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Olaparib, durvalumab, and cyclophosphamide, and a prognostic blood signature in platinum-sensitive ovarian cancer: the randomized phase 2 SOLACE2 trial
SOLACE2 (ACTRN12618000686202) investigates whether 12-weeks of olaparib, or cyclophosphamide-olaparib priming, improves subsequent durvalumab-olaparib progression-free survival (PFS), and is superior to olaparib monotherapy without any priming, in platinum-sensitive recurrent ovarian cancer (n = 114). We also evaluate the utility of CUP-CC assay, an immune signature of C-C chemokine receptor type 4 up-regulation, chemokines, and cytokines. Priming… →
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Long-term safety and efficacy of upadacitinib in Japanese patients with rheumatoid arthritis and inadequate response to conventional synthetic disease-modifying antirheumatic drugs: 5-year results from the SELECT-SUNRISE randomised controlled trial
CONCLUSIONS: Upadacitinib showed sustained efficacy with no new safety signals identified through 5 years of treatment and is a long-term treatment option for Japanese patients with rheumatoid arthritis and csDMARDs-IR. →
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Safety of Using Risk Stratification Along With High-Sensitivity Cardiac Troponin in the Emergency Department: A Secondary Analysis
CONCLUSIONS: Risk stratification with high-sensitivity cardiac troponin reduced length of stay and increased discharge from the emergency department in both low- and intermediate-risk patients with suspected acute coronary syndrome. Patients discharged from the emergency department were at lower risk of subsequent myocardial infarction or cardiac death at 1 year. (High-Sensitivity Cardiac Troponin on Presentation to… →
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What Stablecoin Regulation Means for Business
Carolyn Geason-Beissel/MIT SMR | Getty Images For much of the 20th century, speaking on the phone across state lines was a luxury good — a conversation that ran a tab by the minute, all controlled by the Bell System in its private fiefdom. Decades later, policy rewired the economics of the communications infrastructure. The AT&T… →
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Generalist AI Introduces GEN-θ: A New Class of Embodied Foundation Models Built for Multimodal Training Directly on High-Fidelity Raw Physical Interaction
Generalist AI Introduces GEN-θ: A New Class of Embodied Foundation Models Built for Multimodal Training Directly on High-Fidelity Raw Physical Interaction Understanding the Target Audience The primary audience for GEN-θ encompasses professionals in robotics, artificial intelligence, and business management sectors, particularly those involved in research and development, product management, and strategic implementation of AI technologies.… →
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Clinical trial of feasibility for mindfulness intervention for patients with newly diagnosed high grade glioma
CONCLUSIONS: Mindfulness intervention during active treatment for patients with high grade glioma is feasible. Given these results, a larger study has the potential to benefit patients with high grade glioma on active treatment. →
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Does social media promotion influence citation counts? A long-term follow-up to a randomised trial in a general neurosurgical journal
Social media promotion has become mainstream for neurosurgical publications. Any effect of promotion on citation counts would significantly influence academia and is currently not well-studied. We previously reported that structured social media promotion of neurosurgical articles had no significant effect on citation counts, website visits, or PDF downloads at one- and two-years post promotion. In… →
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Pentraxin-3 and Lipocalin-2 are decreased in patients with uveal effusion syndrome
CONCLUSION: Lipocalin-2 and Pentraxin-3 values, which are known to be induced by glucocorticoids, tend to be lower in patients with UES. The results suggest an impairment in the glucocorticoid receptor pathway and underline the hypothesis of a common pathophysiological pathway of CSCR and UES. →
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Impact of Animal-Assisted Interactions on Quality of Life in Children With Relapsed/Refractory Cancer and Their Parents: A Randomized Controlled Pilot Study
BackgroundChildren with cancer are at increased risk for cognitive and physical suffering from side effects of treatment and disease sequelae. Animal-assisted interactions (AAIs) with canine therapy show strong promise to improve physical and psychosocial outcomes for children newly diagnosed with cancer. Few rigorous studies have focused on the role of AAI for children with relapsed/refractory… →
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Targeting Intolerance of Uncertainty During Pregnancy: A Randomized Controlled Trial to Prevent Postpartum Anxiety Disorders
Objective: Postpartum anxiety is common, often underrecognized, and associated with numerous negative outcomes for both the perinatal individual and their infant. Despite its high prevalence and burden, research focused on preventative strategies for postpartum anxiety remains very limited. This study investigated whether a 6-week cognitive behavioral therapy protocol targeting intolerance of uncertainty (CBT-IU) during pregnancy… →
