiofrequency thermal coagulation in moderate and severe trigeminal postherpetic neuralgia and its impact on serum IL-1β and IL-6 levels
CONCLUSION: Gasserian ganglion RF-TC is a safe, effective TPHN treatment, achieving significant pain reduction and proinflammatory cytokine suppression.
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Value of targeted next-generation sequencing in pathogen detection for neonates with respiratory distress syndrome: a prospective randomized controlled trial
CONCLUSIONS: tNGS significantly improves the pathogen detection rate in neonates with moderate to severe RDS and offers advantages in the rapid identification of co-infections and reduction of antibiotic treatment duration, suggesting it has clinical utility and potential for wider adoption.
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Low-dose rapamycin alleviates clinical symptoms of fatigue and PEM in ME/CFS patients via improvement of autophagy: a pilot study
CONCLUSIONS: Low-dose rapamycin effectively reduced PEM and other key symptoms in patients with ME/CFS, as measured by BAS, SSS, MFI, and SF-36. Future studies should encompass dose optimization and develop a diagnostic tool to identify responders with mTOR-mediated autophagy disruption.
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Diagnostic performance of a 250-ml net ultrafiltration challenge to identify risk of preload-dependence in critically ill patients undergoing continuous renal replacement therapy: a randomized, cross-over trial
CONCLUSIONS: A 250-ml UF(NET) challenge had acceptable diagnostic performance to identify preload-independent patients becoming preload-dependent during CRRT, with no detectable difference between fast and slow challenges. A CCI variation ≥ 5% during a PM in preload-independent patients may help identify those at risk of becoming preload-dependent.
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Investigation of the effectiveness of cooling spray on mammography comfort
Breast cancer is one of the most common cancer types in recent years. Early diagnosis of breast cancer increases the success of treatment. Breast cancer screening is thus highly critical. Mammography is a screening tool that is still globally valid. I would propose that Mammography can potentially be painful. In our study, we aimed to…
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Use of a Generative Pretrained Transformer to Answer Questions and Facilitate a Large Randomized Controlled Trial
CONCLUSIONS: This novel use of a customized GPT suggests it could be valuable in support of clinical sites within a large trial. Further research should confirm equivalent accuracy and safety through a direct comparison to human support.
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Randomized trial of the effect of esomeprazole on functional dyspepsia during Ramadan fasting
Dyspeptic symptoms are frequently encountered during Ramadan and may be exacerbated by changes in eating habits. We assessed the efficacy of esomeprazole in patients with functional dyspepsia (FD) who fasted during Ramadan. In this randomized, double-blind controlled study, 245 patients diagnosed with FD who completed Ramadan fasting were randomly assigned (1:1 ratio) to receive either…
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Linked color imaging improves polyp miss rates in total colonoscopy in a multicenter randomized back to back trial
Linked color imaging (LCI) was developed to detect gastrointestinal neoplasms. The current study aimed to determine whether the use of LCI, compared with white-light imaging (WLI), can improve the miss rates of colorectal polyp. A multicenter, randomized back-to-back study was conducted in 16 Japanese endoscopy units. Patients were randomized according to examination: tandem colonoscopy with…
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Effects on chemotherapy-induced peripheral neuropathy by moderate strength training in combination with whole-body vibration in breast cancer patients
CONCLUSION: Both strength training alone and combined with WBV are feasible and safe during chemotherapy. Although WBV did not provide additional benefits over strength training alone, both interventions showed potential protective effects against CIPN symptoms.