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Assessing Fidelity to HIV Index Case Testing Protocols in Malawian Clinical Settings: Results From a Cluster Randomized Controlled Trial
CONCLUSIONS: The digital training substantially improved HCW fidelity to index and contact client protocols. A decentralized digital training can be used to improve HCW counselling behaviour. Future research should explore the methods of assessing fidelity in trials of complex digital training interventions in other settings. →
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Changes in ectopic lipids, insulin sensitivity, and beta cell function after a low-fat vegan diet in adults with type 2 diabetes: a 16-week single-arm clinical trial
CONCLUSIONS: On an ad libitum low-fat plant-based (vegan) dietary intervention, the participants with type 2 diabetes experienced reductions in ectopic fat, particularly visceral and hepatocellular fat, improvements in insulin sensitivity, reductions in AGEs, and improvements in beta-cell function. →
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Association Between a Hybrid Video-Guided Multicomponent Exercise Program With Staff Assistance and Free-Living Gait in Older Adults With Knee and Low Back Pain: Secondary Analysis of a Randomized Controlled Trial
CONCLUSIONS: A 12-week hybrid exercise program may improve the quality of daily-life walking, with the clearest effect observed on step length. Given the attenuation after multiplicity-aware interpretation and in sensitivity analyses, these findings should be interpreted as suggestive rather than definitive. →
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Estimating the Economic Value of Supported Online Parent-Led Cognitive Behavioral Therapy to Prevent Child Anxiety Problems: Economic Evaluation of the MYCATS Cluster Randomized Controlled Trial
CONCLUSIONS: OSI+TS is cost-effective compared to usual school provision, supporting its future implementation for children at risk of anxiety problems. →
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Is This a Job for a Human or AI?
As firms eagerly scramble to integrate AI into their workflow, it can feel a bit like throwing spaghetti at the wall. Maybe AI will improve customer service? Maybe it can focus on low-level work? Maybe it will help with analysis, streamline supply chains, or write better executive talking points? This experimentation to see what sticks… →
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Effect of amaranth flatbread on maternal anthropometry during pregnancy: Evidence from a cluster-randomized controlled trial in Southern Ethiopia
CONCLUSIONS: Daily consumption of amaranth grain flatbread significantly improved maternal anthropometric indicators, suggesting its potential as a sustainable nutritional intervention to enhance maternal nutritional status in resource-limited settings. These findings support integration of nutrient-rich traditional foods into maternal dietary programs. →
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Immunohistochemistry for c-MET, HLA class II, and CD68 does not show prognostic value in early-stage classic Hodgkin lymphoma patients in the EORTC-GELA H9 intergroup randomised trial
CONCLUSIONS: Using a rigorous statistical approach, we found that none of the three candidate biomarkers correlated with patient outcomes. While this lack of validation may be explained by trial-specific factors, such as risk-adapted treatment, the exclusion of advanced-stage patients, or challenges in scoring, these biomarkers provide insufficient prognostic value for implementation in clinical practice. →
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The Effect of Cerebellar tDCS On Inhibitory Control in Healthy Adults: Exploring Trait Moderation
Transcranial direct current stimulation (tDCS) research on inhibitory control (IC) has largely focused on prefrontal targets, with inconsistent results, while the cerebellum’s contribution to executive control networks remains underexplored. This study examines whether cerebellar anodal tDCS modulates IC in healthy adults, using both proactive (Go/No-Go) and reactive (Stop Signal) inhibition measures, and explores whether dispositional… →
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Microperimetry Sensitivity Changes at the Functional Transition Zone and at the EZ Margins in X-Linked Retinitis Pigmentosa Treated With Gene Therapy
CONCLUSIONS: High-dose AAV-RPGR gene therapy was associated with improved MP outcomes and greater ATE inside FTZ and intact EZ; however, loci with ≥7 dB improvement did not correlate with baseline EZ margin distance, highlighting challenges in prespecifying localized ≥7 dB changes. →
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Psychosocial mediators for the impact of personal genomic risk information on melanoma prevention and early detection behaviors
CONCLUSIONS AND RELEVANCE: The effectiveness of precision prevention and early detection interventions may be enhanced by targeting key psychosocial mediators through tailored communication of personal melanoma risk. →
