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Effect of electroacupuncture at Yifeng (TE17) and Fengchi (GB20) on prognosis of moderate-to-severe peripheral facial paralysis in the acute stage: a randomized controlled trial
CONCLUSION: Electroacupuncture at Yifeng (TE17) and Fengchi (GB20) can effectively promote the recovery of voluntary movement in the middle and lower facial muscles of patients with moderate-to-severe peripheral facial paralysis in the acute stage, and improve their physical and social functions, demonstrating a high clinical application value. →
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Mammographic surveillance in breast cancer patients aged 50 years or older: a synopsis of the Mammo-50 RCT
CONCLUSION: For patients aged ≥ 50 years and 3 years post diagnosis, less-frequent mammograms were non-inferior and cost-effective compared with annual mammograms, with no detriment to patients’ quality of life. Mammo-50 provides evidence to inform guideline development. →
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Timing matters in type 2 diabetes: Early high-Fiber nutrition enhances glycemic control and reshapes gut microbiota
Early, intensive dietary intervention may open a therapeutic window for type 2 diabetes (T2D) remission. We conducted a randomized, 2:1 crossover trial in 34 newly diagnosed overweight or obese patients with T2D. Participants were assigned to receive either high-fiber nutritional therapy (HFNT)-a 7-day very-low-calorie, high-fiber diet followed by a 23-day standard diabetes diet-or conventional diabetes… →
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Olaparib combined with abiraterone in HRR-mutated metastatic hormone-sensitive prostate cancer: a single-arm phase II trial
CONCLUSION: In this phase II single-arm study, olaparib plus abiraterone and ADT showed preliminary activity and a manageable safety profile in patients with HRR-mutated mHSPC, but these findings need to be confirmed in larger phase III studies. →
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User perspectives on the Molbio Truenat platform and tuberculosis assays for decentralised testing in Mozambique and Tanzania
CONCLUSIONS: The Truenat platform and TB assays were perceived as easy to use by health providers, and as acceptable and feasible across stakeholder groups. Its implementation in decentralised settings was considered a preferred alternative to off-site Xpert testing for TB in Mozambique and Tanzania. →
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How Leaders Can Move Past Personal Obstacles
Brian Stauffer/theispot.com Imagine you’re Gabrielle, a senior leader at a fast-growing tech company. Two of your top performers are also your biggest headaches, and they’re making everyone miserable — most of all, you. One is technically brilliant but undermines colleagues’ ideas with sly sarcasm and strategic inaction. The other is a creative powerhouse but belittles… →
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Podcast: Why Companies Can’t Keep Their Climate Commitments
We’d like to think that businesses have the power to make a difference on the climate. It’s why we pressure them to make commitments to reduce their emissions. That way, we can hold them to their word. Many such commitments were made after the Paris Accords. But today? Most companies aren’t even close to achieving… →
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Evaluating the Efficacy of Intranasal Montelukast in Pediatric Acute Asthma Attacks: A Single-blinded, Placebo-controlled Clinical Trial
Asthma is a common chronic respiratory disease in children, often leading to acute exacerbations marked by dyspnea, cough, and wheezing, which frequently necessitate emergency medical care. While standard therapies are effective, the exploration of novel drug delivery routes continues. Oral montelukast is a recognized treatment, but the efficacy of its intranasal formulation for acute attacks… →
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Sintilimab plus cisplatin and nab-paclitaxel induction treatment for locally advanced borderline-resectable oesophageal squamous cell carcinoma: A single-arm, prospective, phase 2 study (NEOCRTEC2001)
CONCLUSIONS: The regimen under investigation did not exhibit the anticipated statistical benefit in enhancing surgical conversion rates for BR-ESCC. Nevertheless, the treatment strategy of induction immunochemotherapy followed by surgery resulted in significant tumour downstaging and a significant pathological complete response rate. Patients who achieved R0 resection exhibited improved survival outcomes. →
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Beyond efficacy: pulse duration is crucial for adverse events in pulsed dye laser therapy for rosacea
CONCLUSION: Both pulse durations effectively reduced erythema, but 10 ms demonstrated more favorable tolerability. →
