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Eppikajutsuto for Treatment of Lymphatic Malformations in Children: A Nonrandomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this nonrandomized clinical trial of children with LMs, eppikajutsuto was associated with a reduction in lesion volume and was well tolerated. Further studies, including randomized clinical trials, are warranted to confirm these findings. →
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Anyscale and NovaSky Team Releases SkyRL tx v0.1.0: Bringing Tinker Compatible Reinforcement Learning RL Engine To Local GPU Clusters
Anyscale and NovaSky Team Releases SkyRL tx v0.1.0: Bringing Tinker Compatible Reinforcement Learning RL Engine To Local GPU Clusters Understanding the Target Audience The target audience for the SkyRL tx v0.1.0 release primarily includes AI developers, data scientists, and machine learning engineers who are focused on reinforcement learning (RL) applications. These professionals are often working… →
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Proteins linked to type II interferon response in Sjögren’s disease: novel indicators for disease monitoring and predicting treatment response to leflunomide and hydroxychloroquine combination therapy
CONCLUSION: These data support a significant role for a type II IFN-associated immune response in SjD pathogenesis, which is targeted by LEF/HCQ. Proteins associated with type II IFN-driven immune responses hold potential to monitor disease activity and predict treatment response. →
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Comprehensive microbial and clinical profiling of functional constipation: A stratified comparative study of age and constipation subtype
CONCLUSION: Significant differences in microbial composition and function were observed across age groups and constipation subtypes in FC, suggesting underlying pathophysiological heterogeneity and providing a basis for precision diagnosis and treatment. →
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The anti-inflammatory effects of dexamethasone implants in eyes with heavy silicone oil: a prospective study on vitrectomy for diabetic retinopathy
CONCLUSION: To our knowledge, this first study of dexamethasone implants with HSO in PDR suggests intraoperative DEX may be a safe, potentially beneficial adjunct for diabetic TRD undergoing phacoemulsification plus vitrectomy with HSO, reducing inflammation and number of anti-VEGF injections over 3 months, and offering useful directions for future research in this preliminary prospective evaluation… →
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The effectiveness of symptom-oriented mind mapping combined with problem-based learning in critical care clerkships: a randomized controlled trial
CONCLUSION: The study demonstrated that the SOM-PBL approach significantly enhanced medical students’ knowledge integration and clinical decision-making efficiency during ICU clerkships. However, no significant improvement was observed in procedural skills. These findings offer both theoretical and practical value for innovating critical care medical education by effectively addressing knowledge fragmentation and bridging the theory-practice gaps. →
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Population Pharmacokinetic and Pharmacokinetic-Pharmacodynamic Analysis for Clazakizumab in Patients With End-Stage Kidney Disease Undergoing Dialysis
The inflammatory cytokine interleukin-6 (IL-6) plays a significant role in the progression of cardiovascular disease (CVD). We evaluated the impact of clazakizumab, a monoclonal antibody targeting the IL-6 ligand, upon high-sensitivity C-reactive protein (hs-CRP) as part of the dose-finding phase 2b trial. In this randomized, double-blind trial, adults with cardiovascular disease and/or diabetes receiving maintenance… →
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Nano3D: A Training-Free Approach for Efficient 3D Editing Without Masks
Nano3D revolutionizes 3D asset editing by enabling training-free, part-level shape modifications like removal, addition, and replacement without any manual masks. Developed by researchers from Tsinghua University, Peking University, HKUST, CASIA, and ShengShu, Nano3D bridges the gap between text-driven 2D editing and 3D object manipulation. Unlike existing 3D editing methods that require time-consuming optimization or mask… →
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Triangle Splatting+: Differentiable Rendering with Opaque Triangles
Triangle Splatting+ redefines 3D scene reconstruction and rendering by directly optimizing opaque triangles, the fundamental primitive of computer graphic, in a fully differentiable framework. Unlike Gaussian Splatting or NeRF-based approaches, it delivers real-time, game-engine-ready meshes without post-processing, enabling instant compatibility with engines like Unity or Unreal. Developed by researchers from the University of Liège, Simon… →
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An interactive digital behaviour change intervention to decrease incidence of sexually transmitted infections among users of STI self-sampling websites: a feasibility RCT
CONCLUSIONS: A full trial is feasible. Despite the low recruitment rate, there are sufficiently high numbers of young people accessing web-based sexually transmitted infection testing (585,000 per year based on most recent data) to achieve the required sample. Suggested strategies to address the potential for under- and over-representation of some demographic subgroups at M12 should… →
