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The Effect of Probiotic Use on Gut Leakage Measured by Zonulin and its Relation to P Cresyl Sulfate and Inflammation in Hemodialysis Patients: A prospective controlled clinical study
CONCLUSIONS: Probiotic administration in hemodialysis patients improved intestinal barrier integrity, reduced gut-derived toxin levels, and lowered systemic inflammation. →
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Effect of vitamin D supplementation on metabolic syndrome and atherosclerosis biomarkers in epilepsy: a randomized controlled trial
CONCLUSION: Vitamin D supplementation (2,000 IU/day) effectively restores 25(OH)D levels and improves adiponectin and hs-CRP in epilepsy patients on enzymatic ASMs, suggesting a potential benefit for cardiovascular risk reduction. However, vitamin D alone did not prevent the rise in homocysteine, likely due to the concurrent cessation of B-vitamin supplementation. →
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Modified Cryotherapy During Final Irrigation Reduces Postoperative Pain and Anxiety in Pediatric Primary Molar Root Canal Therapy
CONCLUSION: Modified cryotherapy applied during final root canal irrigation significantly reduces short-term postoperative pain and enhances clinical cooperation in school-age children. →
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Response of reticulocyte and red blood cell indices to single-dose intravenous iron in pregnant women with moderate iron deficiency anemia: secondary analysis of the RAPIDIRON trial
CONCLUSION: Intravenous iron therapy produces a more rapid and pronounced improvement in maternal red cell and reticulocyte indices than oral iron in moderately anemic pregnant women. Ret-He and IRF are emerging as early and sensitive biomarkers of iron availability and erythropoietic activity, with potential clinical utility for early detection of treatment response and optimization of… →
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Randomized Clinical Trial of Imagery Stabilization and Rescripting Therapy for Psychiatric Outpatients with Posttraumatic Stress Disorder
CONCLUSION: Our findings suggest that ISRT is a safe and effective treatment option for PTSD. →
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Why Adventure Matters in Long Working Lives
Emma Hanquist/Ikon Images In my ongoing exploration about the patterns and changes in how people approach their working lives, I’ve found myself looking back at my own memories from over five decades of work. What stands out is not simply the steady progression of roles and achievements but the disproportionate impact of recurring moments of… →
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Take 5: Social Media … IRL?
For better or worse, social media is now just … media. Scrolling through the feeds has become a daily—if not hourly—ritual for people around the world, and it’s the primary way most of us get our news, stay connected with friends, and find our next big purchase. The ubiquity of social-media apps makes them fertile… →
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Podcast: The Climate Crisis Is Here. Will We Ever Fix It?
To be sustainable these days, at least in America, can feel like a full-time job. You’re supposed to buy the right things, avoid the wrong ones, recycle perfectly, waste nothing, think about every decision … and even then, it’s hard to know if any of it is actually making a difference. So the question is,… →
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The effectiveness of care coordination on medication adherence among high-need, high-cost commercially insured beneficiaries: A randomized controlled trial
CONCLUSIONS: We found that care coordination did not improve medication adherence in HNHC beneficiaries. Our results align with prior studies and emphasize the challenges of improving adherence within a complex HNHC beneficiary population. →
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Heart Attack Education and EMS Response in High-Risk, Low EMS Usage Areas: A Stepped-Wedge Cluster-Randomized Trial
CONCLUSIONS AND RELEVANCE: In this community ACS education trial conducted in high-risk regions, the intervention did not improve EMS use or prehospital care-seeking. External contextual factors, including the COVID-19 pandemic and natural disasters, appeared to influence patient behavior and may have attenuated intervention effects, highlighting the complexity of achieving behavioral change through community education alone. →
