Clinical Trials
Category Added in a WPeMatico Campaign
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Safety findings from the phase 1/2 MOSAIC study of miransertib for patients with PIK3CA-related overgrowth spectrum or Proteus syndrome
CONCLUSION: Miransertib was safe and tolerable in participants with a confirmed diagnosis of PROS or Proteus syndrome. Future investigations are needed to determine whether patients receive measurable clinical benefit from miransertib.
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The VIP trial: a randomised controlled trial of the clinical effectiveness of a Victim Improvement Package (VIP) for the reduction of continued symptoms of depression or anxiety in older victims of community crime in an English city
CONCLUSIONS: Community crime had long-lasting impacts. The police are ideally placed to screen for distress, present in 35% of victims, but only 58% of participants were recruited and the cognitive-behavioural therapy was not delivered competently. Further research on victim care and improving the delivery and quality of therapy is required.
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Adherence to Quality-of-Care Indicators and Mortality Outcomes in Patients With MRSA Bacteremia: A Post Hoc Analysis of the CAMERA2 Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this post hoc analysis of a randomized clinical trial, health care practitioners of trial participants had greater adherence to QCIs for MRSA bacteremia management compared with practitioners of nontrial patients. Trial participation was not associated with lower mortality.
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Modified Target Delineation and Moderately Hypofractionated Radiotherapy for High-Grade Glioma: A Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this randomized clinical trial, modified target delineation with HSIB-IMRT demonstrated comparable PFS and OS to standard IMRT in patients with newly diagnosed HGG, while significantly reducing the irradiation target volume without increasing the recurrence rates outside the target volume. These results suggest valuable insights for future research aimed at personalized, reduced…
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Effect of Ciprofol on Postoperative Delirium in Elderly Patients Undergoing Hip Surgery: A Randomized Controlled Trial
CONCLUSION: In this study, we found that ciprofol was associated with a lower incidence of POD and had a minimal impact on circulatory function. SIRT3 expression and POD were correlated. A serum SIRT3 level less than 1.565 ng/mL on postoperative day 1 may indicate a likelihood of POD, highlighting its potential diagnostic value.
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Feasibility of a Randomized Controlled Trial of Large AI-Based Linguistic Models for Clinical Reasoning Training of Physical Therapy Students: Pilot Randomized Parallel-Group Study
CONCLUSIONS: While LLMs have the potential to enhance specific digital competencies in physical therapy students, their practical integration into the curriculum faces challenges. Future studies should focus on improving student engagement with LLMs and extending the training period to determine the feasibility of integrating this tool into physical therapy education and maximize benefits.
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Prospective comparison of static versus dynamic images in abdominal ultrasound education — a randomised controlled trial
CONCLUSION: Dynamic images in ultrasound education improve comprehension of pathological findings over static images. These insights should inform the development and adaptation of future training programs and educational materials to enhance the quality of ultrasound education and diagnostic accuracy.
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Exploring the effects of outdoor physical work in the heat, with or without sodium bicarbonate supplementation, on markers of acute kidney injury
Acute kidney injury (AKI) has been observed after prolonged physical activity in the heat. Although a range of strategies to reduce the incidence of AKI have been investigated, sodium bicarbonate (SB) supplementation may mitigate metabolic stress during physical exertion and potentially alleviate renal workload by lowering glomerular filtration demand, reducing bicarbonate reabsorption, and preserving kidney…
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Assessing the Role of Statins as an Adjunctive Anti-VEGF Therapy for Clinically Significant Macular Edema (CSME) in Type 2 Diabetes Mellitus
CONCLUSIONS: Low-dose atorvastatin (10-20 mg) as an adjunct to anti-VEGF therapy resulted in better functional and anatomical outcomes in diabetic patients with CSME compared to high-dose atorvastatin. These findings suggest potential additional benefits of low-dose statins in managing patients with chronic subdural hematoma (CSME).
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Effects of erythromycin dosage on clinical outcomes in stable non-cystic fibrosis bronchiectasis: A randomized controlled trial
CONCLUSION: The oral erythromycin regimen at a dose of 500 mg/d can improve the lung function and quality of life of stable NCFB patients.