Clinical Trials
Category Added in a WPeMatico Campaign
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Extracellular vesicles from bronchoalveolar lavage fluid provide insights into the inhaled corticosteroids treatment response in COPD
CONCLUSIONS: Our findings highlight the potential of BALF-derived EVs as a biomarker source for predicting ICS responsiveness in COPD. The CST family, especially CST1, potentially serves as a valuable indicator for identifying patients who are more likely to benefit from ICS treatment.
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Efficacy and safety of dapagliflozin in patients hospitalized with COVID-19 with and without type 2 diabetes: a prespecified analysis of the DARE-19 randomized trial
CONCLUSIONS: Initiating dapagliflozin in patients hospitalized for acute COVID-19 was well tolerated and safe, irrespective of T2D status. Serum biomarker levels remained stable and comparable between treatment groups, indicating no increased risk of adverse metabolic or renal effects with dapagliflozin in this clinical scenario.
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Efficacy of superior laryngeal nerve block in reducing retching during transesophageal echocardiography: a randomized controlled trial
CONCLUSIONS: Bilateral iSLN block significantly reduces the incidence of retching and oropharyngeal mucosal bleeding, while improving patient comfort, increasing the rapid TEE probe insertion rate, and stabilizing MAP during TEE examination. This technique can significantly improve patient experience and safety during TEE procedures.
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Dexamethasone for 12 weeks for reducing fatigue in patients receiving palliative chemotherapy: A Phase 3, Placebo-Controlled, Randomized Controlled Trial
CONCLUSION: Dexamethasone did not significantly reduce cancer-associated fatigue or improve QOL in patients receiving palliative chemotherapy. The findings highlight the need to explore alternative, more effective interventions for managing fatigue in this population.
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Effect of nasal mask oxygenation on incidence of hypoxemia during gastroscopy with propofol sedation in patients at risk of hypoxemia: a prospective randomized controlled study
CONCLUSION: In patients with obesity or OSA, nasal mask oxygenation during gastroscopy with propofol sedation significantly reduced the incidences of hypoxemia, subclinical respiratory depression, and severe hypoxemia without increasing other adverse events.
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Effects of sacubitril/valsartan on hypertensive heart disease: the REVERSE-LVH randomized phase 2 trial
Diffuse interstitial fibrosis is associated with adverse outcomes in hypertensive heart disease and may be reversible. Sacubitril/valsartan could offer greater anti-fibrotic effects than valsartan alone. In the REVERSE-LVH phase 2 open-labelled trial (clinicaltrials.gov NCT: 03553810; funded by the National Medical Research Council of Singapore), 78 patients with essential hypertension and left ventricular hypertrophy (LVH) were…
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A randomized controlled trial comparing treatment efficacy between rapid maxillary expansion and adenotonsillectomy in pediatric obstructive sleep apnea
CONCLUSION: RME and AT significantly improved sleep-related respiratory parameters in patients with POSA. RME demonstrated comparable efficacy to AT in reducing AHI and improving LAST, MSAT, and REM sleep time. However, AT provided significantly better improvement in clinical symptoms and quality of life.
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THE EFFICACY OF RANIBIZUMAB COMBINED WITH SUBSCLERAL TRABECULAR SURGERY IN THE TREATMENT OF NEOVASCULAR AGE-RELATED MACULAR DEGENERATION
CONCLUSION: The clinical effect of subscleral trabecular surgery combined with intravitreal injection of ranibizumab in the treatment of NVG patients is positive, which can more effectively correct the visual acuity and intraocular pressure of patients.
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Psychosocial Intervention and Rehabilitation Utilization Together Improve Pain and Function After Traumatic Orthopaedic Injuries: A Secondary Analysis of a Randomized Controlled Trial
CONCLUSION: The combination of TOR and rehabilitation utilization resulted in short-term improvements in physical function after traumatic orthopaedic injury. Participants who received TOR experienced clinically meaningful short-term improvements in pain, pain catastrophizing, and pain anxiety. These data may support the inclusion of screening for psychological response to injury within routine clinical practice. For patients with…
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Machine Learning-Based Cognitive Assessment With The Autonomous Cognitive Examination: Randomized Controlled Trial
CONCLUSIONS: In this study, we evaluated if the ACoE could reliably phenotype cognitive symptoms relative to the assessments of established standard paper-based cognitive assessments. We found that the ACoE reliably phenotypes patient cognition, which can be used to screen patients. In the future, these cognitive phenotypes may be used to diagnose specific etiologies.