Clinical Trials
Category Added in a WPeMatico Campaign
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Evaluating relapse prophylaxis in addition to interdisciplinary multimodal pain therapy for back pain: a randomised controlled trial
CONCLUSION: Findings of this study show improvements in the secondary outcomes. The results indicate that further studies are needed to determine how to sustainably reduce days off work due to back pain.
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Physical fitness and clinically assessed disease burden in long-term childhood cancer survivors-The SURfit study
CONCLUSION: CCS participating in an exercise intervention trial experienced a high burden of adverse health outcomes. Increased physical fitness was associated with reduced disease burden for all survivors, emphasizing the importance of encouraging fitness improvements, regardless of cancer history.
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Efficacy and safety of upadacitinib as monotherapy or combined with elsubrutinib for the treatment of systemic lupus erythematosus: results through 104 weeks in a long-term extension study
CONCLUSIONS: In this LTE study, upadacitinib monotherapy and upadacitinib/elsubrutinib combined were well tolerated and continued to demonstrate beneficial effects on SLE disease activity, glucocorticoid dose and flares through 104 weeks.
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Oestrogen replacement combined with resistance exercise in older women with knee osteoarthritis: a randomised, double-blind, placebo-controlled clinical trial
CONCLUSIONS: ERT did not confer significant additive benefits to resistance exercise overall but may improve outcomes in early-stage KOA and mental health domains. These exploratory findings warrant further investigation.
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Minimal vs Specialized Exercise Equipment for Pulmonary Rehabilitation: A Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: This randomized clinical trial found that PR-min demonstrated noninferiority to PR-gym for exercise capacity, dyspnea, and health-related quality of life. PR-min can expand the number of settings where PR can be provided, thus improving patient accessibility.
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Effects of occupational therapy on hand function in patients with systemic sclerosis: a randomized controlled trial
Hand involvement is one of the most disabling features of systemic sclerosis (SSc). Although occupational therapy is frequently employed in rheumatic conditions, its particular effects in SSc have not been studied in detail yet. This study aimed to evaluate the impact of a structured three-week occupational therapy program on hand function in SSc. This randomized…
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Factors associated with distress over time in women with breast cancer undergoing radiotherapy: insights from a pilot study assessing a digital information tool
CONCLUSION: The results indicate no statistically significant effect on distress; however, there is a potential indication of a reduction in distress, suggesting that the digital information tool may offer some benefits. Further research is required to confirm this relationship.
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Association of Intraoperative Hypotension with Postoperative Nausea and Vomiting in Laparoscopic Gastrointestinal Surgery: A Secondary Analysis of a Randomized Trial
CONCLUSIONS: Intraoperative hypotension was not associated with PONV in patients at high risk of PONV who underwent laparoscopic gastrointestinal surgery.
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Two is Better Than One: Potentiating Cognitive Remediation With Aerobic Exercise to Improve Cognition in Schizophrenia With a Randomized Controlled Trial
CONCLUSIONS: While preliminary, these findings suggest that a combined intervention of CR+AE allows greater improvements across core cognitive domains. In a wider perspective, this study also underscores the potential value of implementing aerobic exercise in rehabilitative approaches aimed at addressing cognitive dysfunction in schizophrenia.
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Spinal Anaesthesia Versus General Anaesthesia for Patients With Tibia Shaft Fractures-A Randomized Controlled Study
CONCLUSION: Spinal anaesthesia was not associated with higher compartment pressures compared to general anaesthesia. These findings suggest that prevailing concerns and recommendations about spinal anaesthesia for tibia shaft fracture surgery may need reconsideration and challenge recommendations favouring general anaesthesia as the primary method.