Clinical Trials
Category Added in a WPeMatico Campaign
-
Reducing blood pressure variability-results from a single-arm proof of concept prospective trial
Increased variability in systolic blood pressure, expressed as the coefficient of variation (BPCoV), is associated with poor cardiovascular outcomes. Variability could be due to episodic non-adherence to medical recommendations in some patients. Reports of targeted attempts to mitigate such variation are lacking. A behavioral intervention targeted at patients with initially high BPCoV may decrease variability.…
-
Assessing participants’ experiences with the COVID-19 symptom diary in a clinical trial
During a phase 2/3 study of twice-daily nirmatrelvir 300 mg coadministered with ritonavir 100 mg versus placebo for 5 days (NCT05011513), participants reported presence and severity of COVID-19 symptoms using a COVID-19 symptom diary in accordance with FDA guidance. Here, we aimed to evaluate the content validity of the COVID-19 symptom diary and global impression…
-
Clinical efficacy of endocrinotherapy combined with Shenqi Pills on patients with hormone-sensitive prostate cancer
CONCLUSION: Endocrinotherapy combined with Shenqi Pills is safe and effective in HSPC and can reduce the risk of death in HSPC patients, and the earlier the intervention, the longer the overall survival of the patients. In addition, this treatment regimen can increase the PSA response rate, improve patients’ quality of life, and reduce the renal-yang…
-
Study on the treatment of chronic nonbacterial prostatitis caused by dampness-heat stasis with Oxalis Formula combined with transacupuncture
CONCLUSION: The combination of Oxalicao Formula and transacupuncture for treating CNP characterized by dampness-heat stasis demonstrates significant therapeutic benefits, which has considerable clinical application value.
-
Psychological intervention based on the extension and expansion of positive psychology model improves psychosexual resilience and erectile function in patients with psychogenic ED
CONCLUSION: For the treatment of pED, PERMA-based psychological intervention in addition to active medication contributes to elevating the psychological resilience and improving the erectile function of the patients.
-
Sertraline hydrochloride combined with compound chamomile lidocaine gel for the treatment of premature ejaculation
CONCLUSION: Sertraline hydrochloride combined with compound chamomile lidocaine gel is definitely effective in the treatment of PE, which can significantly improve the patients’ quality of sexual life, with a high safety and low incidence of adverse reactions.
-
Randomized controlled trial on the clinical efficacy of hernia needle combined with single port laparoscopic scrotal approach and testicular arch fixation for the treatment of middle and low cryptorchidism in children
CONCLUSION: HN-SLATO has a significant clinical efficiency and high safety in the treatment of mid-low cryptorchidism in children, which can effectively improve intraoperative fixation and postoperative aesthetics of the testis, as well as reduce pain, serum inflammatory indicators and postoperative complications.
-
Effects of high-protein nutritional supplementation on nutritional status, physical function, and quality of life in older gastric cancer patients receiving neoadjuvant chemotherapy: a randomized trial
CONCLUSIONS: High-protein ONS improved nutritional status and reduced malnutrition risk in older gastric cancer patients undergoing NAC. Further research is needed to assess the long-term effects of ONS on physical function and quality of life.
-
Successfully Reducing Sitting Time Can Improve Metabolic Flexibility
Impaired metabolic flexibility (MetFlex; the ability to regulate substrate oxidation) and sedentary behavior are both linked to cardiometabolic diseases, but the relationship between the two is not fully elucidated. This study investigated the effects of reduced sedentary time on MetFlex. Sixty-four sedentary adults with metabolic syndrome were randomized into intervention (INT, n = 33) and…
-
Beyond the splint: efficacy and safety of kinesio taping for non-operative management of finger injuries
BACKGROUND: This prospective comparative study aimed to evaluate the efficacy of kinesio-taping (KT), buddy taping (BT), and conventional splinting in managing finger joint sprains and fractures across pediatric and adult populations, with a focus on functional recovery and patient-centered outcomes.