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Theoretical Cost-Effectiveness of PCSK9 Inhibitors in Stroke Due to Intracranial Atherosclerosis
CONCLUSIONS AND RELEVANCE: This theoretical framework suggests that alirocumab and evolocumab were cost-effective for preventing recurrent stroke in patients with severe intracranial atherosclerosis, with all agents cost-effective under current cost-sharing programs offered by commercial and Medicare plans. →
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Effects of acute HMB-FA supplementation on antioxidant status and muscle damage in Elite Judoka: a randomized pilot trial
CONCLUSION: Acute post-exercise HMB-FA supplementation in elite judo athletes did not significantly influence muscle damage or oxidative stress markers but transiently increased antioxidant enzyme activities (CAT, GPX, and SOD). These findings suggest an enzyme-specific effect and highlight the need for future studies using more precise oxidative-stress markers and cellular assays to better evaluate antioxidant responses;… →
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Serum Biomarkers and CT-Derived Muscle Indices in Sarcopenia Associated with Pancreatic Neoplasm: A Comparative Clinical Study
Background: Sarcopenia is a frequent and clinically relevant condition in patients with pancreatic neoplasm, contributing to poor prognosis, reduced therapeutic tolerance, and increased mortality. The identification of reliable circulating biomarkers, alongside imaging-based muscle assessment, may improve early detection and risk stratification. Methods: This randomized prospective study included 61 patients, of whom 36 had pancreatic neoplasm… →
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Effects of incentive spirometer added to standard rehabilitation in previously hospitalized adults with post-COVID-19 condition: a randomized controlled trial
CONCLUSION: Adding incentive spirometry to standard rehabilitation improved peak expiratory flow and reduced dyspnoea in adults with post-COVID-19 condition, supporting its use as a low-cost adjunct for respiratory symptom management. →
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Phase II trial of combination radiation, hormone, and immunotherapy in grade group 5 prostate cancer
CONCLUSIONS: Nivolumab combined with SOC was associated with encouraging FFBR in this high-risk GG5 PCa population and may represent a promising therapeutic intensification strategy. The Decipher immunosuppression score may serve as a predictive biomarker for response. These findings warrant further investigation in randomized trials. →
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The Innovation Advantage GenAI Can’t Give You
Eliot Wyatt/Ikon Images For most of modern business times, competitive advantage belonged to whoever had the best ideas. Better ideas meant better products, which meant more customers, which meant more revenue and profit. The entire innovation industry — consultancies, design firms, brainstorming retreats fueled by sticky notes and gallons of La Croix — was built… →
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Why You Should Take Feedback Personally
Gina Fong would like to offer some feedback … on feedback. Fong, a consumer anthropologist and clinical assistant professor of marketing at the Kellogg School, wants us to rethink the ways we give and receive evaluation in the workplace. And she starts by dispelling a common myth. “We are told a lie with… →
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Evaluating the effects of trifocals and extended depth of focus intraocular lens implantation on stereopsis and contrast sensitivity in cataract patients
CONCLUSION: Both IOLs provided good stereopsis and contrast sensitivity in the early postoperative period. However, by 1 month, EDOF IOLs demonstrated significantly better stereopsis and improved contrast sensitivity. →
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Quantitative flow ratio versus fractional flow reserve: 2-year follow-up of the FAVOR III Europe trial
CONCLUSIONS: The excess risks associated with QFR-guided revascularisation compared with FFR were confined to the first year. From 1 to 2 years, the rates of MACE developed similarly in the QFR and the FFR groups. →
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Effects of Daily Saskatoon Berry Supplementation on Cardiometabolic Health, Gut Microbiota, and Short-Chain Fatty Acids in Healthy Adults
Saskatoon berry (SB), a traditional food of Indigenous people, has been associated with cardiometabolic benefits in animal models; however, its effects on humans remain unclear. This study investigated the effects of dried SB consumption on cardiometabolic outcomes, gut microbiota, and short-chain fatty acids (SCFAs) profiles in healthy adults. In a 10-week, single-arm, and open-label trial,… →
