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Message-Based vs Video-Based Psychotherapy for Depression: A Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this sequential multiple assignment randomized clinical trial comparing MBP with VBP, there were no differences between groups on improvement in depression or social functioning. More participants in the VBP group disengaged from treatment, while VBP also had greater therapeutic alliance early in treatment among nonresponders. There were no differential effects from… →
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Impact of astaxanthin on oxidative markers, uric acid, and clinical symptoms in heart failure: a randomized clinical trial
CONCLUSION: These findings suggest that ASX supplementation may be effective in improving oxidative stress biomarkers and clinical status in patients with HF. →
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A Neuroaffirmative, Self-Determination Theory-Based Psychosocial Intervention for Adults With Attention-Deficit/Hyperactivity Disorder: Randomized Feasibility Study
CONCLUSIONS: This study suggests that a randomized controlled trial of an SDT-based psychosocial intervention with nondeficit-based outcomes for adults with ADHD is feasible and recommended. →
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Multilevel and multicomponent intervention to promote colorectal cancer screening among Vietnamese Americans: a cluster randomized trial
CONCLUSIONS: This multicomponent intervention significantly improved CRC screening rates among Vietnamese Americans, highlighting the importance of community engagement and tailored health interventions that addresses individual and community level barriers. →
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How to Build Ethically Aligned Autonomous Agents through Value-Guided Reasoning and Self-Correcting Decision-Making Using Open-Source Models
«`html How to Build Ethically Aligned Autonomous Agents through Value-Guided Reasoning and Self-Correcting Decision-Making Using Open-Source Models In this tutorial, we explore how to build an autonomous agent that aligns its actions with ethical and organizational values. We utilize open-source Hugging Face models running locally in Colab to simulate a decision-making process that balances goal… →
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Fight Versus Flight: When a Leader’s Fears Turn Into Anger
Carolyn Geason-Beissel/MIT SMR | Getty Images You probably understand that the typical responses to fear are fight or flight. Two other options are freeze and fawn, which, like flight, are used by people trying to avoid or minimize a scary situation. In the context of leadership advice, we’ve tended to focus on the flight response… →
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Podcast: Managing Layoffs without Compromising Your Morals
Like it or not, making layoffs is a skill. “ They are just a predictable part of business and they are an important part of building business literacy,” says Brooke Vuckovic, a clinical professor of management and organizations at Kellogg. But middle managers, especially those early in their careers, are still caught off guard when it… →
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Safety, Efficacy, and Immunogenicity of a Salmonella Paratyphi A Vaccine
CONCLUSIONS: In healthy U.K. adults who were challenged with S. Paratyphi A in a controlled human infection model, a two-dose series of CVD 1902 led to protection against S. Paratyphi A infection without safety concerns. (Funded by the Medical Research Council; VASP ISRCTN Registry number, 15485902.). →
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European Study of Prostate Cancer Screening — 23-Year Follow-up
CONCLUSIONS: Long-term follow-up confirms a sustained reduction in deaths from prostate cancer with PSA testing, alongside an improved harm-benefit ratio. Future screening strategies should adopt risk-based approaches to minimize overdiagnosis while maintaining clinical benefits. (Funded by the Dutch Cancer Society and others; ERSPC ISRCTN registry number, ISRCTN49127736.). →
