-
Intended isocaloric time-restricted eating shifts circadian clocks but does not improve cardiometabolic health in women with overweight
Time-restricted eating (TRE) is a promising strategy to improve metabolic outcomes. However, it remains unclear whether TRE has cardiometabolic benefits in an isocaloric setting and whether its effects depend on the eating timing. We conducted a randomized crossover trial in 31 women with overweight or obesity to directly compare the effects of a 2-week early… →
-
Association between intraoperative hypotension during brain tumor resection and postoperative delirium: A secondary analysis of a randomized controlled trial
CONCLUSIONS: The current results could not indicate intraoperative hypotension of mean arterial pressure lower than 65 mmHg associated with delirium after frontotemporal brain tumor resection. →
-
Microsoft Releases Agent Lightning: A New AI Framework that Enables Reinforcement Learning (RL)-based Training of LLMs for Any AI Agent
Microsoft Releases Agent Lightning: A New AI Framework that Enables Reinforcement Learning (RL)-based Training of LLMs for Any AI Agent Understanding the Target Audience The target audience for Microsoft’s Agent Lightning comprises AI developers, product managers, and business executives in tech sectors focusing on AI applications. These individuals are primarily concerned with integrating AI solutions… →
-
Brief Video Intervention to Increase Treatment-Seeking Intentions Among Young Adults With Psychiatric Symptoms: A Randomized Controlled Trial
Objective: Brief social contact-based video interventions are effective in decreasing self-stigma and increasing treatment-seeking intentions. The present study is the first to target essential workers with self-reported anxiety, depression, and posttraumatic stress disorder (PTSD) symptoms during the COVID-19 pandemic. We hypothesized that viewers of the intervention would show greater increases in treatment-seeking intentions than nonviewers… →
-
Multi-wave locked system laser therapy in chronic non-specific neck pain: a double-blind placebo randomized-controlled trial
CONCLUSIONS: Both MLS Laser and Sham Laser therapies resulted in statistically significant improvements in pain, disability, and movement velocity. However, these changes were not clinically meaningful. MLS Laser therapy provided more pronounced and sustained pain relief and improved range of motion in head movements. →
-
Cost-utility analysis of a polylactic acid matrix versus a collagen dressing for the closure of diabetic foot ulcers
CONCLUSION: PLA dermal matrices provide a cost-effective alternative to collagen dressings, promoting faster wound closure, improved quality of life, and reduced healthcare costs. These results support the adoption of PLA as a preferred treatment for DFUs. →
-
Investigation of the Relevance of CYP3A4 Inhibition on the Pharmacokinetics of the Novel P2X3 Antagonist Filapixant: Results of In Vitro Explorations and a Fixed-Sequence Clinical Trial with Itraconazole in Healthy Volunteers
Hypersensitized P2X3 receptor signaling has been described to play a role in several disorders, including chronic cough. The goal of our in vitro and in vivo studies was to investigate the biotransformation and the influence of CYP3A4 inhibition on the pharmacokinetics of the selective P2X3 antagonist filapixant. Metabolic turnover of filapixant in human liver microsomes… →
-
The establishment and application of an early warning scoring system for neonatal pneumonia based on information technology
CONCLUSION: The application of an early warning scoring system for neonatal pneumonia based on information technology can shorten the time to symptom resolution, improve respiratory status, normalize blood gas indices, and reduce the incidence of complications. →
-
Liquid AI Releases LFM2-ColBERT-350M: A New Small Model that brings Late Interaction Retrieval to Multilingual and Cross-Lingual RAG
Liquid AI Releases LFM2-ColBERT-350M: A New Small Model that Brings Late Interaction Retrieval to Multilingual and Cross-Lingual RAG Target Audience Analysis The target audience for the LFM2-ColBERT-350M model primarily includes data scientists, AI researchers, and business managers in tech companies focused on natural language processing (NLP) and information retrieval. These professionals are often tasked with… →